Randomized controlled clinical trials and meta-analyses
(Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 24, 2015 Category: Orthopaedics Source Type: research

Comorbidities, bone-sparing agent prescription history and their determinants among postmenopausal women in UK primary care settings: a retrospective database study
Conclusions Several patient characteristics were associated with discontinuation of, or switching between, bone-sparing treatments. Patients receiving bone-sparing medication other than oral bisphosphonates were more likely to have comorbid conditions and a history of fracture and to have taken an oral bisphosphonate previously. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 19, 2015 Category: Orthopaedics Source Type: research

Incidence of hip fracture in Kuwait: a national registry-based study
Conclusions The hip fracture age-standardized incidence rates in the Kuwaiti subpopulation aged 50 years and above are rising and expected to increase substantially in the coming decades. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - November 17, 2015 Category: Orthopaedics Source Type: research

Differential effect of predictors of bone mineral density and hip geometry in postmenopausal women: a cross-sectional study
Abstract Summary Osteoporosis is an important health problem in postmenopausal women. Lactation duration (LD), parity, menopause duration (MD), and body mass index (BMI) are important predictors of bone mineral density (BMD) and osteoporotic fractures in them. In addition, they have site-specific effects on BMD. Introduction Osteoporosis is especially prevalent in postmenopausal women. The aim of the study was to determine the effects of age, parity, LD, MD, and BMI on BMD at different sites and hip geometry in postmenopau...
Source: Archives of Orthopaedic and Trauma Surgery - November 10, 2015 Category: Orthopaedics Source Type: research

Change in incidence of hip fracture in Gwangju City and Jeonnam Province, Korea, over 20 years
Conclusions The incidence of fractures increased considerably between 1991 and 2001, with less increase in the ensuing 10 years. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 22, 2015 Category: Orthopaedics Source Type: research

Reassessment of osteoporosis-related femoral fractures and economic burden in Saudi Arabia
Conclusions Osteoporosis-related femoral fractures in Saudi Arabia are significant causes of morbidity besides incurring economic burden. We believe that a National Fracture Registry needs to be established, and osteoporosis awareness programs should be instituted in every part of Saudi Arabia so that these patients can be diagnosed early and treated appropriately to reduce both the number of fractures and the economic burden of the fractures. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 22, 2015 Category: Orthopaedics Source Type: research

Change in incidence of hip fracture in Gwangju City and Jeonnam Province, Korea, over 20 years
Conclusions The incidence of fractures increased considerably between 1991 and 2001, with less increase in the ensuing 10 years. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 22, 2015 Category: Orthopaedics Source Type: research

Reassessment of osteoporosis-related femoral fractures and economic burden in Saudi Arabia
Conclusions Osteoporosis-related femoral fractures in Saudi Arabia are significant causes of morbidity besides incurring economic burden. We believe that a National Fracture Registry needs to be established, and osteoporosis awareness programs should be instituted in every part of Saudi Arabia so that these patients can be diagnosed early and treated appropriately to reduce both the number of fractures and the economic burden of the fractures. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - October 22, 2015 Category: Orthopaedics Source Type: research

Is allopurinol use associated with an excess risk of osteoporotic fracture? A National Prescription Registry study
Abstract Summary Using a Danish Register cohort of 86,039 adult new allopurinol users and propensity score matched controls, we found that gout requiring allopurinol prescription was associated with an increased fracture risk. Purpose Gout, an acute inflammatory arthritis, is common and associated with elevated serum urate, obesity and high alcohol consumption. The mainstay of therapy is the urate-lowering agent, allopurinol. Here, we report the relationship between allopurinol prescription and fracture in a large registry population. ...
Source: Archives of Orthopaedic and Trauma Surgery - October 19, 2015 Category: Orthopaedics Source Type: research

Compliance and persistence with treatment with parathyroid hormone for osteoporosis. A Danish national register-based cohort study
Abstract Summary Medical intervention is important in the treatment of osteoporosis, and compliance with medical treatment is essential for an optimal outcome. Based on Danish national registers, we found that compliance with parathyroid hormone (PTH) treatment is high and associated with marital status, working status, and type of PTH treatment. Purpose Compliance and persistence are essential for an optimal outcome during medical treatment of osteoporosis. We aimed to evaluate compliance and persistence with treatment wi...
Source: Archives of Orthopaedic and Trauma Surgery - October 1, 2015 Category: Orthopaedics Source Type: research

Relationships between self-reported lifetime physical activity, estimates of current physical fitness, and aBMD in adult premenopausal women
Conclusions Past PA > 7 METS was positively associated with aBMD, and such activity should probably constitute a relatively high proportion of all weekly PA to positively affect aBMD. The findings warrant more detailed investigations in a prospective study, specifically also investigating the potentially negative effects of high impact PA on tibial aBMD. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 30, 2015 Category: Orthopaedics Source Type: research

