A comprehensive analysis of the angiogenesis-related genes in glioblastoma multiforme vs. brain lower grade glioma
Conclusions: VEGFA and CXCL8 are important factors for angiogenesis, which are suggested to have significant roles during tumorigenesis. Our results provide further evidence that VEGFA and CXCL8 could induce angiogenesis and promote LGG to progress into GBM. These findings could be useful in developing novel targeted therapeutics approaches in the future.Resumo Os tumores cerebrais s ão uma das causas mais comuns de mortes relacionadas ao câncer em todo o mundo. A angiogênese tem caráter crítico em gliomas malignos de alto grau, como o glioblastoma multiforme. Objetivo: O objetivo deste estudo foi analisar comparat...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Resolution of headache after reduction of prolactin levels in hyperprolactinemic patients
Conclusion: Data allow us to conclude that, in this series, in the majority of cases the reduction in the level of PRL was followe3d by cessation or relief of the pain.Resumo Os adenomas secretores de prolactina (PRL) est ão associados à alta incidência de cefaleia. O papel da hiperprolactinemia no contexto da dor de cabeça não está claro, nem o efeito da redução dos níveis da PRL na cefaleia. Métodos: O presente estudo longitudinal avaliou pacientes hiperprolactinêmicos (69), quanto à presença e às c aracterísticas da cefaleia antes e após o tratamento da hiperprolactinemia. Resultados: Cefaleia foi r...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats
Conclusions: Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.Resumo Objetivo: O ácido fito-hormônio abscísico (ABA) existe como molécula sinalizadora em vários tipos de organismos, de multicelulares a células e tecidos animais. Foi demonstrado que o ABA tem efeito antinociceptivo em roedores. O presente estudo foi desenhado para avaliar o possível papel da PKA e da ERK f osforilada (p-ERK) nos efeitos antinociceptivos do ABA intratecal (i.t.) em ratos Wistar machos. Métodos: Os animais foram canulados por via i.t. e di...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study
Conclusion: The samba protocol seems to be feasible and saf e for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.Resumo Fundamentos: Novos protocolos aplicados na reabilita ção da doença de Parkinson possibilitam diferentes estratégias de atuação para profissionais de saúde, além de um novo leque de atividades para estes indivíduos. Entretanto, não se encontrou na literatura qualquer protocolo de ...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Clinical performance of fixed-pressure Sphera Duo® hydrocephalus shunt
Conclusion: Sphera Duo® shunt system is safe when used in adult patients suffering from hydrocephalus, pseudotumor cere bri or arachnoid cyst.Resumo Introdu ção: As complicações da hidrodinâmica cerebral em pacientes com derivação ventriculoperitoneal são frequentemente relacionadas ao malfuncionamento do sistema. O objetivo deste estudo retrospectivo de coorte de centro único é avaliar a segurança e performance clínica do Sistema Sphera® Duo quando utilizado em adultos com hidrocefalia, pseudotumor cerebral ou cistos aracnoides. Métodos: Avaliamos os prontuários de 112 pacientes adultos submetidos a c...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Association between cognitive impairment and criteria for frailty syndrome among older adults
Conclusion: Older adults with frailty have a greater likelihood of concomitant cognitive impairment than prefrail and robust older adults. The prevalence of cognitive impairment and frailty is consistent with data reported in literature. The present findings contribute to the investigation of cognitive frailty.Resumo A associa ção entre comprometimento cognitivo e fragilidade tem sida estudada em idosos e os critérios de fragilidade e níveis de fragilidade podem também apresentar influência na função cognitiva. Objetivo: Analisar a associação entre comprometimento cognitivo e os critérios de fragilidade em id...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Arquivos 2020
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
CLIPPERS: a recognizable image of a treatable disease
ABSTRACT A brief history of the syndrome discovered by Andreas Rett is reported in this paper. Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian fam...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Fulminant toxoplasmosis presenting as isolated myelitis
ABSTRACT A brief history of the syndrome discovered by Andreas Rett is reported in this paper. Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian fam...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Radiologic and histologic findings in Sjögren's sensory neuronopathy
ABSTRACT A brief history of the syndrome discovered by Andreas Rett is reported in this paper. Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian fam...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Rett syndrome: the Brazilian contribution to the gene discovery
ABSTRACT A brief history of the syndrome discovered by Andreas Rett is reported in this paper. Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian fam...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
First stages towards the establishment of Brazilian neurology faculties
ABSTRACT The establishment of modern medicine in Brazil was marked by the arrival of the Portuguese Court in 1808, when the Bahia and Rio de Janeiro Faculties of Medicine were founded. The French School of Medicine exerted a strong influence on Brazilian medicine and on the main pioneers of Brazilian neurology. The elite of “ Parisian neurology ” trained students and doctors from around the world, and were mentors to the pioneers of Brazilian neurology in the early 20th century. In this article, the authors review the origins of neurology faculties in Brazilian medicine and the main pioneers of Brazilian neurology. Ne...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats
In this study, male Wistar rats were randomly divided into a control group (saline), irisin (0.5, 1, and 1.5 μ g/rat), and dimethyl sulfoxide (DMSO). After treatment, the population spike (PS) amplitude and slope of excitatory postsynaptic potentials (EPSP) were measured in the DG of rats in vivo. Moreover, following completion of the experiments, the stimulating and recording sites in the hippocampus were confirmed histologically from brain sections. Furthermore, biochemical assays like malondialdehyde (MDA), total antioxidant capacity (TAC), and total oxidant status (TOS) were evaluated (the antioxidant markers were ana...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis
Conclusion: The study confirmed the initial hypothesis. The longitudinal analysis of CSF lactate is an important predictor of prognosis in acute BM.RESUMO As meningites bacterianas (MB) est ão associadas à alta morbidade e mortalidade. O lactato no líquido cefalorraquidiano (LCR) pode ser usado como biomarcador de prognóstico nas MB. A hipótese desse estudo é que os níveis de lactato no LCR se mantém elevados entre pacientes com MB aguda que evoluem para óbito, ao contrário d o que ocorre em pacientes com bom prognóstico. Objetivo: Avaliar o uso potencial do lactato e outros marcadores no LCR como indicador de ...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Home physical exercise program: analysis of the impact on the clinical evolution of patients with normal pressure hydrocephalus
Conclusion: The developed program of home physical exercise was easily applied and there was good acceptance by most patients with NPH included in the research. There was a statistically significant improvement with the 10 weeks of home physical exercises in the sub-items: activities of daily living, static balance and functional capacity, for both groups. In the sub-item dynamic balance and gait, there was a statistically significant improvement for both groups, but with a higher score for the group with a ventriculoperitoneal shunt. There was no statistically significant difference for the sub-items: quality of life, NPH...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
