Fighting nature with nature: antiviral compounds that target retroviruses
Arch Microbiol. 2024 Feb 28;206(3):130. doi: 10.1007/s00203-024-03846-3.ABSTRACTThe human immunodeficiency virus (HIV) is a type of lentivirus that targets the human immune system and leads to acquired immunodeficiency syndrome (AIDS) at a later stage. Up to 2021, there are millions still living with HIV and many have lost their lives. To date, many anti-HIV compounds have been discovered in living organisms, especially plants and marine sponges. However, no treatment can offer a complete cure, but only suppressing it with a life-long medication, known as combined antiretroviral therapy (cART) or highly active antiretrovir...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Zhen Yun Siew Elishea Asudas Chia Ting Khoo Gang Hyeon Cho Kenny Voon Chee-Mun Fang Source Type: research
Interplay between dental caries pathogens, periodontal pathogens, and sugar molecules: approaches for prevention and treatment
Arch Microbiol. 2024 Feb 28;206(3):127. doi: 10.1007/s00203-024-03856-1.ABSTRACTGlobally, oral diseases affect nearly 3.5 billion people, accounting for 4.6% of the healthcare expenditure. Common oral diseases include dental caries and periodontal disease, associated with biofilms formed by cariogenic pathogens. Epidemiological studies associate carbohydrates with these diseases due to the sugars metabolized by cariogenic pathogens. This review focuses on dental caries and periodontal pathogens, quorum sensing, lectin-carbohydrate interactions, and various sugar molecules. Cariogenic sugars significantly influence biofilms...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Kranti Kiran Reddy Ealla Neema Kumari Srikanth Chintalapani Supriya Uppu Vikas Sahu Vishnu Priya Veeraraghavan Pratibha Ramani Sharaschandra Reddy Govindool Source Type: research
A review on endophytic fungi: a potent reservoir of bioactive metabolites with special emphasis on blight disease management
Arch Microbiol. 2024 Feb 28;206(3):129. doi: 10.1007/s00203-023-03828-x.ABSTRACTPhytopathogenic microorganisms have caused blight diseases that present significant challenges to global agriculture. These diseases result in substantial crop losses and have a significant economic impact. Due to the limitations of conventional chemical treatments in effectively and sustainably managing these diseases, there is an increasing interest in exploring alternative and environmentally friendly approaches for disease control. Using endophytic fungi as biocontrol agents has become a promising strategy in recent years. Endophytic fungi ...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Murad Muhammad Abdul Basit Kashif Ali Haris Ahmad Wen-Jun Li Ayesha Khan Heba I Mohamed Source Type: research
Production of Escovopsis conidia and the potential use of this parasitic fungus as a biological control agent of leaf-cutting ant fungus gardens
This study was carried out to investigate the use of different substrates for the production of Escovopsis conidia and verify the virulence of four different isolates cultured on four types of substrates using a novel bioassay. Escovopsis isolates were molecularly identified, based on Internal Transcribed Spacer (ITS) nucleotide sequences. To evaluate conidial production, suspensions (1 × 106 conidia mL-1) of each Escovopsis isolate were inoculated onto four substrates (parboiled rice, white rice, rolled oats, and corn grits). After 14 days, conidial yields were assessed. The virulence of each isolate cultured on the four...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Raymyson R S Queiroz Thais B P Teodoro Aline T Carolino Ricardo O B Bitencourt Willians G Souza Marcela S B Boechat Roberto R Sobrinho Gerson A Silva Richard I Samuels Source Type: research
Fighting nature with nature: antiviral compounds that target retroviruses
Arch Microbiol. 2024 Feb 28;206(3):130. doi: 10.1007/s00203-024-03846-3.ABSTRACTThe human immunodeficiency virus (HIV) is a type of lentivirus that targets the human immune system and leads to acquired immunodeficiency syndrome (AIDS) at a later stage. Up to 2021, there are millions still living with HIV and many have lost their lives. To date, many anti-HIV compounds have been discovered in living organisms, especially plants and marine sponges. However, no treatment can offer a complete cure, but only suppressing it with a life-long medication, known as combined antiretroviral therapy (cART) or highly active antiretrovir...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Zhen Yun Siew Elishea Asudas Chia Ting Khoo Gang Hyeon Cho Kenny Voon Chee-Mun Fang Source Type: research
