What do veterinary professionals and clients want? Using discrete choice methods in veterinary research to determine preferences
Am J Vet Res. 2024 Feb 12:1-7. doi: 10.2460/ajvr.23.10.0228. Online ahead of print.ABSTRACTDiscrete choice methods (DCMs) are a suite of research techniques for identifying individual preferences using choice information. Widely utilized by other fields yet rarely employed in veterinary research, DCMs have tremendous potential to improve veterinary healthcare by understanding and incorporating owner and veterinary professionals' (encompassing veterinarians, veterinary clinicians, technicians, receptionists, attendants, etc) preferences to optimize the care continuum. DCMs have several advantages over other stated preferenc...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Catherine N H Groves Jason B Coe Lauren E Grant Source Type: research

Low levels of microRNA-21 in neutrophil-derived exosomes may contribute to airway smooth muscle hyperproliferation in horses with severe asthma
Am J Vet Res. 2024 Feb 12:1-8. doi: 10.2460/ajvr.23.11.0267. Online ahead of print.ABSTRACTOBJECTIVE: Neutrophilic inflammation is associated with the degree of airway obstruction in severe equine asthma (SEA), but the contribution of these leukocytes to bronchial remodeling remains ill defined. Neutrophils could cause structural alterations of the airways by the release of exosomes, a type of cell-derived nanoparticles that can modify the biology of local and distant cells. Neutrophil-derived exosomes have been shown to increase airway smooth muscle (ASM) cell proliferation in humans and horses. Therefore, this study aime...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Amandine Vargas Sophie Mainguy-Seers Roxane Boivin Jean-Pierre Lavoie Source Type: research

Vesicular stomatitis virus in two species of rhinoceros at a California zoological park
Am J Vet Res. 2024 Feb 24:1-10. doi: 10.2460/ajvr.23.12.0284. Online ahead of print.ABSTRACTOBJECTIVE: To describe an outbreak of vesicular stomatitis virus (VSV) in southern white rhinoceros (SWR; Ceratotherium simum simum) and greater one-horned rhinoceros (GOHR; Rhinoceros unicornis) at a safari park in San Diego, CA, from May to September 2023.ANIMALS: 21 SWR and 5 GOHR in professionally managed care.METHODS: Rhinoceros of both species presented with a range of clinical signs and severities. Lesion locations were categorized as cutaneous (coronary bands, heels and soles, limbs, ventrum, neck folds, and ears) and mucocu...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Erin R Berlin Matthew E Kinney Lauren L Howard Kathryn L Perrin Paula Rodriguez Steven V Kubiski Kristen A Phair Source Type: research

Cardiovascular disease in central bearded dragons (Pogona vitticeps): 54 cases (2007-2022)
Am J Vet Res. 2024 Feb 23:1-12. doi: 10.2460/ajvr.23.10.0241. Online ahead of print.ABSTRACTOBJECTIVE: To describe the clinical features, histopathologic lesions, and outcome of cardiovascular disease in central bearded dragons.ANIMALS: 54 bearded dragons.METHODS: Retrospective evaluation of captive bearded dragons with antemortem imaging or postmortem diagnosis of cardiovascular disease from 2007 to 2022 from 6 hospitals.RESULTS: The total prevalence of cardiovascular disease was 3.3% (54/1,655). Physical examination findings were available in 46 cases with change in mentation being the most common finding (n = 28/46 [60....
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Sarah M Ozawa Kursten V Pierce Amy B Alexander Krista A Keller Danielle K Tarbert David Sanchez-Migallon Guzman Miranda J Sadar Julie D Sheldon Danielle M Meritet Source Type: research

Evaluation of a novel, sensitive thyroid-stimulating hormone assay as a diagnostic test for thyroid disease in cats
Am J Vet Res. 2024 Feb 23:1-11. doi: 10.2460/ajvr.23.12.0278. Online ahead of print.ABSTRACTOBJECTIVE: Clinicians commonly use thyroid-stimulating hormone (TSH) concentrations to diagnose thyroid disorders in humans and dogs. In cats, canine TSH chemiluminescent immunoassays (CLIA) assays are commonly used to measure TSH, but these TSH-CLIAs cannot measure low TSH concentrations (< 0.03 ng/mL) and therefore cannot distinguish between low-normal concentrations and truly low TSH concentrations (characteristic of hyperthyroidism). Our aim was to evaluate a novel TSH assay based on bulk acoustic wave (BAW) technology that h...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Mark E Peterson Eric Dougherty Mark Rishniw Source Type: research

