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Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04859-w. Online ahead of print.ABSTRACTLong-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of B...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Qu Xz Sun Zq Liu L Ong Hs Source Type: research

Neferine Pretreatment Attenuates Isoproterenol-Induced Cardiac Injury Through Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats
In conclusion, the study provides strong evidence that pretreatment with neferine protects rats from ISO-induced heart damage.PMID:38526658 | DOI:10.1007/s12010-024-04917-3 (Source: Applied Biochemistry and Biotechnology)
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Xiaoqian Sun Yongwen Gu Xinghua Liu Praveen Kumar Korla Junjun Hao Source Type: research

Mechanism of Cell-Killing Activity of Plantaricin LD1 Against Escherichia coli ATCC 25922
In this study, we have performed a detailed mechanism of action of plantaricin LD1 against Escherichia coli ATCC 25922 considering Micrococcus luteus MTCC 106 as control. The plantaricin LD1 showed a minimum inhibitory concentration (MIC) of 34.57 µg/mL and a minimum bactericidal concentration (MBC) of 138.3 µg/mL against M. luteus MTCC 106, whereas MIC 69.15 µg/mL and MBC 276.6 µg/mL were found against E. coli ATCC 25922. The efflux of potassium ions, dissipation of membrane potential (∆ψ), and transmembrane pH gradient (∆pH) of plantaricin LD1-treated cells suggested the membrane-acting nature of plantaricin LD1...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Manoj Kumar Yadav Santosh Kumar Tiwari Source Type: research

Optimization of Spore Production in Bacillus coagulans Using Response Surface Methodology Approach
This study investigated the spore densities and formation efficiency of B. coagulans. The optimal medium formulation consisted of yeast extract (1.00 g L-1), potassium acetate (20.00 g L-1), and MnSO4 (0.01 g L-1 and 0.03 g L-1). After reaching the optimal medium, a response surface regression equation was established based on the results of central composite design (CCD) experimental designs to optimize time, temperature, and pH parameters. The predicted results thus obtained were in good agreement (R2 = 95.19%) with the results obtained by performing experiments. Multiple regression analysis and analysis of variance (ANO...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Seyedeh Habibeh Mirmajidi Cambyz Irajie Amir Savardashtaki Navid Nezafat Mohammad Hossein Morowvat Younes Ghasemi Source Type: research

Molecular Identification and Phytochemical Analysis and Bioactivity Assessment of Catharanthus roseus Leaf Extract: Exploring Antioxidant Potential and Antimicrobial Activities
In conclusion, C. roseus has the most promise as an antibacterial and antioxidant agent.PMID:38526661 | DOI:10.1007/s12010-024-04902-w (Source: Applied Biochemistry and Biotechnology)
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Velusamy Arulvendhan Periyakali Saravana Bhavan Rajapandian Rajaganesh Source Type: research

Nano-delivery Systems and Therapeutic Applications of Phytodrug Mangiferin
This article provides effective guidance for researchers who desire to work on the formulation and development of an effective delivery method for improved magniferin therapeutic effectiveness.PMID:38526662 | DOI:10.1007/s12010-024-04906-6 (Source: Applied Biochemistry and Biotechnology)
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Madhuri Baghel Ishita Baghel Pramila Kumari Meenakshi Bharkatiya Garvita Joshi Kalyani Sakure Hemant Badwaik Source Type: research

Chromatographic Fingerprinting of Cacao Pod Husk Extracts (Theobroma cacao L.): Exploring Antibacterial, Antioxidant, and Antidiabetic Properties with In Silico Molecular Docking Analysis
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04912-8. Online ahead of print.ABSTRACTNatural drugs derived from plants are becoming more popular because of their apparent biological efficacy, affordability, and safety. A byproduct of cocoa farms, cocoa pod husk (CPH), is often disregarded yet contains an abundance of phenolic chemicals that have antimicrobial and antioxidant features, which has led to intensive investigation into possible biomedical applications. In order to identify crucial functional groups and phytochemical components, we carefully examined the 80% ethanol and dichloromethane extracts of...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Hany M Abd El-Lateef Mai M Khalaf Manal F Abou Taleb Mohamed Gouda Source Type: research

