American Journal of Physiology. Renal Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section
Am J Physiol Renal Physiol. 2024 Mar 28. doi: 10.1152/ajprenal.00086.2024. Online ahead of print.NO ABSTRACTPMID:38545649 | DOI:10.1152/ajprenal.00086.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Robert A Fenton David H Ellison Source Type: research

< em > MFSD12 < /em > depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis
In conclusion, MFSD12 mRNA depletion reduced cystine levels in both tested models without improvement of the proximal tubular function in the ctns-/- zebrafish embryo. Additionally, the apparent toxicity of higher mfsd12a TB MO concentrations on the zebrafish development, warrants further evaluation.PMID:38545650 | DOI:10.1152/ajprenal.00014.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Tjessa Bondue Laleh Khodaparast Ladan Khodaparast Sara Cairoli Bianca Maria Goffredo Rik Gijsbers Lambertus van den Heuvel Elena Levtchenko Source Type: research

The Calcium-sensing receptor (CaSR) has only a PTH-dependent role in the acute response of renal phosphatetransporters to phosphate intake
Am J Physiol Renal Physiol. 2024 Mar 28. doi: 10.1152/ajprenal.00009.2024. Online ahead of print.ABSTRACTThe kidney controls systemic inorganic phosphate (Pi) levels by adapting reabsorption to Pi intake. Renal Pi reabsorption is mostly mediated by sodium-phosphate cotransporters NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) which are tightly controlled by various hormones including parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). PTH and FGF23 rise in response to Pi intake and decrease NaPi-IIa and NaPi-IIc brush border membrane abundance enhancing phosphaturia. Phosphaturia and transporter regulation occur ...
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Arezoo Daryadel Catharina J K üng Bet ül Haykir Sibylle Sabrautzki Martin Hrab ě de Angelis Nati Hernando Isabel Rubio-Aliaga Carsten A Wagner Source Type: research

Renal vascular control during normothermia and passive heat stress in healthy younger men and women
Am J Physiol Renal Physiol. 2024 Mar 28. doi: 10.1152/ajprenal.00034.2024. Online ahead of print.ABSTRACTWe tested the hypothesis that the renal vasoconstrictor and vasodilator responses will be greater in younger women compared to men during passive heat stress. Twenty-five healthy adults [12 women (early follicular phase), 13 men] completed two experimental visits, heat stress or normothermic time-control, assigned in a block-randomized crossover design. During heat stress, core temperature was increased by ~0.8°C in the first hour before commencing a 2-min cold pressor test (CPT). Core temperature remained clamped and ...
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Jessica A Freemas Morgan L Worley Mikaela C Gabler Hayden W Hess Curtis S Goss Tyler B Baker Blair D Johnson Christopher L Chapman Zachary J Schlader Source Type: research

Regulation of the water channel Aquaporin-2 by Cullin E3 ubiquitin ligases
In conclusion, CRLs play a vital role in mediating some of the effects of VP to increase AQP2 plasma membrane accumulation and AQP2 abundance. Whether modulation of cullin activity can contribute to body water homeostasis requires further studies.PMID:38545647 | DOI:10.1152/ajprenal.00049.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Sathish K Murali James A McCormick Robert A Fenton Source Type: research

Atavistic Behavior of Macrophages in the Injured Kidney
Am J Physiol Renal Physiol. 2024 Mar 28. doi: 10.1152/ajprenal.00085.2024. Online ahead of print.NO ABSTRACTPMID:38545648 | DOI:10.1152/ajprenal.00085.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 28, 2024 Category: Physiology Authors: Karl A Nath Source Type: research

Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia/reperfusion injury in a sex-dependent manner
We examined the impact of parental obesity on offspring kidney function, morphology, and markers of kidney damage after acute kidney injury (AKI). Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were fed N (HN) or H diet (HH) after weaning. All offspring groups were submitted to bilateral AKI by clamping the left and right renal pedicles for 30 min. Compared to male NH and NN offspring from lean parents, male HH and HN offspring from obese parents exhibited higher kidney injury markers such as urinar...
Source: American Journal of Physiology. Renal Physiology - March 21, 2024 Category: Physiology Authors: Jussara M do Carmo John E Hall Xuemei Dai Nikaela Aitken Kylie Larson Emilio M Luna-Suarez Zhen Wang Ana C M Omoto Alan Mouton Xuan Li Luzia N S Furukawa Viktoria Woronik Alexandre A da Silva Source Type: research

Hyperphosphatemia and Zinc Deficiency in Chronic Kidney Disease: Unpacking Their Interconnected Roles and Nutritional Implications
Am J Physiol Renal Physiol. 2024 Mar 21. doi: 10.1152/ajprenal.00052.2024. Online ahead of print.NO ABSTRACTPMID:38511220 | DOI:10.1152/ajprenal.00052.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 21, 2024 Category: Physiology Authors: Clintoria R Williams Source Type: research

< u > Cardioprotective effect of intradialytic exercise on left atrial mechanics < /u >
CONCLUSION: Even a short duration of IDE at moderate intensity is effective in preventing hemodialysis-associated decline in LA reservoir function. Further research is needed to explore the long-term benefits of IDE on LA function.PMID:38511221 | DOI:10.1152/ajprenal.00380.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 21, 2024 Category: Physiology Authors: Claire Maufrais Matthieu Josse Laure Patrier Antoine Grandperrin Myriam Isnard C écile Turc-Baron St éphane Nottin St éphane Mandigout Jean-Paul Cristol Philippe Obert Source Type: research

Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy
In conclusion, our data indicate that in the mouse model of IgAN, sparsentan targets immune and inflammatory processes leading to protection from mesangial hypercellularity.PMID:38511222 | DOI:10.1152/ajprenal.00253.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - March 21, 2024 Category: Physiology Authors: Colin Reily Zina Moldoveanu Tiziano Pramparo Stacy Hall Zhi-Qiang Huang Terri Rice Lea Novak Radko Komers Celia P Jenkinson Jan Novak Source Type: research