Human Intestinal Microbiota: Interaction Between Parasites and the Host Immune Response
The human gut is a highly complex ecosystem with an extensive microbial community, and the influence of the intestinal microbiota reaches the entire host organism. For example, the microbiome regulates fat storage, stimulates or renews epithelial cells, and influences the development and maturation of the brain and the immune system. Intestinal microbes can protect against infection by pathogenic bacteria, viruses, fungi and parasites. Hence, the maintenance of homeostasis between the gut microbiota and the rest of the body is crucial for health, with dysbiosis affecting disease. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 28, 2017 Category: Research Authors: Oswaldo Partida-Rodr íguez, Angélica Serrano-Vázquez, Miriam E. Nieves-Ramírez, Patricia Moran, Liliana Rojas, Tobias Portillo, Enrique González, Eric Hernández, B. Brett Finlay, Cecilia Ximenez Tags: Review Article Source Type: research
Conditional Inference Tree for Multiple Gene-Environment Interactions on Myocardial Infarction
Identifying gene-environment interaction in the context of multiple environmental factors has been a challenging task. We aimed to use conditional inference tree (CTREE) to strata myocardial infarction (MI) risk synthesizing information from both genetic and environmental factors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 16, 2017 Category: Research Authors: Zhijun Wu, Xiuxiu Su, Haihui Sheng, Yanjia Chen, Xiang Gao, Le Bao, Wei Jin Tags: Original Article Source Type: research
Conditional Inference Tree for Multiple Gene-Environment Interactions on Myocardial Infarction Among Chinese Men
Identifying gene-environment interaction in the context of multiple environmental factors has been a challenging task. We aimed to use conditional inference tree (CTREE) to strata myocardial infarction (MI) risk synthesizing information from both genetic and environmental factors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 16, 2017 Category: Research Authors: Zhijun Wu, Xiuxiu Su, Haihui Sheng, Yanjia Chen, Xiang Gao, Le Bao, Wei Jin Tags: Original Article Source Type: research
Correlations of Serum Cyclophilin A and Melatonin Concentrations with Hypertension-induced Left Ventricular Hypertrophy
Cyclophilin A (CyPA) is an abundantly expressed pro-inflammatory cytokine and a major secreted oxidative stress-induced factor (SOXF). Melatonin is an important chronobiological regulatory molecule that is mainly released from the pineal gland and exerts antioxidant effects by acting as a radical scavenger. Based on accumulating evidence, both CyPA and melatonin play important roles in cardiovascular diseases. However, further investigations are required to determine whether CyPA and melatonin are associated with hypertension-induced left ventricular hypertrophy (LVH). (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 14, 2017 Category: Research Authors: Hongyan Su, Tongshuai Chen, Jingyuan Li, Jie Xiao, Shujian Wang, Xiaobin Guo, Peili Bu Tags: Original Article Source Type: research
Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins
In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 13, 2017 Category: Research Authors: B ünyamin Özgeriş, Yusuf Akbaba, Özlem Özdemir, Hasan Türkez, Süleyman Göksu Tags: Original Article Source Type: research
Microbiota and Aging. A Review and Commentary
Although there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation. (Source: Archi...
Source: Archives of Medical Research - December 8, 2017 Category: Research Authors: Carmen Garc ía-Peña, Teresa Álvarez-Cisneros, Ricardo Quiroz-Baez, Robert P. Friedland Tags: Review Article Source Type: research
Combined Raloxifene and Letrozole for Breast Cancer Patients
Raloxifene, an anti-osteoporotic drug, is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole, another anticancer drug. However, the cytotoxic effect of their combination on human breast cancer (MCF-7) and human embryonic kidney (HEK) cell lines is not known. MCF-7 and HEK cell lines were treated with different graded doses of letrozole, raloxifene and their combination, then incubated for 24 –48 h. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 8, 2017 Category: Research Authors: Divya Vohora, Abul Kalam, Ankita Leekha, Sushama Talegaonkar, Anita Kamra Verma Tags: Preliminary Report Source Type: research
Hygiene Hypothesis in Asthma Development: Is Hygiene to Blame?
Industrialized countries have registered epidemic rates on allergic diseases, such as hay fever, asthma, eczema, and food allergies. The Hygiene Hypothesis was born from work made by Dr. David Strachan, who observed that younger siblings were less susceptible to eczema and asthma, and proposed that this was a result of increased transmission of infectious agents via unhygienic practices within a household. This initial hypothesis was then reframed as the old friends/microbiota hypothesis, implicating non-pathogenic commensal microorganisms as the source of immunomodulatory signals necessary to prevent immune-mediated chron...
Source: Archives of Medical Research - December 7, 2017 Category: Research Authors: Erik van Tilburg Bernardes, Marie-Claire Arrieta Tags: Review Article Source Type: research
Regulation of SIRT3/FOXO1 Signaling Pathway in Rats with Non-alcoholic Steatohepatitis by Salvianolic Acid B
To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 7, 2017 Category: Research Authors: Yingchun Wang, Juan Chen, Weizong Kong, Ruiping Zhu, Kai Liang, Quanxiang Kan, Yanhong Lou, Xiangyu Liu Tags: Original Article Source Type: research
Gut Microbiome and Antibiotics
Despite that the human gastrointestinal tract is the most populated ecological niche by bacteria in the human body, much is still unknown about its characteristics. This site is highly susceptible to the effects of many external factors that may affect in the quality and the quantity of the microbiome. Specific factors such as diet, personal hygiene, pharmacological drugs and the use of antibiotics can produce a significant impact on the gut microbiota. The effect of these factors is more relevant early in life, when the gut microbiota has not yet fully established. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 5, 2017 Category: Research Authors: Tadasu Iizumi, Thomas Battaglia, Victoria Ruiz, Guillermo I. Perez Perez Tags: Review Article Source Type: research
