FRAX ® based intervention thresholds for management of osteoporosis in Singaporean women
ConclusionThe ITs for osteoporosis treatment in Singapore show marked variations across ethnicities. Weighted mean thresholds may overcome the dilemma of intervening at different thresholds for different ethnicities. Choosing fixed ITs may have to involve trade-offs between sensitivity and specificity. FRAX ®-based age-dependent or the fixed intervention thresholds suggested as an alternative to be considered for use in Singapore though further studies on the societal and health economic impacts of choosing these thresholds in Singapore are needed. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 19, 2018 Category: Orthopaedics Source Type: research

The effect of a high-impact jumping intervention on bone mass, bone stiffness and fitness parameters in adolescent athletes
ConclusionsA 9-month jumping intervention can improve bone mass, bone stiffness and muscular fitness in adolescent males participating in non-osteogenic sports, such as swimming and cycling.Clinical Trial RegistrationISRCTN17982776. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 17, 2018 Category: Orthopaedics Source Type: research

Prevalence of osteoporosis with the World Health Organization diagnostic criteria in the Eastern Mediterranean Region: a systematic review and meta-analysis
ConclusionsOur findings indicate a considerable prevalence of osteoporosis among the people of the EMR. The prevalence has increased during recent years, showing that osteoporosis is becoming a critical health problem in this region. Prevention and control measures need to be implemented by health service authorities. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 17, 2018 Category: Orthopaedics Source Type: research

Is trabecular bone score less affected by degenerative-changes at the spine than lumbar spine BMD?
This study in men reports that trabecular bone score may be less affected by spinal degenerative-changes.PurposeA recent tool for assessing trabecular microarchitecture at the lumbar spine, trabecular bone score (TBS), provides information about bone health complementary to lumbar spine areal BMD (here referred to as BMD). In men, mean BMD increases with increasing age due to degenerative-changes at the spine including osteophytes and aortic calcification. The aim of this study was to investigate whether TBS is similarly affected by the presence of degenerative-changes in men.MethodsThis study included 728 men aged 40 &nda...
Source: Archives of Orthopaedic and Trauma Surgery - November 16, 2018 Category: Orthopaedics Source Type: research

Chronic kidney disease predicts a lower probability of improvement in patient-reported experience measures among patients with fractures: a prospective multicenter cohort study
ConclusionsThe presence of CKD predicts a significantly lower probability of PREM improvement among fracture patients. An early emphasis on renal function during fracture care should be considered. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 16, 2018 Category: Orthopaedics Source Type: research

Chronic hemodialysis is associated with lower trabecular bone score, independent of bone mineral density: a case-control study
ConclusionsHD patients have lower TBS than controls matched for LS BMD, indicating altered bone microarchitecture. Also, the magnitude of TBS reduction in HD patients is constant at any LS BMD. Adjustment for TBS partially corrects the absolute 10-year fracture risk. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 13, 2018 Category: Orthopaedics Source Type: research

Correspondence between bone mineral density and intervertebral disc degeneration across age and sex
ConclusionsOur results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 12, 2018 Category: Orthopaedics Source Type: research

Changes in bone mineral density (BMD): a longitudinal study of osteoporosis patients in the real-world setting
ConclusionsOsteoporosis patients are unlikely to improve femoral neck T-scores over 1.2  years. Additional studies are needed to determine the optimal time to repeat BMD testing while receiving osteoporosis treatment and to determine whether fracture risk is reduced in patients who achieve target T-scores. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 12, 2018 Category: Orthopaedics Source Type: research

Cost-effectiveness of a home safety intervention to prevent falls in impaired elderly people living in the community
ConclusionsProvided that the rate of falls is a valid surrogate endpoint for the rate of fall-related hip fractures, HSM could be a promising approach for investments in preventive options targeting the reduction of fall-related fractures in elderly women. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 9, 2018 Category: Orthopaedics Source Type: research

Osteoporosis in postmenopausal women in this decade: a bibliometric assessment of current research and future hotspots
ConclusionWe concluded that the USA and Europe were the most productive regions on PMOP, with a high prevalence of articles supported by pharmaceutical companies. Key word focus gradually shifted from “diagnosis” to “treatment” and then to precision medicine orientated “basic research”. It is recommended to pay attention to potential research hotspots, such as “miRNA,” “abaloparatide,” and “adipokine”. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 7, 2018 Category: Orthopaedics Source Type: research

