Evaluation of brass alloy density as tissue equivalence bolus using electron density phantom and optical density method
This study is aimed to evaluate the brass alloy density in order to better understand the brass qualities as a bolus in radiotherapy. The mass density of brass alloy determined in this work are using solid approaches, i) traditional density method, ii) Computed Tomography (CT) number using electron density phantom and CT scan and iii) mean pixel value via ImageJ software. According to ANOVA F (2,6) 2.982, p0.126, there was no statistically significant difference between the groups. As a result, all methods for calculating the density of brass alloy are valid. The X2 test of CT number of brass plug to breast substitute in e...
Source: Applied Radiation and Isotopes - June 17, 2022 Category: Radiology Authors: Sakinah Buang Nik Noor Ashikin Nik Ab Razak Mohd Zahri Abdul Aziz NurSyatina Raof Source Type: research

Activation analysis and evaluation of the radionuclide inventories, decay heat for European DEMO divertor components
Appl Radiat Isot. 2022 Jun 7;187:110314. doi: 10.1016/j.apradiso.2022.110314. Online ahead of print.ABSTRACTThis work presents neutron flux calculation results and specific decay heat and activity for the European DEMO reactor divertor structure. Two DEMO 2017 models were used in calculations; one with a homogenised WCLL breeder blanket and the other with a homogenised HCPB breeder blanket. The neutron flux calculations were performed using MCNP6 code with JEFF 3.2 nuclear data. Activation and decay heat calculations were performed using the FISPACT-II code with TENDL - 2017 nuclear data library.PMID:35714517 | DOI:10.1016...
Source: Applied Radiation and Isotopes - June 17, 2022 Category: Radiology Authors: Simona Breidokaite Tim Eade Thomas Berry Gediminas Stankunas Andrius Tidikas Source Type: research

Improvement of doxorubicin radioiodination and in-vivo cancer suppression via loading in nanosilver system
This study aimed at improving the radioiodination of doxorubicin (DOX) and its localization in cancer cell for theranostic purposes. To achieve this goal, a composite of DOX with polyvinyl pyrrolidone (PVP) and silver nanoparticles (AgNPs) was prepared. Both DOX and (DOX/PVP/AgNPs) were radiolabelled with iodine-125 [125I] and optimized using iodogen as a preferable oxidizing agent. The maximum obtained radiochemical yields for both systems were 79.9% and 96.6%, respectively. Interestingly, the biodistribution study revealed that [125I]DOX/PVP/AgNPs had an effective localization on tumors. Moreover, Target/control target (...
Source: Applied Radiation and Isotopes - June 16, 2022 Category: Radiology Authors: Nourihan S Farrag Hanan A El-Sabagh Abdulaziz Mohsen Al-Mahallawi Wael Mamdouh Abeer M Amin Ahmed Abd El-Bary Source Type: research

Improvement of doxorubicin radioiodination and in-vivo cancer suppression via loading in nanosilver system
This study aimed at improving the radioiodination of doxorubicin (DOX) and its localization in cancer cell for theranostic purposes. To achieve this goal, a composite of DOX with polyvinyl pyrrolidone (PVP) and silver nanoparticles (AgNPs) was prepared. Both DOX and (DOX/PVP/AgNPs) were radiolabelled with iodine-125 [125I] and optimized using iodogen as a preferable oxidizing agent. The maximum obtained radiochemical yields for both systems were 79.9% and 96.6%, respectively. Interestingly, the biodistribution study revealed that [125I]DOX/PVP/AgNPs had an effective localization on tumors. Moreover, Target/control target (...
Source: Applied Radiation and Isotopes - June 16, 2022 Category: Radiology Authors: Nourihan S Farrag Hanan A El-Sabagh Abdulaziz Mohsen Al-Mahallawi Wael Mamdouh Abeer M Amin Ahmed Abd El-Bary Source Type: research

Intermetallic cobalt-gallium targets for production of germanium radioisotopes
Appl Radiat Isot. 2022 May 28;187:110307. doi: 10.1016/j.apradiso.2022.110307. Online ahead of print.ABSTRACTIncreasing interest in targeted radionuclide therapy motivates the development of new radionuclides. The unique emission spectrum from 71Ge make it an ideal candidate for probing microdosimetric effects of low energy electrons absent confounding photon dose. This work reports a novel intermetallic target of Co and Ga for accelerator production of no-carrier-added 69/71Ge and a new method to isolate the Ge in high yields and purities.PMID:35696750 | DOI:10.1016/j.apradiso.2022.110307 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 13, 2022 Category: Radiology Authors: C J Kutyreff T E Barnhart Y H Lo S Happel R J Nickles P A Ellison E Aluicio-Sarduy J W Engle Source Type: research

