Frequency of HLA-DRB1 Alleles in Rheumatoid Arthritis Patients in Zahedan, Southeast Iran
CONCLUSION: The data suggest that the DRB1*10 allele is a risk factor and DRB1*03 is protective for RA in this population. Ann Saudi Med 2011; 31(2): 171-173PMID: 21422655 DOI: 10.4103/0256-4947.78205 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

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  With great honor I have read the valuable comments entitled“NK cell: an unforgettable lymphocyte " on the case report“Delayed Presentation of (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Prevalence of Chronic Obstructive Pulmonary Disease Among Smokers Attending Primary Healthcare Clinics in Saudi Arabia
CONCLUSION: Underdiagnosis of COPD in primary healthcare clinics in Saudi Arabia is common, but its extent is not different from the corresponding data available in the literature for other countries. Use of spirometry as a routine test for all patients older than 40 years of age and with a smoking history can help in early detection and proper diagnosis of COPD, which subsequently will help in implementation of preventive measures. Ann Saudi Med 2011; 31(2): 129-133PMID: 21403413 DOI: 10.4103/0256-4947.77485 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Urine Iodine Excretion in Patients with Euthyroid Noduler Disease
CONCLUSION: In this study, iodine deficiency was associated with an increase in thyroid nodule volumes. Smoking rates were higher in iodine deficient groups. It is thought that smoking impairs iodine intake or absorption consistent with a previous report. Ann Saudi Med 2011; 31(2): 167-170PMID: 21422654 DOI: 10.4103/0256-4947.78204 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

NK Cell: An Unforgettable Lymphocyte (Comment on " Delayed Presentation of Severe Combined Immunodeficiency due to Prolonged maternal T Cell Engraftment " )
PMID: 21422659DOI: 10.4103/0256-4947.78209 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Epidemiology of Sickle Cell Disease in Saudi Arabia
Sickle cell disease (SCD) is an autosomal recessive disorder characterized by production of abnormal hemoglobin S and is associated with high morbidity and mortality. Information about the prevalence of SCD in Saudi Arabia is patchy and probably underestimated, but studies have reported that SCD is a relatively common genetic disorder in this part of the world. The prevalence of SCD in Saudi Arabia varies significantly in different parts of the country, with the highest prevalence is in the Eastern province, followed by the southwestern provinces. The reported prevalence for sickle-cell trait ranges from 2% to 27%, and up ...
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research

Accidental Inhalation of Mercury Vapor in a Child
PMID: 21422658DOI: 10.4103/0256-4947.78208 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

The Prognostic Value of the Glasgow Coma Scale, Serum Acetylcholinesterase and Leukocyte Levels in Acute Organophosphorus Poisoning
CONCLUSION: Although serum Cholinesterase values can be used in the quick diagnosis, their efficiency at predicting outcome in patients with OP poisoning has not been established. It has also been determined that serum leukocyte values have no prognostic value in OP poisoning, but GCS values have been found to be effective in predicting the outcome. Ann Saudi Med 2011 ; 31 (2): 163-166PMID: 21422653 DOI: 10.4103/0256-4947.78203 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Ambiguous Genitalia: Two Decades of Experience
CONCLUSION: Ambiguous genitalia, currently termed disorders of sex development (DSD), is not uncommon in our community. Increased awareness, a detailed history, and a careful physical examination, coupled with appropriate laboratory and radiological investigations aid in early diagnosis and avoid serious sequelae.  Ann Saudi Med 2011; 31(3): 284-288PMID: 21623059 DOI: 10.4103/0256-4947.81544 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research

Cold Agglutinin Disease in Fibrolamellar Hepatocellular Carcinoma: A Rare Association with a Rare Cancer Variant
We report a case of a woman aged 18 years diagnosed with a welI -differentiated hepatocellular carcinoma of the fibrolamellar subtype, who was shown to have CAD also. Her general condition, including CAD, improved after targeted therapy with sorafenib for the hepatocellular carcinoma and only conservative measures for the CAD that consisted of avoidance of cold. In summary, although it is an extremely rare association and less common than lymphoproliferative disorders, CAD can be associated with solid tumors. Ann Saudi Med 2011: 31(2): 197-200PMID: 21293066 DOI: 10.4103/0256-4947.76409 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Intra-Articular Lipoma Arborescens of the Knee Joint
We describe a case in a 26-year-old man who presented with intermittent pain and swelling of the left knee joint for the previous 2 years. Physical examination showed only tenderness over the medial line of the left knee joint. MRI found only joint effusion; therefore, the patient was referred to the orthopedic clinic where he underwent arthroscopy, which revealed a diffuse yellow soft tissue synovial papillary growth involving both medial and lateral gutters of the suprapatellar pouch. A biopsy reported intra-articular LA. This is the first case of LA reported in Saudi Arabia. LA should be included in the clinical and rad...
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Six-year Outcome of the National Premarital Screening and Genetic Counseling Program for Sickle Cell Disease and β-thalassemia in Saudi Arabia
CONCLUSION: Six years of premarital screening in Saudi Arabia markedly reduced the number of at-risk marriages, which may considerably reduce the genetic disease burden in Saudi Arabia in the next decades. Ann Saudi Med 2011; 31 (3): 229-235PMID: 21623050 DOI: 10.4103/0256-4947.81527 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research

RE: Water Pipe (Shisha) Smoking Among Male Students of Medical Colleges in the Eastern Region of Saudi Arabia
DOI: 10.4103/0256-4947.75795PMID: 21245608 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 1 Source Type: research

Response to Oral Glidazide in a Pre-Pubertal Child with Hepatic Nuclear Factor-1 Alpha Maturity Onset Diabetes of the Young
The term " maturity onset diabetes of the young " (MODY) describes a heterogeneous group of monogenic diabetes of which hepatic nuclear factor-1 alpha (HNF-1α) MODY is the most common. Patients with HNF-1α mutations typically present after puberty, and oral sulfonylureas (SU) have been shown to be effective in adults with this condition. A 7-year-old boy presented with asymptomatic hyperglycemia ranging between 6.2 and 10.1 mmol/L and glycosuria for nearly a year. The child's initial HbA1c was 6.9% and the pancreatic Islet cell autoantibodies were negative. His response to the oral glucose tolerance test (OGTT)...
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

Epithelioid Sarcoma of the Orbit
We present the third case of orbital primary epithelioid sarcoma. Ann Saudi Med 2011:31 (2): 187-189PMID: 21242638 DOI: 10.4103/0256-4947.75589 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research