Analytical and Bioanalytical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PFAS ghosts: how to identify, evaluate, and exorcise new and existing analytical interference
Anal Bioanal Chem. 2024 Jan 27. doi: 10.1007/s00216-024-05125-y. Online ahead of print.ABSTRACTWith increasing public awareness of PFAS, and their presence in biological and environmental media across the globe, comes a matching increase in the number of PFAS monitoring studies. As more matrices and sample cohorts are examined, there are more opportunities for matrix interferents to appear as PFAS where there are none (i.e., "seeing ghosts"), impacting subsequent reports. Addressing these ghosts is vital for the research community, as proper analytical measurements are necessary for decision-makers to understand the presen...
Source: Analytical and Bioanalytical Chemistry - January 27, 2024 Category: Chemistry Authors: Jacqueline Bangma Kitrina M Barry Christine M Fisher Susan Genualdi Theresa C Guillette Carin A Huset James McCord Brian Ng Benjamin J Place Jessica L Reiner Anna Robuck Alix E Rodowa Source Type: research

Improved sensitivity and automation of a multi-step upconversion lateral flow immunoassay using a 3D-printed actuation mechanism
Anal Bioanal Chem. 2024 Mar;416(6):1517-1525. doi: 10.1007/s00216-024-05156-5. Epub 2024 Jan 27.ABSTRACTThe development of sensitive point-of-care (POC) assay platforms is of interest for reducing the cost and time of diagnostics. Lateral flow assays (LFAs) are the gold standard for POC systems, but their sensitivity as such is inadequate, for example, in the case of cardiac diagnostics. The performance can be improved by incorporating different steps, such as pre-incubation to prolong the interaction time between sample and reporter for immunocomplex formation, and washing steps for background reduction. However, for POC ...
Source: Analytical and Bioanalytical Chemistry - January 27, 2024 Category: Chemistry Authors: Kirsti Raiko Oskari N ääjärvi Miikka Ekman Sonja Koskela Tero Soukka Iida Martiskainen Teppo Salminen Source Type: research

Gold nanomaterials: important vectors in biosensing of breast cancer biomarkers
Anal Bioanal Chem. 2024 Jan 26. doi: 10.1007/s00216-024-05151-w. Online ahead of print.ABSTRACTBreast cancer (BC) is one of the most common malignant tumors in women worldwide, and its incidence is increasing every year. Early diagnosis and treatment are critical to improve the curability and prognosis of patients. However, existing detection methods often suffer from insufficient sensitivity and specificity, which limits their clinical application. Fortunately, the rapid development of nanotechnology offers new possibilities for diagnosing BC. For example, the unique physicochemical properties of gold nanomaterials (Au NM...
Source: Analytical and Bioanalytical Chemistry - January 26, 2024 Category: Chemistry Authors: Liu Liu Hongjie Xiong Xuemei Wang Hui Jiang Source Type: research

The sensor applications for prostate and lung cancer biomarkers in terms of electrochemical analysis
Anal Bioanal Chem. 2024 Jan 27. doi: 10.1007/s00216-024-05134-x. Online ahead of print.ABSTRACTProstate and lung cancers are the most common types of cancer and affect a large part of the population around the world, causing deaths. Therefore, the rapid identification of cancer can profoundly impact reducing cancer-related death rates and protecting human lives. Significant resources have been dedicated to investigating new methods for early disease detection. Cancer biomarkers encompass various biochemical entities, including nucleic acids, proteins, sugars, small metabolites, cytogenetic and cytokinetic parameters, and w...
Source: Analytical and Bioanalytical Chemistry - January 26, 2024 Category: Chemistry Authors: Nadia Bounoua Ahmet Cetinkaya Ensar Piskin S Irem Kaya Sibel A Ozkan Source Type: research

Comprehensive metabolome characterization and comparison between two sources of Dragon's blood by integrating liquid chromatography/mass spectrometry and chemometrics
Anal Bioanal Chem. 2024 Jan 27. doi: 10.1007/s00216-024-05159-2. Online ahead of print.ABSTRACTDragon's Blood (DB) serves as a precious Chinese medicine facilitating blood circulation and stasis dispersion. Daemonorops draco (D. draco; Qi-Lin-Jie) and Dracaena cochinchinensis (D. cochinchinenesis; Long-Xue-Jie) are two reputable plant sources for preparing DB. This work was designed to comprehensively characterize and compare the metabolome differences between D. draco and D. cochinchinenesis, by integrating liquid chromatography/mass spectrometry and untargeted metabolomics analysis. Offline two-dimensional liquid chromat...
Source: Analytical and Bioanalytical Chemistry - January 26, 2024 Category: Chemistry Authors: Jia Lou Xiao-Yan Xu Bei Xu Hong-da Wang Xue Li He Sun Xin-Yuan Zheng Jun Zhou Ya-Dan Zou Hong-Hua Wu Yue-Fei Wang Wen-Zhi Yang Source Type: research