Individualized evaluation of lumbar bone mineral density in children with cerebral palsy
AbstractSummaryLumbar spine bone mineral density (LS-BMD) assessed by dual-energy X-ray absorptiometry (DXA) is used in children with cerebral palsy (CP) to evaluate bone health. LS-BMD results in children with CP are influenced significantly by their height, BMI, and mobility level. An adjustment for these parameters might improve the clinical significance of the method.Purpose/introductionDXA evaluation is considered useful in children with CP to assess bone health. For this purpose, LS-BMD is often used. The aim of the study was to estimate the effect of height, BMI, and reduced mobility level of children with CP on LS-...
Source: Archives of Orthopaedic and Trauma Surgery - November 5, 2018 Category: Orthopaedics Source Type: research

Changes in bone mineral density in women before critical illness: a matched control nested cohort study
ConclusionIn a cohort of women with predominantly surgical ICU admission, bone health prior to critical illness was comparable to age- and medication-matched controls, with a relative increase in femoral neck bone mass immediately prior to critical illness. These findings suggest critical illness-related bone loss cannot be entirely explained as a continuation of pre-morbid bone trajectory. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 5, 2018 Category: Orthopaedics Source Type: research

A brief history of FRAX
ConclusionFRAX provides an advance in fracture risk assessment and a reference technology platform for future improvements in performance characteristics. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 31, 2018 Category: Orthopaedics Source Type: research

Individualized evaluation of lumbar bone mineral density and bone mineral apparent density in children and adolescents
AbstractSummaryLumbar spine bone mineral density (LS-BMD) assessed by dual-energy X-ray absorptiometry (DXA) is used in children to evaluate bone health. LS-BMD results in children are influenced significantly by height and BMI. An adjustment for these parameters may improve the clinical use of the method.Purpose/IntroductionDXA evaluation is considered useful in children to assess bone health. For this purpose, lumbar spine bone mineral density (LS-BMD) and bone mineral apparent density (LS-BMAD) are often used. The aim of the study was to estimate the effect of height and BMI on LS-BMD and LS-BMAD in children and adolesc...
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2018 Category: Orthopaedics Source Type: research

Long-term effects of inhaled corticosteroids on bone mineral density in older women with asthma or COPD: a registry-based cohort study
ConclusionsThe highest tertile of ICS use was associated with a slightly lower hip BMD at baseline and slightly greater reduction in total hip BMD over time in older women with asthma or COPD. No adverse effects on BMD were seen from low to moderate ICS exposure. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2018 Category: Orthopaedics Source Type: research

Judicious use of DXA-BMD in assessing fracture risk by using clinical risk factors in the Indian population
This study was planned to compare the FRAX scores for the risk for major osteoporotic fracture (FRAX-MOF) and hip fracture (FRAX-HF) in patients with fragility fractures (cases) and those admitted for other indications (controls) in the orthopedic ward in our institute.MethodsHistorical and anthropometric data were prospectively recorded from 500 consecutive patients admitted in the orthopedic ward in in Medanta, the Medicity, Gurgaon, India. The receiver operating characteristic (ROC) curves were constructed for FRAX-MOF and FRAX-HF and the area under the curve (AUC) was calculated between cases and controls.ResultsThe FR...
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2018 Category: Orthopaedics Source Type: research

Calcitriol treatment in patients with low vitamin D levels
AbstractSummaryThe aim of the the study is to compare the effects of cholecalciferol and calcitriol on bone mineral metabolism in women with vitamin D deficiency. Calcitriol was associated with a significant increase in bone mineral density at the lumbar spine in patients with low vitamin D levels.Purpose/introductionActive vitamin D analogs may have larger impact in decreasing bone loss and fracture rate compared to cholecalciferol in osteoporosis. However, their effects in the treatment of vitamin D deficiency compared to cholecalciferol are not clear. The aim of the present study is to compare the effects of cholecalcif...
Source: Archives of Orthopaedic and Trauma Surgery - October 23, 2018 Category: Orthopaedics Source Type: research

