Analytical and Bioanalytical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Screening anabolic androgenic steroids in human urine: an application of the state-of-the-art gas chromatography-Orbitrap high-resolution mass spectrometry
This study provides a rationale for GC-Orbitrap-HRMS in drug metabolism and non-targeted screening.PMID:38573345 | DOI:10.1007/s00216-024-05272-2 (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - April 4, 2024 Category: Chemistry Authors: Ziyi Ji Lei Liao Yuqi Ge Mengpan Liu Xian Fang Haoyi Sun Siying Zheng Xiaojun Deng Source Type: research

Development of a corn flour certified reference material for the accurate determination of zearalenone
Anal Bioanal Chem. 2024 Apr 3. doi: 10.1007/s00216-024-05265-1. Online ahead of print.ABSTRACTA certified reference material (CRM, KRISS 108-01-002) for zearalenone in corn flour was developed to assure reliable and accurate measurements in testing laboratories. Commercially available corn flour underwent freeze-drying, pulverization, sieving, and homogenization. The final product was packed in amber bottles, approximately 14 g per unit, and preserved at -70 °C. 13C18-Zearalenone was used as an internal standard (IS) for the certification of zearalenone by isotope-dilution liquid chromatography-tandem mass spectrometry (I...
Source: Analytical and Bioanalytical Chemistry - April 3, 2024 Category: Chemistry Authors: Yared Getachew Lijalem Mohamed A Gab-Allah Hyeonwoo Yu Kihwan Choi Byungjoo Kim Source Type: research

Development and validation of a GC-MS/MS method for the determination of iodoacetic acid in biological samples
This study provides the first data on the in vivo distribution in and excretion of IAA by mammals following oral exposure.PMID:38568233 | DOI:10.1007/s00216-024-05266-0 (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - April 3, 2024 Category: Chemistry Authors: Hanning Yu Linying Wu Dongliang Xuan Qian Peng Weidong Qu Ying Zhou Source Type: research

Multiresidue analysis of bat guano using GC-MS/MS
Anal Bioanal Chem. 2024 Apr 2. doi: 10.1007/s00216-024-05263-3. Online ahead of print.ABSTRACTBats are the second largest mammalian order and are an endangered species group with a strong need for contamination monitoring. To facilitate non-invasive monitoring of the ecological burden in bat populations, a multiresidue method for the simultaneous quantification of 119 analytes including pesticides, persistent organic pollutants (POPs), active pharmaceutical ingredients (APIs), polycyclic aromatic hydrocarbons (PAHs), UV blockers, plasticizers, and other emerging pollutants in bat guano with gas chromatography tandem mass s...
Source: Analytical and Bioanalytical Chemistry - April 2, 2024 Category: Chemistry Authors: Michelle Peter Nikita Bakanov Xenia Mathgen Carsten A Br ühl Michael Veith Christoph M üller Source Type: research

Fast, sensitive LC-MS resolution of < mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" > < mml:mi > α < /mml:mi > < /mml:math > -hydroxy acid biomarkers via SPP-teicoplanin and an alternative UV detection approach
Anal Bioanal Chem. 2024 Apr 3. doi: 10.1007/s00216-024-05248-2. Online ahead of print.ABSTRACTEnantioseparation of α -hydroxy acids is essential since specific enantiomers of these compounds can be used as disease biomarkers for diagnosis and prognosis of cancer, brain diseases, kidney diseases, diabetes, etc., as well as in the food industry to ensure quality. HPLC methods were developed for the enantioselective separation of 11 α -hydroxy acids using a superficially porous particle-based teicoplanin (TeicoShell) chiral stationary phase. The retention behaviors observed for the hydroxy acids were HILIC, reversed phase, ...
Source: Analytical and Bioanalytical Chemistry - April 2, 2024 Category: Chemistry Authors: Saba Aslani Daniel W Armstrong Source Type: research

