The increasing need for a new Italian legislation to facilitate execution of observational studies assuring ethics and the highest standards of scientific and methodological quality. Editorial.
Authors: Petrini C, Fiori G, Gussoni G, Cazzaniga S, Corrao G, Lovato V, Manfellotto D, Mastromauro F, Mugelli A PMID: 32959789 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Migration and dementia in Europe: towards a culturally competent approach and provision of care. Editorial.
Authors: Canevelli M, Vanacore N PMID: 32959790 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Could we fight healthcare-associated infections and antimicrobial resistance with probiotic-based sanitation? Commentary.
Authors: Caselli E, Purificato I Abstract Healthcare-associated infections (HAI) affect every year about 4 million hospitalized patients in the EU, causing over 33 000 deaths as a direct consequence and over 1.1 billion € associated costs. Besides the persistent microbial contamination of the hospital environment, a major cause is the rampant antimicrobial resistance (AMR) of the HAI-associated pathogens. The hospital environment itself is in fact a reservoir of resistant pathogens, apparently not sufficiently controlled by conventional chemical-based sanitation. A recently published study, the SAN-ICA study, ...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Demographic and socio-economic determinants of poor HIV-risk perception at first HIV diagnosis: analysis of the HIV Surveillance data, Italy 2010-2016.
CONCLUSIONS: In Italy there is a high percentage of HIV-infected people with poor HIV-risk perception. Poorer HIV-risk perception was associated with both, least and high deprivation, low education, older age, male gender, heterosexual and IDU groups. Our results could be relevant to address targeted HIV testing policies at both local and national levels. PMID: 32959792 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Microbiological ascertainment in patients with pneumonia: the experience of a teaching hospital in Rome.
CONCLUSION: The proportion of microbiological ascertaiment in pneumonia remains less than 50%. Albeit in line with other evidence, this result should call the attention on the impact of unknown etiological diagnosis on antibiotic treatment and resistance. PMID: 32959793 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Pharmacology and legal status of cannabidiol.
Authors: Brunetti P, Lo Faro AF, Pirani F, Berretta P, Pacifici R, Pichini S, Busardò FP Abstract Cannabidiol (CBD) is the second most abundant cannabinoid present in Cannabis sativa L. It is not associated with psychotropic activity and is capable to mitigate the psychotomimetic effects produced by tetrahydrocannabinol (THC). The latest cannabis decriminalization policies and the high applicability in therapeutic and technologic-industrial fields, have determined an exponential marketing growth of foods, cosmetics and in particularly medicinal products containing CBD, which are easily available for consumer...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure.
We present a pooled cohort study on long-term mortality in exposed workers. METHODS: Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period. RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increase...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Suicidal behaviour and non-suicidal self-injury in children and adolescents seen at an Italian paediatric emergency department.
The objective of the study is to describe non-fatal self-harm - including suicidal behaviour (SB), suicidal ideation (SI) and non-suicidal self-injury (NSSI) - observed at an Italian paediatric emergency department (ED). METHODS: Retrospective analysis of the clinical records of patients admitted to ED from 2011 to 2016, who underwent child psychiatry consultation (CPc). We analyzed: rates of CPc for SB, SI and NSSI; risk factors for SB and SI in patients admitted to the hospital's Child Psychiatry Unit after a CPc; and, correlations between NSSI and SB/SI. RESULTS: The rate of CPc for SB, SI and NSSI switched from...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

A qualitative study of family carers views on how end-of-life communication contributes to palliative-oriented care in nursing home.
CONCLUSION: Clear and in-depth communication provides insight into residents' and family carers' preferences for care and treatment at the end-of-life, and increases understanding and shared decision-making. PMID: 32959797 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Tailored screening and dedicated funding for direct acting antiviral drugs: how to keep Italy on the road to hepatitis C virus elimination?
CONCLUSIONS: Establishing an ad hoc fund for DAAs for each Italian Region, binding resources both for case finding, through active screening and activities for rapid linkage to care and treatment, is of paramount importance, in order to keep Italy on track to achieve the WHO elimination targets by 2030. PMID: 32959798 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Lack of protection for measles among Italian nurses. A potential for hospital outbreak.
This study included 358 nurses. 77.7% (217) had a protective measles-specific IgG antibodies level. Protection rate was higher among workers aging 40 years (82.6% vs 68.7%; p
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Cancer stem cell targeted therapies.
