Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery
Conclusion: In SMA patients with previous spinal surgery, the use of imaging-guided intervention is necessary for administering intrathecal nusinersen. Transforaminal technique is indicated in patients for whom the interlaminar space is not available, and injections should always be guided by either CT or fluoroscopy.RESUMO Introdu ção: A atrofia muscular espinal (AME) é uma desordem neurodegenerativa dos motoneurônios inferiores frequentemente associada à ocorrência de deformidade da coluna vertebral. Nusinersena é um oligonucleotídeo antisense que aumenta os níveis da proteína SMN, sendo administrado através ...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Prevalence of multiple sclerosis in key cities of Brazil. A study in Joinville, Southern Brazil
Conclusions: Despite its latitude location and European colonization, the prevalence rate was below expectation. The intense internal migration from regions with lower MS prevalence rates to Joinville may have played a role in attenuating the increased risk of MS associated with latitude gradient and European ancestry. Prevalence studies in other cities from Southern Brazil with no significant internal migration and taking part in this broad project may clarify this issue.RESUMO Introdu ção: O Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla (EM) (BCTRIMS) lançou uma iniciativa para determinar a preva...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Parkinson's disease effect on autonomic modulation: an analysis using geometric indices
Conclusions: The results suggest a reduction in the parasympathetic autonomic modulation and global variability in individuals with PD compared to controls, regardless of sex, age, and bod y mass index.RESUMO Introdu ção: A doença de Parkinson (DP) produz alterações autonômicas, que indicam menor modulação parassimpática e variabilidade global, mas que devem ser investigadas quanto aos métodos geométricos. Objetivo: Investigar a modulação autonômica em indivíduos com DP, por meio de índices de v ariabilidade da frequência cardíaca (VFC) obtidos pelos métodos geométricos. Métodos: Estudo transversal,...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Knowledge and attitudes in dementia held by general practitioners in the primary care setting of Botucatu, São Paulo, Brazil
Conclusions: More training for GPs on dementia should be provided.RESUMO Introdu ção: A doença de Alzheimer é a principal causa de demência em todo o mundo. Apesar das evidências alarmantes sobre a prevalência de demência, a condição ainda é subdiagnosticada por clínicos gerais na atenção primária. A detecção precoce da doença é benéfica para pacientes e fami liares, que devem receber orientações abrangentes sobre como lidar com as complicações relacionadas às demências, abrangendo aspectos médicos, familiares e sociais, proporcionando assim uma oportunidade de planejar o futuro. Objetivo: O ob...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Small vessel occlusion and syphilis in patients with first-ever ischemic stroke
Conclusion: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis.RESUMO Introdu ção: A sífilis é uma doença endêmica, especialmente em países de baixa e média renda, com acometimento vascular descrito em grandes vasos (aortite), porém nenhuma relação clara foi reconhecida em paciente com acidente vascular cerebral, exceto para aqueles com sífilis meningovascular. O bjetivos: Investigar a relação entre...
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

The relationship of syphilis to small vessel stroke in the absence of neurosyphilis: real or imaginary?
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - March 19, 2021 Category: Neurology Source Type: research

Thanks to Editorial Board of Arquivos de Neuro-Psiquiatria
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Reply to the letter “Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination”
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Multifocal T2-/DWI-hyperintense cerebral lesions in COVID-19 not necessarily imply demyelination
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Solitaire stent retriever failure during thrombectomy: is there any image that can predict non-recanalization?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Facial paralysis in the acute form of Chagas disease
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Complicated retropharyngeal abscess: an atypical cause of myelopathy
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

The controversial Third Reich history of Hans Creutzfeldt: was he a supporter or just another adept of the “hand washing policy”?
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt ’ s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, ...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Denny-Brown and Pennybacker: 80 years after their pioneering article on electromyography, fibrillation and fasciculation
We present a historical review, highlighting the role of Professor Derek Denny-Brown and doctor Joseph Buford Pennybacker in the development of current electromyography (EMG), of the 80 years since the publication of his original report in 1938 on fasciculation and fibrillation potentials and the subsequent studies describing most of the electrical changes necessary to perform and interpret the EMG.RESUMO Os autores apresentam uma revis ão histórica destacando o papel do Professor Derek Denny-Brown e do doutor Joseph Buford Pennybacker no desenvolvimento da eletromiografia atual, ao longo dos oitenta anos de seu artigo o...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research

Acute hepatic porphyrias for the neurologist: current concepts and perspectives
Conclusions: This review article highlights the main biochemical, pathophysiological, clinical, and therapeutic aspects of acute hepatic porphyrias in clinical practice.RESUMO Introdu ção: As porfirias hepáticas agudas representam um grupo de doenças metabólicas hereditárias complexas em expansão, decorrentes de erros inatos do metabolismo, envolvendo a via de biossíntese do grupamento heme. Objetivo: realizar revisão dos principais aspectos clínicos e terapêuticos as sociados com as porfirias hepáticas agudas. Métodos: Os autores realizaram ampla revisão não-sistemática sobre conceitos atuais e conhecim...
Source: Arquivos de Neuro-Psiquiatria - February 26, 2021 Category: Neurology Source Type: research