A distinctive histidine residue is essential for in vivo glycation ‐inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Rupam Sahoo, Pamela Ghosh, Michael Chorev, Jose A Halperin Tags: Research Article Source Type: research

Diagnosis of thrombotic thrombocytopenic purpura among patients with adamts13 activity 10 ‐20%
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Adanma Ayanambakkam, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George Tags: Correspondence Source Type: research

Ibrutinib ‐associated Pneumocystis jirovecii pneumonia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Regina Lee, Afrouz Nayernama, S. Christopher Jones, Tanya Wroblewski, Peter E. Waldron Tags: Correspondence Source Type: research

Bmp2 controls iron homeostasis in mice independent of Bmp6
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Susanna Canali, Chia ‐Yu Wang, Kimberly B. Zumbrennen‐Bullough, Abraham Bayer, Jodie L. Babitt Tags: Research Article Source Type: research

Treatment of Individuals Who Cannot Receive Blood Products for Religious or Other Reasons
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Carlton D. Scharman, Joseph J. Shatzel, Edward Kim, Thomas G. DeLoughery Tags: Critical Review Source Type: research

Rare complication of treated immune thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 12, 2017 Category: Hematology Authors: Radhika Gangaraju, Anton Rets, Kristi J Smock, Nahla M Heikal Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Efficacy of daratumumab ‐based therapies in patients with relapsed, refractory multiple myeloma treated outside of clinical trials
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 11, 2017 Category: Hematology Authors: Arjun Lakshman, Jithma P. Abeykoon, Shaji K. Kumar, S. Vincent Rajkumar, David Dingli, Francis K. Buadi, Wilson I. Gonsalves, Nelson Leung, Angela Dispenzieri, Taxiarchis V. Kourelis, Ronald S. Go, Martha Q. Lacy, Miriam A. Hobbs, Yi Lin, Rahma Warsame, J Tags: Research Article Source Type: research

Gender and survival in essential thrombocythemia: A two ‐center study of 1,494 patients
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2017 Category: Hematology Authors: Ayalew Tefferi, Silvia Betti, Daniela Barraco, Mythri Mudireddy, Sahrish Shah, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, Naseema Gangat, Giacomo Coltro, Paola Guglielmelli, Alessandro M. Vannucchi Tags: Research Article Source Type: research

CLL progression after one cycle of FCR: Richter's transformation versus EBV ‐associated lympho‐proliferation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2017 Category: Hematology Authors: Preetesh Jain, Jan A. Burger, Joseph D. Khoury Tags: DIAGNOSTIC IMAGING IN HEMATOLOGY Source Type: research

Risk factors and a prognostic model for post ‐splenectomy survival in myelofibrosis
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Authors: Ayalew Tefferi, Mythri Mudireddy, Naseema Gangat, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, David M. Nagorney Tags: Research Article Source Type: research

Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment
Abstract Disease OverviewChronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. The disease typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B cells. DiagnosisThe diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B lymphocytes, which identify a clonal B‐cell population carrying the CD5 antigen and B‐cell markers. PrognosisTwo prognostic staging systems exist, the Rai and Binet staging systems, which are established by p...
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Authors: Michael Hallek Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 7, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

SIRT1 Activates the Expression of Fetal Hemoglobin Genes
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 4, 2017 Category: Hematology Authors: Yan Dai, Tyngwei Chen, Heba Ijaz, Elizabeth H Cho, Martin H Steinberg Tags: Research Article Source Type: research

Emerging role of bevacizumab in management of patients with symptomatic hepatic involvement in Hereditary Hemorrhagic Telangiectasia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Ajay Chavan, Silke Schumann ‐Binarsch, Bernhard Schmuck, Franziska Oltmer, Urban Geisthoff, Florian Hoppe, Kornelia Wirsching, Juergen Klempnauer, Michael Manns, Rohit Philip Thomas, Claus‐Henning Köhne Tags: Correspondence Source Type: research

Outcomes after 18 Months of Eliglustat Therapy in Treatment ‐Naïve Adults with Gaucher Disease Type 1: The Phase 3 ENGAGE Trial
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Pramod K. Mistry, Elena Lukina, Hadhami Ben Turkia, Suma P. Shankar, Hagit Baris, Marwan Ghosn, Atul Mehta, Seymour Packman, Gregory Pastores, Milan Petakov, Sarit Assouline, Manisha Balwani, Sumita Danda, Evgueniy Hadjiev, Andres Ortega, Sebastiaan J.M. Tags: Research Article Source Type: research

