Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of < em > Clostridioides difficile < /em >
This study demonstrated the potent antibacterial activity of IBZ against a large collection of C. difficile strains including multidrug-resistant strains. This study highlights the therapeutic potential of IBZ against multidrug-resistant strains of C. difficile.PMID:38364016 | DOI:10.1128/aac.01621-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 16, 2024 Category: Microbiology Authors: Eug énie Bassères Taryn A Eubank Khurshida Begum M Jahangir Alam Jinhee Jo Thanh M Le Chris K Lancaster Anne J Gonzales-Luna Kevin W Garey Source Type: research

Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax
Antimicrob Agents Chemother. 2024 Feb 15:e0149723. doi: 10.1128/aac.01497-23. Online ahead of print.ABSTRACTBacillus anthracis is a Gram-positive Centers for Disease Control and Prevention category "A" biothreat pathogen. Without early treatment, inhalation of anthrax spores with progression to inhalational anthrax disease is associated with high fatality rates. Gepotidacin is a novel first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and is being evaluated for use against biothreat and conventional pathogens. Gepotidacin selectively inhibits bacterial D...
Source: Antimicrobial Agents and Chemotherapy - February 15, 2024 Category: Microbiology Authors: Jamese J Hilliard Charles Jakielaszek Frank Mannino Mohammad Hossain Lian Qian Cindy Fishman Samandra Demons Jeremy Hershfield Carl Soffler Riccardo Russo Lisa Henning Joseph Novak Karen O'Dwyer Source Type: research

Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax
Antimicrob Agents Chemother. 2024 Feb 15:e0149723. doi: 10.1128/aac.01497-23. Online ahead of print.ABSTRACTBacillus anthracis is a Gram-positive Centers for Disease Control and Prevention category "A" biothreat pathogen. Without early treatment, inhalation of anthrax spores with progression to inhalational anthrax disease is associated with high fatality rates. Gepotidacin is a novel first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and is being evaluated for use against biothreat and conventional pathogens. Gepotidacin selectively inhibits bacterial D...
Source: Antimicrobial Agents and Chemotherapy - February 15, 2024 Category: Microbiology Authors: Jamese J Hilliard Charles Jakielaszek Frank Mannino Mohammad Hossain Lian Qian Cindy Fishman Samandra Demons Jeremy Hershfield Carl Soffler Riccardo Russo Lisa Henning Joseph Novak Karen O'Dwyer Source Type: research

Erratum for Estabrook et al., "Epidemiology of Resistance Determinants Identified in Meropenem-Nonsusceptible < em > Enterobacterales < /em > Collected as Part of a Global Surveillance Study, 2018 to 2019"
Antimicrob Agents Chemother. 2024 Feb 13:e0164023. doi: 10.1128/aac.01640-23. Online ahead of print.NO ABSTRACTPMID:38349140 | DOI:10.1128/aac.01640-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 13, 2024 Category: Microbiology Authors: Mark Estabrook Astrid Muyldermans Daniel Sahm Denis Pierard Gregory Stone Eric Utt Source Type: research

Inhibition of AMPK activation in < em > Echinococcus granulosus < /em > sensu stricto limits the parasite's glucose metabolism and survival
In this study, we found that targeted knockdown of EgAMPKα or a small-molecule AMPK inhibitor inhibited the viability of E. granulosus sensu stricto (s.s.) and disrupted the ultrastructure. The results of in vivo experiments showed that the AMPK inhibitor had a significant therapeutic effect on E. granulosus s.s.-infected mice and resulted in the loss of cellular structures of the germinal layer. In addition, the inhibition of the EgAMPK/EgGLUT1 pathway limited glucose uptake and glucose metabolism functions in E. granulosus s.s.. Overall, our results suggest that EgAMPK can be a potential drug target for CE and that inhi...
Source: Antimicrobial Agents and Chemotherapy - February 13, 2024 Category: Microbiology Authors: Mingzhi Yan Hui Liu Yansen Su Xiaojuan Bi Ning Yang Renyong Lin Guodong L ü Source Type: research