Association between HIV infection and bone mineral density in climacteric women
Abstract Summary A cross-sectional study was conducted with the purpose of evaluating bone mineral density in HIV seropositive and seronegative climacteric women. HIV infection was negatively associated with bone mineral density in the lumbar spine Purpose To assess bone mineral density (BMD) and its associated factors in HIV seropositive and seronegative climacteric women Methods A cross-sectional study with 537 women (273 HIV seropositive and 264 HIV seronegative) aged between ...
Source: Archives of Orthopaedic and Trauma Surgery - September 29, 2015 Category: Orthopaedics Source Type: research

Growth in bone and body size among Asian and white girls in the Female Adolescent Maturation (FAM) study
Conclusions Asian girls had more upper body (subscapular) fat at age 10 years and gained height and hip and abdomen circumferences more slowly than Asian-White and White girls. Asian girls had greater bone SOS and BUA at age 10 years but gained bone at similar rates to White girls. Physical activity was especially important to bone growth before age 12 years. However, ethnic differences remained after adjusting for physical activity, demographic, and dietary factors. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 15, 2015 Category: Orthopaedics Source Type: research

Non-linear pattern of age-specific bone mineral density and related factors in women: data from the 5 th Korea National Health and Nutrition Examination Survey
Conclusions The BMD of Korean women in reproductive period could be largely attributed to the nonlinear effects of age and body compositional factors. Intervention targeting these factors could be critical for maintaining peak BMD. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 15, 2015 Category: Orthopaedics Source Type: research

Growth in bone and body size among Asian and white girls in the Female Adolescent Maturation (FAM) study
Conclusions Asian girls had more upper body (subscapular) fat at age 10 years and gained height and hip and abdomen circumferences more slowly than Asian-White and White girls. Asian girls had greater bone SOS and BUA at age 10 years but gained bone at similar rates to White girls. Physical activity was especially important to bone growth before age 12 years. However, ethnic differences remained after adjusting for physical activity, demographic, and dietary factors. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 15, 2015 Category: Orthopaedics Source Type: research

Non-linear pattern of age-specific bone mineral density and related factors in women: data from the 5 th Korea National Health and Nutrition Examination Survey
Conclusions The BMD of Korean women in reproductive period could be largely attributed to the nonlinear effects of age and body compositional factors. Intervention targeting these factors could be critical for maintaining peak BMD. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 15, 2015 Category: Orthopaedics Source Type: research

Use of anti-osteoporotic drugs in central Norway after a forearm fracture
Conclusions The use of AOD after a forearm fracture was low. An increased focus on osteoporosis in fracture patients is needed for secondary fracture prevention. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 3, 2015 Category: Orthopaedics Source Type: research

Adolescent undernutrition and early adulthood bone mass in an urbanizing rural community in India
Conclusions Current lean mass was a more important determinant of bone mass than thinness during adolescence in this population. Weight gain during late adolescence and young adulthood coupled with improvement in lean mass may help to mitigate any adverse effects that pre-adulthood undernutrition may have on bone mass accrual. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - September 1, 2015 Category: Orthopaedics Source Type: research

Incidence of hip fracture in Brazil and the development of a FRAX model
Conclusions The FRAX tool is the first to provide a country-specific fracture prediction model for Brazil. It is based on the original FRAX methodology, which has been externally validated in several independent cohorts. Despite some limitations, the strengths make the Brazilian FRAX tool a good candidate for implementation into clinical practice. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 25, 2015 Category: Orthopaedics Source Type: research

Compliance and persistence with daily, weekly, and monthly bisphosphonates for osteoporosis in Japan: analysis of data from the CISA
Abstract Summary Compliance and persistence with daily, weekly, and monthly bisphosphonates (BPs) for osteoporosis were assessed using data from the Platform for Clinical Information Statistical Analysis (CISA) database that contains data of prescriptions in 13 university hospitals in Japan. The analysis revealed compliance and persistence improved as the dosing interval increases. Purpose BPs are an effective first-line therapy for osteoporosis, but adherence is low. Compliance (medication possession ratio, MPR) and persistence (time to discontin...
Source: Archives of Orthopaedic and Trauma Surgery - August 22, 2015 Category: Orthopaedics Source Type: research

New vertebral fractures after vertebroplasty: 2-year results from a randomised controlled trial
Conclusion For patients undergoing VP, our study did not demonstrate significant increases in subsequent fracture risk beyond that experienced by those with vertebral fractures who did not undergo the procedure. However, because of the non-significant numerical increases observed, studies with adequate power are needed to draw definite conclusions about fracture risk. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 14, 2015 Category: Orthopaedics Source Type: research

Validation of a modified FRAX® tool for improving outpatient efficiency—part of the “Catch Before a Fall” initiative
Discussion Our modified tool provides a simple, accurate and reliable method for patients to self-report their own FRAX® score outside the clinical contact period, thus releasing the HCP from the time required to complete the questionnaire and potentially increasing our capture rate of at-risk patients. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 14, 2015 Category: Orthopaedics Source Type: research

