Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model
ConclusionThe FRAX model should enhance accuracy of determining fracture probability among the Kazakh population and help guide decisions about treatment. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 27, 2020 Category: Orthopaedics Source Type: research

Effects of smoking habit change on hospitalized fractures: a retrospective cohort study in a male population
ConclusionsLonger time since smoking cessation in men may lead to decreased risk for fractures, especially lumbar and other site fractures. Physicians should counsel patients at risk for fractures both to quit smoking and to maintain abstinence from smoking. Further studies may be required to help comprehend how smoking cessation can affect fracture risk. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 27, 2020 Category: Orthopaedics Source Type: research

Epidemiology of hip fractures in Bulgaria: development of a country-specific FRAX model
ConclusionThe FRAX model should enhance accuracy of determining fracture probability among the Bulgarian population and help guide decisions about treatment. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 27, 2020 Category: Orthopaedics Source Type: research

Development and efficacy of a computerized decision support system for osteoporosis management in the community
AbstractSummaryComputerized alerts for primary care physicians, provided during visits of patients who met treatment guidelines based on their electronic medical records, are an efficient method to raise awareness to many otherwise missed cases, especially after fracture.PurposeMeasure the efficacy of an automated real-time alert which was developed to assist osteoporosis management in the community.MethodsThe study population included treatment na ïve patients with T-score ≤ − 2.5 or hip or vertebral fracture in a 2 million member Israeli health fund. On each ambulatory visit to a primar...
Source: Archives of Orthopaedic and Trauma Surgery - February 26, 2020 Category: Orthopaedics Source Type: research

Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase —reference intervals and confounders for two bone formation markers
AbstractSummaryBone formation markers bone-specific alkaline phosphatase and osteocalcin are used in many clinical situations. Therefore, we calculated reference intervals for the two markers and investigated how they are influenced by several factors including sex and age. Furthermore, we established clinically relevant reference intervals for the two markers.ObjectiveThe bone turnover markers (BTMs), bone-specific alkaline phosphatase (bone ALP), and osteocalcin (OC), are frequently measured formation markers. The purpose of this study was to establish reference intervals (RIs) for the two BTMs in a general adult Danish ...
Source: Archives of Orthopaedic and Trauma Surgery - February 24, 2020 Category: Orthopaedics Source Type: research

Vertebral fracture assessment by dual-energy X-ray absorptiometry along with bone mineral density in the evaluation of postmenopausal osteoporosis
ConclusionVF was seen in more than two-thirds of the postmenopausal women referred for osteoporosis evaluation. VFA identified additional patients with VF whose BMD was not in the osteoporotic range. Incorporation of VFA to BMD will assist in documenting prevalent vertebral fracture which is an independent risk factor for incident fragility fracture irrespective of the BMD. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 24, 2020 Category: Orthopaedics Source Type: research

Calcium intake in an adult Ukrainian population
AbstractSummaryThis is a first large epidemiological study of calcium intake in Ukrainian population. The data from 1518 outpatient subjects aged 20 –89 years old showed that the mean level of calcium intake composed 615.6 mg/day (735.4 mg/day in males and 565.6 mg/day in females, p 
Source: Archives of Orthopaedic and Trauma Surgery - February 23, 2020 Category: Orthopaedics Source Type: research

Impact of changes in fat mass and lean soft tissue on bone mineral density accrual in adolescents engaged in different sports: ABCD Growth Study
ConclusionsChanges in LST were the most relevant determinant of BMD accrual in the lower limbs, mainly among adolescents engaged in sports. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 23, 2020 Category: Orthopaedics Source Type: research

Cumulative network meta-analyses, practice guidelines, and actual prescriptions for postmenopausal osteoporosis: a meta-epidemiological study
ConclusionsIn postmenopausal osteoporosis, there was no apparent discrepancy between guideline recommendations and drug prescribing rankings, with the exception of vDCa, when we used cumulative NMAs as references. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 23, 2020 Category: Orthopaedics Source Type: research

Associations between bone mineral density and coronary artery disease: a meta-analysis of cross-sectional studies
ConclusionsLow BMD was not associated with the prevalence of CAD. Without age adjustment, the BMD of CADs is significantly lower than that of non-CADs, and the patients with lower BMD are inclined to more severe coronary artery lesions. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 23, 2020 Category: Orthopaedics Source Type: research

