A novel hepatitis B virus capsid assembly modulator QL-007 inhibits HBV replication and infection through altering capsid assembly
In conclusion, our findings underscore the potential of QL-007 as an effective agent against HBV replication and introduce it as a novel CpAM for the antiviral treatment of chronic hepatitis B.PMID:37683938 | DOI:10.1016/j.antiviral.2023.105715 (Source: Antiviral Research)
Source: Antiviral Research - September 8, 2023 Category: Virology Authors: Jingyuan Xi Zhiqiang Gu Chunyan Sun Zimin Chen Ting Zhang Ran Chen Tianyu Liu Hao Liao Jun Zou Danli Yang Qiang Xu Jie Wang Guochao Wei Zhe Cheng Fengmin Lu Xiangmei Chen Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713 (Source: Antiviral Research)
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713 (Source: Antiviral Research)
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713 (Source: Antiviral Research)
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713 (Source: Antiviral Research)
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