Authors: Testa U, Pelosi E, Castelli G Abstract In normal dividing tissues, cell homeostasis is maintained by rare cellular elements, the stem cells, that have the unique property of self-renewal and differentiation to generate a population of functionally mature tissue elements. Recent studies carried out in the last three decades support the existence of stem cells also in tumors, the so-called cancer stem cells. Cancer stem cells have the property of initiating and maintaining tumor growth, are able to self-renew and to differentiate, are the main drivers of intra- and inter-tumoral heterogeneity and the main ce...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Male circumcision: ritual, science and responsibility.
CONCLUSION: In order to adequately safeguard public health, particularly that of minors, there is a pressing need for thorough discussion of whether the National Health Service should perform MC on minors free of charge or, at least, for a reduced fee. The implementation of targeted campaigns may raise awareness of the importance of proper safety measures in MC. PMID: 32959801 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Bacterial coinfections in COVID-19: an underestimated adversary.
Authors: Fattorini L, Creti R, Palma C, Pantosti A, Unit of Antibiotic Resistance and Special Pathogens, Unit of Antibiotic Resistance and Special Pathogens of the Department of Infectious Diseases, Istituto Superiore di Sanità, Rome Abstract Current literature shows that secondary bacterial infections, although less frequent than in previous influenza pandemics, affect COVID-19 patients. Mycoplasma pneumoniae, Staphylococcus aureus, Legionella pneumophila, Streptococcus pneumoniae, Haemophilus and Klebsiella spp. are the main species isolated. Of note, Mycobacterium tuberculosis-COVID-19 coinfections are al...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Schiavonia Hospital response to COVID-19 outbreak: a first single-center experience.
CONCLUSIONS: SH changed its organization three times in less than two months. From the point of view of the Medical Direction of the Hospital the challenges had been many but it allowed to consolidate an organizational model which could answer to health needs during the emergency situation. PMID: 32959803 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

COVID-19 mortality among migrants living in Italy.
Authors: Canevelli M, Palmieri L, Raparelli V, Punzo O, Donfrancesco C, Lo Noce C, Vanacore N, Brusaferro S, Onder G, Italian National Institute of Health COVID-19 Mortality Group Abstract We aimed to compare COVID-19-specific and all-cause mortality rates among natives and migrants in Italy and to investigate the clinical characteristics of individuals dying with COVID-19 by native/migrant status. The mortality rates and detailed clinical characteristics of natives and migrants dying with COVID-19 were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (...
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Coronavirus and birth in Italy: results of a national population-based cohort study.
CONCLUSIONS: Clinical features and outcomes of COVID-19 in women who gave birth are similar to those described for the general population, most women developing mild to moderate illness. PMID: 32959805 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Neurophysiological monitoring in neonatal abstinence syndrome from cocaine.
DISCUSSION: Video-EEG recording could be considered an important and objective tool that allows the evaluation of behavioural state and clinical and neurological signs in newborns in utero exposed to psychoactive drugs and the neurophysiological definition of signs and symptoms, which cannot be evaluated by FNAST such as startles and its variability during subsequent days after birth, subclinical seizures or brain injuries. PMID: 32959806 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 24, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

A focus on the rights to self-determination and quality of life in people with mental disabilities. Editorial.
Authors: Cirulli F, Venerosi A PMID: 32567561 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Levels of physical activity, nutrition and body composition in the workplace: reports from a distribution company.
CONCLUSIONS: Job duties can have an influence on the daily habits. Workplaces have great potential to change personal lifestyle choices and a preliminary assessment should be performed in order to propose a tailored intervention. PMID: 32567562 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Verba volant, scripta manent: breastfeeding information and health messages provided to parents in the neonatal discharge summary in the Lazio Region, Italy.
Authors: Colaceci S, Chapin EM, Zambri F, Reali L, Cedrone L, Del Brocco A, Masi M, Mohamed A, Dellafiore F, Nichinonni S, Giusti A Abstract OBJECTIVE: We aimed to evaluate the contents of the neonatal discharge summary (NDS), an important communication tool that should contain evidence-based information. METHODS: A quali-quantitative study of NDSs delivered from 29 hospitals of Lazio (Italy) in 2014 and 2017 was conducted. We used content analysis to assess the written information and logistic regression to estimate the association between outcomes (compliance with the International Code, health messages, and ...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Perception of climate change, loss of social capital and mental health in two groups of migrants from African countries.
