Emerging Technologies in Cardiac Pacing
Annu Rev Med. 2023 Nov 21. doi: 10.1146/annurev-med-051022-042616. Online ahead of print.ABSTRACTCardiac pacing to treat bradyarrhythmias has evolved in recent decades. Recognition that a substantial proportion of pacemaker-dependent patients can develop heart failure due to electrical and mechanical dyssynchrony from traditional right ventricular apical pacing has led to development of more physiologic pacing methods that better mimic normal cardiac conduction and provide synchronized ventricular contraction. Conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system dise...
Source: Annual Review of Medicine - November 21, 2023 Category: General Medicine Authors: Ramya Vajapey Mina K Chung Source Type: research

Emerging Technologies in Cardiac Pacing
Annu Rev Med. 2023 Nov 21. doi: 10.1146/annurev-med-051022-042616. Online ahead of print.ABSTRACTCardiac pacing to treat bradyarrhythmias has evolved in recent decades. Recognition that a substantial proportion of pacemaker-dependent patients can develop heart failure due to electrical and mechanical dyssynchrony from traditional right ventricular apical pacing has led to development of more physiologic pacing methods that better mimic normal cardiac conduction and provide synchronized ventricular contraction. Conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system dise...
Source: Annual Review of Medicine - November 21, 2023 Category: General Medicine Authors: Ramya Vajapey Mina K Chung Source Type: research

Emerging Technologies in Cardiac Pacing
Annu Rev Med. 2023 Nov 21. doi: 10.1146/annurev-med-051022-042616. Online ahead of print.ABSTRACTCardiac pacing to treat bradyarrhythmias has evolved in recent decades. Recognition that a substantial proportion of pacemaker-dependent patients can develop heart failure due to electrical and mechanical dyssynchrony from traditional right ventricular apical pacing has led to development of more physiologic pacing methods that better mimic normal cardiac conduction and provide synchronized ventricular contraction. Conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system dise...
Source: Annual Review of Medicine - November 21, 2023 Category: General Medicine Authors: Ramya Vajapey Mina K Chung Source Type: research

Wearable Devices: Implications for Precision Medicine and the Future of Health Care
Annu Rev Med. 2023 Nov 20. doi: 10.1146/annurev-med-052422-020437. Online ahead of print.ABSTRACTWearable devices are integrated analytical units equipped with sensitive physical, chemical, and biological sensors capable of noninvasive and continuous monitoring of vital physiological parameters. Recent advances in disciplines including electronics, computation, and material science have resulted in affordable and highly sensitive wearable devices that are routinely used for tracking and managing health and well-being. Combined with longitudinal monitoring of physiological parameters, wearables are poised to transform the e...
Source: Annual Review of Medicine - November 20, 2023 Category: General Medicine Authors: Mohan Babu Ziv Lautman Xiangping Lin Milan H B Sobota Michael P Snyder Source Type: research

More Tailored Approaches to Tuberculosis Treatment and Prevention
Annu Rev Med. 2023 Nov 20. doi: 10.1146/annurev-med-100622-024848. Online ahead of print.ABSTRACTRecent advances in the treatment of tuberculosis (TB) have led to improvements unprecedented in our lifetime. Decades of research in developing new drugs, especially for multidrug-resistant TB, have created not only multiple new antituberculous agents but also a new approach to development and treatment, with a focus on maximizing the benefit to the individual patient. Prevention of TB disease has also been improved and recognized as a critical component of global TB control. While the momentum is positive, it will take continu...
Source: Annual Review of Medicine - November 20, 2023 Category: General Medicine Authors: Charles M Bark W Henry Boom Jennifer J Furin Source Type: research

Precision Approaches to Chronic Obstructive Pulmonary Disease Management
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-060622-101239. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a me...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Matthew Moll Edwin K Silverman Source Type: research