Interplay between dental caries pathogens, periodontal pathogens, and sugar molecules: approaches for prevention and treatment
Arch Microbiol. 2024 Feb 28;206(3):127. doi: 10.1007/s00203-024-03856-1.ABSTRACTGlobally, oral diseases affect nearly 3.5 billion people, accounting for 4.6% of the healthcare expenditure. Common oral diseases include dental caries and periodontal disease, associated with biofilms formed by cariogenic pathogens. Epidemiological studies associate carbohydrates with these diseases due to the sugars metabolized by cariogenic pathogens. This review focuses on dental caries and periodontal pathogens, quorum sensing, lectin-carbohydrate interactions, and various sugar molecules. Cariogenic sugars significantly influence biofilms...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Kranti Kiran Reddy Ealla Neema Kumari Srikanth Chintalapani Supriya Uppu Vikas Sahu Vishnu Priya Veeraraghavan Pratibha Ramani Sharaschandra Reddy Govindool Source Type: research
A review on endophytic fungi: a potent reservoir of bioactive metabolites with special emphasis on blight disease management
Arch Microbiol. 2024 Feb 28;206(3):129. doi: 10.1007/s00203-023-03828-x.ABSTRACTPhytopathogenic microorganisms have caused blight diseases that present significant challenges to global agriculture. These diseases result in substantial crop losses and have a significant economic impact. Due to the limitations of conventional chemical treatments in effectively and sustainably managing these diseases, there is an increasing interest in exploring alternative and environmentally friendly approaches for disease control. Using endophytic fungi as biocontrol agents has become a promising strategy in recent years. Endophytic fungi ...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Murad Muhammad Abdul Basit Kashif Ali Haris Ahmad Wen-Jun Li Ayesha Khan Heba I Mohamed Source Type: research
Production of Escovopsis conidia and the potential use of this parasitic fungus as a biological control agent of leaf-cutting ant fungus gardens
This study was carried out to investigate the use of different substrates for the production of Escovopsis conidia and verify the virulence of four different isolates cultured on four types of substrates using a novel bioassay. Escovopsis isolates were molecularly identified, based on Internal Transcribed Spacer (ITS) nucleotide sequences. To evaluate conidial production, suspensions (1 × 106 conidia mL-1) of each Escovopsis isolate were inoculated onto four substrates (parboiled rice, white rice, rolled oats, and corn grits). After 14 days, conidial yields were assessed. The virulence of each isolate cultured on the four...
Source: Archives of Microbiology - February 28, 2024 Category: Microbiology Authors: Raymyson R S Queiroz Thais B P Teodoro Aline T Carolino Ricardo O B Bitencourt Willians G Souza Marcela S B Boechat Roberto R Sobrinho Gerson A Silva Richard I Samuels Source Type: research
Unveiling the hidden language of bacteria: anti-quorum sensing strategies for gram-negative bacteria infection control
Arch Microbiol. 2024 Feb 27;206(3):124. doi: 10.1007/s00203-024-03900-0.ABSTRACTQuorum sensing (QS) is a communication mechanism employed by many bacteria to regulate gene expression in a population density-dependent manner. It plays a crucial role in coordinating various bacterial behaviors, including biofilm formation, virulence factor production, and antibiotic resistance. However, the dysregulation of QS can lead to detrimental effects, making it an attractive target for developing novel therapeutic strategies. Anti-QS approaches aim to interfere with QS signaling pathways, inhibiting the communication between bacteria...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Mahmoud A Elfaky Source Type: research
Nutrient limitation and oxidative stress induce the promoter of acetate operon in Salmonella Typhimurium
Arch Microbiol. 2024 Feb 27;206(3):126. doi: 10.1007/s00203-024-03863-2.ABSTRACTGlyoxylate shunt is an important pathway for microorganisms to survive under multiple stresses. One of its enzymes, malate synthase (encoded by aceB gene), has been widely speculated for its contribution to both the pathogenesis and virulence of various microorganisms. We have previously demonstrated that malate synthase (MS) is required for the growth of Salmonella Typhimurium (S. Typhimurium) under carbon starvation and survival under oxidative stress conditions. The aceB gene is encoded by the acetate operon in S. Typhimurium. We attempted t...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Ratanti Sarkhel Swagatika Priyadarsini Manish Mahawar Source Type: research
