American Journal of Physiology. Renal Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment
In conclusion, although FMD preserves partially glomerular endothelial glycocalyx, loss of lean mass and increased glomerular oxidative stress argue whether such diet regimes are safe in patients with diabetes.PMID:38205540 | DOI:10.1152/ajprenal.00333.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Anouk I M van der Velden Angela Koudijs Sander Kooijman Rosalie G J Rietjens Wendy M P J Sol M Cristina Avramut Gangqi Wang Patrick C N Rensen Ton J Rabelink Johan van der Vlag Bernard M van den Berg Source Type: research

Zebrafish as a model for podocyte research
Am J Physiol Renal Physiol. 2024 Jan 11. doi: 10.1152/ajprenal.00335.2023. Online ahead of print.ABSTRACTPodocytes, specialized postmitotic cells, are central players in various kidney-related diseases. Zebrafish have become a valuable model system for studying podocyte biology because they are genetically easy to manipulate, transparent and their glomerular structure is similar to that of mammals. This review provides an overview of the knowledge of podocyte biology in zebrafish larvae, with particular focus on their essential contribution to understanding the mechanisms that underlie kidney diseases as well as supporting...
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Maximilian Schindler Nicole Endlich Source Type: research

Energy depletion by cell proliferation sensitizes the kidney epithelial cells to injury
Am J Physiol Renal Physiol. 2024 Mar 1;326(3):F326-F337. doi: 10.1152/ajprenal.00023.2023. Epub 2024 Jan 11.ABSTRACTAcute kidney injury activates both proliferative and antiproliferative pathways, the consequences of which are not fully elucidated. If an initial proliferation of the renal epithelium is necessary for the successful repair, the persistence of proliferation markers is associated with the occurrence of chronic kidney disease. We hypothesized that proliferation in stress conditions impacts cell viability and renal outcomes. We found that proliferation is associated with cell death after various stresses in kidn...
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Pierre Galichon Morgane Lannoy Li Li Justine Serre Sophie Vandermeersch David Legouis M Todd Valerius Juliette Hadchouel Joseph V Bonventre Source Type: research

Collecting Duct Water Permeability Inhibition by EGF Is Associated with Decreased cAMP, PKA activity and AQP2 Phosphorylation at Ser269
Am J Physiol Renal Physiol. 2024 Jan 11. doi: 10.1152/ajprenal.00197.2023. Online ahead of print.ABSTRACTPrior studies showed that epidermal growth factor (EGF) inhibits vasopressin-stimulated osmotic water permeability in the renal collecting duct. Here, we investigated the underlying mechanism. Using isolated perfused rat inner medullary collecting ducts (IMCDs), we found that addition of EGF to the peritubular bath significantly decreased 1-deamino-8-D-arginine vasopressin (dDAVP)-stimulated water permeability, confirming prior observations. The inhibitory effect of EGF on water permeability was associated with a reduct...
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Chung-Lin Chou Kavee Limbutara Anika R Kao Jevin Z Clark Ellen H Nein Viswanathan Raghuram Mark A Knepper Source Type: research

Central role of podocytes in mediating cellular cross talk in glomerular health and disease
Am J Physiol Renal Physiol. 2024 Mar 1;326(3):F313-F325. doi: 10.1152/ajprenal.00328.2023. Epub 2024 Jan 11.ABSTRACTPodocytes are highly specialized epithelial cells that surround the capillaries of the glomeruli in the kidney. Together with the glomerular endothelial cells, these postmitotic cells are responsible for regulating filtrate from the circulating blood with their organized network of interdigitating foot processes that wrap around the glomerular basement membrane. Although podocyte injury and subsequent loss is the hallmark of many glomerular diseases, recent evidence suggests that the cell-cell communication b...
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Nehaben A Gujarati Andrew K Chow Sandeep K Mallipattu Source Type: research

Is Fibroblast Growth Factor 23 the main culprit for cardiovascular disease in chronic kidney disease?
Am J Physiol Renal Physiol. 2024 Jan 11. doi: 10.1152/ajprenal.00379.2023. Online ahead of print.NO ABSTRACTPMID:38205545 | DOI:10.1152/ajprenal.00379.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Carsten A Wagner Isabel Rubio Aliaga Daniela Egli-Spichtig Source Type: research

Exercise for Chronic Kidney Disease Patients: From Cells to Systems to Function
Am J Physiol Renal Physiol. 2024 Jan 11. doi: 10.1152/ajprenal.00302.2023. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is among the leading causes of death and disability in the United States, affecting an estimated 800 million adults globally. The underlying pathophysiology of CKD is complex creating challenges to its management. Primary risk factors for the development and progression of CKD include diabetes mellitus, hypertension, age, obesity, diet, inflammation, and physical inactivity. The high prevalence of diabetes and hypertension in patients with CKD increases the risk for secondary consequences su...
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Jared M Gollie Alice S Ryan Sabyasachi Sen Samir S Patel Peter F Kokkinos Michael O Harris-Love Joel D Scholten Marc R Blackman Source Type: research

Rusting from the inside: Kidney specific ferroportin deficiency and associated iron overload dictates susceptibility to acute kidney injury and fibrosis
Am J Physiol Renal Physiol. 2024 Jan 11. doi: 10.1152/ajprenal.00384.2023. Online ahead of print.NO ABSTRACTPMID:38207098 | DOI:10.1152/ajprenal.00384.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - January 11, 2024 Category: Physiology Authors: Yogesh Scindia Source Type: research

First Author Highlights
Am J Physiol Renal Physiol. 2024 Jan 1;326(1):i-ii. doi: 10.1152/ajprenal.2024.326.1.AU.NO ABSTRACTPMID:38190353 | DOI:10.1152/ajprenal.2024.326.1.AU (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - January 8, 2024 Category: Physiology Source Type: research

Recent Advances in Understanding the Kidney Circadian Clock Mechanism
Am J Physiol Renal Physiol. 2024 Jan 4. doi: 10.1152/ajprenal.00214.2023. Online ahead of print.ABSTRACTCircadian rhythms are endogenous biological oscillations that regulate various physiological processes in organisms, including kidney function. The kidney plays a vital role in maintaining homeostasis by regulating water and electrolyte balance, blood pressure, and excretion of metabolic waste products, all of which display circadian rhythmicity. For this reason, studying the circadian regulation of the kidney is of importance, and time of day is a biological and experimental variable which must be considered. Over the p...
Source: American Journal of Physiology. Renal Physiology - January 4, 2024 Category: Physiology Authors: Alexandria Juffre Michelle L Gumz Source Type: research

Macrophage Polarization and Signaling in Diabetic Kidney Disease: A Catalyst for Disease Progression
Am J Physiol Renal Physiol. 2023 Dec 28. doi: 10.1152/ajprenal.00266.2023. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a serious complication of diabetes affecting millions of people worldwide. Macrophages, a critical immune cell type, are central players in the development and progression of DKD. In this comprehensive review, we delve into the intricate role of macrophages in DKD, examining how they can become polarized into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. We explore the signaling pathways involved in macrophage recruitment and polarization in the kidneys, including the key cytok...
Source: American Journal of Physiology. Renal Physiology - December 28, 2023 Category: Physiology Authors: Natalie Youssef Mohamed H Noureldein Mansour E Riachi Antony Haddad Assaad A Eid Source Type: research