Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes
ObjectiveWe investigated the association of plasma amyloid beta (Abeta)40, Abeta42, and total tau (tTau) with the presence of Alzheimer pathological changes in cognitively normal individuals with subjective cognitive decline (SCD).MethodsWe included 248 subjects with SCD (61 ± 9 years, 42% female, Mini‐Mental State Examination = 28 ± 2) from the SCIENCe project and Amsterdam Dementia Cohort. Subjects were dichotomized as amyloid abnormal by cerebrospinal fluid (CSF) and positron emission tomography (PET). Baseline plasma Abeta40, Abeta42, and tTau were measured using Simoa technology. Associations between ...
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Inge M. W. Verberk,
Rosalinde E. Slot,
Sander C. J. Verfaillie,
Hans Heijst,
Niels D. Prins,
Bart N. M. van Berckel,
Philip Scheltens,
Charlotte E. Teunissen,
Wiesje M. van der Flier Tags: Research Article Source Type: research
Loss of Protocadherin ‐12 Leads to Diencephalic‐Mesencephalic Junction Dysplasia Syndrome
ObjectiveTo identify causes of the autosomal ‐recessive malformation, diencephalic‐mesencephalic junction dysplasia (DMJD) syndrome.MethodsEight families with DMJD were studied by whole ‐exome or targeted sequencing, with detailed clinical and radiological characterization. Patient‐derived induced pluripotent stem cells were derived into neural precursor and endothelial cells to study gene expression.ResultsAll patients showed biallelic mutations in the nonclusteredprotocadherin ‐12 (PCDH12) gene. The characteristic clinical presentation included progressive microcephaly, craniofacial dysmorphism, psychomotor dis...
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Alicia Guemez ‐Gamboa,
Ahmet Okay Çağlayan,
Valentina Stanley,
Anne Gregor,
Maha S. Zaki,
Sahar N. Saleem,
Damir Musaev,
Jennifer McEvoy‐Venneri,
Denice Belandres,
Naiara Akizu,
Jennifer L. Silhavy,
Jana Schroth,
Rasim Ozgur Rosti,
Bret Tags: Research Article Source Type: research
Expanded Disability Status Scale Progression Assessment Heterogeneity in Multiple Sclerosis According to Geographical Areas
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Francesca Bovis,
Alessio Signori,
Luca Carmisciano,
Ilaria Maietta,
Joshua R. Steinerman,
Thomas Li,
Aaron P. Tansy,
Maria Pia Sormani Source Type: research
Cross ‐Sectional Study of a United Kingdom Cohort of Neonatal Vein of Galen Malformation
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Francesca Lecce,
Fergus Robertson,
Adam Rennie,
Anne ‐Marie Heuchan,
Paula Lister,
Sanjay Bhate,
Jo Bhattacharya,
Stefan Brew,
Lakshmi Kanagarajah,
Adam Kuczynski,
Mark J. Peters,
Deborah Ridout,
Anne Schmitt,
Claire Toolis,
Faraneh Vargha Source Type: research
Pallidal and Thalamic Neural Oscillatory Patterns in Tourette's Syndrome
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Wolf ‐Julian Neumann,
Julius Huebl,
Christof Brücke,
Roxanne Lofredi,
Andreas Horn,
Assel Saryyeva,
Kirsten Müller‐Vahl,
Joachim K. Krauss,
Andrea A. Kühn Source Type: research
Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Inge M. W. Verberk,
Rosalinde E. Slot,
Sander C. J. Verfaillie,
Hans Heijst,
Niels D. Prins,
Bart N. M. van Berckel,
Philip Scheltens,
Charlotte E. Teunissen,
Wiesje M. van der Flier Source Type: research
Is It Time to Reconsider the Classic Neurological Examination?
