Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Guangwei Du,
Mechelle M. Lewis,
Christopher Sica,
Lan Kong,
Xuemei Huang Tags: Research Article Source Type: research
Switching the manufacturer of antiepileptic drugs is associated with higher risk of seizures: A nationwide study of prescription data in Germany
ObjectiveDespite bioequivalence, the exchangeability of antiepileptic drugs in clinical settings is disputed. Therefore, we investigated the risk for recurrent seizures after switching the manufacturer of the same drug in a large German cohort.MethodsAnonymous patient data from practice neurologists throughout Germany between 2011 and 2016 were collected using the IMS Disease Analyzer database (QuintilesIMS, Frankfurt, Germany). People with epilepsy were included if at least 2 prescriptions within 360 days and 1 within 180 days prior to the index date were available. The cohort was separated into a seizure group and seizur...
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Johannes D. Lang,
Karel Kostev,
M üjgan Dogan Onugoren,
Stephanie Gollwitzer,
Wolfgang Graf,
Tamara Müller,
David G. Olmes,
Hajo M. Hamer Tags: Research Article Source Type: research
KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy ‐lysosome defect
ObjectiveSeveral small case series identifiedKCTD7 mutations in patients with a rare autosomal recessive disorder designated progressive myoclonic epilepsy (EPM3) and neuronal ceroid lipofuscinosis (CLN14). Despite the name KCTD (potassium channel tetramerization domain), KCTD protein family members lack predicted channel domains. We sought to translate insight gained from yeast studies to uncover disease mechanisms associated with deficiencies in KCTD7 of unknown function.MethodsNovelKCTD7 variants in new and published patients were assessed for disease causality using genetic analyses, cell ‐based functional assays of ...
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Kyle A. Metz,
Xinchen Teng,
Isabelle Coppens,
Heather M. Lamb,
Bart E. Wagner,
Jill A. Rosenfeld,
Xianghui Chen,
Yu Zhang,
Hee Jong Kim,
Michael E. Meadow,
Tim Sen Wang,
Edda D. Haberlandt,
Glenn W. Anderson,
Esther Leshinsky ‐Silver,
Weim Tags: Research Article Source Type: research
Human pegivirus ‐1 associated leukoencephalitis: Clinical and molecular features
We report on 2 adult female patients with fatal leukoencephalitis associated with human pegivirus ‐1 (HPgV‐1) brain infection. Neuroimaging showed inflammatory changes in cerebral white matter. Brain‐derived HPgV‐1 RNA sequences clustered phylogenetically with other pegiviruses despite an 87‐nucleotide deletion in the viral nonstructural (NS)2 gene. Neuropathology disclosed lymphocyte infiltration and gliosis predominantly in brain white matter. HPgV‐1 NS5A antigen was detected in lymphocytes as well as in astrocytes and oligodendrocytes. HPgV‐1 neuroadaptation should be considered in the differential diagnos...
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Erin F. Balcom,
Matthew A.L. Doan,
William G. Branton,
Juan Jovel,
Gregg Blevins,
Beste Edguer,
Tom C. Hobman,
Elaine Yacyshyn,
Derek Emery,
Adrian Box,
Frank K.H. van Landeghem,
Christopher Power Tags: Brief Communication Source Type: research
Brain ‐State Dependent Stimulation boosts functional recovery following stroke
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Natalie Mrachacz ‐Kersting,
Andrew J.T. Stevenson,
Helle R. M. Jørgensen,
Kåre Eg Severinsen,
Susan Aliakbaryhosseinabadi,
Ning Jiang,
Dario Farina Tags: Research Article Source Type: research
Tocilizumab treatment for new ‐onset refractory status epilepticus
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Jin ‐Sun Jun,
Soon‐Tae Lee,
Ryul Kim,
Kon Chu,
Sang Kun Lee Tags: Brief Communication Source Type: research
Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Guangwei Du,
Mechelle M. Lewis,
Christopher Sica,
Lan Kong,
Xuemei Huang Tags: Research Article Source Type: research
Switching the manufacturer of antiepileptic drugs is associated with higher risk of seizures: A nationwide study of prescription data in Germany
ObjectiveDespite bioequivalence, the exchangeability of antiepileptic drugs in clinical settings is disputed. Therefore, we investigated the risk for recurrent seizures after switching the manufacturer of the same drug in a large German cohort.MethodsAnonymous patient data from practice neurologists throughout Germany between 2011 and 2016 were collected using the IMS Disease Analyzer database (QuintilesIMS, Frankfurt, Germany). People with epilepsy were included if at least 2 prescriptions within 360 days and 1 within 180 days prior to the index date were available. The cohort was separated into a seizure group and seizur...
