The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research

Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research

The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research

Medicare Negotiation's Drug Reformulation Problem
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M24-0138. Online ahead of print.NO ABSTRACTPMID:38684103 | DOI:10.7326/M24-0138 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Matthew Vogel Benjamin N Rome Aaron S Kesselheim William B Feldman Source Type: research

Annals Video Summary - Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials
Ann Intern Med. 2024 Apr 30:eM240739. doi: 10.7326/M24-0739. Online ahead of print.NO ABSTRACTPMID:38684098 | DOI:10.7326/M24-0739 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Source Type: research

Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
CONCLUSION: This emulated target trial showed that SGLT2i use was associated with a lower risk for dialysis, cardiovascular events, DKA, and AKI than no SGLT2i use in patients with T2D and stage 5 CKD.PRIMARY FUNDING SOURCE: National Health Research Institutes, Taiwan.PMID:38684099 | DOI:10.7326/M23-1874 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Fu-Shun Yen Chii-Min Hwu Jia-Sin Liu Yi-Ling Wu Keong Chong Chih-Cheng Hsu Source Type: research

The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research

Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research

The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research

Medicare Negotiation's Drug Reformulation Problem
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M24-0138. Online ahead of print.NO ABSTRACTPMID:38684103 | DOI:10.7326/M24-0138 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Matthew Vogel Benjamin N Rome Aaron S Kesselheim William B Feldman Source Type: research

Annals Video Summary - Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials
Ann Intern Med. 2024 Apr 30:eM240739. doi: 10.7326/M24-0739. Online ahead of print.NO ABSTRACTPMID:38684098 | DOI:10.7326/M24-0739 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Source Type: research

Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
CONCLUSION: This emulated target trial showed that SGLT2i use was associated with a lower risk for dialysis, cardiovascular events, DKA, and AKI than no SGLT2i use in patients with T2D and stage 5 CKD.PRIMARY FUNDING SOURCE: National Health Research Institutes, Taiwan.PMID:38684099 | DOI:10.7326/M23-1874 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Fu-Shun Yen Chii-Min Hwu Jia-Sin Liu Yi-Ling Wu Keong Chong Chih-Cheng Hsu Source Type: research

The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research

Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research

The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research