What is a reasonable rate for specific osteoporosis drug therapy in older fragility fracture patients?
AbstractBackgroundOsteoporosis is the most common condition contributing to 95% of fractures in older patients hospitalized for fracture treatment. Despite the significant impact of fragility fractures on patient morbidity and mortality, efforts in optimizing osteoporotic treatment and prevention remain inadequate. In contrast, in patients with limited life expectancy, withholding specific osteoporosis drug treatment appears reasonable. The threshold between under- and overtreatment is still unclear.MethodsIn 2016, we implemented a fracture liaison service (FLS) for 18  months to improve the quality of osteoporosis ca...
Source: Archives of Orthopaedic and Trauma Surgery - February 22, 2020 Category: Orthopaedics Source Type: research

‘Nonagenarians’ with a hip fracture: is a different orthogeriatric treatment strategy necessary?
ConclusionNonagenarians differ from patients aged 70 –79 and 80–89 years in baseline characteristics, complication and mortality rates. Differences increased gradually with age. The results of this study can be used, in combination with the Almelo Hip Fracture Score, to deliver efficiently targeted orthogeriatric treatment to the right patient gr oup. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 22, 2020 Category: Orthopaedics Source Type: research

Low-dose and sparse sampling MDCT-based femoral bone strength prediction using finite element analysis
ConclusionOur simulations indicate that up to 50% reduction in radiation dose through sparse sampling can be used for FE-based prediction of femoral failure load. Sparse-sampled MDCT may allow fracture risk prediction and treatment monitoring in osteoporosis with less radiation exposure in the future. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 22, 2020 Category: Orthopaedics Source Type: research

Correlation of bone mineral density with MRI T2* values in quantitative analysis of lumbar osteoporosis
AbstractSummaryWe found that the MRI T2* value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.PurposeTo investigate the T2* quantitative measurement in magnetic resonance imaging (MRI) and its correlation with the bone mineral density (BMD) values evaluated with quantitative computed tomography (QCT) in women with postmenopausal lumbar vertebrae osteoporosis.Materials and methodsEighty-seven postmenopausal women ...
Source: Archives of Orthopaedic and Trauma Surgery - February 22, 2020 Category: Orthopaedics Source Type: research

Distal radius bone microarchitecture: what are the differences between age 25 and old age?
This study reported that the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The magnitude of differences in areal and volumetric bone mineral density (aBMD, vBMD) between older and younger groups was similar.IntroductionAging is strongly associated with bone loss, but little is known about magnitudes of differences in bone microarchitectures, aBMD, and vBMD from peak bone mass (PBM) to senescence. We aimed to describe differences in aBMD, vBMD, and bone microarchitecture parameters at the distal radius between older a...
Source: Archives of Orthopaedic and Trauma Surgery - February 20, 2020 Category: Orthopaedics Source Type: research

The one-year mortality rate in elderly patients with osteoporotic fractures of the pelvis
AbstractSummaryOsteoporosis is a common condition for elderly people. The incidence of osteoporotic pelvic fractures has been increasing. Osteoporotic pelvic fractures are associated with increased mortality rates. Based on the aim of our study, we found out that one-year mortality rate after a pelvic fracture is high and depends on the fracture type.PurposeThe aim of this study was to determine the one-year mortality rate in patients aged 65+ with osteoporotic pelvic fractures depending on the type of fracture according to AO/OTA classification.MethodsPatients aged 65+ with pelvic insufficiency fractures admitted to a sin...
Source: Archives of Orthopaedic and Trauma Surgery - February 20, 2020 Category: Orthopaedics Source Type: research

Management of hospitalised osteoporotic vertebral fractures
ConclusionClinical care pathways for the hospitalised VFF population lack standardisation in Ireland. Key challenges reported by orthopaedic doctors and physiotherapists relate to pain management, osteoporosis medication prescription, clarity on indications for bracing and a lack of fracture liaison services. Clinical guidelines, defined clinical care pathways and high-quality clinical research trials are required for VFF management. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - February 20, 2020 Category: Orthopaedics Source Type: research

Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model
ConclusionThe FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 28, 2020 Category: Orthopaedics Source Type: research

Burden of illness of hip fractures in elderly Dutch patients
ConclusionsHip fractures lead to a burden to patients, resulting from mortality and health-related quality of life reductions, and to society, due to (healthcare) costs. The results of this study can be used in future economic evaluations. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 3, 2020 Category: Orthopaedics Source Type: research

Experience gained from the implementation of the fracture liaison service in Greece
ConclusionThe participation rate remains low and needs improvement. However, we report herein that whenever the treating physician is involved in the FLS structure, patients are more easily convinced to complete the program, to receive anti-osteoporotic treatment, and to stay connected throughout with the outpatient clinic. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 3, 2020 Category: Orthopaedics Source Type: research

Association between osteoporotic femoral neck fractures and DXA-derived 3D measurements at lumbar spine: a case-control study
ConclusionThis study showed the association of DXA-derived measurements at lumbar spine with transcervical hip fractures. A strong association between vBMD at the posterior vertebral elements and transcervical hip fractures was observed, probably because of global deterioration of the cortical bone. Further studies should be carried out to investigate on the relative risk of transcervical fracture in patients with long-term cortical structural deterioration. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 3, 2020 Category: Orthopaedics Source Type: research

A risk factor associated with subsequent new vertebral compression fracture after conservative therapy for patients with vertebral compression fracture: a retrospective observational study
ConclusionsConservative therapies focused on lumbar BMD, functional recovery and pain relief in the acute period may be useful in preventing subsequent VCF. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 3, 2020 Category: Orthopaedics Source Type: research

No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis
ConclusionsThe anti-Rank ligand and PTH analogs have no impact on cardiovascular risk and overall mortality in idiopathic osteoporosis. To better answer the question whether these treatments can reduce the long-term cardiovascular risk, further comparative studies with longer duration are required. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 3, 2020 Category: Orthopaedics Source Type: research

Second rebound-associated vertebral fractures after denosumab discontinuation
AbstractSummaryHere, we report the case of a 69-year-old female who discontinued denosumab to undergo dental treatment. She subsequently suffered rebound-associated vertebral fractures (RVFs) twice. Denosumab is approved in several countries for osteoporosis treatment. Its discontinuation can result in bone turnover rebound increase and rapid bone mineral density loss. Rebound-associated vertebral fractures (RVFs) after discontinuing denosumab have been widely reported. We previously reported the case of a patient who suffered RVFs after discontinuing denosumab to undergo dental treatment. A 69-year-old female suffered fiv...
Source: Archives of Orthopaedic and Trauma Surgery - January 2, 2020 Category: Orthopaedics Source Type: research

Common errors in dual-energy X-ray absorptiometry scans in imaging centers in Ecuador
ConclusionsDXA quality standards exist but are often not implemented in clinical practice. When studies are performed incorrectly, it can lead to important errors in diagnosis and therapy. Physicians interested in the management of osteoporosis, although not directly involved in the performance and interpretation of DXA, should be familiar with the protocols to minimize errors and allow the proper use of bone densitometry. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 2, 2020 Category: Orthopaedics Source Type: research

Advances in the understanding of the role of type-H vessels in the pathogenesis of osteoporosis
ConclusionsThese studies support unique functions for type-H vessels in the bone that may enable new therapeutic approaches to osteoporosis. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - January 2, 2020 Category: Orthopaedics Source Type: research

Comparison of treatment strategies and thresholds for optimizing fracture prevention in Canada: a simulation analysis
ConclusionsChoice of treatment strategy and threshold for osteoporosis management strongly influences the number of individuals for whom pharmacologic treatment would be recommended and on estimated fracture rates in the population. This evidence-based approach to comparing these strategies will help to inform guidelines development in Canada and may be on interest elsewhere. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - December 19, 2019 Category: Orthopaedics Source Type: research

Efficacy of risedronate with cholecalciferol on bone mineral density in Korean patients with osteoporosis
ConclusionsA once-weekly pill containing risedronate and cholecalciferol had the equivalent antiresorptive efficacy on BMD compared with risedronate alone and improved 25(OH) D serum levels after 12  months of treatment without significant adverse events in Korean patients with osteoporosis. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - December 9, 2019 Category: Orthopaedics Source Type: research