CONCLUSIONS: The study suggests that actions to preserve the social capital of a community strongly exposed to climate change can mitigate the impact of change on mental health. PMID: 32567564 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Study on the health status of the population living in Marghera (Venice, Italy) through the use of a longitudinal surveillance system.
Authors: Gessoni F, Macciò S, Barbiellini Amidei C, Simonato L Abstract The aim of this study is to carry out an investigation to evaluate the industrial area of Porto Marghera (the only Site of National Interest - SNI - for clearance operations in the Veneto region) by means of data from the Venetian Epidemiological Surveillance System (SEIVE - Sistema Epidemiologico Integrato di Venezia). In particular, the aim is to assess the extent at which chronic exposure to industrial pollutants contributes to the genesis of non-communicable diseases such as tumors. We have employed healthcare administrative database...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Life planning for people with neurodevelopmental and intellectual disability: effective support, quality of life, and community engagement. Preface.
Authors: Brown I PMID: 32567566 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Life-long individual planning in children with developmental disability: the active role of parents in the Italian experience.
Authors: Ferraro M, Trimarco B, Morganti MC, Marino G, Pace P, Marino L Abstract Many young adults with neurodevelopmental disorders experience poor transition outcomes in key areas, including employment, health care, and independent living. Innovative welfare models highlight the importance of involving the local community, and in particular the parents, as important stakeholders capable to generate services and affect local economy. As indicated by the World Health Organization, the availability of person-centered responses, also providing a health budget, appears to be the basis for taking into account person's ...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Reframing QoL assessment in persons with neurodevelopmental disorders.
Authors: Bertelli M, Francescutti C, Brown I Abstract The paper reviews the international literature on quality of life (QoL) for persons with neurodevelopmental disorders (NDD) in order to define the theoretical frame for optimal assessment. The application of the QoL approach to assessment procedures should be based on three main aspects: shared QoL, personal QoL and family QoL. The first aspect refers to characteristics of individual life that are shared with other people. The second aspect proceeds from the fact that each individual has a changing set of personal attributes that determine the subjective experie...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

New mode of care. Value and limit of the person-centered care planning for people with mental disability.
Authors: Camoni L, Picardi A, Venerosi A Abstract The huge increase of people with mental and intellectual disability worldwide, and the advocacy capacity achieved by these patients, which culminated in the Convention on the Rights of Persons with Disabilities (CRPD), came along the shifts in the way governments deliver public services. In particular, in the last decades, many countries examined how to provide a person with disabilities an acceptable social functioning, improve wellbeing, according to the principles of equity, solidarity and participation. A new political and social-health model was born, called &q...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Social farming as an innovative approach to promote mental health, social inclusion and community engagement.
Authors: Borgi M, Collacchi B, Correale C, Marcolin M, Tomasin P, Grizzo A, Orlich R, Cirulli F Abstract Nature-based contextual factors are being recognized as fundamental for mental health prevention and promotion. Rural areas, indeed, are increasingly recognized as an elective place for the promotion of mental health. In recent years there has been a surge of rurally-based hybrid governance models in which public bodies, local communities and economic actors join forces to create innovative welfare solutions to facilitate the financial (and organizational) challenges faced by the National Health Systems. Using a...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Stress and wellbeing among professionals working with people with neurodevelopmental disorders. Review and intervention perspectives.
Authors: Leoni M, Alzani L, Carnevali D, Cavagnola R, Chiodelli G, Corti S, Fioriti F, Galli ML, Michelini G, Miselli G Abstract Supporting individuals with NDD is extremely demanding, with significant exposure to critical contexts and events, and painful ongoing experiences. Stress and burnout condition is a main concern with growing interest in research, despite the lack of consensus on theoretical explanatory models and modification standards.The paper provides an up-to-date review of risk factors and involved processes, and presents evidence-based procedures and protocols to implement effective preventive actio...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Individual planning starts at school. Tools and practices promoting autonomy and supporting transition to work for adolescents with autism spectrum disorder.
Authors: Laghi F, Trimarco B Abstract There is an increasing need for effective services and strategies to favor the transition from school to post-school/working experience for individuals with disabilities and specifically with autism spectrum disorder (ASD). Post-school options are still limited, and most adults with ASD struggle in finding adequate and stable job opportunities. This work analyzes the increasing number of laws issued in Italy in the last decades in order to improve social and working inclusion. The central role of the individual educational planning (IEP) as part of the broader individual projec...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Neurodevelopmental disorders and development of project of lifein a lifespan perspective: between habilitation and quality of life.
