Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis
ConclusionThis is the first culture‐independent study characterizing the gut microbial community in postinfectious arthritis. Although bacterial factors correlated with disease presence and clinical features of ReA, host genetics also appeared to be a major independent driver of intestinal community composition. Understanding of these gut microbiota–host genetic relationships may further clarify the pathogenesis of postinfectious spondyloarthritides. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 3, 2018 Category: Rheumatology Authors: Julia Manasson, Nan Shen, Helga R. Garcia Ferrer, Carles Ubeda, Isa Iraheta, Adriana Heguy, Joan M. Von Feldt, Luis R. Espinoza, Abraham Garcia Kutzbach, Leopoldo N. Segal, Alexis Ogdie, Jose C. Clemente, Jose U. Scher Tags: Original Article Source Type: research
Implications of elevated C ‐reactive protein and serum amyloid A levels in IgG4‐related disease: comment on the article by Perugino et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 3, 2018 Category: Rheumatology Authors: A. Faiz Karim, Laura E. M. Eurelings, P. Martin Hagen, Jan A. M. Laar Tags: Letters Source Type: research
Cancer immunotherapy in patients with preexisting rheumatologic disease: the Mayo Clinic experience
ConclusionTo our knowledge, this represents the largest single‐center cohort of patients with rheumatologic diseases who were exposed to modern cancer immunotherapy. Only a minority of these patients experienced a flare of their preexisting rheumatologic disease or any other IRAE.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Michael D. Richter, Olga Pinkston, Lisa A. Kottschade, Heidi D. Finnes, Svetomir N. Markovic, Uma Thanarajasingam Tags: Brief Report Source Type: research
Blood T Follicular Regulatory Cells / T Follicular Helper Cells ratio Marks Ectopic Lymphoid Structure Formation and PD ‐1+ICOS+ T Follicular Helper Cells Indicate Disease Activity in Primary Sjögren's Syndrome
ConclusionsBlood Tfr/Tfh ratio and PD‐1+ICOS+ Tfh cells constitute potential novel biomarkers for different features of primary SS. While blood Tfr/Tfh ratio is associated with ectopic lymphoid neogenesis, activated Tfh cells indicate disease activity.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Valter R Fonseca, Vasco C Rom ão, Ana Agua‐Doce, Mara Santos, Dolores López‐Presa, Ana Cristina Ferreira, João Eurico Fonseca, Luis Graca Tags: Full Length Source Type: research
Efficacy and safety of cyclophosphamide treatment in severe juvenile dermatomyositis shown by marginal structural modelling
ConclusionCYC is efficacious with no short‐term side‐effects seen in this study. Improvements in skin, global and muscle disease were observed. Further studies are required to evaluate longer‐term side‐effects.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Claire T. Deakin, Raquel Campanilho ‐Marques, Stefania Simou, Elena Moraitis, Lucy R. Wedderburn, Eleanor Pullenayegum, Clarissa A. Pilkington, Tags: Full Length Source Type: research
The Childhood Arthritis & Rheumatology Research Alliance Consensus Treatment Plans: Towards Comparative Effectiveness in the Pediatric Rheumatic Diseases
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Sarah Ringold, Peter A. Nigrovic, Brian M. Feldman, George A. Tomlinson, Emily von Scheven, Carol A. Wallace, Adam M. Huber, Laura E. Schanberg, Suzanne C. Li, Pamela F. Weiss, Robert C. Fuhlbrigge, Esi M. Morgan, Yukiko Kimura Tags: Review Article Source Type: research
Switched Memory B Cells Are Increased In Oligoarticular And Polyarticular Juvenile Idiopathic Arthritis And Their Change Over Time Is Related To Response To TNF Inhibitors
ConclusionsSwM B‐cells expand during disease course in JIA patients at a faster rate than in healthy children. This increase is more evident in early‐onset JIA; TNFi treatment inhibits this increase in patients who achieve and maintain remission, but not in those with active diseaseThis article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Emiliano Marasco, Angela Aquilani, Simona Cascioli, Gian Marco Moneta, Ivan Caiello, Chiara Farroni, Ezio Giorda, Valentina D'Oria, Denise Pires Marafon, Silvia Magni ‐Manzoni, Rita Carsetti, Fabrizio De Benedetti Tags: Full Length Source Type: research