Development of new matrix reference materials for quantitative urine analysis in drug tests
Anal Bioanal Chem. 2024 Mar;416(6):1427-1441. doi: 10.1007/s00216-024-05142-x. Epub 2024 Jan 25.ABSTRACTAccurate quantitative analyses require standardized methods to control and improve the analytical process in the laboratory. The availability of urine reference materials (RMs) may offer a feasible option to improve the accuracy of urine analysis and to control matrix effects. This paper presents the complete process of the development of matrix RMs in urine, including sample preparation, homogeneity, and stability studies, as well as uncertainty assessment. A freeze-drying process was developed, and freeze-dried human a...
Source: Analytical and Bioanalytical Chemistry - January 25, 2024 Category: Chemistry Authors: Min Lv Yujie Zhi Liying Zhou Zheng Qiao Bin Di Wei Liu Hang Chen Source Type: research

A multi-functional fluorescent probe for visualization of H 2 S and viscosity/polarity and its application in cancer imaging
Anal Bioanal Chem. 2024 Mar;416(6):1375-1387. doi: 10.1007/s00216-024-05130-1. Epub 2024 Jan 25.ABSTRACTAs an important endogenous gasotransmitter, hydrogen sulfide (H2S) plays a critical role in various physiological functions and has been regarded as a biomarker of cancer due to its overexpression in cancer cells. In addition, the early stages of cancer are often accompanied by abnormalities in the intracellular microenvironments, and distinguishing between cancer cell/tissues and normal cell/tissues is of great significance to the accuracy of cancer diagnosis. However, deep insights into the simultaneous detection of H2...
Source: Analytical and Bioanalytical Chemistry - January 25, 2024 Category: Chemistry Authors: Ling Ma Qi Zan Baozhu Zhang Wenjia Zhang Chunmiao Jia Li Fan Source Type: research

Exploring the application limits of different hold-up time markers in supercritical fluid chromatography
Anal Bioanal Chem. 2024 Mar;416(6):1485-1492. doi: 10.1007/s00216-024-05152-9. Epub 2024 Jan 25.ABSTRACTThe study focuses on the application range of nitrous oxide as a hold-up time marker in supercritical fluid chromatography (SFC). This compound has been suggested a decade ago to be used as unretained marker, something that the field of SFC was missing for a long time, since its beneficial properties make it an ideal candidate as hold-up time marker. Determination of the hold-up volume and actual volumetric flow rates have always been problematic in SFC due to the compressibility of carbon dioxide and one part of this is...
Source: Analytical and Bioanalytical Chemistry - January 25, 2024 Category: Chemistry Authors: Csan ád Rédei Alessandro Buratti Martina Catani Attila Felinger Source Type: research

Determination of L-selectin in blood plasma using DNA aptamer-based surface-enhanced Raman spectroscopy assay
In this study, we present a selective DNA-based surface-enhanced Raman spectroscopy (SERS) assay for the detection and determination of L-selectin in biological samples. Two calibration curves (linear in the 40-190 ng mL-1 region and exponential in the 40-500 ng mL-1 region) are fitted to the obtained SERS experimental data, i.e., the ratio of I732/I1334 band intensities (LOQ = 46 ng mL-1). Calculated determination coefficients are found to be R2 = 0.997 for the linear region of the calibration curve and R2 = 0.977 for the exponential region. Moreover, we demonstrate very good selectivity of the assay even in the presence ...
Source: Analytical and Bioanalytical Chemistry - January 9, 2024 Category: Chemistry Authors: Aneta Aniela Kowalska Ariadna B Nowicka Tomasz Szymborski Piotr Cywi ński Agnieszka Kami ńska Source Type: research