Cloning, heterologous expression, and molecular characterization of a highly active and stable non-specific endonuclease from Pseudomonas fluorescens
Arch Microbiol. 2024 Feb 27;206(3):125. doi: 10.1007/s00203-024-03867-y.ABSTRACTNon-specific endonucleases can be used for the digestion of nucleic acids because they hydrolyze DNA/RNA into 3-5 base pairs (bp) length oligonucleotide fragments without strict selectivity. In this work, a novel non-specific endonuclease from Pseudomonas fluorescens (PfNuc) with high activities for both DNA and RNA was successfully cloned and expressed in Escherichia coli. The production of PfNuc in flask scale could be achieved to 1.73 × 106 U/L and 4.82 × 106 U/L for DNA and RNA by investigation of the culture and induction conditions. The...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Ke-Ke Han Qiang Zhou Miao Tian Yang-Nan Li Jing-Yi Zhang Ye-Wang Zhang Source Type: research
Unveiling the hidden language of bacteria: anti-quorum sensing strategies for gram-negative bacteria infection control
Arch Microbiol. 2024 Feb 27;206(3):124. doi: 10.1007/s00203-024-03900-0.ABSTRACTQuorum sensing (QS) is a communication mechanism employed by many bacteria to regulate gene expression in a population density-dependent manner. It plays a crucial role in coordinating various bacterial behaviors, including biofilm formation, virulence factor production, and antibiotic resistance. However, the dysregulation of QS can lead to detrimental effects, making it an attractive target for developing novel therapeutic strategies. Anti-QS approaches aim to interfere with QS signaling pathways, inhibiting the communication between bacteria...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Mahmoud A Elfaky Source Type: research
Nutrient limitation and oxidative stress induce the promoter of acetate operon in Salmonella Typhimurium
Arch Microbiol. 2024 Feb 27;206(3):126. doi: 10.1007/s00203-024-03863-2.ABSTRACTGlyoxylate shunt is an important pathway for microorganisms to survive under multiple stresses. One of its enzymes, malate synthase (encoded by aceB gene), has been widely speculated for its contribution to both the pathogenesis and virulence of various microorganisms. We have previously demonstrated that malate synthase (MS) is required for the growth of Salmonella Typhimurium (S. Typhimurium) under carbon starvation and survival under oxidative stress conditions. The aceB gene is encoded by the acetate operon in S. Typhimurium. We attempted t...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Ratanti Sarkhel Swagatika Priyadarsini Manish Mahawar Source Type: research
Cloning, heterologous expression, and molecular characterization of a highly active and stable non-specific endonuclease from Pseudomonas fluorescens
Arch Microbiol. 2024 Feb 27;206(3):125. doi: 10.1007/s00203-024-03867-y.ABSTRACTNon-specific endonucleases can be used for the digestion of nucleic acids because they hydrolyze DNA/RNA into 3-5 base pairs (bp) length oligonucleotide fragments without strict selectivity. In this work, a novel non-specific endonuclease from Pseudomonas fluorescens (PfNuc) with high activities for both DNA and RNA was successfully cloned and expressed in Escherichia coli. The production of PfNuc in flask scale could be achieved to 1.73 × 106 U/L and 4.82 × 106 U/L for DNA and RNA by investigation of the culture and induction conditions. The...
Source: Archives of Microbiology - February 27, 2024 Category: Microbiology Authors: Ke-Ke Han Qiang Zhou Miao Tian Yang-Nan Li Jing-Yi Zhang Ye-Wang Zhang Source Type: research
Endophytic fungi as a potential source of anti-cancer drug
Arch Microbiol. 2024 Feb 26;206(3):122. doi: 10.1007/s00203-024-03829-4.ABSTRACTEndophytes are considered one of the major sources of bioactive compounds used in different aspects of health care including cancer treatment. When colonized, they either synthesize these bioactive compounds as a part of their secondary metabolite production or augment the host plant machinery in synthesising such bioactive compounds. Hence, the study of endophytes has drawn the attention of the scientific community in the last few decades. Among the endophytes, endophytic fungi constitute a major portion of endophytic microbiota. This review d...
Source: Archives of Microbiology - February 26, 2024 Category: Microbiology Authors: Sukanya Sonowal Urvashee Gogoi Kabyashree Buragohain Ratul Nath Source Type: research