The impact of antibody profile in thrombosis associated with primary antiphospholipid syndrome
Abstract Triple positivity (TP) for antiphospholipid antibodies(aPL) may identify aPL carriers with poorer prognosis. The clinical impact of TP in primary antiphospholipid syndrome(PAPS) remains unclear and further clinical evidences are needed to validate TP as a marker of severity. The aim of this study was to evaluate the impact of TP on the clinical course of PAPS with thrombosis(t‐PAPS). We performed a retrospective analysis of a cohort of t‐PAPS patients, comparing groups of patients with TP and non‐TP profiles according to their demographic, clinical and laboratory features. We included 105 patients with t‐P...
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Sabrina da Silva Saraiva, Bruna de Moraes Mazetto, Lais Quinteiro Tobaldine, Marina Pereira Colella, Erich Vin ícius De Paula, Joyce Annichinno‐Bizzachi, Fernanda Andrade Orsi Tags: Research Article Source Type: research

Engineered red blood cells as therapeutic agents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Mauro Magnani Tags: Commentary Source Type: research

Thrombotic and hemorrhagic complications in idiopathic erythrocytosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 1, 2017 Category: Hematology Authors: Irene Bertozzi, Marco Ruggeri, Ilaria Nichele, Giacomo Biagetti, Elisabetta Cosi, Maria Luigia Randi Tags: Correspondence Source Type: research

Clinical characteristics and outcomes of previously untreated patients with adult onset T ‐acute lymphoblastic leukemia and T‐lymphoblastic lymphoma with hyper‐CVAD based regimens
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Preetesh Jain, Hagop Kantarjian, Nitin Jain, Nicholas J. Short, Cameron C. Yin, Rashmi Kanagal ‐Shamanna, Joseph Khoury, Marina Konopleva, Koji Sasaki, Tapan M. Kadia, Rebecca Garris, Sherry Pierce, Zeev Estrov, William Wierda, Jorge Cortes, Susan O'Bri Tags: CORRESPONDENCE Source Type: research

History of consolidation is prognostic in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation in minimal residual disease ‐negative first complete remission
ConclusionsIn AML patients undergoing allo‐HCT in MRD‐negative CR1, a history of prior consolidation was associated with favorable outcomes. If the path to pre‐HCT MRD negativity includes consolidation, it may identify patients with improved prognosis following HCT in MRD‐negative state. These results warrant validation in larger cohorts. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Armin Rashidi, Michael A. Linden, Todd E. DeFor, Erica Warlick, Nelli Bejanyan, Sophia Yohe, Daniel J. Weisdorf, Celalettin Ustun Tags: RESEARCH ARTICLE Source Type: research

Prospective evaluation of chronic organ damage in adult sickle cell patients: A seven ‐year follow‐up study
In conclusion, 62% of the sickle cell patients in this prospective cohort study developed a new SCD‐related complication in a comprehensive care setting within 7 years of follow‐up. Although the hospital admission rate for VOC remained stable, multiple forms of organ damage increased substantially. These observations underline the need for continued screening for organ damage in all adult patients with SCD. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Charlotte F. J. van Tuijn, Marein Schimmel, Eduard J. van Beers, Erfan Nur, Bart J. Biemond Tags: RESEARCH ARTICLE Source Type: research

Targeted next generation sequencing identifies a novel β‐spectrin gene mutation A2059P in two Omani children with hereditary pyropoikilocytosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Arwa Z. Al ‐Riyami, Achille Iolascon, Shoaib Al‐Zadjali, Immacolata Andolfo, Sahima Al‐Mammari, Francesco Manna, AbdulHakim Al Rawas, May‐Jean King, Roberta Russo Tags: CORRESPONDENCE Source Type: research

Pure erythroid leukemia: The need to gather data on this condition as defined in the World Health Organization classification
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Barbara J. Bain Tags: CORRESPONDENCE Source Type: research

