Novel transcriptional regulator oxtR1 regulates potential ferrodoxin in response to oxygen stress in Treponema denticola
CONCLUSION: The oxygen-sensing regulator OxtR1 plays a role in regulating the expression of a potential ferrodoxin, which may contribute to the response of T. denticola to oxygen-induced stress.PMID:38614291 | DOI:10.1016/j.anaerobe.2024.102852 (Source: Anaerobe)
Source: Anaerobe - April 13, 2024 Category: Microbiology Authors: Yumi Numata Yuichiro Kikuchi Toru Sato Kazuko Okamoto-Shibayama Yutaro Ando Yuri Miyai-Murai Eitoyo Kokubu Kazuyuki Ishihara Source Type: research
Mechanisms of Intestinal Epithelial Cell Damage by Clostridium perfringens
Anaerobe. 2024 Apr 10:102856. doi: 10.1016/j.anaerobe.2024.102856. Online ahead of print.ABSTRACTClostridium perfringens, a Gram-positive bacterium, causes intestinal diseases in humans and livestock through its toxins, related to alpha toxin (CPA), beta toxin (CPB), C. perfringens enterotoxin (CPE), epsilon toxin (ETX), Iota toxin (ITX), and necrotic enteritis B-like toxin (NetB). These toxins disrupt intestinal barrier, leading to various cell death mechanisms such as necrosis, apoptosis, and necroptosis. Additionally, non-toxin factors like adhesins and degradative enzymes contribute to virulence by enhancing colonizati...
Source: Anaerobe - April 12, 2024 Category: Microbiology Authors: O U Lan-Xin Y E Bijin Sun Mingfei Qi Nanshan Li Juan Lv Minna Lin Xuhui Cai Haiming Hu Junjing Song Yongle Chen Xiangjie Zhu Yibin Yin Lijun Zhang Jianfei Liao Shenquan Zhang Haoji Source Type: research
RNA-based regulation in bacteria-phage interactions
Anaerobe. 2024 Apr 6;87:102851. doi: 10.1016/j.anaerobe.2024.102851. Online ahead of print.ABSTRACTInteractions of bacteria with their viruses named bacteriophages or phages shape the bacterial genome evolution and contribute to the diversity of phages. RNAs have emerged as key components of several anti-phage defense systems in bacteria including CRISPR-Cas, toxin-antitoxin and abortive infection. Frequent association with mobile genetic elements and interplay between different anti-phage defense systems are largely discussed. Newly discovered defense systems such as retrons and CBASS include RNA components. RNAs also per...
Source: Anaerobe - April 7, 2024 Category: Microbiology Authors: Marion Saunier Louis-Charles Fortier Olga Soutourina Source Type: research
RNA-based regulation in bacteria-phage interactions
Anaerobe. 2024 Apr 6;87:102851. doi: 10.1016/j.anaerobe.2024.102851. Online ahead of print.ABSTRACTInteractions of bacteria with their viruses named bacteriophages or phages shape the bacterial genome evolution and contribute to the diversity of phages. RNAs have emerged as key components of several anti-phage defense systems in bacteria including CRISPR-Cas, toxin-antitoxin and abortive infection. Frequent association with mobile genetic elements and interplay between different anti-phage defense systems are largely discussed. Newly discovered defense systems such as retrons and CBASS include RNA components. RNAs also per...
Source: Anaerobe - April 7, 2024 Category: Microbiology Authors: Marion Saunier Louis-Charles Fortier Olga Soutourina Source Type: research
RNA-based regulation in bacteria-phage interactions
Anaerobe. 2024 Apr 5:102851. doi: 10.1016/j.anaerobe.2024.102851. Online ahead of print.ABSTRACTInteractions of bacteria with their viruses named bacteriophages or phages shape the bacterial genome evolution and contribute to the diversity of phages. RNAs have emerged as key components of several anti-phage defense systems in bacteria including CRISPR-Cas, toxin-antitoxin and abortive infection. Frequent association with mobile genetic elements and interplay between different anti-phage defense systems are largely discussed. Newly discovered defense systems such as retrons and CBASS include RNA components. RNAs also perfor...
Source: Anaerobe - April 7, 2024 Category: Microbiology Authors: Marion Saunier Louis-Charles Fortier Olga Soutourina Source Type: research
RNA-based regulation in bacteria-phage interactions
Anaerobe. 2024 Apr 5:102851. doi: 10.1016/j.anaerobe.2024.102851. Online ahead of print.ABSTRACTInteractions of bacteria with their viruses named bacteriophages or phages shape the bacterial genome evolution and contribute to the diversity of phages. RNAs have emerged as key components of several anti-phage defense systems in bacteria including CRISPR-Cas, toxin-antitoxin and abortive infection. Frequent association with mobile genetic elements and interplay between different anti-phage defense systems are largely discussed. Newly discovered defense systems such as retrons and CBASS include RNA components. RNAs also perfor...
