American Journal of Physiology. Renal Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: American Journal of Physiology. Renal Physiology - December 7, 2023 Category: Physiology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research

Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - December 7, 2023 Category: Physiology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research

Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: American Journal of Physiology. Renal Physiology - December 7, 2023 Category: Physiology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research

First Author Highlights
Am J Physiol Renal Physiol. 2023 Dec 1;325(6):i-ii. doi: 10.1152/ajprenal.2023.325.6.AU.NO ABSTRACTPMID:38055661 | DOI:10.1152/ajprenal.2023.325.6.AU (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - December 6, 2023 Category: Physiology Source Type: research

SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
In conclusion, first evidence is presented that pretreatment with an SGLT2 inhibitor can attenuate the AA-induced DNA damage response and subsequent nephropathy.PMID:38031729 | DOI:10.1152/ajprenal.00228.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - November 30, 2023 Category: Physiology Authors: Yuji Oe Young Chul Kim Viktoriya S Sidorenko Haiyan Zhang Sadhana Kanoo Natalia Lopez Helen A Goodluck Maria Crespo Masip Volker Vallon Source Type: research

Injury in non-aged podocyte as an accelerator of glomerular aging
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00344.2023. Online ahead of print.NO ABSTRACTPMID:38031730 | DOI:10.1152/ajprenal.00344.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - November 30, 2023 Category: Physiology Authors: Zhengying Fang Kyung Lee John Cijiang He Source Type: research

Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
CONCLUSION: The single-cell platform CyTOF enables detection of significant changes in renal cells, especially in subsets of immune cells in ischemic human kidneys. Endogenous pro-repair cell types in RAS warrant future study for potential immune therapy.PMID:38031731 | DOI:10.1152/ajprenal.00234.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - November 30, 2023 Category: Physiology Authors: Xiang-Yang Zhu Nattawat Klomjit Aditya S Pawar Amrutesh S Puranik Zhi-Zhang Yang Esther Lutgens Alfonso Eirin Amir Lerman Stephen C Textor Lilach O Lerman Source Type: research

Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00162.2023. Online ahead of print.ABSTRACTProtease activated receptor 4 (PAR4) is a GPCR activated by thrombin. It not only contributes most of the platelet-derived thrombin, but also procoagulant microparticle formation, increased fibrin deposition, and initiation of platelet-stimulated inflammation. In addition, PAR4 is expressed on other cell types including endothelial cells. Under inflammatory conditions, PAR4 is overexpressed via epigenetic demethylation of the PAR4 gene, F2RL3. PAR4 knockout studies have determined a role for PAR4 in ischemia reperfusion...
Source: American Journal of Physiology. Renal Physiology - November 30, 2023 Category: Physiology Authors: Kevin Erreger Shirong Cao Yu Pan Mengdi Jiang Ming-Zhi Zhang Raymond C Harris Heidi E Hamm Source Type: research