A reappraisal of the benefit ‐risk profile of hydroxyurea in polycythemia vera: A propensity‐matched study
Abstract The use of hydroxyurea (HU) as first line therapy in polycythemia vera (PV) has been criticized because no solid demonstration that this drug prevents thrombosis or prolongs survival has been so far produced. Here we present the outcomes of a large cohort of patients with PV included in the European Collaborative Low‐dose Aspirin (ECLAP) study. We selected 1,042 patients who, during the follow‐up, had received only phlebotomy (PHL) or HU to maintain the hematocrit level 
Source: American Journal of Hematology - July 29, 2017 Category: Hematology Authors: Tiziano Barbui, Alessandro Maria Vannucchi, Guido Finazzi, Maria Chiara Finazzi, Arianna Masciulli, Alessandra Carobbio, Arianna Ghirardi, Gianni Tognoni Tags: RESEARCH ARTICLE Source Type: research

Multicenter analysis of the use of transjugular intrahepatic portosystemic shunt for management of MPN ‐associated portal hypertension
In conclusion, TIPS can be an effective intervention for MPN‐associated pHTN regardless of etiology. However, TIPS thrombosis is a frequent complication in the MPN population and indefinite anticoagulation post‐TIPS should be considered. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 26, 2017 Category: Hematology Authors: Christopher R. Reilly, Daria V. Babushok, Karlyn Martin, Jerry L. Spivak, Michael Streiff, Ranjeeta Bahirwani, Jeffrey Mondschein, Brady Stein, Alison Moliterno, Elizabeth O. Hexner Tags: RESEARCH ARTICLE Source Type: research

Kidney Function of Transfused Children with Sickle Cell Anemia: Baseline Data from the TWiTCH Study with Comparison to Non ‐Transfused Cohorts
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 25, 2017 Category: Hematology Authors: Ofelia Alvarez, Kerri Nottage, Lara M. Simpson, John Wood, Barry R. Davis, Beng Fuh, Sharada Sarnaik, Banu Aygun, Kathleen Helton, Russell E. Ware Tags: Correspondence Source Type: research

Earlier initiation of transfusional and iron chelation therapies in recently born children with transfusion ‐dependent thalassemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 25, 2017 Category: Hematology Authors: Raffaella Origa, Federica Tatti, Antonietta Zappu, GiovanBattista Leoni, Carlo Dess ì, Paolo Moi, Maddalena Morittu, Valeria Orecchia, AnnaRita Denotti, Maria Paola Pilia, Franco Anni, Maria Perra, Maria Rosaria Casini, Susanna Barella Tags: Correspondence Source Type: research

Plasmapheresis may improve clinical condition in sickle cell disease through its effects on red blood cell rheology
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 25, 2017 Category: Hematology Authors: Elie Nader, Philippe Connes, Yann Lamarre, C éline Renoux, Philippe Joly, Marie‐Dominique Hardy‐Dessources, Giovanna Cannas, Nathalie Lemonne, Samir K. Ballas Tags: Correspondence Source Type: research

Validation of and proposals for refinements of the WHO 2016 classification for myelodysplastic syndromes
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 25, 2017 Category: Hematology Authors: M. F. van Spronsen, T. M. Westers, H. Rozema, G. J. Ossenkoppele, R. E. Kibbelaar, M. Hoogendoorn, A. A. van de Loosdrecht Tags: Correspondence Source Type: research

Inflammatory and endothelial markers during vaso ‐occlusive crisis and acute chest syndrome in sickle cell disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 25, 2017 Category: Hematology Authors: M. Schimmel, B.M. Luken, E. Nur, C.F.J. van Tuijn, J.W. Sins, D.P.M. Brandjes, S.S. Zeerleder, B.J. Biemond Tags: Correspondence Source Type: research

Fetal Hemoglobin in Sickle Cell Anemia: The Arab ‐Indian Haplotype and New Therapeutic Agents
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 24, 2017 Category: Hematology Authors: Alawi H. Habara, Elmutaz M. Shaikho, Martin H. Steinberg Tags: Critical Review Source Type: research