New vertebral fractures after vertebroplasty: 2-year results from a randomised controlled trial
Conclusion For patients undergoing VP, our study did not demonstrate significant increases in subsequent fracture risk beyond that experienced by those with vertebral fractures who did not undergo the procedure. However, because of the non-significant numerical increases observed, studies with adequate power are needed to draw definite conclusions about fracture risk. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 14, 2015 Category: Orthopaedics Source Type: research

Validation of a modified FRAX® tool for improving outpatient efficiency—part of the “Catch Before a Fall” initiative
Discussion Our modified tool provides a simple, accurate and reliable method for patients to self-report their own FRAX® score outside the clinical contact period, thus releasing the HCP from the time required to complete the questionnaire and potentially increasing our capture rate of at-risk patients. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 14, 2015 Category: Orthopaedics Source Type: research

Swedish osteoporosis care
This report encompasses quantitative health outcomes based on Swedish registry data as well as organizational and management aspects. Executive summary Swedish osteoporosis care is characterized by a significant burden of disease, difficulties in identifying high-risk patients, and fragmented pathways for patients in need of secondary fracture prevention. This report aimed to describe the current state, gaps, and challenges in Swedish osteoporosis care, using Swedish national databases, questionnaires, and interviews with healthcare representatives. A secondary aim was to develop...
Source: Archives of Orthopaedic and Trauma Surgery - August 11, 2015 Category: Orthopaedics Source Type: research

Gender comparison of factors associated with age-related differences in bone mineral density
Conclusions Age-related decline in BMD is more pronounced in women than in men, but determinants of BMD are multiple and interrelated. Our study indicates that different factors may be important for bone health of men and women and at different ages. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - August 4, 2015 Category: Orthopaedics Source Type: research

Humeral fractures due to low-energy trauma: an epidemiologicalsurvey in patients referred to a large emergency department in Northern Italy
Abstract Summary This survey describes the epidemiology of approximately 1800 low-energy humeral fractures seen in a large emergency department in Northern Italy over 7 years (2007–2013), highlighting the differences from previous Italian studies. Purpose The purpose of this study was to determine the incidence of humeral fractures due to low-energy trauma in patients 40 years of age or older referred to a large Emergency Department (Parma, Northern Italy) in a 7-year period (2007–2013). Metho...
Source: Archives of Orthopaedic and Trauma Surgery - July 22, 2015 Category: Orthopaedics Source Type: research

Yield and cost-effectiveness of laboratory testing to identify metabolic contributors to falls and fractures in older persons
Conclusions The minimum cost-effective battery for occult metabolic disorders in older adults at risk of falls and fractures should include serum vitamin D, PTH, TSH, creatinine/eGFR, testosterone (in men), and calcium. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - July 21, 2015 Category: Orthopaedics Source Type: research

Bone mineral density screening and its accordance with Canadian clinical practice guidelines from 2000–2013: an unchanging landscape in Saskatchewan, Canada
This study examined the clinical risk factors, therapeutic health behaviors, and bone mineral density (BMD) status of patients who underwent initial DXA testing at a primary care facility in Saskatchewan, Canada, and whether these factors changed over time from 2000 to 2013 in accordance with Canadian clinical practice guidelines. Methods We conducted a retrospective cross-sectional medical chart audit of 800 patients 50 years of age and older who underwent their first DXA test to assess BMD status. Data was extracted from 2000 to 2013 and further stratified into four period...
Source: Archives of Orthopaedic and Trauma Surgery - July 15, 2015 Category: Orthopaedics Source Type: research

High prevalence of hypovitaminosis D in Mexicans aged 14 years and older and its correlation with parathyroid hormone
Abstract Summary A sample of 585 healthy subjects 14 years and older was studied to estimate the status of 25-hydroxyvitamin D (25(OH)D) and its correlation with parathyroid hormone in healthy Mexicans. In 43.6 % of the sample, levels of vitamin D were below 20 ng/mL and showed an inverse relationship with parathyroid hormone (PTH; p 51). Only 9.6 % of the total sample had levels of 25(OH)D above 30 ng/mL; 46.8 % were between 20 and 29 ng/mL, and 43.6 % were below 20 ng/mL. Regarding PTH, a three-phase model was identified using regression...
Source: Archives of Orthopaedic and Trauma Surgery - July 14, 2015 Category: Orthopaedics Source Type: research

Erratum to: Milk fortified with vitamin D could reduce the prevalence of vitamin D deficiency among Japanese female college students
(Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - June 23, 2015 Category: Orthopaedics Source Type: research

Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study
Conclusion CC is a significant predictor of BMD at hip and spine and fracture at spine in both genders. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - June 18, 2015 Category: Orthopaedics Source Type: research

Risk factors for osteoporosis and factors related to the use of DXA in Norway
Conclusions Suboptimal examination rates among high risk and reallocation of scanning capacity to seemingly low-risk individuals were found. Distance to DXA, current smoking, and male sex constituted possible barriers to the case-finding strategy employed. Cheap and more available diagnostic tools for osteoporosis are needed, and risk stratification tools should be employed more extensively. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - June 12, 2015 Category: Orthopaedics Source Type: research