Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil
CONCLUSION: The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1, and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population.PMID:38359266 | DOI:10.1590/1678-7757-2023-0353 (Source: Appl Human Sci)
Source: Appl Human Sci - February 15, 2024 Category: Physiology Authors: Lorraynne Dos Santos Lara Ricardo D Coletta Renato Assis Machado Lilianny Querino Rocha de Oliveira Herc ílio Martelli Júnior Silvia Regina de Almeida Reis Rafaela Scariot Luiz Evaristo Ricci Volpato Source Type: research

Effects of HMGB1/TLR4 on secretion IL-10 and VEGF in human jaw bone-marrow mesenchymal stem cells
CONCLUSIONS: The results indicated that HMGB1 activate TLR4 signaling pathway in Human JBMSCs, which plays a regulatory role in cytokines expression.PMID:38359267 | DOI:10.1590/1678-7757-2023-0304 (Source: Appl Human Sci)
Source: Appl Human Sci - February 15, 2024 Category: Physiology Authors: Jingjing Kong Wei Cheng Lianzhen Chang Jingyi Yu Ronglin Wang Jianli Xie Source Type: research

Effects of HMGB1/TLR4 on secretion IL-10 and VEGF in human jaw bone-marrow mesenchymal stem cells
CONCLUSIONS: The results indicated that HMGB1 activate TLR4 signaling pathway in Human JBMSCs, which plays a regulatory role in cytokines expression.PMID:38359267 | DOI:10.1590/1678-7757-2023-0304 (Source: Appl Human Sci)
Source: Appl Human Sci - February 15, 2024 Category: Physiology Authors: Jingjing Kong Wei Cheng Lianzhen Chang Jingyi Yu Ronglin Wang Jianli Xie Source Type: research

Effects of HMGB1/TLR4 on secretion IL-10 and VEGF in human jaw bone-marrow mesenchymal stem cells
CONCLUSIONS: The results indicated that HMGB1 activate TLR4 signaling pathway in Human JBMSCs, which plays a regulatory role in cytokines expression.PMID:38359267 | DOI:10.1590/1678-7757-2023-0304 (Source: Appl Human Sci)
Source: Appl Human Sci - February 15, 2024 Category: Physiology Authors: Jingjing Kong Wei Cheng Lianzhen Chang Jingyi Yu Ronglin Wang Jianli Xie Source Type: research

Effects of HMGB1/TLR4 on secretion IL-10 and VEGF in human jaw bone-marrow mesenchymal stem cells
CONCLUSIONS: The results indicated that HMGB1 activate TLR4 signaling pathway in Human JBMSCs, which plays a regulatory role in cytokines expression.PMID:38359267 | DOI:10.1590/1678-7757-2023-0304 (Source: Appl Human Sci)
Source: Appl Human Sci - February 15, 2024 Category: Physiology Authors: Jingjing Kong Wei Cheng Lianzhen Chang Jingyi Yu Ronglin Wang Jianli Xie Source Type: research

Role of Structural Peculiarities of Flavonoids in Suppressing AGEs Generated From HSA/Glucose System
Appl Biochem Biotechnol. 2024 Feb 14. doi: 10.1007/s12010-023-04844-9. Online ahead of print.ABSTRACTThe pathogenesis of diabetes is related to the amount of advanced glycation end products (AGEs) that are naturally generated from the attachment of glucose with tissue and circular proteins. Human serum albumin (HSA) is more susceptible to AGE occurrence than other circular proteins due to its sensitive sites and high abundance. Considering the location of hydroxyl groups in the structure of flavonoids, which play a major role in suppressing of AGEs generating pathways, the present study was conducted to compare the effect ...
Source: Appl Human Sci - February 14, 2024 Category: Physiology Authors: Alireza Mohammadpour Morteza Sadeghi Mehran Miroliaei Source Type: research

BM-MSC-Loaded Graphene-Collagen Cryogels Ameliorate Neuroinflammation in a Rat Spinal Cord Injury Model
In this study, we have analyzed the regeneration capability of human bone marrow mesenchymal stem cell (BM-MSC)-loaded graphene-cross-linked collagen cryogels (Gr-Col) in a thoracic (T10-T11) hemisection model of SCI. Our study found that BM-MSC-loaded Gr-Col improves axonal regeneration, reduces neuroinflammation by decreasing astrocyte reactivity, and promotes M2 macrophage polarization. BM-MSC-loaded-Gr-Col demonstrated enhanced regenerative potential compared to Gr-Col and the injury group control. Next-generation sequencing (NGS) analysis revealed that BM-MSC-loaded-Gr-Col modulates the JAK2-STAT3 pathway, thus decrea...
Source: Appl Human Sci - February 14, 2024 Category: Physiology Authors: Gopal Agarwal Abhishek Roy Abhishek A Singh Hemant Kumar Amit Mandoli Akshay Srivastava Source Type: research

Wearable and interactive multicolored photochromic fiber display
Light Sci Appl. 2024 Feb 14;13(1):48. doi: 10.1038/s41377-024-01383-8.ABSTRACTEndowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent, wearable interactive devices. However, significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware. Here, we introduce a mass-produced, wearable, and interactive photochromic fiber that provides uniform multicolored light control. We designed independent waveguides inside the fiber to maint...
Source: Appl Human Sci - February 14, 2024 Category: Physiology Authors: Pan Li Yuwei Wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu Wang Xiaoling Lu Qian Ji Xinyuan Cai Li Liu Chong Hou Ning Zhou Shaowu Pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao Source Type: research