A comparative analysis of biosimilar vs. originator filgrastim in combination with plerixafor for stem cell mobilization in lymphoma and multiple myeloma: a propensity ‐score weighted multicenter approach
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 24, 2017 Category: Hematology Authors: Francesco Lanza, Francesco Saraceni, Annalisa Pezzi, Massimo Martino, Alberto Bosi, Nicola Cascavilla, Pellegrino Musto, Eliana Zuffa, Monica Tani, Claudia Cellini, Daniele Laszlo, Francesca Bonifazi, Tags: CORRESPONDENCE Source Type: research

High prevalence of osteonecrosis among the hemophagocytic lymphohistiocytosis population: Single institution 10 ‐year retrospective data review
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 24, 2017 Category: Hematology Authors: Paul Craig, Shelly Marette, Jutta Ellermann, Surbhi Shah, Takashi Takahashi Tags: CORRESPONDENCE Source Type: research

Current treatment preferences in chronic myeloid leukemia: The Mayo Clinic Physicians' survey
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 21, 2017 Category: Hematology Authors: Kebede Begna, Aref Al ‐Kali, Michelle Elliott, James Foran, Naseema Gangat, William Hogan, Christopher Hook, Jose Leis, Mark Litzow, Ruben Mesa, Jeanne Palmer, Animesh Pardanani, Mrinal Patnaik, Candido Rivera, Lisa Sproat, Raoul Tibes, Alexandra Wolans Tags: Correspondence Source Type: research

Losartan for the nephropathy of sickle cell anemia: A phase ‐2, multicenter trial
This study forms the basis for a phase‐3, randomized, placebo‐controlled trial of losartan for the nephropathy of SCA. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 19, 2017 Category: Hematology Authors: Charles T. Quinn, Santosh L. Saraf, Victor R. Gordeuk, Courtney D. Fitzhugh, Susan E. Creary, Prasad Bodas, Alex George, Ashok B. Raj, Alecia C. Nero, Catherine E. Terrell, Lisa McCord, Adam Lane, Hans C. Ackerman, Yu Yang, Omar Niss, Michael D. Taylor, P Tags: RESEARCH ARTICLE Source Type: research

Cross ‐altitude analysis suggests a turning point at the elevation of 4,500 m for polycythemia prevalence in Tibetans
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 19, 2017 Category: Hematology Authors: Hui Zhang, Yaoxi He, Chaoying Cui, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Yongyue Pan, Qula, Kangmin, Cirenyangji, Baimayangji, Caijuan Bai, Wei Guo, Yangla, Yi Peng, Xiaoming Zhang, Kun Xiang, Zhaohui Yang, Shiming Liu, Tags: CORRESPONDENCE Source Type: research

Juvenile myelomonocytic leukemia in an infant with congenital human immunodeficiency virus and cytomegalovirus infection
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 19, 2017 Category: Hematology Authors: Jessica Bazin, Leena Karnik, Gareth Tudor ‐Williams, Anne M. Kelly, Barbara J. Bain Tags: MORPHOLOGY UPDATE Source Type: research

Cardiac tamponade in myelofibrosis: A Mayo clinic series of nine consecutive cases
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 19, 2017 Category: Hematology Authors: Sravanthi Lavu, Ayalew Tefferi Tags: CORRESPONDENCE Source Type: research

Acute leukemic transformation of myelodysplastic syndrome: Is cytochemistry still relevant?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 19, 2017 Category: Hematology Authors: Imogen Caldwell, Anna Ruskova, Nicola Eaddy, Barbara J. Bain Tags: MORPHOLOGY UPDATE Source Type: research

Frequency, Risk Factors, and Outcomes of Central Nervous System Relapse in Lymphoma Patients Treated with Dose ‐Adjusted EPOCH plus Rituximab
Conclusions The rate of CNS relapse in this patient population approaches 6%, not significantly different from reports on those receiving R‐CHOP. The results of this study suggest that CNS prophylaxis might be more selectively used among patients treated with EPOCH‐R with certain high‐risk features. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 18, 2017 Category: Hematology Authors: M.K. Malecek, A.M. Petrich, S. Rozell, B. Chu, S. Trifilio, N. Galanina, M. Maurer, U. Farooq, B. Link, G.S. Nowakowski, C. Nabhan, A.O. Ayed Tags: Research Article Source Type: research

