Clinical Profiles and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis: A Cluster-Based Approach Based on MR Imaging Metrics [ADULT BRAIN]
CONCLUSIONS: Patients with amyotrophic lateral sclerosis spontaneously segregate according to age and sex-specific patterns of neurodegeneration. Some patients with amyotrophic lateral sclerosis showed an early higher impairment of cortical motor neurons with relative sparing of bulbar motor neurons (cluster 3), while others expressed an opposite pattern (cluster 2). Moreover, 31% of patients showed an early simultaneous impairment of cortical and bulbar motor neurons (cluster 1), and they were characterized by higher disease severity and lower survival. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Milella, G., Introna, A., Mezzapesa, D. M., DErrico, E., Fraddosio, A., Ucci, M., Zoccolella, S., Simone, I. L. Tags: ADULT BRAIN Source Type: research

MR Imaging Signs of Gadolinium Retention Are Not Associated with Long-Term Motor and Cognitive Outcomes in Multiple Sclerosis [ADULT BRAIN]
CONCLUSIONS: Our findings suggest that gadolinium retention in the brains of patients with MS is not associated with long-term motor or cognitive outcomes. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Scaravilli, A., Tranfa, M., Pontillo, G., Falco, F., Criscuolo, C., Moccia, M., Monti, S., Lanzillo, R., Brescia Morra, V., Palma, G., Petracca, M., Tedeschi, E., Elefante, A., Brunetti, A., Cocozza, S. Tags: ADULT BRAIN Source Type: research

Radiology-Pathology and Surgical Correlation in Astroblastoma [PEDIATRICS]
We describe a case with typical imaging and histologic features of an MN1-altered astroblastoma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Sprenger, F., da Silva, E. B., Cavalcanti, M. S., de Almeida Teixeira, B. C. Tags: PEDIATRICS Source Type: research

Stent-Assisted Coiling in the Treatment of Unruptured Intracranial Aneurysms: A Randomized Clinical Trial [INTERVENTIONAL]
CONCLUSIONS: The STAT trial did not show stent-assisted coiling to be superior to coiling alone for wide-neck, large, or recurrent unruptured aneurysms. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Boisseau, W., Darsaut, T. E., Fahed, R., Drake, B., Lesiuk, H., Rempel, J. L., Gentric, J.- C., Ognard, J., Nico, L., Iancu, D., Roy, D., Weill, A., Chagnon, M., Zehr, J., Lavoie, P., Nguyen, T. N., Raymond, J. Tags: INTERVENTIONAL Source Type: research

Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation [ADULT BRAIN]
SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Rigsby, R. K., Brahmbhatt, P., Desai, A. B., Bathla, G., Ebner, B. A., Gupta, V., Vibhute, P., Agarwal, A. K. Tags: ADULT BRAIN Source Type: research

Imaging of Lymphomas Involving the CNS: An Update-Review of the Full Spectrum of Disease with an Emphasis on the World Health Organization Classifications of CNS Tumors 2021 and Hematolymphoid Tumors 2022 [ADULT BRAIN]
SUMMARY: Lymphomas of the CNS are the second most frequent primary brain malignancy in adults after gliomas. Presurgical suspicion of lymphoma greatly impacts patient management. The radiologic features of this tumor have been widely covered in the literature for decades, but under current classifications, mainly corresponding to the most common presentations of the most frequent type: primary diffuse large B-cell lymphoma of the CNS. Nevertheless, rarer presentations of this specific lymphoma and of other World Health Organization lymphoma subtypes with different imaging features are rarely treated. Moreover, important ad...
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Pons-Escoda, A., Naval-Baudin, P., Velasco, R., Vidal, N., Majos, C. Tags: ADULT BRAIN Source Type: research

Perspectives [other]
(Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Ross, J. S. Tags: other Source Type: research

Celebrating 35 Years of the AJNR: March 1988 edition [other]
(Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Tags: other Source Type: research

Postoperative Lumbar Fusion Bone Morphogenic Protein-Related Epidural Cyst Formation [SPINE]
SUMMARY: Bone morphogenetic protein is broadly used in spinal surgery to enhance fusion rates. Several complications have been associated with the use of bone morphogenetic protein, including postoperative radiculitis and pronounced bone resorption/osteolysis. Bone morphogenetic protein–related epidural cyst formation may represent another complication that has not been described aside from limited case reports. In this case series, we retrospectively reviewed imaging and clinical findings of 16 patients with epidural cysts on postoperative MR imaging following lumbar fusion. In 8 patients, mass effect on the thecal ...
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Abel, F., Tan, E. T., Sneag, D. B., Lebl, D. R., Chazen, J. L. Tags: SPINE Source Type: research

