Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: A randomized trial
Abstract Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia (IDA). This randomized, multicenter, double‐blind clinical trial compared the safety, and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with IDA of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1.02 g and 1....
Source: American Journal of Hematology - February 24, 2018 Category: Hematology Authors: N. Franklin Adkinson, William E. Strauss, Iain C. Macdougall, Kristine E. Bernard, Michael Auerbach, Robert F. Kaper, Glenn M. Chertow, Julie S. Krop Tags: RESEARCH ARTICLE Source Type: research

Unusual inclusions in hemoglobin H disease post ‐splenectomy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: Michael Spencer ‐Chapman, Asad Luqmani, D. Mark Layton, Barbara J. Bain Tags: Morphology Update Source Type: research

Effectiveness and safety of anticoagulants for the treatment of venous thromboembolism in patients with cancer
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Source Type: research

MRI for the diagnosis of cardiac and liver iron overload in patients with transfusion ‐dependent thalassemia: An algorithm to guide clinical use when availability is limited
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: Vip Viprakasit, Amr Ajlan, Yesim Aydinok, Basim A.A. Al Ebadi, Hany Dewedar, Ahmed S. Ibrahim, Lamis Ragab, Omar Trad, Ahmed S. Wataify, Lily L.L. Wong, Ali T. Taher Tags: Correspondence Source Type: research

Bendamustine ‐Based conditioning prior to ASCT: Results of a French Multicenter Study of 474 Patients from LYSA Centers
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: Sylvain P. Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie ‐Virginie Larcher, Momar Diouf, Luc Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne Tags: Research Article Source Type: research

Community Counts: Evolution of a National Surveillance System for Bleeding Disorders
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: Marilyn J. Manco ‐Johnson, Vanessa R. Byams, Michael Recht, Becky Dudley, Brandi Dupervil, Diane J. Aschman, Meredith Oakley, Suzanne Kapica, Mariam Voutsis, Steven Humes, Roshni Kulkarni, Althea M. Grant, Tags: Correspondence Source Type: research

Glucosylsphingosine is a reliable response biomarker in Gaucher disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: David Arkadir, Tama Dinur, Shoshana Revel ‐Vilk, Michal Becker Cohen, Claudia Cozma, Marina Hovakimyan, Sabrina Eichler, Arndt Rolfs, Ari Zimran Tags: Correspondence Source Type: research

Chronic neutrophilic leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 23, 2018 Category: Hematology Authors: Ahmad Khoder, Magda Al Obaidi, Anna Babb, Christine Liu, Nicholas C.P. Cross, Barbara J. Bain Tags: Morphology Update Source Type: research

Prognosis in Myelodysplastic Syndromes: The Attractions and Limitations of Simplicity
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 16, 2018 Category: Hematology Authors: David P. Steensma Tags: Commentary Source Type: research

A prospective analysis for prevalence of complications in Thai nontransfusion ‐dependent Hb E/β‐thalassemia and α‐thalassemia (Hb H disease)
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

Safety of anticoagulation in patients with atrial fibrillation and MDS/AML complicated by thrombocytopenia: An unresolved challenge: Can they be managed? A report of three cases and literature review
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

Glucose ‐6‐phosphate‐dehydrogenase deficient red blood cell units are associated with decreased posttransfusion red blood cell survival in children with sickle cell disease
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

Current and potential use of pathological targets in the treatment of Hodgkin lymphoma
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

Nationwide survey on the use of horse antithymocyte globulins (ATGAM) in patients with acquired aplastic anemia: A report on behalf of the French Reference Center for Aplastic Anemia
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Source Type: research

Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of 18F ‐FDG PET/CT in differentiation of nodal metastasis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Authors: Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci Tags: DIAGNOSTIC IMAGING IN HEMATOLOGY Source Type: research

A prospective analysis for prevalence of complications in Thai nontransfusion ‐dependent Hb E/β‐thalassemia and α‐thalassemia (Hb H disease)
Recently, complications in patients with nontransfusion‐dependent thalassemia (NTDT), in particular those with β‐thalassemia intermedia (β‐TI), were found to be significantly different from those in patients with transfusion dependent thalassemia (TDT), mainly β‐thalassemia major (β–TM). However, this information is rather limited in other forms of NTDT. In this prospective study, adult Thai NTDT patients were interviewed and clinically evaluated for thalassemia related complications. Fifty‐seven NTDT patients (age 18‐74 years), 59.6% Hb E/β‐thalassemia and 40.4% Hb H disease, w...
Source: American Journal of Hematology - February 14, 2018 Category: Hematology Authors: Supachai Ekwattanakit, Noppadol Siritanaratkul, Vip Viprakasit Tags: RESEARCH ARTICLE Source Type: research

