Effectiveness and Safety of Anticoagulants for the Treatment of Venous Thromboembolism in Patients With Cancer
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 3, 2018 Category: Hematology Authors: Michael Blake Streiff, Dejan Milentijevic, Keith McCrae, Daniel Yannicelli, Jonathan Fortier, Winnie W. Nelson, Fran çois Laliberté, Concetta Crivera, Patrick Lefebvre, Jeff Schein, Alok A. Khorana Tags: Research Article Source Type: research

Flai (fludarabine, cytarabine, idarubicin) plus low ‐dose gemtuzumab ozogamicin as induction therapy in cd33‐positive aml: Final results and long term outcome of a phase ii multicenter clinical trial
Abstract The aim of this prospective clinical trial was to evaluate the efficacy and safety of a combination of Gemtuzumab‐Ozogamicin (GO) and FLAI scheme (fludarabine, cytarabine, idarubicin) as a first‐line therapy in CD33 positive acute myeloid leukemia (AML). We treated 130 consecutive patients, aged
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Anna Candoni, Cristina Papayannidis, Giovanni Martinelli, Erica Simeone, Michele Gottardi, Ilaria Iacobucci, Filippo Gherlinzoni, Giuseppe Visani, Michele Baccarani, Renato Fanin Tags: Research Article Source Type: research

N ‐acetyl‐L‐cysteine Improves Bone Marrow Endothelial Progenitor Cells in Prolonged Isolated Thrombocytopenia Patients post Allogeneic Hematopoietic Stem Cell Transplantation
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Yuan Kong, Min ‐Min Shi, Yuan‐Yuan Zhang, Xie‐Na Cao, Yu Wang, Xiao‐Hui Zhang, Lan‐Ping Xu, Xiao‐Jun Huang Tags: Research Article Source Type: research

Phenotypes and survival in Erdheim ‐Chester disease: Results from a 165‐patient cohort
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Fleur Cohen ‐Aubart, Jean‐François Emile, Fabrice Carrat, Zofia Helias‐Rodzewicz, Valérie Taly, Frédéric Charlotte, Philippe Cluzel, Jean Donadieu, Ahmed Idbaih, Stéphane Barete, Zahir Amoura, Julien Haroche Tags: Correspondence Source Type: research

Current and potential use of pathological targets in the treatment of Hodgkin lymphoma
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Antonino Carbone, Annunziata Gloghini Tags: Correspondence Source Type: research

Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)
(Source: American Journal of Hematology)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Najibah A. Galadanci, Shehu Umar Abdullahi, Leah D. Vance, Abdulkadir Musa Tabari, Shehi Ali, Raymond Belonwu, Auwal Salihu, Aisha Amal Galadanci, Binta Wudil Jibir, Halima Bello ‐Manga, Kathleen Neville, Fenella J. Kirkham, Yu Shyr, Sharon Phillips, Br Tags: ERRATUM Source Type: research

Multi ‐gene panel testing improves diagnosis and management of patients with hereditary anemias
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 1, 2018 Category: Hematology Authors: Roberta Russo, Immacolata Andolfo, Francesco Manna, Antonella Gambale, Roberta Marra, Barbara Eleni Rosato, Paola Caforio, Valeria Pinto, Piero Pignataro, Kottayam Radhakrishnan, Sule Unal, Giovanna Tomaiuolo, Gian Luca Forni, Achille Iolascon Tags: Research Article Source Type: research

Allogeneic hematopoietic stem cell transplant overcomes the adverse survival effect of very high risk and unfavorable karyotype in myelofibrosis
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 1, 2018 Category: Hematology Authors: Ayalew Tefferi, Daniel K. Partain, Jeanne M. Palmer, James L. Slack, Vivek Roy, William J. Hogan, Mark L. Litzow, Rhett P. Ketterling, Mrinal M. Patnaik Tags: Research Article Source Type: research

Microangiopathy and acute kidney injury in paroxysmal cold hemoglobinuria: A challenge for management
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 30, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 30, 2018 Category: Hematology Source Type: research

Microangiopathy and acute kidney injury in paroxysmal cold hemoglobinuria: A challenge for management
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 30, 2018 Category: Hematology Authors: Neill Storrar, Eve Miller ‐Hodges, John Neary, Jeremy Hughes, Nicole Priddee Tags: SOLVING CLINICAL PROBLEMS IN BLOOD DISEASES Source Type: research

