Annals of Clinical and Laboratory Science This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Shenmai Injection Alleviates Myocardial Ferroptosis via Activating the AKT1/mTOR Pathway in Rats with Acute Myocardial Infarction
CONCLUSION: This study revealed that SMI exerts a protective effect against myocardial injury and ferroptosis caused by AMI via the activation of the AKT1/mTOR pathway.PMID:38514060 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ming Lu Yeying Zhang Xuhui Ma Mingqiu Cen Shidong Lin Xiaolu Qian Jia Yu Xiaoying Huang Zhuxiu Jiang Source Type: research

Idiopathic Hypereosinophilic Syndrome in a Professional Athlete
CONCLUSION: Findings endorse the diagnosis of HES. HES is a rare condition that is difficult to diagnose. Early clinical diagnostic signs of HES may include fatigue, cough, breathlessness, and fever.PMID:38514061 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Sarah Shidid Pakinam Mekki Tamar A Smith-Norowitz Source Type: research

 Technical Note: Comparison of Alinity c Hemoglobin A1c Immunoassay with Premier Hb9210 Automated HPLC Assay: A Preliminary Report
CONCLUSIONS: We conclude that HbA1c assay on the Alinity c analyzer is a viable alternative to HPLC for measuring HbA1c in clinical laboratories but values at the decision points must be interpreted with caution and if necessary should be repeated by a reference HPLC method.PMID:38514062 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ashton Walton Jonathan Meador Kelsey Woodard Sean Tucker Susan McIntyre Amitava Dasgupta Source Type: research

Dexmedetomidine Alleviates Propofol Infusion Syndrome-Induced Myocardial Injury through Inhibiting Ferroptosis Associated with Accumulation of Reactive Oxygen Species
CONCLUSIONS: Dex could alleviate PRIS-induced myocardial injury by inhibiting ferroptosis associated with accumulation of ROS. Combined sedation using propofol and Dex might be a potential strategy for the prevention and treatment of PRIS-induced cardiotoxicity.PMID:38514063 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Jinhui Sun Bing Zhang Qiang Geng Jiayinati Halimujiang Chang Song Min Xi Ting Wang Source Type: research

Predictive and Carcinogenic Roles of Necroptosis-Related miR-425-5p and miR-16-5p in Esophageal Squamous Cell Carcinoma
CONCLUSION: The pro-carcinogenic role of miR-425-5p and miR-16-5p has been observed in esophageal squamous cell carcinoma.PMID:38514064 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Xue Zhidan Xi Kedi Xi Dan Song Xing Sun Rui Source Type: research

Upregulation of miR-499a Targets Beclin1 to Modulate Astrocyte Autophagy and Promote Ischemic Stroke
CONCLUSION: Serum miR-499a in stroke patients may serve as a potential diagnostic indicator. MiR-499a-mediated inhibition of Beclin 1, subsequently leading to suppression of astrocytic autophagy and viability, may represent a pivotal mechanism underlying its promotion of IS.PMID:38514065 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Guanxiu Xian Daihong Song Ying Wei Fugao Huang Hongcheng Luo Source Type: research

Combined Use of Helicobacter pylori Genotyping and CDX2 Expression as a Predictor of Malignant Potential in Gastric Intestinal Metaplasia
CONCLUSION: These GIM subtypes (cagA+ vacAs1m1 H. pylori-positive GIM with negative CDX2 expression) resemble GC and should be evaluated similar to cancerous GIM.PMID:38514066 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mengyuan Zhang Zhong Zhang Lanlan Jiao Li Liang Wei Bo Min Zhang Xiaobo Li Xingwei Fu Xuguang Wang Source Type: research

A Rare Autopsy Case of Aggressive Combined Hepatocellular-Cholangiocarcinoma in 59-Year-Old Female
Ann Clin Lab Sci. 2024 Jan;54(1):106-111.ABSTRACTCombined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation. At autopsy, the liver was diffusel...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ahmed A Ahmed Brandon Gehris Michelle McDonald Suhair Al Salihi L Maximilian Buja Source Type: research

HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma
CONCLUSION: HNRNPC regulated GLUT1/LDHA pathway by stabilizing FOXM1 mRNA to promote the progression and aerobic glycolysis of MM.PMID:38514068 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ningning Wu Yao Zhu Source Type: research

The Monocyte-to-Lymphocyte Ratio on the 6 th Day Postburn Is Associated with Clinical Outcome of Severe Burns
CONCLUSIONS: Our results revealed the dynamic characteristics of the MLR value in the early stage of severe burns, reflecting important changes in the immune/inflammatory related stress response soon after injury, low MLR level was associated with the worsening of disease condition.PMID:38514069 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Lizhu Zhi Yilan Xia Fang Jin Xiaojie He Xingang Wang Xuanliang Pan Source Type: research

Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research

Information About The Association of Clinical Scientists
Ann Clin Lab Sci. 2024 Jan;54(1):133.NO ABSTRACTPMID:38514051 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Source Type: research

 Communication: Evaluation of the Humasis COVID-19 Antigen Rapid Diagnostic Test for the Diagnosis of SARS-CoV-2 Infection
CONCLUSION: Our data suggests that the Humasis Ag-RDT can be a useful diagnostic tool for the detection of SARS-CoV-2 infection.PMID:38514052 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Eungjun Yoon Minhee Kang Hyang Jin Shim Suk-Jin Choi Mi-Ae Jang Ja-Hyun Jang Tae Yeul Kim Hee Jae Huh Nam Yong Lee Source Type: research

Letter to the Editor: Comparing the Novel Parameter 'Slope of the Steepest Part of Hemolysis Curve' to Standard Median Corpuscular Fragility for Evaluating Erythrocyte Stability during Prolonged Storage
CONCLUSION: Prolonged storage of whole blood samples leads to an increase in osmotic fragility and alters the shape of the hemolysis curve. These changes suggest that postponing the osmotic fragility test could lead to diagnostic inaccuracies. These findings suggest that slope value is a more accurate parameter for evaluating erythrocyte stability during storage, compared to commonly used Median corpuscular fragility value. Hence, it has potential importance and can be complementary to the laboratory result of the OFT. Therefore, it can be useful to provide these results jointly with the results of the OFT test.PMID:385140...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Marijana Markovi ć Boras Kristina Kvesi ć Stanislava Tali ć Dragana Pu šić Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research