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Inhibition of < em > Pseudomonas aeruginosa < /em > quorum sensing by chemical induction of the MexEF-oprN efflux pump
Antimicrob Agents Chemother. 2024 Jan 8:e0138723. doi: 10.1128/aac.01387-23. Online ahead of print.ABSTRACTThe cell-to-cell communication system quorum sensing (QS), used by various pathogenic bacteria to synchronize gene expression and increase host invasion potentials, is studied as a potential target for persistent infection control. To search for novel molecules targeting the QS system in the Gram-negative opportunistic pathogen Pseudomonas aeruginosa, a chemical library consisting of 3,280 small compounds from LifeArc was screened. A series of 10 conjugated phenones that have not previously been reported to target bac...
Source: Antimicrobial Agents and Chemotherapy - January 8, 2024 Category: Microbiology Authors: Rasmus Kristensen Jens Bo Andersen Morten Rybtke Charlotte Uldahl Jansen Blaine Gabriel Fritz Rikke Overgaard Kiilerich Jesper Uhd Thomas Bjarnsholt Katrine Qvortrup Tim Tolker-Nielsen Michael Givskov Tim Holm Jakobsen Source Type: research

Structural role of K224 in taniborbactam inhibition of NDM-1
Antimicrob Agents Chemother. 2024 Jan 4:e0133223. doi: 10.1128/aac.01332-23. Online ahead of print.ABSTRACTTaniborbactam (TAN; VNRX-5133) is a novel bicyclic boronic acid β-lactamase inhibitor (BLI) being developed in combination with cefepime (FEP). TAN inhibits both serine and some metallo-β-lactamases. Previously, the substitution R228L in VIM-24 was shown to increase activity against oxyimino-cephalosporins like FEP and ceftazidime (CAZ). We hypothesized that substitutions at K224, the homologous position in NDM-1, could impact FEP/TAN resistance. To evaluate this, a library of codon-optimized NDM K224X clones for mi...
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: Daisuke Ono Maria F Mojica Christopher R Bethel Yoshikazu Ishii Salvador I Drusin Diego M Moreno Alejandro J Vila Robert A Bonomo Source Type: research

The metallo- β-lactamases strike back: emergence of taniborbactam escape variants
Antimicrob Agents Chemother. 2024 Jan 4:e0151023. doi: 10.1128/aac.01510-23. Online ahead of print.ABSTRACTMetallo-β-lactamases (MBLs) have evolved relatively rapidly to become an international public health threat. There are no clinically available β-lactamase inhibitors with activity against MBLs. This may change with the introduction of cefepime-taniborbactam. Herein, we review three manuscripts (S. I. Drusin, C. Le Terrier, L. Poirel, R. A. Bonomo, et al., Antimicrob Agents Chemother 68:e01168-23, 2024, https://doi.org/10.1128/aac.01168-23; C. Le Terrier, C. Viguier, P. Nordmann, A. J. Vila, and L. Poirel, Antimicrob...
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: Pranita D Tamma Jose M Munita Source Type: research

Retraction for Angelakis et al., "Abnormal Weight Gain and Gut Microbiota Modifications Are Side Effects of Long-Term Doxycycline and Hydroxychloroquine Treatment"
Antimicrob Agents Chemother. 2024 Jan 4:e0150923. doi: 10.1128/aac.01509-23. Online ahead of print.NO ABSTRACTPMID:38174939 | DOI:10.1128/aac.01509-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: American Society for Microbiology Source Type: research

Retraction for Angelakis et al., "Vitamin D and Prolonged Treatment with Photosensitivity-Associated Antibiotics"
Antimicrob Agents Chemother. 2024 Jan 4:e0150823. doi: 10.1128/aac.01508-23. Online ahead of print.NO ABSTRACTPMID:38174940 | DOI:10.1128/aac.01508-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 4, 2024 Category: Microbiology Authors: American Society for Microbiology Source Type: research

The metabolic slowdown caused by the deletion of < em > pspA < /em > accelerates protein aggregation during stationary phase facilitating antibiotic persistence
This study highlights the novel role of pspA in maintaining proteostasis, regulating dormancy depth, and affecting antibiotic persistence during stationary phase.PMID:38169282 | DOI:10.1128/aac.00937-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Yingxing Li Xiao Chen Weili Zhang Kefan Fang Jingjing Tian Fangyuan Li Mingfei Han Jingjing Huang Tianshu Sun Fan Bai Mei Cheng Yingchun Xu Source Type: research

Doxycycline versus cephalexin treatment of presumed streptococcal skin and soft tissue infection among adults presenting to the emergency department
Antimicrob Agents Chemother. 2024 Jan 3:e0128223. doi: 10.1128/aac.01282-23. Online ahead of print.ABSTRACTAmong 100 propensity score-matched emergency department patients receiving ≤14 days doxycycline versus cephalexin monotherapy for outpatient treatment of nonpurulent (presumed streptococcal) skin and soft tissue infection, a low rate of 14-day clinical failure was observed [6% each group; odds ratio (OR), 1.34 (0.21-8.69); P = 0.745], defined as hospital admission, i.v. antibiotic therapy, or change in oral antibiotic. Doxycycline may represent a reasonable therapeutic alternative for this indication in regions with...
Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Eric Taylor Michael D Nailor Michelle Feider Shannon Sullivan Kellie J Goodlet Source Type: research