Neurofilament light chain concentration does not correlate with disease status in Labrador Retrievers affected with idiopathic laryngeal paralysis
Am J Vet Res. 2024 Feb 23:1-8. doi: 10.2460/ajvr.23.12.0292. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to investigate whether plasma neurofilament light chain (pNfL) concentration was altered in Labrador Retrievers with idiopathic laryngeal paralysis (ILP) compared to a control population. A secondary aim was to investigate relationships between age, height, weight, and body mass index in the populations studied.ANIMALS: 123 dogs: 62 purebred Labrador Retrievers with ILP (ILP Cases) and 61 age-matched healthy medium- to large-breed dogs (Controls).METHODS: Dogs, recruited from August 1, 2016, to Ma...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Jacquelyn H Perino Margaret Patterson Mehdi Momen Mina Borisova Amanda Heslegrave Henrik Zetterberg Jordan Gruel Emily E Binversie Ryan S Anderson Helena Rylander Starr Cameron Benjamin Miranda Gabi Conidi John Svaren Susannah J Sample Source Type: research

Evaluation of viscoelastic coagulation monitoring parameters and fibrinogen concentrations in healthy dogs undergoing stifle arthroscopy and tibial plateau leveling osteotomy
Am J Vet Res. 2024 Feb 12:1-7. doi: 10.2460/ajvr.23.11.0250. Online ahead of print.ABSTRACTOBJECTIVE: Evaluation of viscoelastic parameters along with Hct percentages, platelet numbers, and fibrinogen concentrations in healthy dogs undergoing elective stifle arthroscopy and tibial plateau leveling osteotomy (TPLO). These results determine if dogs are in a normal, hypocoagulable, or hypercoagulable state at 4 different time points.ANIMALS: Prospective study of 37 client-owned dogs enrolled between February 2, 2022, and November 10, 2022.METHODS: All dogs received a standardized anesthetic protocol. Patients enrolled in the ...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Mackenzie Grace Rebecca Salazar Jose Zayas Philip Allen Source Type: research

Reduced ribonucleotide reductase RRM2 subunit expression increases DNA damage and mitochondria dysfunction in woody breast chickens
In this study, differences in various enzyme activities and increased DNA damage suggest that RRM2-mediated mitochondrial abnormalities may play a role in WB myopathy.PMID:38382194 | DOI:10.2460/ajvr.23.12.0283 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Majid Shakeri Janghan Choi Caitlin Harris Richard Jeff Buhr Byungwhi Kong Hong Zhuang Brian Bowker Source Type: research

What do veterinary professionals and clients want? Using discrete choice methods in veterinary research to determine preferences
Am J Vet Res. 2024 Feb 12:1-7. doi: 10.2460/ajvr.23.10.0228. Online ahead of print.ABSTRACTDiscrete choice methods (DCMs) are a suite of research techniques for identifying individual preferences using choice information. Widely utilized by other fields yet rarely employed in veterinary research, DCMs have tremendous potential to improve veterinary healthcare by understanding and incorporating owner and veterinary professionals' (encompassing veterinarians, veterinary clinicians, technicians, receptionists, attendants, etc) preferences to optimize the care continuum. DCMs have several advantages over other stated preferenc...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Catherine N H Groves Jason B Coe Lauren E Grant Source Type: research

Low levels of microRNA-21 in neutrophil-derived exosomes may contribute to airway smooth muscle hyperproliferation in horses with severe asthma
Am J Vet Res. 2024 Feb 12:1-8. doi: 10.2460/ajvr.23.11.0267. Online ahead of print.ABSTRACTOBJECTIVE: Neutrophilic inflammation is associated with the degree of airway obstruction in severe equine asthma (SEA), but the contribution of these leukocytes to bronchial remodeling remains ill defined. Neutrophils could cause structural alterations of the airways by the release of exosomes, a type of cell-derived nanoparticles that can modify the biology of local and distant cells. Neutrophil-derived exosomes have been shown to increase airway smooth muscle (ASM) cell proliferation in humans and horses. Therefore, this study aime...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Amandine Vargas Sophie Mainguy-Seers Roxane Boivin Jean-Pierre Lavoie Source Type: research

