Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration
Publication date: Available online 7 February 2020Source: Antiviral ResearchAuthor(s): Giulia Aimola, Georg Beythien, Amr Aswad, Benedikt B. KauferAbstractHuman herpesvirus 6A (HHV-6A) and 6B (HHV–6B) are members of the genus Roseolovirus in the Betaherpesvirinae subfamily. HHV-6B infects humans in the first years of life, has a seroprevalence of more than 90% and causes Roseola Infantum, but less is known about HHV-6A. While most other herpesviruses maintain their latent genome as a circular episome, HHV-6A and HHV-6B (HHV-6A/B) have been shown to integrate their genome into the telomeres of infected cells. HHV-6A/B can...
Source: Antiviral Therapy - February 8, 2020 Category: Virology Source Type: research

Editorial Board
Publication date: March 2020Source: Antiviral Research, Volume 175Author(s): (Source: Antiviral Therapy)
Source: Antiviral Therapy - February 8, 2020 Category: Virology Source Type: research

Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate dengue from Zika and West Nile viruses
Publication date: Available online 31 January 2020Source: Antiviral ResearchAuthor(s): Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Sylwia Modrzycka, Marcin Poreba, Rolf Hilgenfeld, Marcin DragAbstractWest Nile virus (WNV) and Dengue virus (DENV) are mosquito-borne pathogenic flaviviruses. The NS2B-NS3 proteases found in these viruses are responsible for polyprotein processing and are therefore considered promising medical targets. Another ortholog of these proteases is found in Zika virus (ZIKV). In this work, we applied a combinatorial chemistry approach – Hybrid Combinatorial Substrate Library (HyCoSuL), to compare ...
Source: Antiviral Therapy - February 1, 2020 Category: Virology Source Type: research

The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells
Publication date: Available online 31 January 2020Source: Antiviral ResearchAuthor(s): Gao Chuan, Lin Chen, Shan-Bo Tang, Qiao-Yun Long, Jia-Li He, Na-An Zhang, Hong-Bing Shu, Zhen-Xia Chen, Min Wu, Lian-Yun LiAbstractHistone positioning and modifications on viral genomes are important factors regulating virus replication. To investigate the dynamics of modified histones on the viral genome and their potential roles in antiviral response, we studied the dynamic changes of histone modifications across the HSV-1 genome in THP-1 cells. Histone modifications were detected on the HSV-1 genome soon after infection, including H...
Source: Antiviral Therapy - February 1, 2020 Category: Virology Source Type: research

Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017–2018
Publication date: Available online 28 January 2020Source: Antiviral ResearchAuthor(s): Emi Takashita, Rod S. Daniels, Seiichiro Fujisaki, Vicki Gregory, Larisa V. Gubareva, Weiijuan Huang, Aeron C. Hurt, Angie Lackenby, Ha T. Nguyen, Dmitriy Pereyaslov, Merryn Roe, Magdi Samaan, Kanta Subbarao, Herman Tse, Dayan Wang, Hui-Ling Yen, Wenqing Zhang, Adam MeijerAbstractThe global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012–13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for ...
Source: Antiviral Therapy - January 30, 2020 Category: Virology Source Type: research