Arhiv za Higijenu Rada i Toksikologiju This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A follow-up on the hesperetin issue in modelling the first electrochemical oxidation potential and antioxidant activity of flavonoids
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):85-86. doi: 10.2478/aiht-2024-75-3823. eCollection 2024 Mar 1.NO ABSTRACTPMID:38548380 | PMC:PMC10978156 | DOI:10.2478/aiht-2024-75-3823 (Source: Arhiv za Higijenu Rada i Toksikologiju)
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Ante Mili čević Source Type: research

Are changes in olanzapine-induced liver enzyme levels associated with GSTT1 , GSTM1 , GSTP1 , and OGG1 gene polymorphisms?
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):61-67. doi: 10.2478/aiht-2024-75-3770. eCollection 2024 Mar 1.ABSTRACTOlanzapine treatment sometimes produces transient liver biochemistry abnormalities, and such drug-induced liver injuries are mainly monitored by measuring blood levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), whereas alpha-glutathione-S-transferase (α-GST) is not routinely measured in clinics, even though it can serve as an earlier and more specific biomarker of liver damage. Susceptibility to drug-induced liver injury can much depend on the gene polymorphisms regulating the activit...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Aylin Elkama Nazl ıcan İlik Mehmet Ak Bensu Karahalil Source Type: research

Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds
This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O2 •-), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Nina Umi ćević Jelena Kotur-Stevuljevi ć Katarina Barali ć Danijela Đukić-Ćosić Evica Antonijevi ć Miljaković Aleksandra Buha Đorđević Marijana Ćurčić Zorica Bulat Biljana Antonijevi ć Source Type: research

Nanoplastics increase in vitro oestrogenic activity of neurotherapeutic drugs
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):68-75. doi: 10.2478/aiht-2024-75-3818. eCollection 2024 Mar 1.ABSTRACTEnvironmental pollution with plastic nanoparticles (PNPs) has rendered hazard assessment of unintentional human exposure to neurotherapeutic drugs through contaminated water and food ever more complicated. Due to their small size, PNPs can easily enter different cell types and cross different biological barriers, while their high surface-to-volume ratio enables higher adsorption of chemicals. This is how PNPs take the role of a Trojan horse as they enhance bioaccumulation of many different pollutants. One of the h...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Lucija Bo žičević Valerije Vr ček Nikolina Perani ć Nikolina Kal čec Ivana Vinkovi ć Vrček Source Type: research

Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part II - the application of the FMECA method to compare manual vs automated preparation
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):41-50. doi: 10.2478/aiht-2024-75-3803. eCollection 2024 Mar 1.ABSTRACTHealthcare workers handling antineoplastic drugs (ADs) in preparation units run the risk of occupational exposure to contaminated surfaces and associated mutagenic, teratogenic, and oncogenic effects of those drugs. To minimise this risk, automated compounding systems, mainly robots, have been replacing manual preparation of intravenous drugs for the last 20 years now, and their number is on the rise. To evaluate contamination risk and the quality of the working environment for healthcare workers preparing ADs, we...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Stefano Dugheri Giovanni Cappelli Donato Squillaci Ilaria Rapi Niccol ò Fanfani Fabrizio Dori Michele Cecchi Viola Sordi Andrea Ghiori Nicola Mucci Source Type: research

Polychlorinated biphenyls in mussels, small pelagic fish, tuna, turtles, and dolphins from the Croatian Adriatic Sea waters: an overview of the last two decades of monitoring
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):15-23. doi: 10.2478/aiht-2024-75-3814. eCollection 2024 Mar 1.ABSTRACTThis review summarises our two decades of polychlorinated biphenyl (PCB) monitoring in different marine organisms along the eastern Adriatic Sea. The aim was to gain an insight into the trends of PCB distribution in order to evaluate the effectiveness of past and current legislation and suggest further action. Here we mainly focus on PCB levels in wild and farmed Mediterranean mussels, wild and farmed bluefin tuna, loggerhead sea turtles, common bottlenose dolphins, and small pelagic fish. The use of artificial in...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Snje žana Herceg Romanić Gordana Menda š Sanja Fingler Vlasta Drevenkar Bosiljka Musta ć Gordana Jovanovi ć Source Type: research

Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase
In conclusion, glyphosate shows a slight binding preference for BChE but exhibits inhibition only in a high concentration range. Our results are in line with studies reporting that its neurotoxic effect is not primarily linked to the cholinergic system.PMID:38548375 | PMC:PMC10978157 | DOI:10.2478/aiht-2024-75-3822 (Source: Arhiv za Higijenu Rada i Toksikologiju)
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Dora Koli ć Vesna Pehar Zrinka Kovarik Source Type: research

Athlete biological passport: longitudinal biomarkers and statistics in the fight against doping
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):24-31. doi: 10.2478/aiht-2024-75-3793. eCollection 2024 Mar 1.ABSTRACTAs novel substances, short time windows, and limits of detection increasingly challenge direct methods of doping detection in sports, indirect tools inevitably take a greater role in the fight against it. One such tool is the athlete biological passport (ABP) - a longitudinal profiling of the measured haematological and biochemical biomarkers, combined with calculated scores, against the background of epidemiological data crucial for doping detection. In both of its modules, haematological and steroidal, ABP param...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Dora Drag čević Vlatka Pand žić Jakšić Ozren Jak šić Source Type: research

Science-based evidence on pathways and effects of human exposure to micro- and nanoplastics
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):1-14. doi: 10.2478/aiht-2024-75-3807. eCollection 2024 Mar 1.ABSTRACTHuman exposure to plastic particles has raised great concern among all relevant stakeholders involved in the protection of human health due to the contamination of the food chain, surface waters, and even drinking water as well as due to their persistence and bioaccumulation. Now more than ever, it is critical that we understand the biological fate of plastics and their interaction with different biological systems. Because of the ubiquity of plastic materials in the environment and their toxic potential, it is imp...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Buket Bakan Nikolina Kal čec Sijin Liu Krunoslav Ili ć Yu Qi Ivona Capjak Lucija Bo žičević Nikolina Perani ć Ivana Vinkovi ć Vrček Source Type: research

Frequency of regular walking among Croatian adults
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):32-40. doi: 10.2478/aiht-2024-75-3808. eCollection 2024 Mar 1.ABSTRACTThe aim of this study was to determine the share of Croatian adults who walk 210 min or more a week and to explore the relationship between regular walking and demographic factors, health-related behaviours, and chronic non-communicable diseases/conditions. To this end, we used the EHIS-PAQ questionnaire and collected self-reported data on minutes spent walking during a typical week from a total of 3,496 respondents. The data were additionally analysed by gender, age, education, residence (urban/rural), counties a...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Slaven Krtali ć Helena Kri žan Sanja Musi ć Milanović Source Type: research

Comparative analysis of organophosphorus versus carbamate pesticide poisoning: a case study
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):81-84. doi: 10.2478/aiht-2024-75-3781. eCollection 2024 Mar 1.ABSTRACTOrganophosphorus poisoning is a critical condition that can cause central nervous system depression, respiratory failure, and death early on. As its clinical manifestations closely resemble those of carbamate pesticide poisoning, the aim of this case study is to present a case of misdiagnosis, initially identifying carbofuran poisoning as organophosphate in a patient suspect of a heatstroke. We also present a case of intentional self-poisoning with organophosphate dichlorvos to underline the likelihood of pesticid...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Jia-Ding Xia Hui Wang Li-Wei Hua Min Xu Xin Zheng Kun Zhang Source Type: research