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An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 26, 2022 Category: Biochemistry Authors: Tatiana Prokaeva Elena S. Klimtchuk Polina Feschenko Brian Spencer Haili Cui Eric J. Burks Roshanak Aslebagh Khaja Muneeruddin Scott A. Shaffer Elizabeth Varghese John L. Berk Lawreen H. Connors Source Type: research

Real-world treatment patterns, costs, and outcomes in patients with AL amyloidosis: analysis of the Optum EHR and commercial claims databases
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 25, 2022 Category: Biochemistry Authors: Angela Dispenzieri Jeffrey Zonder James Hoffman Sandra W. Wong Michaela Liedtke Rafat Abonour Anita D ’Souza Charlene Lee Sarah Cote Ravi Potluri Eric Ammann NamPhuong Tran Annette Lam Sandhya Nair Source Type: research

Pulmonary function tests reveal unrecognised lung dysfunction and have independent prognostic significance in patients with systemic AL amyloidosis
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 25, 2022 Category: Biochemistry Authors: Georgia Trakada Despina Fotiou Anastasios Kallianos Foteini Theodorakakou Magdalini Migkou Maria Gavriatopoulou Nikolaos Kanellias Panagiotis Malandrakis Ioannis Ntanasis-Stathopoulos Evangelos Eleutherakis-Papaiakovou Ioanna Dialoupi Evangelos Terpos Mel Source Type: research

Impact of tafamidis on myocardial strain in transthyretin amyloid cardiomyopathy
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 17, 2022 Category: Biochemistry Authors: Ren é Rettl Franz Duca Christina Binder Theresa-Marie Dachs Bernhard Cherouny Luciana Camuz Ligios Christopher Mann Lore Schrutka Daniel Dalos Silvia Charwat-Resl Roza Badr Eslam Johannes Kastner Diana Bonderman Source Type: research

Predictors of cognitive dysfunction in hereditary transthyretin amyloidosis with liver transplant
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 17, 2022 Category: Biochemistry Authors: Sara Cavaco Ana Martins da Silva Joana Fernandes Ana Paula Sousa Cristina Alves M árcio Cardoso Armando Teixeira-Pinto Teresa Coelho Source Type: research

Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - October 9, 2022 Category: Biochemistry Authors: Fredrik Noborn Christer Thomsen Egor Vorontsov Emanuele Bobbio Carina Sihlbom Jonas Nilsson Christian L. Polte Entela Bollano Kristina Vukusic Joakim Sandstedt G öran Dellgren Kristjan Karason Anders Oldfors G öran Larson Source Type: research

Distribution and progression of cerebral amyloid angiopathy in early-onset V30M (p.V50M) hereditary ATTR amyloidosis
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 30, 2022 Category: Biochemistry Authors: Yusuke Takahashi Kazuhiro Oguchi Yusuke Mochizuki Ken Takasone Naoki Ezawa Akira Matsushima Nagaaki Katoh Masahide Yazaki Yoshiki Sekijima Source Type: research

Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 30, 2022 Category: Biochemistry Authors: Cec ília Monteiro Jaleh S. Mesgarzadeh Jo ão Anselmo Joana Fernandes Marta Novais Carla Rodrigues David L. Powers Evan T. Powers Teresa Coelho Jeffery W. Kelly Source Type: research

Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 19, 2022 Category: Biochemistry Authors: Dianna Quan Laura Obici John L. Berk Yukio Ando Emre Aldinc Matthew T. White David Adams Source Type: research

Selective recognition of human small transthyretin aggregates by a novel monoclonal antibody
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 16, 2022 Category: Biochemistry Authors: A. Cristina Teixeira Maria J. Saraiva Source Type: research

Reduction of cardiac AL amyloid deposition after complete response visualised by PiB-PET imaging
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 16, 2022 Category: Biochemistry Authors: Kazuhiro Oguchi Nagaaki Katoh Yusuke Mochizuki Yusuke Takahashi Akihiro Ueno Ken Takasone Yoshiki Sekijima Source Type: research

Binding of serum-derived amyloid-associated proteins to amyloid fibrils
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 12, 2022 Category: Biochemistry Authors: Yohei Misumi Yuri Tabata Masayoshi Tasaki Konen Obayashi Shiori Yamakawa Toshiya Nomura Mitsuharu Ueda Source Type: research

Functional and morphometric assessment of small-fibre damage in late-onset hereditary transthyretin amyloidosis with polyneuropathy: the controversial relation between small-fibre-related symptoms and diagnostic test findings
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 12, 2022 Category: Biochemistry Authors: Eleonora Galosi Luca Leonardi Pietro Falco Giuseppe Di Pietro Alessandra Fasolino Nicoletta Esposito Caterina Leone Giulia Di Stefano Maurizio Inghilleri Marco Luigetti Antonini Giovanni Andrea Truini Source Type: research

Pupillometric findings in ATTRv patients and carriers: results from a single-centre experience
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - September 6, 2022 Category: Biochemistry Authors: Angela Romano Valeria Guglielmino Andrea Di Paolantonio Giulia Bisogni Mario Sabatelli Giacomo Della Marca Angelo Maria Minnella Martina Maceroni Simone Bellavia Irene Scala Eleonora Sabatelli Eleonora Rollo Marco Luigetti Source Type: research

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial
. (Source: Amyloid: The Journal of Protein Folding Disorders)
Source: Amyloid: The Journal of Protein Folding Disorders - July 23, 2022 Category: Biochemistry Authors: David Adams Ivailo L. Tournev Mark S. Taylor Teresa Coelho Violaine Plant é-Bordeneuve John L. Berk Alejandra Gonz ález-Duarte Julian D. Gillmore Soon-Chai Low Yoshiki Sekijima Laura Obici Chongshu Chen Prajakta Badri Seth M. Arum John Vest Michael Poly Source Type: research