Preparation and evaluation of radioiodinated avanafil: A novel potential radiopharmaceutical for the diagnostic evaluation of erectile dysfunction
Appl Radiat Isot. 2022 Feb 23;183:110160. doi: 10.1016/j.apradiso.2022.110160. Online ahead of print.ABSTRACTAvanafil, a selective second-generation phosphodiesterase-5 inhibitor, was successfully labeled with iodine-125 via electrophilic and different factors affecting the labeling efficiency were studied. The labeled compound exhibited in-vitro stability of more than 24 h with a maximum labeling yield of up to 98.4 ± 1.9 %. Molecular modeling and in-vitro assessment of tracer inhibitory activity were performed to ensure that radiolabeling did not affect its binding ability to the target. Biodistribution studies were per...
Source: Applied Radiation and Isotopes - March 1, 2022 Category: Radiology Authors: O A El-Kawy I T Ibrahim H A Shewatah K M El-Azony Source Type: research

Effect of heating rate on MgB < sub > 4 < /sub > O < sub > 7 < /sub > :Tm,Dy glow curve and its kinetic parameters calculated with different methods
Appl Radiat Isot. 2022 Feb 22;183:110153. doi: 10.1016/j.apradiso.2022.110153. Online ahead of print.ABSTRACTThis paper presents the results of a long experimental work carried out to study the influence of the heating rate (H.R.) on thermally stimulated light emission phenomenon, well known as thermoluminescence (TL) of MgB4O7 activated by Tm and Dy ions (MgB4O7:Tm.Dy) in pellet form. The kinetics parameters, i.e. the activation energy, E, the frequency factor, s, the kinetics order, b and the number of trapped electrons, n0, were determined using the algorithm of sequential quadratic programming glow curve deconvolution ...
Source: Applied Radiation and Isotopes - March 1, 2022 Category: Radiology Authors: P R Gonz ález J Azor ín C Furetta Source Type: research

Monte Carlo calculation of buildup factors for 50  keV-15 MeV photons in tungsten up to 15 mean free paths
Appl Radiat Isot. 2022 Feb 17;183:110150. doi: 10.1016/j.apradiso.2022.110150. Online ahead of print.ABSTRACTExposure buildup factor values of tungsten for a point isotropic source in energy range 0.05-15 MeV up to 15 mfp are computed using Monte Carlo N-Particle code. Buildup factors of this study and ANSI/ANS-6.4.3 at some selected energies and penetration depths are compared. Highest discrepancies are observed for high-energy and/or high penetration depths. Highest error occurs at 15 MeV, amounting to 32%. In the energy range 2-6 MeV, our results show smaller values for all penetration depths and vice versa at higher en...
Source: Applied Radiation and Isotopes - March 1, 2022 Category: Radiology Authors: Dariush Sardari Samaneh Baradaran Farshid Babapour Mofrad Nazanin Marzban Source Type: research

Preparation and evaluation of radioiodinated avanafil: A novel potential radiopharmaceutical for the diagnostic evaluation of erectile dysfunction
Appl Radiat Isot. 2022 Feb 23;183:110160. doi: 10.1016/j.apradiso.2022.110160. Online ahead of print.ABSTRACTAvanafil, a selective second-generation phosphodiesterase-5 inhibitor, was successfully labeled with iodine-125 via electrophilic and different factors affecting the labeling efficiency were studied. The labeled compound exhibited in-vitro stability of more than 24 h with a maximum labeling yield of up to 98.4 ± 1.9 %. Molecular modeling and in-vitro assessment of tracer inhibitory activity were performed to ensure that radiolabeling did not affect its binding ability to the target. Biodistribution studies were per...
Source: Applied Radiation and Isotopes - March 1, 2022 Category: Radiology Authors: O A El-Kawy I T Ibrahim H A Shewatah K M El-Azony Source Type: research

Effect of heating rate on MgB < sub > 4 < /sub > O < sub > 7 < /sub > :Tm,Dy glow curve and its kinetic parameters calculated with different methods
Appl Radiat Isot. 2022 Feb 22;183:110153. doi: 10.1016/j.apradiso.2022.110153. Online ahead of print.ABSTRACTThis paper presents the results of a long experimental work carried out to study the influence of the heating rate (H.R.) on thermally stimulated light emission phenomenon, well known as thermoluminescence (TL) of MgB4O7 activated by Tm and Dy ions (MgB4O7:Tm.Dy) in pellet form. The kinetics parameters, i.e. the activation energy, E, the frequency factor, s, the kinetics order, b and the number of trapped electrons, n0, were determined using the algorithm of sequential quadratic programming glow curve deconvolution ...
Source: Applied Radiation and Isotopes - March 1, 2022 Category: Radiology Authors: P R Gonz ález J Azor ín C Furetta Source Type: research