Estimation and projection about the standardized prevalence of osteoporosis in mainland China
ConclusionWe found that osteoporosis is a serious public health challenge in mainland China. The findings in our study add insight into the epidemiology of osteoporosis and would be beneficial for the prevention and treatment of osteoporosis in mainland China. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - December 6, 2019 Category: Orthopaedics Source Type: research

A meta-analysis of secondary osteoporosis in systemic lupus erythematosus: prevalence and risk factors
ConclusionsOur study found a statistically significant increased risk of OP in SLE patients compared with controls. SLE patients should be actively screened for OP and its consequences. Larger longitudinal studies are needed to confirm this possible association.The prevalence of OP in SLE was 16%. Compared with controls, the risk of OP in SLE was 2.03. There were significant differences of age, disease duration, cumulative glucocorticoid dose, time of glucocorticoid, SLICC, and menopause, while daily glucocorticoid dose, SLEDAI, and BMI had no statistical differences between OP and non-OP cases. (Source: Archives of Orthop...
Source: Archives of Orthopaedic and Trauma Surgery - December 4, 2019 Category: Orthopaedics Source Type: research

The performance of osteoporosis self-assessment tool for Asians (OSTA) in identifying the risk of osteoporosis among Malaysian population aged 40  years and above
This study aimed to validate the performance of OSTA in identifying subjects with osteoporosis determined with DXA.MethodsThis cross-sectional study recruited 786 Malaysians in Klang Valley, Malaysia. Their bone health status was assessed by DXA and OSTA. The association and agreement between OSTA and bone mineral density assessment by DXA were determined by Pearson ’s correlation and Cohen’s kappa, respectively. Receiver operating characteristics (ROC) curves were used to determine the sensitivity, specificity, and area under the curve (AUC) for OSTA.ResultsOSTA and DXA showed a fair association in the study (...
Source: Archives of Orthopaedic and Trauma Surgery - November 28, 2019 Category: Orthopaedics Source Type: research

Breaking the cycle of recurrent fracture: implementing the first fracture liaison service (FLS) in British Columbia, Canada
ConclusionIn BC, the implementation of an FLS program improved investigation and treatment for osteoporosis after low trauma fracture. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 27, 2019 Category: Orthopaedics Source Type: research

East-west gradient in hip fracture incidence in Spain: how much can we explain by following the pattern of risk factors?
The objectives of our study are (1) to estimate the incidence rate and trend of hospital admissions for hip fracture in Spain and by ACs and (2) to analyze risk factors/markers that could explain the variability in the incidence and trend between different ACs.MethodThis work includes 2 studies (TREND-HIP and VAR-HIP).TREND-HIP: retrospective, national, observational study based on the administrative database of the National Health System that includes a Minimum Basic Data Set (MBDS) of hospital admissions.VAR-HIP: ecological study based on the analysis of the results obtained in TREND-HIP study, with different risk factor...
Source: Archives of Orthopaedic and Trauma Surgery - November 27, 2019 Category: Orthopaedics Source Type: research

The health and economic burden of osteoporotic fractures in Singapore and the potential impact of increasing treatment rates through more pharmacological options
ConclusionEfforts to improve the detection, diagnosis, and treatment of osteoporosis are necessary to reduce the growing clinical, economic, and societal burden of fractures in Singapore. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 26, 2019 Category: Orthopaedics Source Type: research

Reduced leg muscle mass and lower grip strength in women are associated with osteoporotic vertebral compression fractures
We examined the relationship between bone mineral density, bone strength, skeletal muscle mass, grip strength, and skin autofluorescence (SAF) in women with osteoporotic vertebral compression fractures (VCF).MethodsA total of 1039 women (mean age 73.3 years) were included in our study. These included 222 cases of VCF (mean 77.8 years) and 817 controls (mean 72.0 years). Lumbar and femur BMD were measured for all participants using dual-energy X-ray absorptiometry (DXA). Bone strength surrogates, such as cross-sectional area (CSA) of the proximal femur, were evaluated using Advanced Hip Assessment software. SAF was measured...
Source: Archives of Orthopaedic and Trauma Surgery - November 23, 2019 Category: Orthopaedics Source Type: research

