Antimicrobial Agents and Chemotherapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The metabolic slowdown caused by the deletion of pspA accelerates protein aggregation during stationary phase facilitating antibiotic persistence
This study highlights the novel role of pspA in maintaining proteostasis, regulating dormancy depth, and affecting antibiotic persistence during stationary phase.PMID:38169282 | DOI:10.1128/aac.00937-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Yingxing Li Xiao Chen Weili Zhang Kefan Fang Jingjing Tian Fangyuan Li Mingfei Han Jingjing Huang Tianshu Sun Fan Bai Mei Cheng Yingchun Xu Source Type: research

Doxycycline versus cephalexin treatment of presumed streptococcal skin and soft tissue infection among adults presenting to the emergency department
Antimicrob Agents Chemother. 2024 Jan 3:e0128223. doi: 10.1128/aac.01282-23. Online ahead of print.ABSTRACTAmong 100 propensity score-matched emergency department patients receiving ≤14 days doxycycline versus cephalexin monotherapy for outpatient treatment of nonpurulent (presumed streptococcal) skin and soft tissue infection, a low rate of 14-day clinical failure was observed [6% each group; odds ratio (OR), 1.34 (0.21-8.69); P = 0.745], defined as hospital admission, i.v. antibiotic therapy, or change in oral antibiotic. Doxycycline may represent a reasonable therapeutic alternative for this indication in regions with...
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Eric Taylor Michael D Nailor Michelle Feider Shannon Sullivan Kellie J Goodlet Source Type: research

Regional spread of an atypical ESBL-producing Escherichia coli ST131H89 clone among different human and environmental reservoirs in Western Switzerland
We describe the inter-regional spread of a novel ESBL-producing Escherichia coli subclone (ST131H89) in long-term care facility residents, general population, and environmental water sources in Western Switzerland between 2017 and 2020. The study highlights the importance of molecular surveillance for tracking emerging antibiotic-resistant pathogens in healthcare and community settings.PMID:38169291 | DOI:10.1128/aac.00925-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Romain Martischang Helena Seth-Smith Tess D Verschuuren Delphine H équet Nadia Ga ïa Patrice Fran çois Ad C Fluit Jan A J W Kluytmans Salome N Seiffert Evelina Tacconelli Abdessalam Cherkaoui Stephan Harbarth Adrian Egli Philipp Kohler Source Type: research

Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics
Antimicrob Agents Chemother. 2024 Jan 3:e0139323. doi: 10.1128/aac.01393-23. Online ahead of print.ABSTRACTAminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunt...
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Eunjeong Shin Yongzhen Zhang Jieqiang Zhou Yinzhi Lang Alaa R M Sayed Carolin Werkman Yuanyuan Jiao Monika Kumaraswamy Zackery P Bulman Brian M Luna J ürgen B Bulitta Source Type: research

Omadacycline pharmacokinetics/pharmacodynamics and efficacy against multidrug-resistant Mycobacterium tuberculosis in the hollow fiber system model
Antimicrob Agents Chemother. 2023 Dec 22:e0108023. doi: 10.1128/aac.01080-23. Online ahead of print.ABSTRACTSeventy-five years ago, first-generation tetracyclines demonstrated limited efficacy in the treatment of tuberculosis but were more toxic than efficacious. We performed a series of pharmacokinetic/pharmacodynamic (PK/PD) experiments with a potentially safer third-generation tetracycline, omadacycline, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Mycobacterium tuberculosis (Mtb) H37Rv and an MDR-TB clinical strain (16D) were used in the minimum inhibitory concentration (MIC) and static concentration...
Source: Antimicrobial Agents and Chemotherapy - December 22, 2023 Category: Microbiology Authors: Sanjay Singh Tawanda Gumbo Gunavanthi D Boorgula Tania A Thomas Julie V Philley Shashikant Srivastava Source Type: research

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model
Antimicrob Agents Chemother. 2023 Dec 22:e0104323. doi: 10.1128/aac.01043-23. Online ahead of print.ABSTRACTMultidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) poses significant challenges to global tuberculosis (TB) control efforts. Host-directed therapies (HDTs) offer a novel approach to TB treatment by enhancing immune-mediated clearance of Mtb. Prior preclinical studies found that the inhibition of heme oxygenase-1 (HO-1), an enzyme involved in heme metabolism, with tin-protoporphyrin IX (SnPP) significantly reduced mouse lung bacillary burden when co-administered with the first-line antitubercular regimen. Here...
Source: Antimicrobial Agents and Chemotherapy - December 22, 2023 Category: Microbiology Authors: Jennie Ruelas Castillo Pranita Neupane Styliani Karanika Stefanie Krug Darla Quijada Andrew Garcia Samuel Ayeh Addis Yilma Diego L Costa Alan Sher Nader Fotouhi Natalya Serbina Petros C Karakousis Source Type: research