Vesicular stomatitis virus in two species of rhinoceros at a California zoological park
Am J Vet Res. 2024 Feb 24:1-10. doi: 10.2460/ajvr.23.12.0284. Online ahead of print.ABSTRACTOBJECTIVE: To describe an outbreak of vesicular stomatitis virus (VSV) in southern white rhinoceros (SWR; Ceratotherium simum simum) and greater one-horned rhinoceros (GOHR; Rhinoceros unicornis) at a safari park in San Diego, CA, from May to September 2023.ANIMALS: 21 SWR and 5 GOHR in professionally managed care.METHODS: Rhinoceros of both species presented with a range of clinical signs and severities. Lesion locations were categorized as cutaneous (coronary bands, heels and soles, limbs, ventrum, neck folds, and ears) and mucocu...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Erin R Berlin Matthew E Kinney Lauren L Howard Kathryn L Perrin Paula Rodriguez Steven V Kubiski Kristen A Phair Source Type: research

Cardiovascular disease in central bearded dragons (Pogona vitticeps): 54 cases (2007-2022)
Am J Vet Res. 2024 Feb 23:1-12. doi: 10.2460/ajvr.23.10.0241. Online ahead of print.ABSTRACTOBJECTIVE: To describe the clinical features, histopathologic lesions, and outcome of cardiovascular disease in central bearded dragons.ANIMALS: 54 bearded dragons.METHODS: Retrospective evaluation of captive bearded dragons with antemortem imaging or postmortem diagnosis of cardiovascular disease from 2007 to 2022 from 6 hospitals.RESULTS: The total prevalence of cardiovascular disease was 3.3% (54/1,655). Physical examination findings were available in 46 cases with change in mentation being the most common finding (n = 28/46 [60....
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Sarah M Ozawa Kursten V Pierce Amy B Alexander Krista A Keller Danielle K Tarbert David Sanchez-Migallon Guzman Miranda J Sadar Julie D Sheldon Danielle M Meritet Source Type: research

Evaluation of a novel, sensitive thyroid-stimulating hormone assay as a diagnostic test for thyroid disease in cats
Am J Vet Res. 2024 Feb 23:1-11. doi: 10.2460/ajvr.23.12.0278. Online ahead of print.ABSTRACTOBJECTIVE: Clinicians commonly use thyroid-stimulating hormone (TSH) concentrations to diagnose thyroid disorders in humans and dogs. In cats, canine TSH chemiluminescent immunoassays (CLIA) assays are commonly used to measure TSH, but these TSH-CLIAs cannot measure low TSH concentrations (< 0.03 ng/mL) and therefore cannot distinguish between low-normal concentrations and truly low TSH concentrations (characteristic of hyperthyroidism). Our aim was to evaluate a novel TSH assay based on bulk acoustic wave (BAW) technology that h...
Source: American Journal of Veterinary Research - February 21, 2024 Category: Veterinary Research Authors: Mark E Peterson Eric Dougherty Mark Rishniw Source Type: research

Hypothermia, anemia, hyperglycemia, and severe hypoglycemia are significant prognostic indicators of death in client-owned ferrets (Mustela putorius furo)
Am J Vet Res. 2024 Feb 19:1-8. doi: 10.2460/ajvr.23.10.0244. Online ahead of print.ABSTRACTOBJECTIVE: To determine whether rectal temperature, Hct, or blood glucose at presentation were associated with all-cause mortality in ferrets (Mustela putorius furo).ANIMALS: 321 client-owned ferrets.METHODS: A medical record database was searched for ferrets from January 2012 through September 2022. Records from 1,189 individual examinations were evaluated. Inclusion criteria were rectal temperature, Hct, and/or blood glucose measured at presentation and data on survival status 7 days postpresentation. Data were included from 321 fe...
Source: American Journal of Veterinary Research - February 15, 2024 Category: Veterinary Research Authors: Hayley S Stratton Sangeeta Rao Miranda J Sadar Source Type: research

Hypothermia, anemia, hyperglycemia, and severe hypoglycemia are significant prognostic indicators of death in client-owned ferrets (Mustela putorius furo)
Am J Vet Res. 2024 Feb 19:1-8. doi: 10.2460/ajvr.23.10.0244. Online ahead of print.ABSTRACTOBJECTIVE: To determine whether rectal temperature, Hct, or blood glucose at presentation were associated with all-cause mortality in ferrets (Mustela putorius furo).ANIMALS: 321 client-owned ferrets.METHODS: A medical record database was searched for ferrets from January 2012 through September 2022. Records from 1,189 individual examinations were evaluated. Inclusion criteria were rectal temperature, Hct, and/or blood glucose measured at presentation and data on survival status 7 days postpresentation. Data were included from 321 fe...
Source: American Journal of Veterinary Research - February 15, 2024 Category: Veterinary Research Authors: Hayley S Stratton Sangeeta Rao Miranda J Sadar Source Type: research