Optimization of a pre-concentration method for the analysis of mercury isotopes in low-concentration foliar samples
Anal Bioanal Chem. 2024 Jan 9. doi: 10.1007/s00216-023-05116-5. Online ahead of print.ABSTRACTHg isotope analysis in samples from background regions is constrained by the presence of low Hg concentration and therefore requires a pre-concentration method. Existing Hg pre-concentration methods are constrained by long sample processing time and limited sample loading capacity. Using foliar samples as a test case, an optimized Hg pre-concentration method is presented that involves the microwave-assisted digestion of samples for Hg isotope analysis with the addition of a pre-digestion step. Microwave-digested foliar samples and...
Source: Analytical and Bioanalytical Chemistry - January 9, 2024 Category: Chemistry Authors: Saeed Waqar Ali Dominik Bo žič Sreekanth Vijayakumaran Nair Igor Živković Jan Ga čnik Teodor-Daniel Andron Marta Jagodic Hudobivnik David Kocman Milena Horvat Source Type: research

Advances in microfluidic technology for sperm screening and in vitro fertilization
Anal Bioanal Chem. 2024 Jan 8. doi: 10.1007/s00216-023-05120-9. Online ahead of print.ABSTRACTAbout 18% of reproductive-age adults worldwide are affected by infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are widely used assisted reproductive technologies (ARTs) aimed at improving clinical outcomes. Efficient and noninvasive selection and isolation of highly motile sperm with intact DNA are essential for the success of IVF and ICSI and can potentially impact the therapeutic efficacy and the health of the offspring. Compared to traditional methods, microfluidic technology offers signifi...
Source: Analytical and Bioanalytical Chemistry - January 8, 2024 Category: Chemistry Authors: Jingtong Ma Qianlin Xie Yusongjia Zhang Qirui Xiao Xiaoyu Liu Chong Qiao Ye Tian Source Type: research

Fluorescent aptasensor mediated with multiple ssDNA for sensitive detection of acetamiprid in vegetables based on magnetic Fe 3 O 4 /C-assisted separation
In this study, magnetic Fe3O4/carbon (Fe3O4/C), a derivative of metal-organic framework MIL-101 (Fe), was synthesized by a two-step calcination method. And a fluorescent sensing strategy was developed for the efficient and sensitive detection of ACE using Fe3O4/C and multiple complementary single-stranded DNA (ssDNA). By using aptamer with multiple complementary ssDNA, the immunity of interference of the aptasensor was improved, and the aptasensor showed high selectivity and sensitivity. When ACE was present, the aptamer (Apt) combined with ACE. The complementary strand of Apt (Cs1) combined with two short complementary st...
Source: Analytical and Bioanalytical Chemistry - January 8, 2024 Category: Chemistry Authors: Baoxin Li Haifang Wang Mengyue Liu Lingjun Geng Shouyi Dou Shengxi Zhai Jingjing Liu Jiashuai Sun Wenping Zhao Yemin Guo Xia Sun Source Type: research

Volatile-compound fingerprinting and discrimination of positional isomers in stamp-pad ink tracing using HS-GC-IMS combined with multivariate statistical analysis
In this study, a comprehensive analysis of the volatile compounds in quick-drying stamp-pad inks from six commonly used brands were performed for the first time, utilizing a combination of headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) and multivariate statistical analysis methods. Visual and comparative analysis of the differential volatile components among different stamp-pad ink samples was conducted using fingerprints and volcano plots. A total of 127 volatile compounds were accurately identified, with ketones, esters, alcohols, and aldehydes being the most abundant compounds in the stamp-pad inks. ...
Source: Analytical and Bioanalytical Chemistry - January 8, 2024 Category: Chemistry Authors: Yinghua Qi Xinhua Lv Junchao Ma Mingyuan Lei Chao Feng Wenhui Lu Zhongyuan Ji Yichen Wang Yuchen Wang Xuebo Li Source Type: research

Lipophilic arsenic compounds in the cultured green alga Chlamydomonas reinhardtii
In this study, arsenic (As) speciation was investigated in the freshwater alga Chlamydomonas reinhardtii treated with 20 μg/L arsenate using fractionation as well as ICP-MS/ESI-MS analyses and was compared with the known As metabolite profile of wild-grown Saccharina latissima. While the total As accumulation in C. reinhardtii was about 85% lower than in S. latissima, the relative percentage of arsenolipids was significantly higher in C. reinhardtii (57.0% vs. 5.01%). As-containing hydrocarbons and phospholipids dominated the hydrophobic As profile in S. latissima, but no As-containing hydrocarbons were detectable in C. r...
Source: Analytical and Bioanalytical Chemistry - January 8, 2024 Category: Chemistry Authors: Andrea Raab Jinyu Zhang Ying Ge Fernando Fern ández-Mendoza J örg Feldmann Source Type: research