Authors: Cavagnola R, Alzani L, Carnevali D, Chiodelli G, Corti S, Fioriti F, Galli ML, Leoni M, Michelini G, Miselli G Abstract For some years, the term "project of life" has become widely used in the field of neurodevelopmental disorders, and, at the same time, it has begun to make its way in many social and health planning documents. However, beyond its relatively widespread use, this term does not yet possess an adequate and shared frame of the main underlying decision-making processes. In particular, there is a need to identify the crucial questions for orienting the choice of goals within the adoles...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Network of services facilitating and supporting job placement for people with autism spectrum disorders. The experience of the ASL Piacenza, Italy.
Authors: Cappa C, Figoli M, Rossi P Abstract The Mental Health Department of Piacenza has recently activated a special program for persons diagnosed with autism spectrum disorders (ASD). The Program engages a number of stakeholders: the users, their families, social and psychiatric services as well as specific associations for autism. The program is aimed to grant a complete and individualized assistance to people with ASD and it is especially focused on the transition to adulthood. In this period, it is necessary to build the "life project" in order to improve functioning and quality of life of users. Th...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

The Integrated and Disability Health Program of AUSL Bologna. The Alstom experience for employment access in high functioning autism spectrum disorders.
Authors: Di Sarro R, Varrucciu N, Di Santantonio A, Bonsi II Abstract The Integrated and Disability Health Program (IDHP) of Bologna deals with the assessment and treatment of both young and adults with high and low functioning autism spectrum disorder (ASD). The IDHP and Alstom Ferroviaria SPA started a highly innovative project for the employment of young adults diagnosed with high functioning ASD. The project consisted of a six months' internship, for a total amount of 560 hours, and a renewal for another 6 months and involved a group of 5 young adults with high-functioning ASD, aged between 18 and 42 years, com...
Source: Annali dell Istituto Superiore di Sanita - June 23, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Priority coding for scheduling pain medication consultations: a simple tool supporting both efficient allocation and sustainability of use of resources. Letter.
Authors: Bednarova R, Miceli L, Rizzardo A PMID: 32242528 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Why research in medicine needs a step back? Editorial.
Authors: Fais S PMID: 32242529 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Epidemiological research as a driver of prevention: the Sibat é study. Commentary.
Epidemiological research as a driver of prevention: the Sibaté study. Commentary. Ann Ist Super Sanita. 2020 Jan-Mar;56(1):6-9 Authors: Ramos-Bonilla JP, Marsili D, Comba P Abstract Although asbestos exposure and risks can be prevented, only five countries in Latin America have banned asbestos, including Colombia. Beginning in 2011, a collaboration between the Istituto Superiore di Sanità in Italy and Universidad de los Andes in Colombia was established, bringing together relevant expertise aiming to improve our understanding of the asbestos problem. An important result of this collaborat...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Additive manufacturing of reconstruction devices for maxillofacial surgery: design and accuracy assessment of a mandibular plate prototype.
Authors: Campioni I, Cacciotti I, Gupta N Abstract Additive manufacturing (AM) presents unique opportunities for medical applications and in particular in maxillofacial surgery for developing patient specific implants. The quality assessment of additive manufactured products is an essential aspect for the real introduction in health services. In this framework, the purpose of the present study is to investigate the possibility of developing prototypes of mandibular plates as preoperative surgical planning models, by verification of design, analysis of internal structure integrity and evaluation of the effects of va...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Prevalence and attitudes to HIV testing among adults visiting public outpatient clinics in Rome: results of the MeDi (Measuring health Disparities in HIV prevention) survey. Part 1.
CONCLUSIONS: This study highlights that, while the percentage of subjects tested is even higher than observed in other western nations, only 44% of subjects, self-reporting risks of contracting HIV, had tested at least once in life and about 40% of university educated subjects self reporting risks of contracting HIV had never tested. PMID: 32242532 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

HIV prevalence among adults in Rome: results of the MeDi (Measuring health Disparities in HIV prevention) survey. Part 2.
CONCLUSIONS: Our study confirms high HIV prevalences among homosexuals/lesbians. Some infections occur in subjects who do not report high risk behaviours for HIV transmission. PMID: 32242533 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Rehabilitation strategies for low anterior resection syndrome. A systematic review.
CONCLUSIONS: In clinical practice patients should evaluate with the LARS and other score for evaluation of urinary and sexual problems. Future research must be implemented with higher quality studies to identify the least invasive and most effective treatment/s. PMID: 32242534 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Syringomyelia and Chiari Syndrome Registry: advances in epidemiology, clinical phenotypes and natural history based on a North Western Italy cohort.
