Hepatitis c in the brazilian public health care system: burden of disease
CONCLUSION: This study showed that most patients are cirrhotic, present high prevalence of cardiometabolic diseases and esophageal varices, reduced HRQoL mainly in terms of pain/discomfort, and work productivity impairment, especially presenteeism. Additionally, we demonstrated that hepatitis C virus imposes an economic burden on Brazilian Health Care System and that most of this cost is due to drug treatment.RESUMO CONTEXTO: A infec ção pelo vírus da hepatite C (HCV) é uma das principais causas de hepatite C crônica e provoca implicações graves para pacientes, familiares e sistema de saúde. OBJETIVO: Os objet...
Source: Arquivos de Gastroenterologia - February 14, 2019 Category: Gastroenterology Source Type: research
Congenital hepatic fibrosis and obliterative portal venopathy without portal hypertension - a review of literature based on an asymptomatic case
ABSTRACT The disease and the case reported here are relevant especially because of their varied clinical presentation, possibility of being associated with other disorders affecting several organs and possible differential diagnoses. Congenital Hepatic Fibrosis is an autosomal recessive disease due to mutation in the PKHD1 gene, which encodes the fibrocystin/polyductine protein. It is a cholangiopathy, characterized by varying degrees of periportal fibrosis and irregular proliferation of bile ducts. Affected patients are typically diagnosed in childhood, but in some cases the disease may remain asymptomatic for many years....
Source: Arquivos de Gastroenterologia - February 14, 2019 Category: Gastroenterology Source Type: research
Chronic hepatitis c is still a problem for the public health care system in brazil
(Source: Arquivos de Gastroenterologia)
Source: Arquivos de Gastroenterologia - February 14, 2019 Category: Gastroenterology Source Type: research
Recommendations of the brazilian society of hepatology for the management of acute kidney injury in patients with cirrhosis
ABSTRACT Acute kidney injury is a common complication of cirrhosis, occurring in up to 20% of patients hospitalized with cirrhosis. This field is rapidly changing, with significant advances in classification, biomarkers and therapy over the last few years. On the behalf of the Brazilian Society of Hepatology, a panel of experts in Hepatology and Nephrology reviewed published evidence to integrate findings and develop the recommendations presented in this manuscript.RESUMO A les ão renal aguda é uma complicação comum da cirrose, acometendo até 20% dos pacientes hospitalizados. Este tema está em rápida evolução devi...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Association of promoter region polymorphisms of interleukin-10 gene with susceptibility to colorectal cancer: a systematic review and meta-analysis
CONCLUSION: In this meta-analysis we found that IL-10 -819T>C polymorphism was associated with significantly increased risk of CRC; while the IL-10 -1082A>G and -592C>A polymorphisms were not associated with CRC risk. The IL-10 -819T>C polymorphism may be important as suspected predictive factor of CRC occurrence.RESUMO CONTEXTO: V ários estudos epidemiológicos têm investigado a associação de polimorfismo da região promotora do gene interleucina-10 (IL-10) com câncer colorretal (CRC), mas por enquanto a conclusão ainda é conflitante e inconclusiva. OBJETIVO: Foi realizada esta meta-análise para a...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
The efficacy of the different endoscopic treatments versus sham, pharmacologic or surgical methods for chronic gastroesophageal reflux disease: a systematic review and meta-analysis
CONCLUSION: This systematic review and meta-analysis shows a good short-term efficacy in favor of endoscopic procedures when comparing them to a sham and pharmacological or surgical treatment. Data on long-term follow up is lacking and this should be explored in future studies.RESUMO CONTEXTO: Os tratamentos endosc ópicos para a doença do refluxo gastroesofágico (DRGE) ainda estão em evolução e a maioria dos estudos publicados abordam o alívio dos sintomas em curto prazo. OBJETIVO: Pretendemos realizar uma revisão sistemática e meta-análise focada na avaliação da eficácia dos diferentes procedim entos end...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
The onset of clinical manifestations in inflammatory bowel disease patients
CONCLUSION: Ulcerative colitis presented a high frequency of intestinal symptoms, and Crohn ’ s disease showed a high frequency of systemic manifestations at the onset of manifestation. There was a long delay in diagnosis, but individuals with more extensive disease and more obvious symptoms showed a shorter delay.RESUMO CONTEXTO: O diagn óstico da doença inflamatória intestinal é frequentemente retardado pela falta de capacidade para reconhecer as suas principais manifestações clínicas. OBJETIVO: Nosso estudo teve como objetivo descrever as manifestações clínicas iniciais em pacientes com doença inflamat...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Target, prescription and infusion of enteral nutritional therapy of critical patients in intensive care unit
CONCLUSION: The administration of ENT in severely ill patients does not meet their actual energy and protein needs. The high occurrence of infusion inadequacies, compared to prescription and to the goals set can generate a negative nutritional balance.RESUMO CONTEXTO: A terapia nutricional enteral (TNE) é a melhor via para a nutrição de pacientes críticos e com melhores impactos no tratamento clínico desses pacientes. OBJETIVO: Investigar a oferta energética e proteica da TNE em pacientes críticos, internados em uma unidade de terapia intensiva (UTI) de um hospital universitário. MÉTODO S: Um estudo prospec...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Honey-derived lactobacillus rhamnosus alleviates helicobacter pylori-induced gastro-intestinal infection and gastric inflammation in c57bl/6 mice: an immuno-histologic study