Cuminaldehyde and Tobramycin Forestall the Biofilm Threats of Staphylococcus aureus: A Combinatorial Strategy to Evade the Biofilm Challenges
In conclusion, the combination of tobramycin and cuminaldehyde presented a successful strategy for combating staphylococcal biofilm-related healthcare threats. This combinatorial approach holds the potential for controlling biofilm-associated infections caused by S. aureus.PMID:38526664 | DOI:10.1007/s12010-024-04914-6 (Source: Applied Biochemistry and Biotechnology)
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Ritwik Roy Payel Paul Poulomi Chakraborty Moumita Malik Sharmistha Das Sudipta Chatterjee Alakesh Maity Monikankana Dasgupta Ranojit Kumar Sarker Sarita Sarkar Anirban Das Gupta Prosun Tribedi Source Type: research

Exploring the Phytochemical Diversity and Antioxidant Potential of the Vietnamese Smilax glabra Roxb: Insights from UPLC-QTOF-MS/MS and Zebrafish Model Studies
This study revealed a wide range of phytochemical compounds, including flavonoids, terpenoids, glycosides, alkaloids, organic acids, phenolics, and steroids. Furthermore, utilizing zebrafish as a model organism, we discovered that these extracts have the surprising ability to greatly improve the survival rate of zebrafish larvae exposed to oxidative stress caused by arsenite (NaAsO2) and hydrogen peroxide (H2O2). Notably, our discoveries suggest the occurrence of new antioxidative pathways in addition to the kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, expanding th...
Source: Applied Biochemistry and Biotechnology - March 23, 2024 Category: Biochemistry Authors: Vu Thanh Nguyen Vo Thi Minh Thao Le Luu Phuong Hanh Thi Hoa Rol Ngo Huynh Phuong Thao Tong Xuan Nguyen Pham Thanh Luu Dinh Thi Thuy Source Type: research

Polyethylene Glycol-Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery
This study seeks to investigate recent developments in the design and synthesis of PEG-based polymer-drug conjugates, emphasizing fresh ideas that fill in existing knowledge gaps and satisfy the increasing need for more potent drug delivery methods. Through an extensive review of the existing literature, this study identifies key challenges and proposes innovative strategies for future investigations. The paper presents a comprehensive framework for designing and synthesizing PEG-based polymer-drug conjugates, including rational molecular design, linker selection, conjugation methods, and characterization techniques. To fu...
Source: Applied Biochemistry and Biotechnology - March 23, 2024 Category: Biochemistry Authors: Vinay Sagar Verma Aakansha Pandey Arvind Kumar Jha Hemant Kumar Ramchandra Badwaik Amit Alexander None Ajazuddin Source Type: research

Metabolomics Approach to Explore Bioactive Natural Products Derived From Plant-Root-Associated Streptomyces
This study aims to screen for bioactive metabolites produced by Streptomyces strains in the plant rhizosphere.Six Streptomyces isolates were cultivated using three modified media to induce the production of diverse metabolites, employing the One Strain Many Compounds (OSMAC) approach. The metabolites present in extracts from fermentation broths were examined through a non-targeted Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) approach coupled with Global Natural Products Social Molecular Networking (GNPS MN). The antimicrobial activity of the extracts was assessed using the disc diffusion method.The strains dem...
Source: Applied Biochemistry and Biotechnology - March 21, 2024 Category: Biochemistry Authors: Ekrem Kum Ebru İnce Source Type: research

Chemical Exposure of Synthetic Pyrethroid on Deltamethrin Under the Selection Pressure over the Generations: A Reproductive Potential Study of Anopheles stephensi
Appl Biochem Biotechnol. 2024 Mar 21. doi: 10.1007/s12010-024-04911-9. Online ahead of print.ABSTRACTBiochemical synthetic pyrethroids, deltamethrin are presently used insecticides for the control of mosquito vector-borne diseases in worldwide. Mosquito re-emergence with diseases becoming a serious problem due to development of insecticide resistance. The comprehensive knowledge on the underlying mechanisms of resistance against deltamethrin is required for implementation of an efficient vector control programme. The assessment of the biological fitness of a mosquito strain exposed to insecticide pressure is extremely vita...
Source: Applied Biochemistry and Biotechnology - March 21, 2024 Category: Biochemistry Authors: Palani Aarumugam Kalimuthu Kovendan Siva Kamalakannan Arulsamy Jebanesan Source Type: research