Effects of HLA ‐B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis
ConclusionEffects of HLA‐B27 on gut microbiota and dysbiosis in SpA are highly dependent on host genetic background and/or environment despite convergence of dysregulated immune pathways. These results indicate an ecological model of dysbiosis where the effects of multiple microbes contribute to the aberrant immune response, rather than a single or small number of microbes driving pathogenesis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 30, 2017 Category: Rheumatology Authors: Tejpal Gill, Mark Asquith, Stephen R. Brooks, James T. Rosenbaum, Robert A. Colbert Tags: Full Length Source Type: research
Editorial: Bench to Bedside —and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Janet E. Pope, Jason J. Lee, Christopher P. Denton Tags: Editorial Source Type: research
Belimumab for the Treatment of Early Diffuse Systemic Sclerosis
ConclusionPatients in both treatment groups experienced significant improvements in MRSS. The median difference was greater in the belimumab group but did not achieve statistical significance in this small pilot study. AEs were similar between the groups. Changes in gene expression were consistent with mechanism of action and showed that clinical response to treatment with belimumab is associated with a significant decrease in profibrotic genes and pathways. Additional studies are needed to determine the role of belimumab in the treatment of dcSSc. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Jessica K. Gordon, Viktor Martyanov, Jennifer M. Franks, Elana J. Bernstein, Jackie Szymonifka, Cynthia Magro, Horatio F. Wildman, Tammara A. Wood, Michael L. Whitfield, Robert F. Spiera Tags: Original Article Source Type: research
Bench to Bedside —and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Janet E. Pope, Jason J. Lee, Christopher P. Denton Tags: Editorial Source Type: research
Loading ‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage Osteoarthritis
ConclusionSince focal stress on the SBP underlying sites of cartilage damage increases during late stages of OA, these findings establish mechanical loading–induced attenuation of sclerostin expression and elevation of bone formation along the SBP surface as the major mechanisms characterizing subchondral bone phenotypes associated with severe late‐stage OA in mice. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J. Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei ‐Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X. Sherry Liu, James H. C. Wang, Lin Han, Motom Tags: Original Article Source Type: research
High levels of DEK autoantibodies in sera of polyarticular JIA patients and in early flare following cessation of anti ‐TNF therapy
ConclusionsDEK autoantibody levels are higher in patients with polyarticular, rather than oligoarticular, JIA and in patients who flare after cessation of anti‐TNF therapy. The C‐terminal 25 aa is the most immunogenic portion of DEK. These findings are of significance with respect to the nature of DEK autoantibodies and their contribution to the pathogenesis and management of JIA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Nirit Mor ‐Vaknin, Miguel Rivas, Maureen Legendre, Smriti Mohan, Ye Yuanfan, Theresa Mau, Anne Johnson, Bin Huang, Lili Zhao, Yukiko Kimura, Steven J. Spalding, Paula W. Morris, Beth S. Gottlieb, Karen Onel, Judyann C. Olson, Barbara S. Edelheit, Michae Tags: Full Length Source Type: research
The Tumor ‐like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Sungyong You, Jung Hee Koh, Lin Leng, Wan ‐Uk Kim, Richard Bucala Tags: Review Article Source Type: research
Hip and knee arthroplasty utilization and outcomes in the United States and Canada: an analysis of New York and Ontario administrative data
ConclusionOntario has higher TJA utilization than NY, but a smaller percentage of hospitals performing these procedures. Patients are more likely to be discharged home and less likely to be readmitted in Ontario. Our results suggest areas where each jurisdiction could improve.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - December 29, 2017 Category: Rheumatology Authors: Peter Cram, Bruce E. Landon, John Matelski, Vicki Ling, Therese A. Stukel, J.Michael Paterson, Rajiv Gandhi, Gillian A. Hawker, Bheeshma Ravi Tags: Full Length Source Type: research
