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Survey among retina specialists in Brazil about inflammatory reactions after intravitreal antiangiogenic therapy
Conclusions: Most specialists reported cases of early-onset inflammation after intravitreal injection of antiangiogenic agents. The incidence of irreversible complications was low. Aflibercept was the most common agent used. The causes of inflammation remain unknown, but we formulated some relevant hypotheses.RESUMO Objetivo: Esta pesquisa teve como objetivo avaliar as caracter ísticas clínicas de pacientes com reações inflamatórias após injeção intravítrea de agentes antiangiogênicos e as técnicas empregadas por especialistas em retina brasileiros. Métodos: Enviamos eletronicamente um questionário de 18 ite...
Source: Arquivos Brasileiros de Oftalmologia - May 29, 2020 Category: Opthalmology Source Type: research

Coronavirus and the eye: what is relevant so far?
(Source: Arquivos Brasileiros de Oftalmologia)
Source: Arquivos Brasileiros de Oftalmologia - May 29, 2020 Category: Opthalmology Source Type: research

Blindness from bilateral pseudomonas endophthalmitis following bilateral simultaneous cataract surgery: Primum non nocere
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt ’ s macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.RESUMO As doen ças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizada...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Clinical studies using stem cells for treatment of retinal diseases: state of the art
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt ’ s macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.RESUMO As doen ças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizada...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Coexistence of papilledema and pseudopapilledema after remission of idiopathic intracranial hypertension by bariatric surgery
This report highlights the coexistence of true papilledema and pseudopapilledema due to optic disk drusen, following remission of idiopathic intracranial hypertension after a bariatric surgery.RESUMO Uma mulher de 37 anos queixou-se de cefaleia ap ós perda visual bilateral nos últimos dois anos. Apresentava história de obesidade e havia sido submetida à cirurgia bariátrica três meses antes, seguida de considerável perda de peso. O exame neuro-oftálmico revelou um disco óptico inchado bilateral. Após uma análise computadorizada dos campos visuais e ressonância magnética do crânio e órbitas, foi feito um diagn...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Pilomatrix carcinoma of the lacrimal caruncle: a case report
ABSTRACT A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. A histological diagnosis of pilomatrix carcinoma was established. To prevent recurrence after surgery, we added bevacizumab (25 mg/mL, 1.25 mg/mL per drop) eye drops four times per day for three months. At the one-year fol...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Regression of macular edema with topical brinzolamide and nepafenac alone and identification of a novel gyrate atrophy mutation
ABSTRACT Gyrate atrophy is a rare metabolic autosomal recessive disorder caused by ornithine aminotransferase enzyme deficiency that leads to characteristic progressive, degenerative chorioretinal findings. Patients complain mostly of low vision, night blindness, and peripheral vision loss. Posterior subcapsular cataract, myopia, choroid neovascularization, and intraretinal cysts may be accompanying factors related to vision loss. We encountered a patient with vision loss secondary to posterior subcapsular cataract and intraretinal cysts. After treatment with topical brinzolamide and nepafenac (and without any diet mo difi...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Evidence of autophagic vesicles in a patient with Lisch corneal dystrophy
ABSTRACT Lisch corneal dystrophy is a rare corneal disease characterized by the distinctive feature of highly vacuolated cells. Although this feature is important, the nature of these vacuoles within corneal cells remains unknown. Here, we sought to analyze corneal cells from a patient diagnosed with Lisch dystrophy to characterize the vacuoles within these cells. Analyses using histopathology examination, confocal microscopy, and transmission electron microscopy were all consistent with previous descriptions of Lisch cells. Importantly, the vacuoles within these cells appeared to be autophagosomes and autolysosomes, and c...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Comparing the postoperative refractive predictability of Pentacam HR and IOLMaster 500 after a multifocal intraocular lens implantation
