Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization
Antiviral Res. 2023 Nov 18:105757. doi: 10.1016/j.antiviral.2023.105757. Online ahead of print.ABSTRACTDespite global vaccination efforts, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and spread globally. Currently, the development of affordable vaccine against Omicron variant of concern (VOC) is necessary. Here, we assessed the safety and immunogenicity of a SARS-CoV-2 vaccine consisting of a live Newcastle disease virus vector expressing the spike (S) protein of Omicron BA.1 administrated intranasally (IN) or intramuscularly (IM) in Golden Syrian hamster model. Immunogenicity studies s...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Qiu-Yan Zhang Hong-Qing Zhang Ya-Nan Zhang Zhe-Rui Zhang Xiao-Dan Li Meng-Chan Hao Yang Zhang Jia-Qi Li Yan-Yan Hu Xiao-Ling Chen Jing Wang Yu-Jia Shi Cheng-Lin Deng Jian-Jun Chen Han-Qing Ye Bo Zhang Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
Licochalcone A regulates viral IRES activity to inhibit enterovirus replication
Antiviral Res. 2023 Nov 18:105755. doi: 10.1016/j.antiviral.2023.105755. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is available. Autophagy is a cellular process that targets cytoplasmic proteins or organelles to the lysosomes for degradation. Enteroviruses strategically harness the host aut...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Yu-Ting Chuang Yu-Li Lin Jing-Yi Lin Source Type: research
Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization
Antiviral Res. 2023 Nov 18:105757. doi: 10.1016/j.antiviral.2023.105757. Online ahead of print.ABSTRACTDespite global vaccination efforts, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and spread globally. Currently, the development of affordable vaccine against Omicron variant of concern (VOC) is necessary. Here, we assessed the safety and immunogenicity of a SARS-CoV-2 vaccine consisting of a live Newcastle disease virus vector expressing the spike (S) protein of Omicron BA.1 administrated intranasally (IN) or intramuscularly (IM) in Golden Syrian hamster model. Immunogenicity studies s...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Qiu-Yan Zhang Hong-Qing Zhang Ya-Nan Zhang Zhe-Rui Zhang Xiao-Dan Li Meng-Chan Hao Yang Zhang Jia-Qi Li Yan-Yan Hu Xiao-Ling Chen Jing Wang Yu-Jia Shi Cheng-Lin Deng Jian-Jun Chen Han-Qing Ye Bo Zhang Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
Licochalcone A regulates viral IRES activity to inhibit enterovirus replication
Antiviral Res. 2023 Nov 18:105755. doi: 10.1016/j.antiviral.2023.105755. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is available. Autophagy is a cellular process that targets cytoplasmic proteins or organelles to the lysosomes for degradation. Enteroviruses strategically harness the host aut...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Yu-Ting Chuang Yu-Li Lin Jing-Yi Lin Source Type: research
Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization
Antiviral Res. 2023 Nov 18:105757. doi: 10.1016/j.antiviral.2023.105757. Online ahead of print.ABSTRACTDespite global vaccination efforts, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and spread globally. Currently, the development of affordable vaccine against Omicron variant of concern (VOC) is necessary. Here, we assessed the safety and immunogenicity of a SARS-CoV-2 vaccine consisting of a live Newcastle disease virus vector expressing the spike (S) protein of Omicron BA.1 administrated intranasally (IN) or intramuscularly (IM) in Golden Syrian hamster model. Immunogenicity studies s...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Qiu-Yan Zhang Hong-Qing Zhang Ya-Nan Zhang Zhe-Rui Zhang Xiao-Dan Li Meng-Chan Hao Yang Zhang Jia-Qi Li Yan-Yan Hu Xiao-Ling Chen Jing Wang Yu-Jia Shi Cheng-Lin Deng Jian-Jun Chen Han-Qing Ye Bo Zhang Source Type: research
Monoglycosylated SARS-CoV-2 receptor binding domain fused with HA < sub > stem < /sub > -scaffolded protein vaccine confers broad protective immunity against SARS-CoV-2 and influenza viruses
This study demonstrated that HSSRmg produced using a monoglycosylation process and combined with the JR300 adjuvant elicits superior cross-strain immune responses against SARS-CoV-2 and influenza viruses in mice compared with S-2P. JR300-adjuvanted HSSRmg has great potential as a coronavirus-influenza vaccine that provides dual protection against SARS-CoV-2 and influenza infections.PMID:37984568 | DOI:10.1016/j.antiviral.2023.105759 (Source: Antiviral Research)
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Chia-Ying Wu Yung-Chieh Tseng Shao-En Kao Li-Yang Wu Jen-Tzu Hou Yu-Chih Yang Pei-Wen Hsiao Juine-Ruey Chen Source Type: research
Generation of whole-porcine neutralizing antibodies of an alphacoronavirus by single B cell antibody technology
In this study, we utilized single B cell antibody technology to obtain a potent neutralizing antibody, C62, which specifically targets the receptor binding domain S1B of the PEDV-S1 protein. C62 exhibited potent neutralizing activity against PEDV and inhibited viral attachment to the cell surface in vitro. Furthermore, the effectiveness of C62 in mitigating PEDV infection was demonstrated in vivo, as evidenced by the delayed onset of diarrhea and reduced mortality rates observed in piglets following oral administration of C62. Our study provides an alternative approach for controlling PEDV infection. Meanwhile, C62 holds p...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Sheng Wang Zhichen Wang Ying Li Shaoyu Tu Jiahui Zou Yanqing Cheng Huawei Zhang Sizhu Suolang Hongbo Zhou Source Type: research
A sulfonamide chalcone inhibited dengue virus with a potential target at the SAM-binding site of viral methyltransferase