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Johannes D. Lang,
Karel Kostev,
M üjgan Dogan Onugoren,
Stephanie Gollwitzer,
Wolfgang Graf,
Tamara Müller,
David G. Olmes,
Hajo M. Hamer Tags: Research Article Source Type: research
Reduced brain amyloid burden in elderly patients with narcolepsy type 1
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: Audrey Gabelle,
Isabelle Jaussent,
Fay çal Ben Bouallègue,
Sylvain Lehmann,
Régis Lopez,
Lucie Barateau,
Caroline Grasselli,
Carole Pesenti,
Delphine Verbizier,
Séverine Béziat,
Denis Mariano‐Goulart,
Bertrand Carlander,
Yves Dauvillier Tags: Research Article Source Type: research
Gender Inequities in the MS Community: A Call for Action
Annals of Neurology, Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: Emmanuelle Waubant Tags: Letter to the Editor Source Type: research
Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
ObjectiveThe present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window.MethodsThis was a prospective, randomized, open ‐label, blinded endpoint clinical trial, enrolling patients with internal carotid artery or middle cerebral artery proximal occlusion within 4.5 to 6 hours from symptom onset. Patients were randomly assigned to receive alteplase alone or alteplase with fingolimod. All patients underwent pretreatme nt and 24‐hour noncontrast computed tomography (CT)/perfusion CT/CT angiography. The coprimary endpoint...
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: De ‐Cai Tian,
Kaibin Shi,
Zilong Zhu,
Jia Yao,
Xiaoxia Yang,
Lei Su,
Sheng Zhang,
Meixia Zhang,
Rayna J. Gonzales,
Qiang Liu,
DeRen Huang,
Michael F. Waters,
Kevin N. Sheth,
Andrew F. Ducruet,
Ying Fu,
Min Lou,
Fu‐Dong Shi Tags: Research Article Source Type: research
Gender Inequities in the MS Community: A Call for Action
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: Emmanuelle Waubant Source Type: research
Reduced brain amyloid burden in elderly patients with narcolepsy type 1
Annals of Neurology,Volume 0, Issue ja, -Not available-. (Source: Annals of Neurology)
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: Audrey Gabelle,
Isabelle Jaussent,
Fay çal Ben Bouallègue,
Sylvain Lehmann,
Régis Lopez,
Lucie Barateau,
Caroline Grasselli,
Carole Pesenti,
Delphine Verbizier,
Séverine Béziat,
Denis Mariano‐Goulart,
Bertrand Carlander,
Yves Dauvillier Source Type: research
The neural basis of induced phantom limb pain relief
This article is protected by copyright. All rights reserved (Source: Annals of Neurology)
Source: Annals of Neurology - November 1, 2018 Category: Neurology Authors: Sanne Kikkert,
Melvin Mezue,
Jacinta O'Shea,
David Henderson ‐Slater,
Heidi Johansen‐Berg,
Irene Tracey,
Tamar R. Makin Tags: Research Article Source Type: research
Genome ‐Wide Meta‐analysis identifies three novel loci associated with stroke
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
Source: Annals of Neurology - November 1, 2018 Category: Neurology Authors: Rainer Malik,
Kristiina Rannikm äe,
Matthew Traylor,
Marios K Georgakis,
Muralidharan Sargurupremraj,
Hugh S Markus,
Jemma C Hopewell,
Stephanie Debette,
Cathie LM Sudlow,
Martin Dichgans,
for the MEGASTROKE consortium and the International Str Tags: Brief Communication Source Type: research