Impact of bisphosphonate compliance on the risk of osteoporotic fracture in France
ConclusionIn conclusion, this study suggested that very high levels of compliance with bisphosphonates are necessary to induce significant decreases in fracture risk. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 19, 2018 Category: Orthopaedics Source Type: research

Association between polycyclic aromatic hydrocarbons and osteoporosis: data from NHANES, 2005 –2014
ConclusionOur study found that 3-hydroxyfluorene was associated with decreased odd of osteoporosis, while 2-hydroxyfluorene was associated with increased odds of osteoporosis. Our study was a cross-sectional study, therefore cohort studies or experimental studies about association of PAH and osteoporosis is needed. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 17, 2018 Category: Orthopaedics Source Type: research

Serum 25-hydroxyvitamin D status, quantitative ultrasound parameters, and their determinants in Greek population
AbstractSummaryVitamin D deficiency and quantitative ultrasound measurements are associated with bone fragility. We assessed these parameters and their correlates. 87.7% of the population has vitamin D inadequacy and this correlated with lifestyle factors. These results contribute to epidemiological data needed for population guidelines for bone health.PurposeVitamin D deficiency and quantitative ultrasound (QUS) parameters are among the most important clinical risk factors of bone fragility. Few data are available for Greek population. The aim of the study was to evaluate the serum 25-hydroxyvitamin D [25(OH)D] level and ...
Source: Archives of Orthopaedic and Trauma Surgery - October 15, 2018 Category: Orthopaedics Source Type: research

Improvement in the primary and secondary prevention of osteoporosis by a Fracture Liaison Service: feedback from a single French center care pathway
ConclusionsCommunication with patients and healthcare professionals through the Fracture Liaison Service was beneficial for patients in terms of fracture prevention. This study supports the development of similar care pathways in other healthcare institutions. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 15, 2018 Category: Orthopaedics Source Type: research

Longitudinal determinants of 12-month changes on bone health in adolescent male athletes
ConclusionsChanges in region-specific lean mass and the type of sport are the most consistent determinants of 12-month changes in aBMD, hip geometry estimates and TBS in adolescent male athletes.Trial registrationISRCTN17982776 (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 10, 2018 Category: Orthopaedics Source Type: research

Effects of anti-osteoporosis medications on total hip arthroplasty risks in osteoporotic patients with hip osteoarthritis in Taiwan: a nationwide cohort study
ConclusionOur results showed that the use of AOMs is not associated with decreased risk of THA in patients with hip OA. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 10, 2018 Category: Orthopaedics Source Type: research

Prevention of low bone mass to achieve high bone density in Mexico: position of the Mexican Association for Bone and Mineral Metabolism
ConclusionsIn summary, most research and clinical practice related to osteoporosis have focused on diagnosis and treatment, but general measures for primary prevention based on addressing modifiable risk factors as a public health priority to delay the onset of loss of bone mass have not been considered by Mexican authorities. Consequently, the AMMOM task force also seeks to provide information on concrete actions to prevent low bone mass. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 10, 2018 Category: Orthopaedics Source Type: research

Association of high-density lipoprotein, triglycerides, and homocysteine with bone mineral density in young Indian tribal women
This study investigated association between lipids and homocysteine (Hcy) with bone mineral density (BMD) in young women as opposed to previous studies on elderly women. HDL, triglyceride, and Hcy are significantly associated with BMD in young women and tobacco and alcohol consumption have no effect on this association.PurposeThe present study investigates whether the association of serum lipids and homocysteine (Hcy) with bone mineral density (BMD) reported mostly in elderly population can be generalized to young or premenopausal women, consequently suggesting screening of young women with low BMD for dyslipidemia or any ...
Source: Archives of Orthopaedic and Trauma Surgery - October 10, 2018 Category: Orthopaedics Source Type: research