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Clifford B. Saper Source Type: research
Outcome of cell suspension allografts in a patient with Huntington's disease
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - October 4, 2018 Category: Neurology Authors: Alexander Maxan,
Sarah Mason,
Martine Saint ‐Pierre,
Emma Smith,
Aileen Ho,
Tim Harrower,
Colin Watts,
Yen Tai,
Nicola Pavese,
Julie C. Savage,
Marie‐Ève Tremblay,
Peter Gould,
Anne E. Rosser,
Stephen B. Dunnett,
Paola Piccini,
Roger A Source Type: research
NBEA: developmental disease gene with early generalized epilepsy phenotypes
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - September 30, 2018 Category: Neurology Authors: Maureen S. Mulhern,
Constance Stumpel,
Nicholas Stong,
Han G. Brunner,
Louise Bier,
Natalie Lippa,
James Riviello,
Rob P.W. Rouhl,
Marlies Kempers,
Rolph Pfundt,
Alexander P.A. Stegmann,
Mary K. Kukolich,
Aida Telegrafi,
Anna Lehman,
for the Source Type: research
Development of a cerebrovascular MRI biomarker for cognitive aging
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - September 28, 2018 Category: Neurology Authors: Prashanthi Vemuri,
Timothy G. Lesnick,
Scott A. Przybelski,
Jonathan Graff ‐Radford,
Robert I. Reid,
Val J. Lowe,
Samantha M. Zuk,
Matthew L. Senjem,
Christopher G. Schwarz,
Jeffrey L. Gunter,
Kejal Kantarci,
Mary M. Machulda,
Michelle M. Mi Source Type: research
Prevalence of amyloid ‐β pathology in distinct variants of primary progressive aphasia
This study shows that the current PPA classification system helps to predict underlying pathology across different cohorts and clinical settings, and suggests that age and APOE genotype should be taken into account when interpreting A β biomarkers in PPA patients.This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - September 26, 2018 Category: Neurology Authors: David Bergeron,
Maria L. Gorno ‐Tempini,
Gil D. Rabinovici,
Miguel A. Santos‐Santos,
William Seeley,
Bruce L. Miller,
Yolande Pijnenburg,
M. Antoinette Keulen,
Colin Groot,
Bart N.M. Berckel,
Wiesje M. Flier,
Philip Scheltens,
Jonathan D. Tags: Research Article Source Type: research
Neuroimaging and clinical outcomes of oral anticoagulant associated ICH
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - September 26, 2018 Category: Neurology Authors: Georgios Tsivgoulis,
Duncan Wilson,
Aristeidis H. Katsanos,
Jo ão Sargento‐Freitas,
Cláudia Marques‐Matos,
Elsa Azevedo,
Tomohide Adachi,
Christian Brelie,
Yoshifusa Aizawa,
Hiroshi Abe,
Hirofumi Tomita,
Ken Okumura,
Joji Hagii,
David J Source Type: research
Prevalence of amyloid ‐β pathology in distinct variants of primary progressive aphasia
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - September 26, 2018 Category: Neurology Authors: David Bergeron,
Maria L. Gorno ‐Tempini,
Gil D. Rabinovici,
Miguel A. Santos‐Santos,
William Seeley,
Bruce L. Miller,
Yolande Pijnenburg,
M. Antoinette Keulen,
Colin Groot,
Bart N.M. Berckel,
Wiesje M. Flier,
Philip Scheltens,
Jonathan D. Source Type: research
Disease progression and outcome measures in spinobulbar muscle atrophy
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - September 26, 2018 Category: Neurology Authors: Julia R. Dahlqvist,
Freja Fornander,
Josefine Stricker Borch,
Sofie T. Oestergaard,
Nanna S. Poulsen,
John Vissing Source Type: research
Scalp Electroencephalographic Biomarkers in Epilepsy Patients with Focal Cortical Dysplasia
Annals of Neurology, EarlyView. (Source: Annals of Neurology)
Source: Annals of Neurology - September 26, 2018 Category: Neurology Authors: Nino Epitashvili,
Victoria Antonio ‐Arce,
Armin Brandt,
Andreas Schulze‐Bonhage Source Type: research