Characterization of a novel material to be used as bolus in radiotherapy with electrons
Appl Radiat Isot. 2022 Feb 16;183:110154. doi: 10.1016/j.apradiso.2022.110154. Online ahead of print.ABSTRACTFeatures of new material to be used as bolus in external radiotherapy were determined and their performance were evaluated. The characterization was carried out using Monte Carlo methods with the Geant4 code where the Percentage Depth Dose (PDD) due to electrons was estimated. In the Monte Carlo model the linear accelerator head was included. Calculated results were experimentally validated with measurements made for 6, 9, 12 and 16 MeV electron beams. The key characteristics of the implemented material were identif...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: J A Diaz-Merchan S A Martinez-Ovalle H R Vega-Carrillo Source Type: research

Prompt gamma activation analysis for determining the elemental composition of archaeological ceramics
Appl Radiat Isot. 2022 Feb 19;183:110152. doi: 10.1016/j.apradiso.2022.110152. Online ahead of print.ABSTRACTThe first experiments were carried out to study the elemental composition of archaeological ceramics using prompt gamma activation analysis (PGAA) at the pulsed reactor IBR-2, Frank Laboratory of Neutron Physics (FLNP) - Joint Institute for Nuclear Research (JINR). A radiation-resistant n-type High Purity Germanium (HPGe) detector was used to measure the radioactivity. The concentrations of 14 elements were determined namely; Al, C, Ca, Fe, Gd, H, K, Mn, Na, P, S, Si, Sm, and Ti. The obtained results were compared w...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: S B Borzakov A Zh Zhomartova A Yu Dmitriev V Yu Koval C Hramco Wael M Badawy Source Type: research

Characterization of a novel material to be used as bolus in radiotherapy with electrons
Appl Radiat Isot. 2022 Feb 16;183:110154. doi: 10.1016/j.apradiso.2022.110154. Online ahead of print.ABSTRACTFeatures of new material to be used as bolus in external radiotherapy were determined and their performance were evaluated. The characterization was carried out using Monte Carlo methods with the Geant4 code where the Percentage Depth Dose (PDD) due to electrons was estimated. In the Monte Carlo model the linear accelerator head was included. Calculated results were experimentally validated with measurements made for 6, 9, 12 and 16 MeV electron beams. The key characteristics of the implemented material were identif...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: J A Diaz-Merchan S A Martinez-Ovalle H R Vega-Carrillo Source Type: research

Prompt gamma activation analysis for determining the elemental composition of archaeological ceramics
Appl Radiat Isot. 2022 Feb 19;183:110152. doi: 10.1016/j.apradiso.2022.110152. Online ahead of print.ABSTRACTThe first experiments were carried out to study the elemental composition of archaeological ceramics using prompt gamma activation analysis (PGAA) at the pulsed reactor IBR-2, Frank Laboratory of Neutron Physics (FLNP) - Joint Institute for Nuclear Research (JINR). A radiation-resistant n-type High Purity Germanium (HPGe) detector was used to measure the radioactivity. The concentrations of 14 elements were determined namely; Al, C, Ca, Fe, Gd, H, K, Mn, Na, P, S, Si, Sm, and Ti. The obtained results were compared w...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: S B Borzakov A Zh Zhomartova A Yu Dmitriev V Yu Koval C Hramco Wael M Badawy Source Type: research

Characterization of a novel material to be used as bolus in radiotherapy with electrons
Appl Radiat Isot. 2022 Feb 16;183:110154. doi: 10.1016/j.apradiso.2022.110154. Online ahead of print.ABSTRACTFeatures of new material to be used as bolus in external radiotherapy were determined and their performance were evaluated. The characterization was carried out using Monte Carlo methods with the Geant4 code where the Percentage Depth Dose (PDD) due to electrons was estimated. In the Monte Carlo model the linear accelerator head was included. Calculated results were experimentally validated with measurements made for 6, 9, 12 and 16 MeV electron beams. The key characteristics of the implemented material were identif...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: J A Diaz-Merchan S A Martinez-Ovalle H R Vega-Carrillo Source Type: research