Lymphoproliferative disorders in patients with chronic myeloproliferative neoplasms: A systematic review
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 28, 2018 Category: Hematology Authors: Monia Marchetti, Alessandra Carobbio, Enrica Capitoni, Tiziano Barbui Tags: Research Article Source Type: research

Methylene blue ‐induced Heinz body hemolytic anemia in a premature neonate
American Journal of Hematology, EarlyView. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Source Type: research

You don't always get what you want: Does hypoxia cause sickle cell crisis?
American Journal of Hematology,Volume 93, Issue 4, Page 475-477, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Source Type: research

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American Journal of Hematology, Ahead of Print. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 475-477, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Source Type: research

You don't always get what you want: Does hypoxia cause sickle cell crisis?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: Thomas D Coates Tags: Commentary Source Type: research

Glucose ‐6‐Phosphate‐Dehydrogenase Deficient Red Blood Cell Units are Associated with Decreased Post‐Transfusion Red Blood Cell Survival in Children with Sickle Cell Disease
Abstract Chronic transfusion therapy (CTT) for sickle cell disease (SCD) reduces disease morbidity by suppressing the amount of circulating hemoglobin S (HbS)‐containing red blood cells (RBC). The effectiveness of CTT depends on the rate of RBC clearance. Glucose‐6‐phosphate dehydrogenase (G6PD) deficient donor RBC may exhibit increased hemolysis, but it is unknown if transfusion of these units results in less effective transfusion outcomes in SCD. Children with SCD on CTT were followed prospectively for multiple transfusions. G6PD activity of transfused units was measured prior to expiration date. HbA clearance (&De...
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: Eyal Sagiv, Ross M. Fasano, Naomi L.C. Luban, Cassandra D. Josephson, Sean R. Stowell, John D. Roback, Richard O. Francis, Marianne E.M. Yee Tags: Research Article Source Type: research

Nationwide Survey on the Use of Horse Antithymocyte Globulins (ATGAM) in Patients with Acquired Aplastic Anemia: A Report on Behalf of the French Reference Center for Aplastic Anemia
This study does illustrate the results of ATGAM with CSA in a true‐life perspective and confirms ATGAM as standard of care IST to treat patients with AA not eligible for HSCT. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 27, 2018 Category: Hematology Authors: R égis Peffault de Latour, Reza Tabrizi, Ambroise Marcais, Thierry Leblanc, Thierry Lamy, Mohamad Mohty, Suzanne Tavitian, Charlotte Jubert, Marlène Pasquet, Claire Galambrun, Stéphanie Nguyen, Jean Yves Cahn, Thorsten Braun, Eric Deconinck, Jacques Ol Tags: Research Article Source Type: research

Toward complement inhibition 2.0: Next generation anticomplement agents for paroxysmal nocturnal hemoglobinuria
Abstract Therapeutic complement inhibition by eculizumab has revolutionized the treatment of paroxysmal nocturnal hemoglobinuria (PNH) with a major impact on its natural history. Nevertheless, emerging unmet clinical needs may benefit from the development of novel complement inhibitors. Novel strategies of complement inhibition exploit different agents targeting C5, as well as compound intercepting the complement cascade at the level of its key component C3, or even upstream at the level of components involved in complement alternative pathway initiation. Many of these agents are already in their clinical development; prel...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Antonio M. Risitano, Serena Marotta Tags: UPDATES IN CLINICAL TRIALS FOR HEMATOLOGICAL DISEASES Source Type: research

Age is a predictor of a small decrease in lung function in children with sickle cell anemia
Abstract The longitudinal pattern of lung function in children with sickle cell anemia (SCA) has shown a decrease in FEV1% predicted, a risk factor for death in adults with SCA, but predictors for this decline are poorly characterized. In a prospective longitudinal multi‐center cohort of children with SCA, we tested the hypotheses that: (1) FEV1% predicted declines over time; and (2) SCA‐specific characteristics and therapy predict this decline. At three clinical centers, children with SCA (HbSS or HbSβ0 thalassemia), unselected for respiratory disease, were enrolled in the Sleep and Asthma Cohort (SAC) study. Stu...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Shaina M. Willen, Robyn Cohen, Mark Rodeghier, Fenella Kirkham, Susan S. Redline, Carol Rosen, Jane Kirkby, Michael R. DeBaun Tags: RESEARCH ARTICLE Source Type: research