Retraction: Role of mesenchymal stem cells versus angiotensin converting enzyme inhibitor in kidney repair
Nephrology (Carlton). 2024 Feb 11. doi: 10.1111/nep.14278. Online ahead of print.ABSTRACTThe retraction has been agreed due to duplications within Figure 2 and the inclusion of figure elements in Figure 1 and 2 that were previously published [1-4]. Thus, the conclusions of this article are considered invalid. The authors have been informed of the decision to retract but did not agree with it. References: 1. Hanaa H. Ahmeda, Wafaa Gh. Shoushab, El-Sayed M. El-Sayed Mahdyb, Laila A. Rashedc, Sara M. Abdob (2013), Influence of adipose tissue derived mesenchymal stem cells in combination with injectable bone substitute on oste...
Source: Appl Human Sci - February 11, 2024 Category: Physiology Source Type: research

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method
Nanotechnol Sci Appl. 2024 Jan 31;17:21-40. doi: 10.2147/NSA.S441324. eCollection 2024.ABSTRACTCurrently, protein-based nanoparticles are in high demand as drug delivery systems due to their exceptional qualities, including nontoxicity, nonantigenicity, and biodegradability. Other qualities include high nutritional value, abundance of renewable resources, excellent drug binding capacity, greater stability during storage and in vivo, as well as ease of upgrading during manufacture. Examples of protein suitable for this purpose include ovalbumin (OVA) derived from egg white, human serum albumin (HSA), and bovine serum albumi...
Source: Appl Human Sci - February 5, 2024 Category: Physiology Authors: Yenni Puspita Tanjung Mayang Kusuma Dewi Vesara Ardhe Gatera Melisa Intan Barliana I Made Joni Anis Yohana Chaerunisaa Source Type: research

Modelling cortical network dynamics
SN Appl Sci. 2024;6(2):36. doi: 10.1007/s42452-024-05624-8. Epub 2024 Jan 29.ABSTRACTWe have investigated the theoretical constraints of the interactions between coupled cortical columns. Each cortical column consists of a set of neural populations where each population is modelled as a neural mass. The existence of semi-stable states within a cortical column is dependent on the type of interaction between the neuronal populations, i.e., the form of the synaptic kernels. Current-to-current coupling has been shown, in contrast to potential-to-current coupling, to create semi-stable states within a cortical column. The inter...
Source: Appl Human Sci - February 1, 2024 Category: Physiology Authors: Gerald Kaushallye Cooray Richard Ewald Rosch Karl John Friston Source Type: research

Measuring criticality in control of complex biological networks
NPJ Syst Biol Appl. 2024 Jan 20;10(1):9. doi: 10.1038/s41540-024-00333-9.ABSTRACTRecent controllability analyses have demonstrated that driver nodes tend to be associated to genes related to important biological functions as well as human diseases. While researchers have focused on identifying critical nodes, intermittent nodes have received much less attention. Here, we propose a new efficient algorithm based on the Hamming distance for computing the importance of intermittent nodes using a Minimum Dominating Set (MDS)-based control model. We refer to this metric as criticality. The application of the proposed algorithm t...
Source: Appl Human Sci - January 20, 2024 Category: Physiology Authors: Wataru Someya Tatsuya Akutsu Jean-Marc Schwartz Jose C Nacher Source Type: research

Waveguide-based augmented reality displays: a highlight
Light Sci Appl. 2024 Jan 18;13(1):22. doi: 10.1038/s41377-023-01371-4.ABSTRACTAugmented reality (AR), which emerged in the 1960s, remains a focal point of interest given its capacity to overlay the real world with digitally presented information through optical combiners. The prevalent combiner, commonly known as the waveguide in the AR literature, is prized for its compact design and generous eyebox-essential elements in human-centric technology. Nonetheless, these combiners encounter unique challenges in meeting various other requirements of the human visual system. This paper highlights a recent review of technological ...
Source: Appl Human Sci - January 17, 2024 Category: Physiology Authors: Jannick P Rolland Jeremy Goodsell Source Type: research

Dental pain report in children and genetic polymorphism (rs4818) in Catechol-O-Methyltransferase (COMT) gene: a cross- sectional study
CONCLUSIONS: The rs4818 polymorphism of the COMT gene is associated with dental pain. Children with the C allele are more likely to report higher levels of pain. Clinical Relevance: Even though the experience of pain is subjective and multifactorial, this study raises the hypothesis that there is a genetic predisposition to dental pain that should be considered in clinical practice.PMID:38198369 | PMC:PMC10786450 | DOI:10.1590/1678-7757-2023-0229 (Source: Appl Human Sci)
Source: Appl Human Sci - January 10, 2024 Category: Physiology Authors: Bruna Leticia Vessoni Menoncin Aluh ê Lopes Fatturi Rafaela Scariot Jos é Vitor Nogara Borges Menezes Jo ão Armando Brancher Juliana Feltrin-Souza Source Type: research

Possible role of ALDH1 and CD44 in lip carcinogenesis
This study aimed to investigate the immunostaining of the putative cancer stem cells (CSC) markers ALDH1 and CD44 in AC (n=30) and LSCC (n=20). ALDH1 positivity was found to be statistically higher in LSCC than in AC lesions (p=0.0045), whilst CD44 expression was statistically higher in AC than in LSCC lesions (p=0.0155). ALDH1+ cells in AC lesions were associated with specific clinical features: a younger age (<60 years old), the female gender, white skin, not smoking or consuming alcohol, and a fast evolution, and not associated with the chronic exposure to UV radiation (p<0.0001). CD44 positivity was associated wi...
Source: Appl Human Sci - December 21, 2023 Category: Physiology Authors: Rafael Carneiro Ortiz Gabriele Gomes Gois Camila Alves Costa N ádia Lago Costa Camila Oliveira Rodini Source Type: research