Prompt gamma activation analysis for determining the elemental composition of archaeological ceramics
Appl Radiat Isot. 2022 Feb 19;183:110152. doi: 10.1016/j.apradiso.2022.110152. Online ahead of print.ABSTRACTThe first experiments were carried out to study the elemental composition of archaeological ceramics using prompt gamma activation analysis (PGAA) at the pulsed reactor IBR-2, Frank Laboratory of Neutron Physics (FLNP) - Joint Institute for Nuclear Research (JINR). A radiation-resistant n-type High Purity Germanium (HPGe) detector was used to measure the radioactivity. The concentrations of 14 elements were determined namely; Al, C, Ca, Fe, Gd, H, K, Mn, Na, P, S, Si, Sm, and Ti. The obtained results were compared w...
Source: Applied Radiation and Isotopes - February 26, 2022 Category: Radiology Authors: S B Borzakov A Zh Zhomartova A Yu Dmitriev V Yu Koval C Hramco Wael M Badawy Source Type: research

Molten salt/liquid metal extraction: Electrochemical behaviors and thermodynamics properties of La, Pr, U and separation factors of La/U and Pr/U couples in liquid gallium cathode
Appl Radiat Isot. 2022 Feb 10;182:110149. doi: 10.1016/j.apradiso.2022.110149. Online ahead of print.ABSTRACTThe electrochemical behavior of lanthanides (La, Pr) and actinide (U) on inert W and liquid Ga electrodes in LiCl-KCl molten salt as well as their related thermodynamic properties were experimentally determined for further Lns/Ans separation. The results indicate that the reductions of La3+ and Pr3+ in LiCl-KCl melts are both one-step process with three electrons exchanged, and the reactions are quasi-reversible processes at low scan rate. Temperature dependencies of apparent standard redox potentials of La(Ga), Pr(...
Source: Applied Radiation and Isotopes - February 24, 2022 Category: Radiology Authors: Hengbin Xu Wei Zhang Changshui Wang Mingshuai Yang Taihong Yan Yongde Yan Milin Zhang Source Type: research

Improvement of metrological characteristics of a new industrial facility for gold-bearing ore gamma activation analysis
Appl Radiat Isot. 2022 Feb 12;182:110147. doi: 10.1016/j.apradiso.2022.110147. Online ahead of print.ABSTRACTThe results of the development and research of the characteristics of a new gamma activation analysis (GAA) facility, created for the quantitative analysis of gold-bearing ores in real conditions of a gold-mining enterprise, are presented. The values of the gold detection limit (3σ), measured from the spectra of certified reference samples with an ultralow background level, were 0.025-0.028 ppm with a single irradiation. In this case, the root-mean-square measurement error for a gold concentration of 1 ppm did not ...
Source: Applied Radiation and Isotopes - February 24, 2022 Category: Radiology Authors: A Sokolov M Demsky A Pesterev V Gostilo V Kondratjev V Moshkov Source Type: research

Molten salt/liquid metal extraction: Electrochemical behaviors and thermodynamics properties of La, Pr, U and separation factors of La/U and Pr/U couples in liquid gallium cathode
Appl Radiat Isot. 2022 Feb 10;182:110149. doi: 10.1016/j.apradiso.2022.110149. Online ahead of print.ABSTRACTThe electrochemical behavior of lanthanides (La, Pr) and actinide (U) on inert W and liquid Ga electrodes in LiCl-KCl molten salt as well as their related thermodynamic properties were experimentally determined for further Lns/Ans separation. The results indicate that the reductions of La3+ and Pr3+ in LiCl-KCl melts are both one-step process with three electrons exchanged, and the reactions are quasi-reversible processes at low scan rate. Temperature dependencies of apparent standard redox potentials of La(Ga), Pr(...
Source: Applied Radiation and Isotopes - February 24, 2022 Category: Radiology Authors: Hengbin Xu Wei Zhang Changshui Wang Mingshuai Yang Taihong Yan Yongde Yan Milin Zhang Source Type: research

Improvement of metrological characteristics of a new industrial facility for gold-bearing ore gamma activation analysis
Appl Radiat Isot. 2022 Feb 12;182:110147. doi: 10.1016/j.apradiso.2022.110147. Online ahead of print.ABSTRACTThe results of the development and research of the characteristics of a new gamma activation analysis (GAA) facility, created for the quantitative analysis of gold-bearing ores in real conditions of a gold-mining enterprise, are presented. The values of the gold detection limit (3σ), measured from the spectra of certified reference samples with an ultralow background level, were 0.025-0.028 ppm with a single irradiation. In this case, the root-mean-square measurement error for a gold concentration of 1 ppm did not ...
Source: Applied Radiation and Isotopes - February 24, 2022 Category: Radiology Authors: A Sokolov M Demsky A Pesterev V Gostilo V Kondratjev V Moshkov Source Type: research