EDTA ‐related degranulation mimicking storage pool disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 12, 2018 Category: Hematology Authors: Marco Amoruso, Lorenzo Alberio, Monika Nagy Tags: Images in Hematology Source Type: research

Predictive value of the new renal response criteria in AL amyloidosis treated with high dose melphalan and stem cell transplantation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 12, 2018 Category: Hematology Authors: Andrea Havasi, Gheorghe Doros, Vaishali Sanchorawala Tags: Correspondence Source Type: research

Lymphoproliferative disorders in patients with chronic myeloproliferative neoplasms: A systematic review
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 10, 2018 Category: Hematology Source Type: research

Phenotypes and survival in Erdheim ‐Chester disease: Results from a 165‐patient cohort
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 10, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 10, 2018 Category: Hematology Source Type: research

Mayo CALR mutation type classification guide using alpha helix propensity
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 9, 2018 Category: Hematology Authors: Terra L. Lasho, Christy M. Finke, Alexander Tischer, Animesh Pardanani, Ayalew Tefferi Tags: Correspondence Source Type: research

Decitabine improves response rate and prolongs progression ‐free survival in older patients with newly diagnosed acute myeloid leukemia and with monosomal karyotype: A subgroup analysis of the DACO‐016 trial
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Agnieszka Wierzbowska, Ewa Wawrzyniak, Agnieszka Pluta, Tadeusz Robak, Grzegorz J. Mazur, Anna Dmoszynska, Jaroslav Cermak, Albert Oriol, Daniel Lysak, Chris Arthur, Margaret Doyle, Liang Xiu, Farhad Ravandi, Hagop M. Kantarjian Tags: Correspondence Source Type: research

The spleen of patients with myelofibrosis harbors defective mesenchymal stromal cells
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Source Type: research

Long ‐term effects of crizotinib in ALK‐positive tumors (excluding NSCLC): A phase 1b open‐label study
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Source Type: research

Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial
Abstract Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia. This randomized, multicenter, double‐blind clinical trial compared the safety and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with iron deficiency anemia of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1.02 g and 1.50 g. Composite ...
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: N. Franklin Adkinson, William E. Strauss, Iain C. Macdougall, Kristine E. Bernard, Michael Auerbach, Robert F. Kaper, Glenn M. Chertow, Julie S. Krop Tags: Research Article Source Type: research

Longitudinal detection of DNMT3AR882H transcripts in patients with acute myeloid leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Tiziana Ottone, Valentina Alfonso, Licia Iaccarino, Syed Khizer Hasan, Melissa Mancini, Mariadomenica Divona, Serena Lavorgna, Laura Cicconi, Paola Panetta, Luca Maurillo, Maria Ilaria Del Principe, Maria Irno Consalvo, Luca Franceschini, Daniela Francesc Tags: Correspondence Source Type: research

Mutations and prognosis in myelodysplastic syndromes: Karyotype ‐adjusted analysis of targeted sequencing in 300 consecutive cases and development of a genetic risk model
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Naseema Gangat, Mythri Mudireddy, Terra L. Lasho, Christy M. Finke, Maura Nicolosi, Natasha Szuber, Mrinal M. Patnaik, Animesh Pardanani, Curtis A. Hanson, Rhett P. Ketterling, Ayalew Tefferi Tags: Research Article Source Type: research

Ruxolitinib as First ‐Line Treatment in Secondary Hemophagocytic Lymphohistiocytosis: A Second Experience
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 8, 2018 Category: Hematology Authors: Inuk Zandvakili, Caitlin B. Conboy, Ayed O. Ayed, Elizabeth J. Cathcart ‐Rake, Ayalew Tefferi Tags: Correspondence Source Type: research

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring
Abstract Disease overviewChronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults. DiagnosisCML is characterized by a balanced genetic translocation, t(9;22)(q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR‐ABL1 fusion oncogene, which in turn translates...
Source: American Journal of Hematology - February 7, 2018 Category: Hematology Authors: Elias Jabbour, Hagop Kantarjian Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue information – table of contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 7, 2018 Category: Hematology Tags: ISSUE INFORMATION – TABLE OF CONTENTS Source Type: research