Prevalence of vitamin D deficiency in postmenopausal high- and low-energy fracture patient
This study evaluated the prevalence of vitamin D deficiency in postmenopausal women with fractures and revealed a high prevalence of vitamin D deficiency regardless of whether the injury mechanism was high or low energy. However, the prescription rate of vitamin D supplementation was lower in the high-energy compared to the low-energy injury group.PurposeThe present study aimed to investigate the prevalence of vitamin D deficiency in postmenopausal women with fractures from low-energy and high-energy injuries and to determine differences in the prevalence of vitamin D deficiency and the rate of postoperative vitamin D supp...
Source: Archives of Orthopaedic and Trauma Surgery - October 10, 2018 Category: Orthopaedics Source Type: research

Plain radiograghs of lumbar spine in patients with low back pain
The objective of this study is to evaluate commonest finding in patients with LBP to guide physicians for improved management.MethodsThis work was a retrospective study. Plain films of these patients with LBP at the University of Nigeria Teaching Hospital, Enugu, were assessed by two radiologists. Findings documented and analyzed using IBM ’S SPSS 22. Association was determined using chi-square with level of significance,p 
Source: Archives of Orthopaedic and Trauma Surgery - October 7, 2018 Category: Orthopaedics Source Type: research

The prevalence of overtreatment of osteoporosis: results from the PAADRN trial
ConclusionIn our sample of older adults, overuse of osteoporosis pharmacotherapy was only 8.1%. Nevertheless, overtreatment exposes patients to possible risk with negligible chance of benefit and should be minimized.Trial registrationclinicaltrials.gov identifier: NCT01507662 (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 28, 2018 Category: Orthopaedics Source Type: research

New FRAX-based intervention and assessment thresholds for the Ecuadorian population
(Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 24, 2018 Category: Orthopaedics Source Type: research

High calcium intake in men not women is associated with all-cause mortality risk: Melbourne Collaborative Cohort Study
AbstractSummaryThe risk of mortality associated with high dietary calcium is uncertain. Unlike a highly publicised study in Swedish women, high dietary calcium intake in men —not women—was associated with increased all-cause mortality.PurposeThe association of dietary calcium with mortality is controversial. A study of women from the Swedish Mammography Cohort (SMC) suggested higher calcium was associated with higher mortality risk, whilst a study of Australian adults from the Melbourne Collaborative Cohort Study (MCCS) suggested higher intakes were associated with lower mortality risk. Thus, we aimed to perfor...
Source: Archives of Orthopaedic and Trauma Surgery - September 21, 2018 Category: Orthopaedics Source Type: research

Defining sarcopenia in terms of skeletal health
ConclusionsIn men, low ALM/height2 or grip strength played a role in fragility fractures. In women, only the combination of low ALM/BMI and grip strength had discriminatory power for fragility fractures. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 20, 2018 Category: Orthopaedics Source Type: research

An epidemiological analysis of osteoporotic characteristics in patients affected with rheumatoid arthritis in Kazakhstan
AbstractPurposeWe aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan.MethodsFour hundred six RA patients (90.6% females) with 397 controls —unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN), and US_T-scores.ResultsIn the RA affected female population, ~  80% suffered ...
Source: Archives of Orthopaedic and Trauma Surgery - September 19, 2018 Category: Orthopaedics Source Type: research

Correction to: Psychometric performance of the Romanian version of the SarQoL ®, a health-related quality of life questionnaire for sarcopenia
The name and surname of the authors have been inverted. The correct order would be like this: Andrea IldikoGasparik, GabrielaMihai, CharlotteBeaudart, OlivierBruyere, Raluca-MonicaPop, Jean-YvesReginster, Ionela MariaPascanu. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 17, 2018 Category: Orthopaedics Source Type: research

In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture: the Spanish registry of osteoporotic femur fractures prospective cohort study
ConclusionsDespite suboptimal surgical delay, post-hip fracture mortality is low in Spanish hospitals. The secondary fracture prevention gap is unacceptably high at>  85%, in spite of virtually universal anti-thrombotic and antibiotic prophylaxis. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 14, 2018 Category: Orthopaedics Source Type: research