Intermetallic cobalt-gallium targets for production of germanium radioisotopes
Appl Radiat Isot. 2022 May 28;187:110307. doi: 10.1016/j.apradiso.2022.110307. Online ahead of print.ABSTRACTIncreasing interest in targeted radionuclide therapy motivates the development of new radionuclides. The unique emission spectrum from 71Ge make it an ideal candidate for probing microdosimetric effects of low energy electrons absent confounding photon dose. This work reports a novel intermetallic target of Co and Ga for accelerator production of no-carrier-added 69/71Ge and a new method to isolate the Ge in high yields and purities.PMID:35696750 | DOI:10.1016/j.apradiso.2022.110307 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 13, 2022 Category: Radiology Authors: C J Kutyreff T E Barnhart Y H Lo S Happel R J Nickles P A Ellison E Aluicio-Sarduy J W Engle Source Type: research

Intermetallic cobalt-gallium targets for production of germanium radioisotopes
Appl Radiat Isot. 2022 May 28;187:110307. doi: 10.1016/j.apradiso.2022.110307. Online ahead of print.ABSTRACTIncreasing interest in targeted radionuclide therapy motivates the development of new radionuclides. The unique emission spectrum from 71Ge make it an ideal candidate for probing microdosimetric effects of low energy electrons absent confounding photon dose. This work reports a novel intermetallic target of Co and Ga for accelerator production of no-carrier-added 69/71Ge and a new method to isolate the Ge in high yields and purities.PMID:35696750 | DOI:10.1016/j.apradiso.2022.110307 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 13, 2022 Category: Radiology Authors: C J Kutyreff T E Barnhart Y H Lo S Happel R J Nickles P A Ellison E Aluicio-Sarduy J W Engle Source Type: research

Differential effects of cancer modifying agents during radiation therapy on Ehrlich solid tumor-bearing mice: A comparative investigation of metformin and ascorbic acid
CONCLUSIONS: The study added more preclinical evidence on the utility of metformin in cancer treatment during radiotherapy. Metformin was shown to reduce lipid peroxidation in irradiated healthy tissues, increase tumor cytotoxicity, downregulate critical pathways involved in tumor progression and proliferation, and enhance tumor apoptosis. Controlled clinical trials using metformin are highly warranted.PMID:35688071 | DOI:10.1016/j.apradiso.2022.110305 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 10, 2022 Category: Radiology Authors: Mennat-Allah Ali Magdy M Khalil Asmaa K Al-Mokaddem Samira H Aljuaydi M M Ahmed Heba M A Khalil Source Type: research

Differential effects of cancer modifying agents during radiation therapy on Ehrlich solid tumor-bearing mice: A comparative investigation of metformin and ascorbic acid
CONCLUSIONS: The study added more preclinical evidence on the utility of metformin in cancer treatment during radiotherapy. Metformin was shown to reduce lipid peroxidation in irradiated healthy tissues, increase tumor cytotoxicity, downregulate critical pathways involved in tumor progression and proliferation, and enhance tumor apoptosis. Controlled clinical trials using metformin are highly warranted.PMID:35688071 | DOI:10.1016/j.apradiso.2022.110305 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 10, 2022 Category: Radiology Authors: Mennat-Allah Ali Magdy M Khalil Asmaa K Al-Mokaddem Samira H Aljuaydi M M Ahmed Heba M A Khalil Source Type: research

Differential effects of cancer modifying agents during radiation therapy on Ehrlich solid tumor-bearing mice: A comparative investigation of metformin and ascorbic acid
CONCLUSIONS: The study added more preclinical evidence on the utility of metformin in cancer treatment during radiotherapy. Metformin was shown to reduce lipid peroxidation in irradiated healthy tissues, increase tumor cytotoxicity, downregulate critical pathways involved in tumor progression and proliferation, and enhance tumor apoptosis. Controlled clinical trials using metformin are highly warranted.PMID:35688071 | DOI:10.1016/j.apradiso.2022.110305 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 10, 2022 Category: Radiology Authors: Mennat-Allah Ali Magdy M Khalil Asmaa K Al-Mokaddem Samira H Aljuaydi M M Ahmed Heba M A Khalil Source Type: research