Novel Therapeutic and Program-Based Approaches to Opioid Use Disorders
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050522-033924. Online ahead of print.ABSTRACTOpioid use disorder continues to drive overdose deaths in many countries, including the United States. Illicit fentanyl and its analogues have emerged as key contributors to the complications and mortality associated with opioid use disorder. Medications for opioid use disorder treatment, such as methadone and buprenorphine, are safe and substantially reduce opioid use, infectious complications, and mortality risk, but remain underutilized. Polysubstance use and emerging substances such as xylazine and designer benzodiazepines ...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Patricia Liu P Todd Korthuis Bradley M Buchheit Source Type: research

Interventional Pulmonology: Extending the Breadth of Thoracic Care
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050922-060929. Online ahead of print.ABSTRACTInterventional pulmonary medicine has developed as a subspecialty focused on the management of patients with complex thoracic disease. Leveraging minimally invasive techniques, interventional pulmonologists diagnose and treat pathologies that previously required more invasive options such as surgery. By mitigating procedural risk, interventional pulmonologists have extended the reach of care to a wider pool of vulnerable patients who require therapy. Endoscopic innovations, including endobronchial ultrasound and robotic and ele...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Yaron B Gesthalter Colleen L Channick Source Type: research

Precision Approaches to Chronic Obstructive Pulmonary Disease Management
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-060622-101239. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a me...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Matthew Moll Edwin K Silverman Source Type: research

Novel Therapeutic and Program-Based Approaches to Opioid Use Disorders
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050522-033924. Online ahead of print.ABSTRACTOpioid use disorder continues to drive overdose deaths in many countries, including the United States. Illicit fentanyl and its analogues have emerged as key contributors to the complications and mortality associated with opioid use disorder. Medications for opioid use disorder treatment, such as methadone and buprenorphine, are safe and substantially reduce opioid use, infectious complications, and mortality risk, but remain underutilized. Polysubstance use and emerging substances such as xylazine and designer benzodiazepines ...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Patricia Liu P Todd Korthuis Bradley M Buchheit Source Type: research

Interventional Pulmonology: Extending the Breadth of Thoracic Care
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050922-060929. Online ahead of print.ABSTRACTInterventional pulmonary medicine has developed as a subspecialty focused on the management of patients with complex thoracic disease. Leveraging minimally invasive techniques, interventional pulmonologists diagnose and treat pathologies that previously required more invasive options such as surgery. By mitigating procedural risk, interventional pulmonologists have extended the reach of care to a wider pool of vulnerable patients who require therapy. Endoscopic innovations, including endobronchial ultrasound and robotic and ele...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Yaron B Gesthalter Colleen L Channick Source Type: research

Precision Approaches to Chronic Obstructive Pulmonary Disease Management
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-060622-101239. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a me...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Matthew Moll Edwin K Silverman Source Type: research

Novel Therapeutic and Program-Based Approaches to Opioid Use Disorders
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050522-033924. Online ahead of print.ABSTRACTOpioid use disorder continues to drive overdose deaths in many countries, including the United States. Illicit fentanyl and its analogues have emerged as key contributors to the complications and mortality associated with opioid use disorder. Medications for opioid use disorder treatment, such as methadone and buprenorphine, are safe and substantially reduce opioid use, infectious complications, and mortality risk, but remain underutilized. Polysubstance use and emerging substances such as xylazine and designer benzodiazepines ...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Patricia Liu P Todd Korthuis Bradley M Buchheit Source Type: research

Interventional Pulmonology: Extending the Breadth of Thoracic Care
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-050922-060929. Online ahead of print.ABSTRACTInterventional pulmonary medicine has developed as a subspecialty focused on the management of patients with complex thoracic disease. Leveraging minimally invasive techniques, interventional pulmonologists diagnose and treat pathologies that previously required more invasive options such as surgery. By mitigating procedural risk, interventional pulmonologists have extended the reach of care to a wider pool of vulnerable patients who require therapy. Endoscopic innovations, including endobronchial ultrasound and robotic and ele...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Yaron B Gesthalter Colleen L Channick Source Type: research

Precision Approaches to Chronic Obstructive Pulmonary Disease Management
Annu Rev Med. 2023 Oct 12. doi: 10.1146/annurev-med-060622-101239. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a me...
Source: Annual Review of Medicine - October 12, 2023 Category: General Medicine Authors: Matthew Moll Edwin K Silverman Source Type: research