Efficacy and safety of rituximab for systemic lupus erythematosus ‐associated immune cytopenias: A multicenter retrospective cohort study of 71 adults
In conclusion, RTX seems effective and relatively safe for treating SLE‐associated immune cytopenias. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Alexandra Serris, Zahir Amoura, Florence Canou ï‐Poitrine, Benjamin Terrier, Eric Hachulla, Nathalie Costedoat‐Chalumeau, Thomas Papo, Olivier Lambotte, David Saadoun, Miguel Hié, Philippe Blanche, Bertrand Lioger, Jacques‐Eric Gottenberg, Bertran Tags: RESEARCH ARTICLE Source Type: research

Centrifugation ‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells
Abstract Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation‐based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here, we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4‐6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using...
Source: American Journal of Hematology - January 25, 2018 Category: Hematology Authors: Eszter V örös, Nathaniel Z. Piety, Briony C. Strachan, Madeleine Lu, Sergey S. Shevkoplyas Tags: RESEARCH ARTICLE Source Type: research

A prospective analysis for prevalence of complications in Thai non ‐transfusion‐dependent Hb E/β‐thalassemia and α‐thalassemia (Hb H disease)
Conclusions: For the first time, this prospective study provided the current prevalence of NTDT related complications in a Southeast Asian population with a different underlying genetic basis compared with previous studies. Although individual prevalence of each complication might differ from other studies, several important clinical factors such as splenectomy, degree of anemia, and iron overload seem to be determining risks of developing these complications consistently across different ethnicities. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 23, 2018 Category: Hematology Authors: Supachai Ekwattanakit, Noppadol Siritanaratkul, Vip Viprakasit Tags: Research Article Source Type: research

The spleen of patients with myelofibrosis harbors defective mesenchymal stromal cells
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 23, 2018 Category: Hematology Authors: Maria Antonietta Avanzini, Vittorio Abbonante, Paolo Catarsi, Irene Dambruoso, Melissa Mantelli, Valentina Poletto, Elisa Lenta, Paola Guglielmelli, Stefania Croce, Lorenzo Cobianchi, Basilio Jemos, Rita Campanelli, Elisa Bonetti, Christian Andrea Di Budu Tags: Research Article Source Type: research

Safety of anticoagulation in patients with atrial fibrillation and MDS/AML complicated by thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 21, 2018 Category: Hematology Authors: Jessica Caro, Shyamala Navada Tags: Correspondence Source Type: research

Voxelotor (GBT440), a first ‐in‐class hemoglobin oxygen‐affinity modulator, has promising and reassuring preclinical and clinical data
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Jeremie H. Estepp Tags: Commentary Source Type: research

Long ‐term effects of crizotinib in ALK‐positive tumors (excluding NSCLC): A phase 1b open‐label study
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Carlo Gambacorti ‐Passerini, Sergey Orlov, Li Zhang, Fadi Braiteh, Huiqiang Huang, Taito Esaki, Keizo Horibe, Jin‐Seok Ahn, Joseph T. Beck, William Jeffrey Edenfield, Yuankai Shi, Matthew Taylor, Kenji Tamura, Brian A. Van Tine, Shang‐Ju Wu, Jolanda Tags: Research Article Source Type: research

Band 3 phosphorylation induces irreversible alterations of stored red blood cells
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 20, 2018 Category: Hematology Authors: Slim Azouzi, Marc Romana, Nobuto Arashiki, Yuichi Takakuwa, Wassim El Nemer, Thierry Peyrard, Yves Colin, Pascal Amireault, Caroline Le Van Kim Tags: Correspondence Source Type: research

Pan ‐Pseudothrombocytopenia: An Unusual Case of Platelet Clumping
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Hany Elmariah, Satish Shanbhag Tags: Images in Hematology Source Type: research

Concomitant cutaneous squamous cell carcinoma and chronic lymphocytic leukemia in a patient: The utility of 18F ‐FDG PET/CT in differentiation of nodal metastasis
American Journal of Hematology,Volume 93, Issue 4, Page 597-598, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 597-598, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Source Type: research

