Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis
CONCLUSIONS: Chronic metformin use was associated with slightly and nonsignificantly less delirium. However, patients who used metformin had clinically meaningfully fewer major complications, mostly stage 2 to 3 kidney injury. While not statistically significant, the reduction was substantial and warrants further investigation because there is currently no effective preventive measure for perioperative renal injury. Benefit would be especially meaningful if it could be produced by acute perioperative treatment. Finally, metformin was associated with faster hospital discharge, although not by a clinically meaningful amount....
Source: Anesthesia and Analgesia - March 22, 2024 Category: Anesthesiology Authors: Stephania Paredes Ayoub Harb Julian R össler Maede Zookaei Nikoo Kurt Ruetzler Alparslan Turan Xuan Pu Daniel I Sessler Source Type: research
Care of the Pediatric Patient for Ambulatory Tonsillectomy With or Without Adenoidectomy: The Society for Ambulatory Anesthesia Position Statement
Anesth Analg. 2024 Mar 22. doi: 10.1213/ANE.0000000000006645. Online ahead of print.ABSTRACTThe landscape of ambulatory surgery is changing, and tonsillectomy with or without adenoidectomy is one of the most common pediatric surgical procedures performed nationally. The number of children undergoing tonsillectomy on an ambulatory basis continues to increase. The 2 most common indications for tonsillectomy are recurrent throat infections and obstructive sleep-disordered breathing. The most frequent early complications after tonsillectomy are hemorrhage and ventilatory compromise. In areas lacking a dedicated children's hosp...
Source: Anesthesia and Analgesia - March 22, 2024 Category: Anesthesiology Authors: Marjorie P Brennan Audra M Webber Chhaya V Patel Wanda A Chin Steven F Butz Niraja Rajan Source Type: research
Brain-Hazardous Medications and Potential Subadequate Antidepressant Dosing in Older Surgical Patients Receiving Home Antidepressants: An Observational Study of a Large US Health System
CONCLUSIONS: Older surgical patients receiving antidepressants are frequently prescribed brain-hazardous medications and potentially subadequate antidepressant doses. Those receiving subadequate antidepressant doses may be at risk for worse postoperative outcomes compared to patients receiving adequate doses. The role of preoperative medication optimization to improve outcomes for older surgical patients should be evaluated.PMID:38507476 | DOI:10.1213/ANE.0000000000006952 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Bethany R Tellor Pennington Katherine J Holzer Bradley A Fritz Simon Haroutounian Kevin Y Xu Amanda Tedder Alex Kronzer Michael S Avidan Eric J Lenze Source Type: research
Abstracts of International Research Society & amp; Society of Critical Care Anesthesiologists 2023 Annual Meetings: Erratum
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006784. Online ahead of print.NO ABSTRACTPMID:38507503 | DOI:10.1213/ANE.0000000000006784 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Source Type: research
James Watt, of Steam Engine Fame, Offered Inhaled Carbon Monoxide for Putative Therapeutic Action
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006955. Online ahead of print.ABSTRACTJames Watt (1736-1819) is remembered as a steam engine innovator and industrial magnate. A polymath, he was also a hands-on contributor to the Medical Pneumatic Institution of Thomas Beddoes. Watt recruited Humphry Davy, who there discovered analgesic action of inhaled nitrous oxide in 1799. Watt also built pneumatic equipment, and he introduced a gas mixture, dubbed hydro-carbonate, as a medical tonic. The bioactive component was carbon monoxide, a readily-lethal inhibitor of the transport and utilization of respiratory oxygen. Des...
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Olivia W Xu Jingping Wang Theodore A Alston Source Type: research
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
CONCLUSIONS: These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.PMID:38507523 | DOI:10.1213/ANE.0000000000006941 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Jia Yan Hoai Ton Jing Yan Yuanlin Dong Zhongcong Xie Hong Jiang Source Type: research
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
CONCLUSIONS: NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.PMID:38507554 | DOI:10.1213/ANE.0000000000006964 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Li Xu Yu Wang Yang Jiao Yulin Huang Rui Xu Xiaoping Gu Wei Zhang Zhengliang Ma Source Type: research
Evaluation of Thrombin and Plasmin Generation Velocity Ratios during Progressive Plasma Dilution
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006946. Online ahead of print.NO ABSTRACTPMID:38507557 | DOI:10.1213/ANE.0000000000006946 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Rui Terada Yuko Mishima BreAnna Le Amir L Butt Jerrold H Levy Kenichi A Tanaka Source Type: research
Brain-Hazardous Medications and Potential Subadequate Antidepressant Dosing in Older Surgical Patients Receiving Home Antidepressants: An Observational Study of a Large US Health System
CONCLUSIONS: Older surgical patients receiving antidepressants are frequently prescribed brain-hazardous medications and potentially subadequate antidepressant doses. Those receiving subadequate antidepressant doses may be at risk for worse postoperative outcomes compared to patients receiving adequate doses. The role of preoperative medication optimization to improve outcomes for older surgical patients should be evaluated.PMID:38507476 | DOI:10.1213/ANE.0000000000006952 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Bethany R Tellor Pennington Katherine J Holzer Bradley A Fritz Simon Haroutounian Kevin Y Xu Amanda Tedder Alex Kronzer Michael S Avidan Eric J Lenze Source Type: research
Abstracts of International Research Society & amp; Society of Critical Care Anesthesiologists 2023 Annual Meetings: Erratum
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006784. Online ahead of print.NO ABSTRACTPMID:38507503 | DOI:10.1213/ANE.0000000000006784 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Source Type: research
James Watt, of Steam Engine Fame, Offered Inhaled Carbon Monoxide for Putative Therapeutic Action
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006955. Online ahead of print.ABSTRACTJames Watt (1736-1819) is remembered as a steam engine innovator and industrial magnate. A polymath, he was also a hands-on contributor to the Medical Pneumatic Institution of Thomas Beddoes. Watt recruited Humphry Davy, who there discovered analgesic action of inhaled nitrous oxide in 1799. Watt also built pneumatic equipment, and he introduced a gas mixture, dubbed hydro-carbonate, as a medical tonic. The bioactive component was carbon monoxide, a readily-lethal inhibitor of the transport and utilization of respiratory oxygen. Des...
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Olivia W Xu Jingping Wang Theodore A Alston Source Type: research
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
CONCLUSIONS: These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.PMID:38507523 | DOI:10.1213/ANE.0000000000006941 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Jia Yan Hoai Ton Jing Yan Yuanlin Dong Zhongcong Xie Hong Jiang Source Type: research
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
CONCLUSIONS: NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.PMID:38507554 | DOI:10.1213/ANE.0000000000006964 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Li Xu Yu Wang Yang Jiao Yulin Huang Rui Xu Xiaoping Gu Wei Zhang Zhengliang Ma Source Type: research
Evaluation of Thrombin and Plasmin Generation Velocity Ratios during Progressive Plasma Dilution
Anesth Analg. 2024 Mar 18. doi: 10.1213/ANE.0000000000006946. Online ahead of print.NO ABSTRACTPMID:38507557 | DOI:10.1213/ANE.0000000000006946 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Rui Terada Yuko Mishima BreAnna Le Amir L Butt Jerrold H Levy Kenichi A Tanaka Source Type: research
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
CONCLUSIONS: Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.PMID:38493440 | DOI:10.1213/ANE.0000000000006911 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 17, 2024 Category: Anesthesiology Authors: Jiayi Gong Peter Jones Chris Frampton Kebede Beyene Amy Hai Yan Chan Source Type: research