Sampling of microplastics at a materials recovery facility
Anal Bioanal Chem. 2024 Apr 1. doi: 10.1007/s00216-024-05231-x. Online ahead of print.ABSTRACTDetecting, separating, and characterizing airborne microplastics from other airborne particulates is currently challenging due to the various instrumental constraints and related sample preparation hurdles that must be overcome. The ability to measure these real-world environments is needed to better assess the risks associated with microplastics. To that end, the current study focused on developing a methodology for sampling and characterizing airborne microplastics. Particulate sampling was carried out at a municipal materials r...
Source: Analytical and Bioanalytical Chemistry - April 1, 2024 Category: Chemistry Authors: Abigail P Lindstrom Joseph M Conny Diana L Ortiz-Montalvo Source Type: research

Development of an analytical method for the determination of more than 300 pesticides and metabolites in the particulate and gaseous phase of ambient air
Anal Bioanal Chem. 2024 Apr 1. doi: 10.1007/s00216-024-05254-4. Online ahead of print.ABSTRACTPesticides can enter the atmosphere during spraying or after application, resulting in environmental or human exposure. The study describes the optimisation and validation of analytical methods for the determination of more than 300 pesticides in the particulate and gaseous phases of the air. Pesticides were sampled with high-volume air samplers on glass-fibre filters (GFFs) and glass columns filled with polyurethane foam (PUF) and XAD-2 resin. Comparing different extraction methods, a QuEChERS extraction with acetonitrile was sel...
Source: Analytical and Bioanalytical Chemistry - April 1, 2024 Category: Chemistry Authors: Freya Debler Juergen Gandrass Source Type: research

Three-way junction structure-mediated reverse transcription-free exponential amplification reaction for pathogen RNA detection
Anal Bioanal Chem. 2024 Apr 1. doi: 10.1007/s00216-024-05264-2. Online ahead of print.ABSTRACTSince RNA is an important biomarker of many infectious pathogens, RNA detection of pathogenic organisms is crucial for disease diagnosis and environmental and food safety. By simulating the base mismatch during DNA replication, this study presents a novel three-way junction structure-mediated reverse transcription-free exponential amplification reaction (3WJ-RTF-EXPAR) for the rapid and sensitive detection of pathogen RNA. The target RNA served as a switch to initiate the reaction by forming a three-way junction (3WJ) structure wi...
Source: Analytical and Bioanalytical Chemistry - April 1, 2024 Category: Chemistry Authors: Xinguang Zhang Yang Li Qing Wang Chao Jiang Yuting Shan Yao Liu Cuiping Ma Qunqun Guo Chao Shi Source Type: research

Development of an isotope dilution mass spectrometry assay for the quantification of insulin based on signature peptide analysis
In this study, a signature peptide (GFFYTPK) obtained from tryptic digestion of insulin was selected as a surrogate for insulin. Then, the optimal conditions for signature peptide analysis through mass spectrometry detection and enzymatic digestion were determined. The analytical performance of this method was assessed and validated using porcine insulin-certified reference material. The linear range of the insulin calibration curve ranged from 0.05 ~ 2 mass ratios, with recoveries ranging from 96.15 to approximately 101.15%. The limit of detection was 0.19 ng/mL, and the limit of quantification was 0.63 ng/mL. The quantit...
Source: Analytical and Bioanalytical Chemistry - March 31, 2024 Category: Chemistry Authors: Shangying Ma Rimei He Tingting Jiang Zhishang Hu Zihong Ye Wei Mi Source Type: research

Handling of problematic ion chromatograms with the Automated Target Screening (ATS) workflow for unsupervised analysis of high-resolution mass spectrometry data
Anal Bioanal Chem. 2024 Apr 1. doi: 10.1007/s00216-024-05245-5. Online ahead of print.ABSTRACTLiquid chromatography (LC) or gas chromatography (GC) coupled to high-resolution mass spectrometry (HRMS) is a versatile analytical method for the analysis of thousands of chemical pollutants that can be found in environmental and biological samples. While the tools for handling such complex datasets have improved, there are still no fully automated workflows for targeted screening analysis. Here we present an R-based workflow that is able to cope with challenging data like noisy ion chromatograms, retention time shifts, and multi...
Source: Analytical and Bioanalytical Chemistry - March 31, 2024 Category: Chemistry Authors: Georg Braun Martin Krauss Stephanie Spahr Beate I Escher Source Type: research