Evans syndrome secondary to undiagnosed chronic lymphocytic leukemia in a patient with unexplained bleeding
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Christopher B. Hergott, Olga Pozdnyakova Tags: Images in Hematology Source Type: research

Microangiopathy and acute kidney injury in paroxysmal cold haemoglobinuria – a challenge for management
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Neill Storrar, Eve Miller ‐Hodges, John Neary, Jeremy Hughes, Nicole Priddee Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Concomitant cutaneous squamous cell carcinoma and CLL in a patient: The utility of 18F ‐ FDG PET/CT in differentiation of nodal metastasis
Conclusion: This report describes the role of 18F‐FDG PET/CT in differentiation of the single sub‐centimeter metastatic nodal disease from cSCC from the remainder innumerable leukemia infiltrated nodes. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 17, 2018 Category: Hematology Authors: Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci Tags: Diagnostic Imaging in Hematology Source Type: research

Urinary Orosomucoid is Associated with Progressive Chronic Kidney Disease Stage in Patients with Sickle Cell Anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Marina Jerebtsova, Santosh L. Saraf, Simran Soni, Nowah Afangbedji, Xionghao Lin, Rasha Raslan, Victor R. Gordeuk, Sergei Nekhai Tags: Correspondence Source Type: research

A retrospective survey of exposure history to chemotherapy or radiotherapy in 940 consecutive patients with primary myelofibrosis
American Journal of Hematology,Volume 93, Issue 4, Page E103-E107, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Source Type: research

Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia
American Journal of Hematology,Volume 93, Issue 4, Page E107-E109, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E103-E107, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E107-E109, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Source Type: research

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function
Abstract The extracellular matrix (ECM) is a key acellular structure in constant remodeling to provide tissue cohesion and rigidity. Deregulation of the balance between matrix deposition, degradation, and crosslinking results in fibrosis. Bone marrow fibrosis (BMF) is associated with several malignant and nonmalignant pathologies severely affecting blood cell production. BMF results from abnormal deposition of collagen fibers and enhanced lysyl oxidase‐mediated ECM crosslinking within the marrow, thereby increasing marrow stiffness. Bone marrow stiffness has been recently recognized as an important regulator of blood cel...
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Orly Leiva, Catherine Leon, Seng Kah Ng, Pierre Mangin, Christian Gachet, Katya Ravid Tags: CRITICAL REVIEW Source Type: research

A retrospective survey of exposure history to chemotherapy or radiotherapy in 940 consecutive patients with primary myelofibrosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 12, 2018 Category: Hematology Authors: Maura Nicolosi, Mythri Mudireddy, Mrinal M. Patnaik, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi Tags: Correspondence Source Type: research

Inhaled Corticosteroid Use to Prevent Severe Vaso ‐occlusive Episode Recurrence in Children Between 1 and 4 With Sickle Cell Disease: A Multicenter Feasibility Trial
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Authors: Leah Vance Utset, Zalaya Ivy, Shaina M. Willen, Mark Rodeghier, Amanda Watt, Leann Schilling, Chantel L. Jenkins, Stefanie Pepper, Barbara Speller ‐Brown, Deepika S. Darbari, Suvankar Majumdar, Olufolake Adisa, Michael R. DeBaun Tags: Correspondence Source Type: research

Inhaled corticosteroid use to prevent severe vaso ‐occlusive episode recurrence in children between 1 and 4 years of age with sickle cell disease: a multicenter feasibility trial
American Journal of Hematology,Volume 93, Issue 4, Page E101-E103, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Source Type: research

Effect of eptifibatide on inflammation during acute pain episodes in sickle cell disease
American Journal of Hematology,Volume 93, Issue 4, Page E99-E101, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E101-E103, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E99-E101, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Source Type: research

Effect of Eptifibatide on Inflammation During Acute Pain Episodes in Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - January 11, 2018 Category: Hematology Authors: Julia E. Brittain, Ciprian Anea, Payal Desai, Jack Delaney, Adam McDonald, Stephen W. Looney, Nigel S. Key, Leslie V. Parise, Kenneth I. Ataga Tags: Correspondence Source Type: research