Conclusions: Pentacam HR significantly differed from IOLMaster 500 when calculating keratometry. As regards the anterior chamber depth, the two devices were equally accurate.RESUMO Objetivo: Comparar a previsibilidade refrativa p ós-operatória do IOLMaster 500 e Pentacam HR com base nos valores de ceratometria e profundidade de câmara anterior nos olhos com indicação de implante de lentes intraoculares multifocais. Métodos: Estudo retrospectivo realizado em 118 olhos tratados com facoemulsificação e implante de len tes intraoculares multifocal. Apenas os olhos que atingiram a emetropia na refração dinâmica ...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Relationships between corneal biomechanics and the structural and functional parameters of glaucoma damage
Conclusions: Distinct correlations were identified between the corneal hysteresis and corneal resistance factor values and the functional and structural parameters in the primary open-angle glaucoma and control groups. Corneal hysteresis and corneal resistance factor may have different roles in the pathophysiology of glaucoma.RESUMO Objetivo: Investigar as rela ções entre (i) espessura da camada de fibras nervosas da retina, topografia do nervo óptico e parâmetros do campo visual e (ii) propriedades biomecânicas da córnea, em controles normais e pacientes com hiperten são ocular e glaucoma primário de ângulo aber...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Intra- and interobserver reliability of a modified distraction test based on digital images to assess lower eyelid horizontal tension
Conclusion: A high intra- and interobserver concordance was observed in the studied method to quantify lower eyelid tension. The proposed method is simple and easily reproducible, and to the best our knowledge, this is the first method that quantifies lower eyelid horizontal tension on the basis of digital image processing. This modified distraction test might be useful in studies quantifying lower eyelid horizontal tension.RESUMO Objetivo: A frouxid ão palpebral inferior é avaliada classicamente por meio de testes de “ snap-back ” e “ distraction test ” . O objetivo deste estudo foi avaliar a reprodutibilidad...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Optical coherence tomography angiography findings in patients with branch retinal vein occlusion treated with Anti-VEGF
Conclusion: Optical coherence tomography angiography enables qualitative and quantitative evaluations during follow-up of patients treated for branch retinal vein occlusion.RESUMO Objetivo: Investigar as altera ções na microvascu latura da retina em pacientes tratados com anti-VEGF para ede ma macular secundário à oclusão de ramo da veia retiniana. Métodos: Foram examinados 38 olhos de 19 pacientes para o estudo. Medimos as densidades dos vasos do plexo capilar superficial e profunda (%), áreas da zona avascular foveal (mm2) e espessura macular central. Resultados: Os valores do plexo capilar superficial e profun...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Patterns of ocular trauma in elderly patients in an urban population-the Bronx experience
Conclusions: Ocular injuries in elderly Bronx patients most commonly occurred in females due to falls in the home/nursing home setting. Public health measures addressing identifiable individual and environmental risks in these common locations would be most beneficial in reducing the incidence of ocular injuries in this population.RESUMO Objetivo: Avaliar as caracter ísticas das lesões oculares de idosos nas internações por grandes traumatismos em um centro urbano de trauma nível I de 2008 a 2015. Métodos: Realizou-se uma revisão retrospectiva de prontuários de pacientes com mais de 65 anos internados com lesõ...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline
Conclusion: Doxycycline improved meibomian gland dysfunction, ocular symptoms, and ocular surface in patients with rosacea. Even though some patients experienced worsening meibomian gland dysfunction and symptoms, no subject experienced any serious complications after administration of low-dose isotretinoin.RESUMO Objetivos: Comparar o impacto das altera ções oculares entre o tratamento sistêmico de doxiciclina e isotretinoína em baixa dosagem em pacientes com rosácea papulopustulosa moderada a grave. Métodos: Os pacientes form randomizados para receber isotretinoína 0,3 a 0,4 mg/kg (grupo A) ou doxiciclina 100mg/...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research

Inter-eye osmolarity differences in patients with symptomatic and non-symptomatic dry eyes
Conclusion: Tear film inter-eye osmolarity differences are significantly higher in severe dry eye disease symptoms.RESUMO Objetivo: Analisar se as diferen ças entre osmolaridade entre os olhos foram relacionadas à sintomatologia do olho seco. Métodos: Um total de 135 participantes foram recrutados aleatoriamente entre os indivíduos da Clínica de Optometria da Faculdade de Optometria (Universidade de Santiago de Compostela). Em uma única sessã o agendada após o recrutamento, o Índice de Doenças da Superfície Ocular foi preenchido seguindo as instruções padrão e as mensurações do TearLab foram feitas em a...
Source: Arquivos Brasileiros de Oftalmologia - March 9, 2020 Category: Opthalmology Source Type: research