Budget Impact of Microbial Cell-Free DNA Testing Using the Karius ® Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
ConclusionsThe Karius Test may offer a valuable and timely option for the diagnosis of invasive fungal infection through its non-invasive approach and subsequent cost savings. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - September 16, 2020 Category: Health Management Source Type: research

Estimating Catastrophic Health Expenditures from Household Surveys: Evidence from Living Standard Measurement Surveys (LSMS)-Integrated Surveys on Agriculture (ISA) from Sub-Saharan Africa
ConclusionThe burden of catastrophic health expenditures remains large. In order to reduce this burden, public health expenditures need to be expanded as an alternative. This calls for renewed attention to expand public revenues as the most sustainable methods of financing health expenditures in Africa. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - September 9, 2020 Category: Health Management Source Type: research

Potential Unintended Consequences of National Infectious Disease Screening Strategies in Deceased Donor Kidney Transplantation: A Cost-Effectiveness Analysis
ConclusionBefore implementing nucleic acid screening outside of increased infectious-risk organs, its false-positivity rate should be directly studied to ensure that its use does not detrimentally affect transplantation numbers, quality-adjusted life-years, and costs. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - September 3, 2020 Category: Health Management Source Type: research

Comment on: “The Italian NHS: What Lessons to Draw from COVID-19?”
(Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 23, 2020 Category: Health Management Source Type: research

Is the Choice of Cost-Effectiveness Threshold in Cost-Utility Analysis Endogenous to the Resulting Value of Technology? A Systematic Review
ConclusionsCost-effectiveness thresholds represent the hypothesis tests of typical CUAs. Our analysis highlights that most CUAs that cite high CETs also result in greater ICERs for the novel interventions that they investigate; thus, these interventions would otherwise not have been cost effective at lower CETs. Selection of a CET may come after the ICER is calculated to infer value that suits a hypothesis. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 18, 2020 Category: Health Management Source Type: research

Systematic Review and Critique of Methods for Economic Evaluation of Digital Mental Health Interventions
ConclusionsThis study represents the first attempt to understand the appropriateness of the methodologies used to evaluate the value for money of DMHIs, helping work towards consensus and methods ’ harmonisation on these complex interventions. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 16, 2020 Category: Health Management Source Type: research

Price Reduction of Anticancer Drugs from 2007 to 2019 in South Korea: The Impact of Pharmaceutical Cost-Containment Policies
ConclusionsThe incidence of price reduction of anticancer drugs increased gradually due to various repricing mechanisms. Although these mechanisms are effective, improvements can be made. Well-designed mechanisms that actively regulate price adjustment are needed to establish repricing policies that adequately reflect changes in the value of drugs over their entire life cycle. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 12, 2020 Category: Health Management Source Type: research

Cost-Utility Analysis of Dapagliflozin Versus Saxagliptin Treatment as Monotherapy or Combination Therapy as Add-on to Metformin for Treating Type 2 Diabetes Mellitus
ConclusionsCompared with DAPA  + SAXA or SAXA, DAPA appears to be a cost-effective therapy as add-on to MET for Chinese patients whose T2DM is insufficiently controlled by MET. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 11, 2020 Category: Health Management Source Type: research

Cost Effectiveness of Introducing Etonorgestrel Contraceptive Implant into India ’s Current Family Welfare Programme
ConclusionAdding the etonorgestrel implant to the public health system would be cost effective for India, with a feasible budgetary allocation. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - August 9, 2020 Category: Health Management Source Type: research

Curos ™ Disinfection Caps for the Prevention of Infection When Using Needleless Connectors: A NICE Medical Technologies Guidance
AbstractCentral line-associated bloodstream infections (CLABSIs) are primary, laboratory confirmed bloodstream infections in patients with a central line within 48  h of symptom onset. Catheter-related bloodstream infection (CRBSI) is a more specific term used when the cause of infection has been confirmed by catheter tip cultures. CLABSIs and CRBSIs occur as a result of bacteraemia originating from intravenous catheters. Bloodstream infections are associated with increased length of stay, mortality and increased cost in treatment. The ability of Curos™, a disinfecting cap for needleless connectors of vascular access li...
Source: Applied Health Economics and Health Policy - August 4, 2020 Category: Health Management Source Type: research

Revisiting the Relationship Between Price Regulation and Pharmaceutical R & amp;D Investment
ConclusionThe findings suggest that investment decisions of firms are most likely driven by long-run inter-firm differences, and that firm effects strongly determine firm strategies in terms of R&D investment. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - July 14, 2020 Category: Health Management Source Type: research

Systematic Review of Health State Utility Values Used in European Pharmacoeconomic Evaluations for Chronic Hepatitis C: Impact on Cost-Effectiveness Results
ConclusionsThe CUAs for CHC were found to apply to various HSUVs from different utility elicitation studies in the same health state. This variability in HSUVs has the potential to significantly affect ICER and ICER-based reimbursement decisions. A rigorous selection of HSUVs in CUAs to inform healthcare resource allocation is suggested for future studies of CUAs and for guideline development. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - July 13, 2020 Category: Health Management Source Type: research

Implementing Lifestyle Change Interventions to Prevent Type 2 Diabetes in US Medicaid Programs: Cost Effectiveness, and Cost, Health, and Health Equity Impact
ConclusionsIn the long-term, investments in LCIs for Medicaid beneficiaries are likely to improve health and to decrease healthcare expenditures. However, population health and health equity impact would be low and healthcare expenditure savings from a narrow Medicaid perspective would be much smaller than from a healthcare system perspective. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - June 30, 2020 Category: Health Management Source Type: research

Evaluating Equity in Health Financing Using Benefit Incidence Analysis: A Framework for Accounting for Quality of Care
AbstractEquity in health care financing has gained increased attention in low- and middle-income countries (LMICs) following the renewed global interest in universal health coverage (UHC), a key component of the sustainable development goals (SDGs). UHC requires that people have access to the health services they need without risking financial hardship. Health financing is central to UHC and many LMICs have initiated reforms to align their health financing systems with the goals of UHC. Evaluation of the equity impact of these reforms has become a growing area of research, especially in countries with large health inequali...
Source: Applied Health Economics and Health Policy - June 21, 2020 Category: Health Management Source Type: research

Using Eye-Tracking Technology with Older People in Memory Clinics to Investigate the Impact of Mild Cognitive Impairment on Choices for EQ-5D-5L Health States Preferences
ConclusionsThis exploratory study provided important insights into the information processes adopted by older people with varying levels of cognitive functioning when choosing between alternative EQ-5D-5L health states of varying survival duration and specifically the relationships between cognitive capacity, task complexity and the extent of ANA. Recent advances in econometric modelling of health state valuation data have demonstrated the added value of capturing ANA information as this can be accounted for in the DCE data analysis, thereby improving the precision of model estimates. Eye-tracking technology can usefully i...
Source: Applied Health Economics and Health Policy - June 21, 2020 Category: Health Management Source Type: research