CONCLUSIONS: First Italian epidemiological data (prevalence, incidence) on Chiari and syringomyelia was collected, according to shared diagnostic Recommendations. Future perspectives include the adoption of these Recommendations at national level to standardize the access to diagnosis and care process and promote multicenter clinical trials. PMID: 32242535 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Long-term consequences in survivors of critical illness. Analysis of incidence and risk factors.
This study investigates the incidence of long-term consequences in survivors of critical illness 6 months after ICU care. A retrospective analysis of the risk factors was also completed. METHODS: A mixed-method design was used. A qualitative design was used in the questionnaire study (phase 1), and a quantitative design was used for the retrospective study (phase 2). RESULTS: 116 patients were interviewed. Forty-eight patients (41.4%) reported at least one long-term consequence 6 months after ICU discharge. The most frequent consequences were anxiety (n = 33, 28.4%), depression (n = 32, 27.6%) and chronic pain (n =...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Effectiveness of psycho-educational intervention to promote mental health focused on emotional intelligence in middle-school.
CONCLUSION: The results show a remarkable and positive impact of the approach above all on the "outcome-oriented" EI. Significant results were also observed about the indicator concerning irrational beliefs. The same significant results were found about learning abilities (goal definition, problem-solving and communication skills). The main limit is the study design (lack of randomization). Further evaluation is needed. PMID: 32242537 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Malaria in pediatric age in the Piedmont Region.
CONCLUSIONS: At present, lacking an effective vaccine, the prevention and implementation of standard precautions such as chemoprophylaxis, represent the safest strategy to put into practice to eradicate the disease especially for the groups at greater risk as visiting friends and relatives. PMID: 32242538 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Evolution of Italian laws banning trafficking, use and abuse of psychotropic drugs.
Authors: Di Luca NM, Busardò FP, Pirani F, Varì MR Abstract The penalty system implemented by Italian law still represents a barrier against psychoactive drugs and drug addiction, especially at a time when the age of first consumption has considerably dropped. Presidential Decree n. 309 of October 9, 1990 entitled "Consolidation of the laws governing drugs and psychotropic substances, the prevention, treatment and rehabilitation of drug addicts", and referred to as Presidential Decree 309/90, is the reference text for the cultivation, production, trade and use of narcotics and other psychoac...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Prevalence and correlates of food insecurity among children in high-income European countries. A systematic review.
CONCLUSIONS: Achieving food security means designing targeted policies and interventions, both at a national and EU level. Policymakers and governments should make the appropriate efforts to deliver food security as a public good. PMID: 32242540 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Effects of a practice-focused nutrition intervention in Hungarian adolescents.
CONCLUSIONS: Findings suggest a positive impact of this intervention. Measures to mitigate unhealthy changes during the summer break are needed. PMID: 32242541 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Social cognition deficit and genetic vulnerability to schizophrenia in 22q11 deletion syndrome.
Authors: Frascarelli M, Padovani G, Buzzanca A, Accinni T, Carlone L, Ghezzi F, Lattanzi GM, Fanella M, Putotto C, Di Bonaventura C, Girardi N, Pasquini M, Biondi M, Di F Abstract INTRODUCTION: 22q11.2 microdeletion syndrome (22q11DS) is associated with a 25% risk of psychotic onset. MATERIALS AND METHODS: The sample consist of 120 subjects: 39 schizophrenics (SCZ); 20 siblings of schizophrenic patients (SIB); 34 22q11DS non-psychotic patients (DEL); 17 22q11DS psychotic patients (DEL_scz); 30 control subjects (CS). Social cognition was evaluated with the awareness of social interference test. Intelligence Quot...
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Application of effect-based methods (EBMs) in a river basin: a preliminary study in Central Italy.
CONCLUSIONS: Further results will aim to support the local authorities in adopting measures to reduce and to eliminate the sources of chemical pollution in the study area. PMID: 32242543 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Identification of two novel LDLR variants by Next Generation Sequencing.
CONCLUSIONS: This study showed that an effective NGS-based pipeline led to a definitive diagnosis in two FH families, allowing to plan their therapeutic treatment. Although the functional consequence of the two LDLR variants needs to be assessed in vitro, the in silico analysis and high preservation of the two amino acid positions observed in the LDLR protein, across different animal species, suggest that both variants are deleterious. PMID: 32242544 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - April 4, 2020 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research