Combination of DXA and BIS body composition measurements is highly correlated with physical function —an approach to improve muscle mass assessment
AbstractSummaryRationale: Fluid volume estimates may help predict functional status and thereby improve sarcopenia diagnosis.Main Result: Bioimpedance-derived fluid volume, combined with DXA, improves identification of jump power over traditional measures.Significance: DXA-measured lean mass should be corrected for fluid distribution in older populations; this may be a surrogate of muscle quality.PurposeSarcopenia, the age-related loss of muscle mass and function, negatively impacts functional status, quality of life, and mortality. We aimed to determine if bioimpedance spectroscopy (BIS)-derived estimates of body water co...
Source: Archives of Orthopaedic and Trauma Surgery - September 14, 2018 Category: Orthopaedics Source Type: research

In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture: the Spanish registry of osteoporotic femur fractures prospective cohort study
ConclusionsDespite suboptimal surgical delay, post-hip fracture mortality is low in Spanish hospitals. The secondary fracture prevention gap is unacceptably high at>  85%, in spite of virtually universal anti-thrombotic and antibiotic prophylaxis. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 14, 2018 Category: Orthopaedics Source Type: research

Combination of DXA and BIS body composition measurements is highly correlated with physical function —an approach to improve muscle mass assessment
AbstractSummaryRationale: Fluid volume estimates may help predict functional status and thereby improve sarcopenia diagnosis.Main Result: Bioimpedance-derived fluid volume, combined with DXA, improves identification of jump power over traditional measures.Significance: DXA-measured lean mass should be corrected for fluid distribution in older populations; this may be a surrogate of muscle quality.PurposeSarcopenia, the age-related loss of muscle mass and function, negatively impacts functional status, quality of life, and mortality. We aimed to determine if bioimpedance spectroscopy (BIS)-derived estimates of body water co...
Source: Archives of Orthopaedic and Trauma Surgery - September 14, 2018 Category: Orthopaedics Source Type: research

Global sagittal alignment in elderly patients with osteoporosis and its relationship with severity of vertebral fracture and quality of life
ConclusionOsteoporotic patients with VCF showed worse global sagittal alignment and decreased quality of life. The number and severity of VCF had a negative influence on global sagittal balance, which indicates that poorer sagittal global alignment may imply worse quality of life and more severe VCF. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 7, 2018 Category: Orthopaedics Source Type: research

Cost-effectiveness analysis of drugs for osteoporosis treatment in elderly Japanese women at high risk of fragility fractures: comparison of denosumab and weekly alendronate
ConclusionsAssuming willingness-to-pay as US$50,000/QALY, denosumab treatment for 75-year-old Japanese women with a BMD of 65% of YAM and a history of previous vertebral body fracture was cost-effective compared with alendronate treatment. Among over 75  years of age, denosumab treatment might be more cost-effective than alendronate for patients with a BMD of 65% of YAM or lower. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 29, 2018 Category: Orthopaedics Source Type: research

Progressive bone impairment with age and pubertal development in neurofibromatosis type I
AbstractSummaryBone density impairment represents an established complication in adults with neurofibromatosis type 1, while few data exist in the pediatric population. Age- and gender-adjusted bone mass decreases with age and pubertal development, identifying childhood as the best time frame to introduce prevention strategies aiming at peak bone mass achievement.PurposeThe present study aims at evaluating bone mineral density (BMD) in a population of children with neurofibromatosis type I (NF-1), with particular focus on changes occurring during growth and pubertal development.MethodsBone metabolic markers and bone status...
Source: Archives of Orthopaedic and Trauma Surgery - August 27, 2018 Category: Orthopaedics Source Type: research

Grip strength cutpoints for youth based on a clinically relevant bone health outcome
ConclusionsGrip strength is strongly related to TBLH_BMC, and the proposed cutpoints demonstrated acceptable classification accuracy for screening healthy youth and tracking healthy bone development in community settings. The utility of the cutpoints should be further examined in more diverse populations of youth. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 27, 2018 Category: Orthopaedics Source Type: research

Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010
ConclusionsWe observed declining trends in MOF and hip fracture for both sexes. However, a lower rate of decrease of hip fracture and an increasing trend in vertebral fracture was noticed among men. Considering our observations and the major economic burden which accompanies this devastating disease, more attention should be paid to MOF, especially in men. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 27, 2018 Category: Orthopaedics Source Type: research