Somatic mutations identified at diagnosis by exome sequencing can predict response to imatinib in chronic phase CML patients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 18, 2017 Category: Hematology Authors: Luca Mologni, Rocco Piazza, Praveen Khandelwal, Alessandra Pirola, Carlo Gambacorti ‐Passerini Tags: Correspondence Source Type: research

Pure erythroid leukemia: the need gather data on this condition as defined in the World Health Organisation classification
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 14, 2017 Category: Hematology Authors: Barbara J. Bain Tags: Correspondence Source Type: research

Causes of early death in multiple myeloma patients treated with high ‐dose therapy followed by autologous stem cell transplantation: A study based on the nationwide Danish Multiple Myeloma Registry
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Kristian Thidemann Andersen, Tobias Klausen, Niels Abildgaard, Mette Klarskov Andersen, Niels Frost Andersen, Ulf Christian Fr ølund, Carsten Helleberg, Eigil Kjeldsen, Per Pedersen, Sissel Helm‐Petersen, Asta Svirskaite, Birgitte Preiss, Peter Gimsing Tags: Correspondence Source Type: research

Nucleophosmin 1 (NPM1) Mutations in Chronic Myelomonocytic Leukemia and Their Prognostic Relevance
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Rangit Vallapureddy, Terra L. Lasho, Katherine Hoversten, Christy M. Finke, Rhett Ketterling, Curtis Hanson, Naseema Gangat, Ayalew Tefferi, Mrinal M. Patnaik Tags: Correspondence Source Type: research

Clinical Significance of Prothrombin G20210A Mutation in Homozygous Patients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Amit Shemesh, Ron Hoffman, Yona Nadir, Anat Keren ‐Politansky, Manuel Monreal, Benjamin Brenner, Inna Tzoran Tags: Correspondence Source Type: research

Association of pancreatic MRI R2* with blood glucose and cardiac MRI R2* among thalassemia major patients in Indonesia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Pustika Amalia Wahidiyat, Damayanti Sekarsari, Nitish Basant Adnani, Siti Ayu Putriasih, Vasili Berdoukas Tags: Correspondence Source Type: research

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain
Abstract The painful vaso‐occlusive crises (VOC) that characterize sickle cell disease (SCD) progress over hours from the asymptomatic steady‐state. SCD patients report that VOC can be triggered by stress, cold exposure and pain itself. We anticipated that pain could cause neural‐mediated vasoconstriction, decreasing regional blood flow and promoting entrapment of sickle cells in the microvasculature. Therefore, we measured microvascular blood flow in the fingers of both hands using plethysmography and laser‐Doppler flowmetry while applying a series of painful thermal stimuli on the right forearm in 23 SCD patients...
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Maha Khaleel, Mammen Puliyel, Payal Shah, John Sunwoo, Roberta M. Kato, Patjanaporn Chalacheva, Wanwara Thuptimdang, Jon Detterich, John C Wood, Jennie Tsao, Lonnie Zeltzer, Richard Sposto, Michael C.K. Khoo, Thomas D. Coates Tags: Research Article Source Type: research

Response to Dr. Bain's comment on our review article: Pure Erythroid Leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2017 Category: Hematology Authors: Wei Wang, Sa Wang, L. Jeffrey Medeiros, Joseph D. Khoury Tags: Correspondence Source Type: research

POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management
Abstract Disease OverviewPOEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Diagnoses are often delayed because the syndrome is rare and can be mistaken for other neurologic disorders, most commonly chronic inflammatory demyelinating polyrad...
Source: American Journal of Hematology - July 12, 2017 Category: Hematology Authors: Angela Dispenzieri Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES: A CONTINUING MEDICAL EDUCATION SERIES Source Type: research

Mantle cell lymphoma: 2017 update on diagnosis, risk ‐stratification, and clinical management
Abstract Disease OverviewMantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood and bone marrow with a short remission duration to standard therapies and a median overall survival (OS) of 4‐5 years. DiagnosisDiagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t (11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1. Cyclin D1 is detected by immunohistochemistry in 98% of cases. The absence of SOX‐11 or a low Ki...
Source: American Journal of Hematology - July 12, 2017 Category: Hematology Authors: Julie M. Vose Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES: A CONTINUING MEDICAL EDUCATION SERIES Source Type: research