Conebeam CT as an Adjunct to Digital Subtraction Myelography for Detection of CSF-Venous Fistulas [SPINE]
SUMMARY: Lateral decubitus digital subtraction myelography is an effective technique for precisely localizing CSF-venous fistulas, a common cause of spontaneous intracranial hypotension. However, despite an optimal imaging technique, digital subtraction myelography fails to identify some CSF-venous fistulas for a variety of reasons. Here, we describe a technique involving conebeam CT performed during intrathecal contrast injection as an adjunct to digital subtraction myelography, allowing identification of some otherwise-missed CSF-venous fistulas. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Madhavan, A. A., Cutsforth-Gregory, J. K., Benson, J. C., Brinjikji, W., Mark, I. T., Verdoorn, J. T. Tags: SPINE Source Type: research

Modified Dynamic CT Myelography for Type 1 and 2 CSF Leaks: A Procedural Approach [SPINE]
CONCLUSIONS: Modified dynamic CT myelography performed with single scan acquisitions, smaller volume of contrast, and reduced scan coverage can reduce the radiation dose for type 1 and 2 CSF leak detection. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Mamlouk, M. D., Shen, P. Y., Dahlin, B. C. Tags: SPINE Source Type: research

Medullary Tegmental Cap Dysplasia: Fetal and Postnatal Presentations of a Unique Brainstem Malformation [PEDIATRICS]
CONCLUSIONS: This is the first study to describe a series of 13 patients with medullary tegmental cap dysplasia. The cap has different shapes: distinct in Joubert-Boltshauser syndrome and fibrodysplasia ossificans progressive. Due to the variations in the clinical, imaging, and postmortem findings, we conclude that there are multiple etiologies and pathophysiology. We suggest that in some patients, the pathophysiology might be abnormal axonal guidance. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Gafner, M., Garel, C., Leibovitz, Z., Valence, S., Krajden Haratz, K., Oegema, R., Mancini, G. M. S., Heron, D., Bueltmann, E., Burglen, L., Rodriguez, D., Huisman, T. A. G. M., Lequin, M. H., Arad, A., Kidron, D., Muqary, M., Gindes, L., Lev, D., Boltsha Tags: PEDIATRICS Source Type: research

Neuroimaging Features of Biotinidase Deficiency [PEDIATRICS]
In this report comprising 14 patients from multiple centers, we demonstrate the MR imaging patterns of this disorder at various age groups. Knowledge of these patterns in the appropriate clinical context will help guide early diagnosis of this treatable metabolic disorder. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Biswas, A., McNamara, C., Gowda, V. K., Gala, F., Sudhakar, S., Sidpra, J., Vari, M. S., Striano, P., Blaser, S., Severino, M., Batzios, S., Mankad, K. Tags: PEDIATRICS Source Type: research

Diagnostic Utility of 3D Gradient-Echo MR Imaging Sequences through the Filum Compared with Spin-Echo T1 in Children with Concern for Tethered Cord [PEDIATRICS]
CONCLUSIONS: While T1 3D gradient-echo MR images may have decreased the acquisition time and are more motion-resistant than conventional T1 FSE sequences, they are less sensitive and may miss small fatty intrathecal lesions. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Rafiee, F., Mehan, W. A., Rincon, S., Rohatgi, S., Rapalino, O., Buch, K. Tags: PEDIATRICS Source Type: research

Increased Labyrinthine T1 Postgadolinium Signal Intensity Is Associated with the Degree of Ipsilateral Sensorineural Hearing Loss in Patients with Sporadic Vestibular Schwannoma [HEAD & NECK]
CONCLUSIONS: Increased ipsilateral labyrinthine postgadolinium signal intensity is associated with hearing loss in patients with vestibular schwannoma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 9, 2023 Category: Radiology Authors: Welby, J. P., Benson, J. C., Lohse, C. M., Carlson, M. L., Lane, J. I. Tags: HEAD & amp; NECK Source Type: research