Radiological consequence analysis for hypothetical accidental release from Nigerian Research Reactor-1
Appl Radiat Isot. 2022 Jun 2;186:110308. doi: 10.1016/j.apradiso.2022.110308. Online ahead of print.ABSTRACTRadiological dispersion study is a key element in safety analysis report (SAR) of every nuclear facility for the purpose of emergency response planning. In this work, computational approach was used to determine the total effective dose and ground deposition at critical positions onsite and offsite of the Nigerian Research Reactor-1 (NIRR-1) facility which will be useful in the ongoing development of final SAR for NIRR-1 Low Enriched Uranium (LEU) core. In the methodology used, NIRR-1 LEU core was depleted with TRITO...
Source: Applied Radiation and Isotopes - June 8, 2022 Category: Radiology Authors: J Simon Y V Ibrahim D J Adeyemo N N Garba A Asuku S Bello I K Ibikunle Source Type: research

Radiological consequence analysis for hypothetical accidental release from Nigerian Research Reactor-1
Appl Radiat Isot. 2022 Jun 2;186:110308. doi: 10.1016/j.apradiso.2022.110308. Online ahead of print.ABSTRACTRadiological dispersion study is a key element in safety analysis report (SAR) of every nuclear facility for the purpose of emergency response planning. In this work, computational approach was used to determine the total effective dose and ground deposition at critical positions onsite and offsite of the Nigerian Research Reactor-1 (NIRR-1) facility which will be useful in the ongoing development of final SAR for NIRR-1 Low Enriched Uranium (LEU) core. In the methodology used, NIRR-1 LEU core was depleted with TRITO...
Source: Applied Radiation and Isotopes - June 8, 2022 Category: Radiology Authors: J Simon Y V Ibrahim D J Adeyemo N N Garba A Asuku S Bello I K Ibikunle Source Type: research

Radiological consequence analysis for hypothetical accidental release from Nigerian Research Reactor-1
Appl Radiat Isot. 2022 Jun 2;186:110308. doi: 10.1016/j.apradiso.2022.110308. Online ahead of print.ABSTRACTRadiological dispersion study is a key element in safety analysis report (SAR) of every nuclear facility for the purpose of emergency response planning. In this work, computational approach was used to determine the total effective dose and ground deposition at critical positions onsite and offsite of the Nigerian Research Reactor-1 (NIRR-1) facility which will be useful in the ongoing development of final SAR for NIRR-1 Low Enriched Uranium (LEU) core. In the methodology used, NIRR-1 LEU core was depleted with TRITO...
Source: Applied Radiation and Isotopes - June 8, 2022 Category: Radiology Authors: J Simon Y V Ibrahim D J Adeyemo N N Garba A Asuku S Bello I K Ibikunle Source Type: research

Aerial gamma-ray spectrometric survey data as a guide for probable hydrocarbon accumulations at Abu-Zeneima/Al-Tur area, Southwestern Sinai, Egypt
Appl Radiat Isot. 2022 May 20;186:110290. doi: 10.1016/j.apradiso.2022.110290. Online ahead of print.ABSTRACTA method using surface and aerial gamma-ray spectral measurements to explore the hydrocarbon accumulations in Abu-Zeneima/Al-Tur area of Southwestern Sinai, Egypt, was selected due to both its structural setting and its location in close proximity to the Gulf of Suez, which represents one of the important sites of oil production in Egypt. Examination of the normalized potassium map (KD %) shows low concentrations above Abu-Alaqah, Thebes, and Kariem formations, while normalized equivalent uranium map (eUD %) shows a...
Source: Applied Radiation and Isotopes - June 6, 2022 Category: Radiology Authors: Mohammed A Shaheen Hussein F Abd El Salam Ali M El Hawary Source Type: research

UV/Vis dose response of a reusable PMMA-NaCl polymer composite
CONCLUSION: The 2-mm-thick PMMA-NaCl polymer-composite sheet could measure absorbed radiation doses from 6 MV X-ray photons down to 5 Gy. Because the sample is reusable, it can be used in a cost-effective two-dimensional radiation dosimeter to ensure the quality of medical linacs.PMID:35660984 | DOI:10.1016/j.apradiso.2022.110293 (Source: Applied Radiation and Isotopes)
Source: Applied Radiation and Isotopes - June 6, 2022 Category: Radiology Authors: Iqbal Tariq Mariatti Jaafar Siti Khatijah Abdul Razak Wan Fatihah Wan Sohaimi Ahmad Lutfi Yusoff Source Type: research