The sunshine under our skin: public knowledge and practices about vitamin D deficiency in Al Ain, United Arab Emirates
ConclusionsOur findings demonstrate a mismatch between knowledge and awareness, and attitude implying the need of educating people to improve their attitude toward consuming vitamin D rich food and supplements. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 22, 2019 Category: Orthopaedics Source Type: research

Hospital staff participation in a national hip fracture audit: facilitators and barriers
ConclusionsTo improve participation in a nationwide clinical audit, it seems that the data collection should either be performed by additional staff or be automated. Active participation is facilitated if audit data is made available to other parties, such as insurers, healthcare authorities or policymakers. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 21, 2019 Category: Orthopaedics Source Type: research

Bone-filling mesh container versus percutaneous kyphoplasty in treating K ümmell’s disease
AbstractSummaryK ümmell’s disease (eponymous name for osteonecrosis and collapse of a vertebral body due to ischemia and non-union of anterior vertebral body wedge fractures after major trauma) cannot heal spontaneously. Bone-filling mesh container (BFMC) can significantly relieve pain, help the correction of kyp hosis, and may prevent cement leakage. This pilot study may provide the basis for the design of future studies.PurposeTo compare the effectiveness and safety of BFMC and percutaneous kyphoplasty (PKP) for treatment of K ümmell’s disease.MethodsFrom August 2016 to May 2018, 40 patients with K ...
Source: Archives of Orthopaedic and Trauma Surgery - November 18, 2019 Category: Orthopaedics Source Type: research

Correction to: Effect of periodic abstinence from dairy products for approximately half of the year on bone health in adults following the Christian Orthodox Church fasting rules for decades
The original version of this article, published on 27 June 2019, unfortunately contained a mistake. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 14, 2019 Category: Orthopaedics Source Type: research

Impact of reference point selection on DXA-based measurement of forearm bone mineral density
ConclusionsGiven equal ability to determine BMD at the 1/3 radius accurately, the radial endplate or the bifurcation of the ulna and radius should be preferentially selected as the reference point for routine forearm BMD measurements in order to avoid situations in which the ultra-distal radius BMD cannot be determined. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 9, 2019 Category: Orthopaedics Source Type: research

Correlation between osteoporotic vertebral fracture and abdominal trunk muscle strength in middle-aged and older women
ConclusionsAbdominal trunk muscle weakness in middle-aged and older women was associated with OVF. The strength measurement can be a risk assessment of OVF. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 31, 2019 Category: Orthopaedics Source Type: research

Fragility fractures and imminent fracture risk in Hong Kong: one of the cities with longest life expectancies
ConclusionsFollowing an initial fracture, prompt treatment strategies should be adopted to avoid imminent risk of fractures. This window of opportunity in the first 2  years is a golden period to treat osteoporosis and prevent falls. Our post hoc analysis has shown that male patients and patients older than 95 are at even higher risk. Clinicians and allied healthcare professionals should be alert on these patients. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2019 Category: Orthopaedics Source Type: research

Increased risk of osteoporosis in patients with peptic ulcer: a follow-up study using a national sample cohort
This study aimed to evaluate the association between peptic ulcer disease (PUD) and the occurrence of osteoporosis using a national sample cohort from South Korea.MethodsUsing the national cohort study from the Korean National Health Insurance Service, we extracted data for patients with PUD (n = 50,002) and for 1:1 matched control participants (n = 50,002); we then analyzed the occurrence of osteoporosis from 2002 to 2013. The patients were matched according to age, sex, income, region of residence, and past medical history. A stratified Cox proportional hazards model was used to analyze the hazard ratios (HRs) and the 95...
Source: Archives of Orthopaedic and Trauma Surgery - October 29, 2019 Category: Orthopaedics Source Type: research

Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008 –2011
AbstractSummaryWe compared the relationship between physical activity (PA) and bone mineral density (BMD) in men and women aged over 50  years. Only moderate-to-vigorous PA was positively associated with hip BMD in men. There was no association between PA and BMD at any site in women.IntroductionPhysical activity (PA) is widely recommended for osteoporosis. However, epidemiological data regarding the intensity or volume of PA required for bone health are lacking. We aimed to investigate and compare the relationship between PA and bone mineral density (BMD) in men and women.MethodsThis population-based cross-sectional ...
Source: Archives of Orthopaedic and Trauma Surgery - October 26, 2019 Category: Orthopaedics Source Type: research

Higher serum alkaline phosphatase activity in infants born to vitamin D –deficient mothers
AbstractSummaryOur research shows that the newborns of vitamin D –deficient mothers have higher serum alkaline phosphatase (ALP) activity compared with those of vitamin D–non-deficient mothers, which is likely related to increased bone turnover rather than just being a marker for bone formation. This has a potential negative impact on fetal bone development a nd subsequent skeletal growth.Purpose/introductionLow maternal serum 25-hydroxy vitamin D (25(OH)D) level during pregnancy contributes to vitamin D deficiency in infants at birth, which is associated with multiple potential adverse effects on fetal skeleta...
Source: Archives of Orthopaedic and Trauma Surgery - October 25, 2019 Category: Orthopaedics Source Type: research

The role of bone mineral density in therapeutic decision-making using the Fracture Risk Assessment Tool (FRAX): a sub-study of the Taiwan OsteoPorosis Survey (TOPS)
ConclusionsThe FRAX scores are influenced by age, irrespective of the consideration of BMD. FRAX − BMD is able to identify more subjects for therapeutic intervention in the elderly population. We should reconsider the role of BMD at different ages for therapeutic decision-making. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 24, 2019 Category: Orthopaedics Source Type: research

Effects of postoperative osteoporosis treatment on subsequent fracture and the 5-year survival rates after hemiarthroplasty for hip fracture
ConclusionsAccording to our results, elderly patients who underwent hemiarthroplasty for an osteoporotic hip fracture were not commonly screened or treated for osteoporosis. Our results demonstrated no significant difference between the groups in terms of subsequent fracture. However, we observed a significant high 5-year survival rate among patients who received the osteoporosis treatment. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 18, 2019 Category: Orthopaedics Source Type: research

Fatty infiltration of paraspinal muscles is associated with bone mineral density of the lumbar spine
AbstractSummaryA total of 88 subjects were enrolled to investigate the relationship between paraspinal muscle fatty infiltration and lumbar bone mineral density (BMD) using chemical shift encoding-based water-fat MRI and quantitative computed tomography (QCT), respectively. A moderate inverse correlation between paraspinal muscle proton density fat fraction and lumbar QCT-BMD was found with age, sex, and BMI controlled.PurposeTo investigate the relationship between paraspinal muscle fatty infiltration and lumbar bone mineral density (BMD).MethodsA total of 88 subjects were enrolled in this study (52 females, 36 males; age,...
Source: Archives of Orthopaedic and Trauma Surgery - October 15, 2019 Category: Orthopaedics Source Type: research

Analysis of volumetric BMD in people with Down syndrome using DXA-based 3D modeling
AbstractSummaryWe analyzed volumetric bone mineral density, by 3D analysis, in 76 people with Down syndrome and 76 controls. People with Down syndrome, particularly men, have a lower hip volumetric bone mineral density than the general population. Besides, volumetric bone mineral density declines more rapidly in Down syndrome.IntroductionPeople with Down syndrome (DS) have a lower areal bone mineral density (aBMD) estimated by dual-energy X-ray absorptiometry (DXA). However, they have smaller-sized bones, which could influence the measurements. Therefore, our objective was to determine volumetric BMD in these patients.Mate...
Source: Archives of Orthopaedic and Trauma Surgery - September 7, 2019 Category: Orthopaedics Source Type: research

Mortality and physical dependence following fragility hip fracture: data from a regional hip fracture registry in Sri Lanka
ConclusionsThere is an increased risk of death following hip fracture and the risk was higher in the first 12  months compared with the next 12 months. Men had higher crude mortality compared with women and 58% patients had limitations in daily activities at 12 months, post-fracture. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 6, 2019 Category: Orthopaedics Source Type: research