CONCLUSION: Honey-derived L. rhamnosus probiotics provides similar results as clarithromycin in terms of improvement of H. pylori infection and gastritis in C57BL/6 Mice model, without its cons of antibiotic resistance.RESUMO CONTEXTO: O Helicobacter pylori (H. pylori) foi reconhecido em 1983 por Marechal e Warren como protagonista principal na fisiopatologia de gastrite e úlceras gástricas. Quase metade da população mundial está infectada por H. pylori. O regime terapêutico atual contra H. pylori inclui o uso de um inibidor da bomba de prótons associada a dois ou mais antibióticos. No entanto, a eficácia deste...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Insulin resistance reduction after sustained virological response with direct acting antiviral:not every population improves
CONCLUSION: In the general population, glucose and HOMA-IR values increased at t-SVR12, but insulin decreased. In the special population, glucose, insulin, HOMA-IR and Delta HOMA-IR decreased at t-SVR12.RESUMO CONTEXTO: A infec ção pelo vírus da hepatite C (VHC) é um grave problema de saúde pública, que afeta aproximadamente 170 milhões de pessoas no mundo. A infecção crônica pelo VHC está associada à resistência à insulina hepática e a um risco aumentado de diabetes. Os doentes infetados pelo VHC foram bem documentados. OBJETIVO: Avaliar o modelo de avaliação da homeostase do índice de resistência ...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Hepatitis b and c in pregnant women attended by a prenatal program in an universitary hospital in rio de janeiro, brazil: retrospective study of seroprevalence screening
CONCLUSION: A high prevalence of HBsAg was observed, higher than the expected for the evaluated region; there was a prevalence of anti-HCV, consistent with the current Brazilian reality; and a likely low rate of hepatitis B immunization, with a relatively high rate of susceptibility to this infection and no case of co-infection between B and C viruses and HIV. It is emphasized not only the need to trace hepatitis B and C, without exceptions, during prenatal care, since even though the current advances in therapy may not cure, at least they may allow a better quality of life for patients with chronic disease and the mandat...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Acute gastroenteritis associated with norovirus gii.4 variants
CONCLUSION: These findings reinforce the need to study the molecular epidemiology of NoV infections in acute gastroenteritis.RESUMO CONTEXTO: Norov írus (NoV) é o agente etiológico mais importante nas gastroenterites agudas e infecta indivíduos de todas as idades, especialmente crianças no Brasil e no mundo. O NoV GII.4 é o genótipo mais prevalente em todo o mundo devido a sua elevada diversidade genética. No Brasil, principalmente no N ordeste, poucos estudos têm sido desenvolvidos a fim de identificar e caracterizar molecularmente o NoV. OBJETIVO: O presente estudo teve como objetivo detectar e descrever a ...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Metachronous colorectal liver metastases has better prognosis - is it true?
CONCLUSION: Metachronous colorectal hepatic metastasis was associated with a worse prognosis for overall survival. There was no difference in recurrence-free survival between metachronous and synchronous metastases.RESUMO CONTEXTO: As met ástases hepáticas de câncer colorretal representam um importante problema de saúde pública devido à incidência crescente de câncer colorretal pelo mundo. A metástase hepática colorretal sincrônica está associada a pior sobrevida, no entanto, o pior prognóstico é assunto controverso. O BJETIVO: O objetivo do estudo foi avaliar a sobrevida livre de recorrência e a sobrev...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Analysis of risk factors and postoperative complications in patients with crohn’s disease
CONCLUSION: The complication rate observed in this study is similar to published data. The duration of the disease, the penetrating behavior, the size of the removed specimen, the duration of the surgery, and BMI are important risk factors for perioperative complications in Crohn ’ s disease.RESUMO CONTEXTO: O índice de complicações pós-operatórias é maior em pacientes com doença de Crohn do que em outras cirurgias abdominais decorrentes de outras afecções benignas. A prevenção e o manejo de tais complicações constituem importante fator no tratamento desses pacientes. OBJETIVO: Os objetivos deste traba...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
Correlation between nonalcoholic fatty liver disease features and levels of adipokines and inflammatory cytokines among morbidly obese individuals
CONCLUSION: Adiponectin levels were inversely correlated with the severity of fibrosis and steatohepatitis, whereas IL-8 levels were higher in individuals with liver fibrosis among individuals with obesity and NAFLD undergoing bariatric surgery. The use of these markers to asses s NAFLD may bring significant information within similar populations.RESUMO CONTEXTO: A doen ça hepática gordurosa não-alcoólica (DHGNA) é a hepatopatia mais comum no mundo. OBJETIVO: Investigar correlações entre as apresentações histopatológicas da DHGNA e os níveis de adipocinas (adiponectina, leptina e resistina) e marcadores sis...
Source: Arquivos de Gastroenterologia - December 12, 2018 Category: Gastroenterology Source Type: research