Source: Anaerobe - April 7, 2024 Category: Microbiology Authors: Marion Saunier Louis-Charles Fortier Olga Soutourina Source Type: research
RNA-based regulation in bacteria-phage interactions
Anaerobe. 2024 Apr 5:102851. doi: 10.1016/j.anaerobe.2024.102851. Online ahead of print.ABSTRACTInteractions of bacteria with their viruses named bacteriophages or phages shape the bacterial genome evolution and contribute to the diversity of phages. RNAs have emerged as key components of several anti-phage defense systems in bacteria including CRISPR-Cas, toxin-antitoxin and abortive infection. Frequent association with mobile genetic elements and interplay between different anti-phage defense systems are largely discussed. Newly discovered defense systems such as retrons and CBASS include RNA components. RNAs also perfor...
Source: Anaerobe - April 7, 2024 Category: Microbiology Authors: Marion Saunier Louis-Charles Fortier Olga Soutourina Source Type: research
The small acid-soluble proteins of spore-forming organisms: Similarities and differences in function
Anaerobe. 2024 Apr 4:102844. doi: 10.1016/j.anaerobe.2024.102844. Online ahead of print.ABSTRACTThe small acid-soluble proteins are found in all endospore-forming organisms and are a major component of spores. Through their DNA binding capabilities, the SASPs shield the DNA from outside insults (e.g., UV and genotoxic chemicals). The absence of the major SASPs results in spores with reduced viability when exposed to UV light and, in at least one case, the inability to complete sporulation. While the SASPs have been characterized for decades, some evidence suggests that using newer technologies to revisit the roles of the S...
Source: Anaerobe - April 6, 2024 Category: Microbiology Authors: Hailee N Nerber Joseph A Sorg Source Type: research
The small acid-soluble proteins of spore-forming organisms: Similarities and differences in function
Anaerobe. 2024 Apr 4:102844. doi: 10.1016/j.anaerobe.2024.102844. Online ahead of print.ABSTRACTThe small acid-soluble proteins are found in all endospore-forming organisms and are a major component of spores. Through their DNA binding capabilities, the SASPs shield the DNA from outside insults (e.g., UV and genotoxic chemicals). The absence of the major SASPs results in spores with reduced viability when exposed to UV light and, in at least one case, the inability to complete sporulation. While the SASPs have been characterized for decades, some evidence suggests that using newer technologies to revisit the roles of the S...
Source: Anaerobe - April 6, 2024 Category: Microbiology Authors: Hailee N Nerber Joseph A Sorg Source Type: research
Approaching toxigenic Clostridia from a one health perspective
We present examples showing use of these resources in surveillance, including capacity to assess linkages among clinical, environmental, and foodborne reservoirs and to further research investigations into factors promoting their persistence and virulence in different settings.PMID:38552896 | DOI:10.1016/j.anaerobe.2024.102839 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Laura M Cersosimo Jay N Worley Lynn Bry Source Type: research
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection
Anaerobe. 2024 Mar 27:102842. doi: 10.1016/j.anaerobe.2024.102842. Online ahead of print.ABSTRACTLate anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.PMID:38552897 | DOI:10.1016/j.anaerobe.2024.102842 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Isaura Rigo Mary K Young Mayuresh M Abhyankar Feifan Xu Girija Ramakrishnan Farha Naz William A Petri Gregory R Madden Source Type: research
Approaching toxigenic Clostridia from a one health perspective
We present examples showing use of these resources in surveillance, including capacity to assess linkages among clinical, environmental, and foodborne reservoirs and to further research investigations into factors promoting their persistence and virulence in different settings.PMID:38552896 | DOI:10.1016/j.anaerobe.2024.102839 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Laura M Cersosimo Jay N Worley Lynn Bry Source Type: research
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection
Anaerobe. 2024 Mar 27:102842. doi: 10.1016/j.anaerobe.2024.102842. Online ahead of print.ABSTRACTLate anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.PMID:38552897 | DOI:10.1016/j.anaerobe.2024.102842 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Isaura Rigo Mary K Young Mayuresh M Abhyankar Feifan Xu Girija Ramakrishnan Farha Naz William A Petri Gregory R Madden Source Type: research
Approaching toxigenic Clostridia from a one health perspective
We present examples showing use of these resources in surveillance, including capacity to assess linkages among clinical, environmental, and foodborne reservoirs and to further research investigations into factors promoting their persistence and virulence in different settings.PMID:38552896 | DOI:10.1016/j.anaerobe.2024.102839 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Laura M Cersosimo Jay N Worley Lynn Bry Source Type: research
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection
Anaerobe. 2024 Mar 27:102842. doi: 10.1016/j.anaerobe.2024.102842. Online ahead of print.ABSTRACTLate anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.PMID:38552897 | DOI:10.1016/j.anaerobe.2024.102842 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Isaura Rigo Mary K Young Mayuresh M Abhyankar Feifan Xu Girija Ramakrishnan Farha Naz William A Petri Gregory R Madden Source Type: research