Antiviral Res. 2023 Nov 13;220:105753. doi: 10.1016/j.antiviral.2023.105753. Online ahead of print.ABSTRACTDengue infection is a global health problem as climate change facilitates the spread of mosquito vectors. Infected patients could progress to severe plasma leakage and hemorrhagic shock, where current standard treatment remains supportive. Previous reports suggested that several flavonoid derivatives inhibited mosquito-borne flaviviruses. This work aimed to explore sulfonamide chalcone derivatives as dengue inhibitors and to identify molecular targets. We initially screened 27 sulfonamide chalcones using cell-based an...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Van Cao I Putu Sukanadi Naphat Loeanurit Aphinya Suroengrit Wattamon Paunrat Vipanee Vibulakhaopan Kowit Hengphasatporn Yasuteru Shigeta Warinthorn Chavasiri Siwaporn Boonyasuppayakorn Source Type: research
Generation of whole-porcine neutralizing antibodies of an alphacoronavirus by single B cell antibody technology
In this study, we utilized single B cell antibody technology to obtain a potent neutralizing antibody, C62, which specifically targets the receptor binding domain S1B of the PEDV-S1 protein. C62 exhibited potent neutralizing activity against PEDV and inhibited viral attachment to the cell surface in vitro. Furthermore, the effectiveness of C62 in mitigating PEDV infection was demonstrated in vivo, as evidenced by the delayed onset of diarrhea and reduced mortality rates observed in piglets following oral administration of C62. Our study provides an alternative approach for controlling PEDV infection. Meanwhile, C62 holds p...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Sheng Wang Zhichen Wang Ying Li Shaoyu Tu Jiahui Zou Yanqing Cheng Huawei Zhang Sizhu Suolang Hongbo Zhou Source Type: research
A sulfonamide chalcone inhibited dengue virus with a potential target at the SAM-binding site of viral methyltransferase
Antiviral Res. 2023 Nov 13:105753. doi: 10.1016/j.antiviral.2023.105753. Online ahead of print.ABSTRACTDengue infection is a global health problem as climate change facilitates the spread of mosquito vectors. Infected patients could progress to severe plasma leakage and hemorrhagic shock, where current standard treatment remains supportive. Previous reports suggested that several flavonoid derivatives inhibited mosquito-borne flaviviruses. This work aimed to explore sulfonamide chalcone derivatives as dengue inhibitors and to identify molecular targets. We initially screened 27 sulfonamide chalcones using cell-based antivi...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Van Cao I Putu Sukanadi Naphat Loeanurit Aphinya Suroengrit Wattamon Paunrat Vipanee Vibulakhaopan Kowit Hengphasatporn Yasuteru Shigeta Warinthorn Chavasiri Siwaporn Boonyasuppayakorn Source Type: research
Generation of whole-porcine neutralizing antibodies of an alphacoronavirus by single B cell antibody technology
In this study, we utilized single B cell antibody technology to obtain a potent neutralizing antibody, C62, which specifically targets the receptor binding domain S1B of the PEDV-S1 protein. C62 exhibited potent neutralizing activity against PEDV and inhibited viral attachment to the cell surface in vitro. Furthermore, the effectiveness of C62 in mitigating PEDV infection was demonstrated in vivo, as evidenced by the delayed onset of diarrhea and reduced mortality rates observed in piglets following oral administration of C62. Our study provides an alternative approach for controlling PEDV infection. Meanwhile, C62 holds p...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Sheng Wang Zhichen Wang Ying Li Shaoyu Tu Jiahui Zou Yanqing Cheng Huawei Zhang Sizhu Suolang Hongbo Zhou Source Type: research
A sulfonamide chalcone inhibited dengue virus with a potential target at the SAM-binding site of viral methyltransferase
Antiviral Res. 2023 Nov 13:105753. doi: 10.1016/j.antiviral.2023.105753. Online ahead of print.ABSTRACTDengue infection is a global health problem as climate change facilitates the spread of mosquito vectors. Infected patients could progress to severe plasma leakage and hemorrhagic shock, where current standard treatment remains supportive. Previous reports suggested that several flavonoid derivatives inhibited mosquito-borne flaviviruses. This work aimed to explore sulfonamide chalcone derivatives as dengue inhibitors and to identify molecular targets. We initially screened 27 sulfonamide chalcones using cell-based antivi...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Van Cao I Putu Sukanadi Naphat Loeanurit Aphinya Suroengrit Wattamon Paunrat Vipanee Vibulakhaopan Kowit Hengphasatporn Yasuteru Shigeta Warinthorn Chavasiri Siwaporn Boonyasuppayakorn Source Type: research
Generation of whole-porcine neutralizing antibodies of an alphacoronavirus by single B cell antibody technology
In this study, we utilized single B cell antibody technology to obtain a potent neutralizing antibody, C62, which specifically targets the receptor binding domain S1B of the PEDV-S1 protein. C62 exhibited potent neutralizing activity against PEDV and inhibited viral attachment to the cell surface in vitro. Furthermore, the effectiveness of C62 in mitigating PEDV infection was demonstrated in vivo, as evidenced by the delayed onset of diarrhea and reduced mortality rates observed in piglets following oral administration of C62. Our study provides an alternative approach for controlling PEDV infection. Meanwhile, C62 holds p...
Source: Antiviral Research - November 15, 2023 Category: Virology Authors: Sheng Wang Zhichen Wang Ying Li Shaoyu Tu Jiahui Zou Yanqing Cheng Huawei Zhang Sizhu Suolang Hongbo Zhou Source Type: research
