Pulmonary and cerebral microvasculopathy in a patient with sickle cell disease: A role for dense red blood cells?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Amandine Ségot, Jean‐François Deux, Titien Thuillier, Bernard Maitre, Frédéric Galactéros, Pablo Bartolucci Tags: Imaging in Hematology Source Type: research

Deferiprone‐induced agranulocytosis: 20 years of clinical observations
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Fernando Tricta, Jack Uetrecht, Renzo Galanello, John Connelly, Anna Rozova, Michael Spino, Jan Palmblad Tags: Research Article Source Type: research

Management of relapsed and refractory multiple myeloma in modern times: Incorporating new agents into decision‐making
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Charles A. Clark, Robert F. Cornell, Emma C. Scott, Jae Chung, Luciano J Costa Tags: Critical Review Source Type: research

Neuroblastoma in the bone marrow
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Edward Renaudon‐Smith, Marc Arca, Akwasi Osei‐Yeboah, Leena Karnik, Barbara J. Bain Tags: Morphology Update Source Type: research

The Prognostic Impact of Bone Marrow Fibrosis in Primary Myelofibrosis. Reply
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Paola Guglielmelli, Alessandro M. Vannucchi, Tags: Correspondence Source Type: research

Histological transformation to diffuse large B‐cell lymphoma in patients with Waldenström macroglobulinemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 13, 2016 Category: Hematology Authors: Jorge J. Castillo, Joshua Gustine, Kirsten Meid, Toni Dubeau, Zachary R. Hunter, Steven P. Treon Tags: Research Article Source Type: research

MR Imaging in non ‐hepatosplenic extramedullary hematopoiesis in primary myelofibrosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 11, 2016 Category: Hematology Authors: Linda Calistri, Lisa Pieri, Raffaella Santi, Cosimo Nardi, Alessandro Maria Vannucchi, Stefano Colagrande Tags: Images in Hematology Source Type: research

Unrelated donors are associated with improved relapse ‐free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation
Reduced intensity allogeneic stem cell transplantation (RI alloSCT) is a potentially curative treatment approach for patients with myelodysplastic syndrome (MDS). It is currently unclear if older related donors are better than younger unrelated donors for patients with MDS undergoing RI alloSCT. We retrospectively studied 53 consecutive MDS patients who underwent RI alloSCT between April 2007 and June 2014 and evaluated associations between donor type and outcomes with adjustment for significant covariates. 34 patients (median age: 64 years) and 19 patients (median age: 60 years) received allografts from unrelated and rela...
Source: American Journal of Hematology - July 11, 2016 Category: Hematology Authors: Clinton Yam, Lisa Crisalli, Selina M. Luger, Alison W. Loren, Elizabeth O. Hexner, Noelle V. Frey, James K. Mangan, Amy Gao, Edward A. Stadtmauer, David L. Porter, Ran Reshef Tags: Research Article Source Type: research

Unrelated donors are associated with improved relapse‐free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation
Reduced intensity allogeneic stem cell transplantation (RI alloSCT) is a potentially curative treatment approach for patients with myelodysplastic syndrome (MDS). It is currently unclear if older related donors are better than younger unrelated donors for patients with MDS undergoing RI alloSCT. We retrospectively studied 53 consecutive MDS patients who underwent RI alloSCT between April 2007 and June 2014 and evaluated associations between donor type and outcomes with adjustment for significant covariates. 34 patients (median age: 64 years) and 19 patients (median age: 60 years) received allografts from unrelated and rela...
Source: American Journal of Hematology - July 11, 2016 Category: Hematology Authors: Clinton Yam, Lisa Crisalli, Selina M. Luger, Alison W. Loren, Elizabeth O. Hexner, Noelle V. Frey, James K. Mangan, Amy Gao, Edward A. Stadtmauer, David L. Porter, Ran Reshef Tags: Research Article Source Type: research

Circulating aberrant plasma cells allow risk stratification of patients with myeloma
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 11, 2016 Category: Hematology Authors: Adela Periago, José A. Campillo, Anna Mrowiec, Lourdes Gimeno, Natividad R. Montes, María V. Martínez‐Sánchez, Valentin Cabañas‐Perianes, Carmen García‐Garay, José M. Bolarin, Adela Blasco‐Mogorrón, Manuel Muro, Mercedes Berenguer, José M Tags: Correspondence Source Type: research

Impact of blood transfusion on gene expression in human reticulocytes
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 6, 2016 Category: Hematology Authors: Olivier Salamin, Laura Barras, Neil Robinson, Norbert Baume, Jean‐Daniel Tissot, Yannis Pitsiladis, Martial Saugy, Nicolas Leuenberger Tags: Correspondence Source Type: research

A Phase II study of two dose levels of ofatumumab induction followed by maintenance therapy in symptomatic, previously untreated chronic lymphocytic leukemia (CLL)
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - July 6, 2016 Category: Hematology Authors: Ian W. Flinn, Amy S. Ruppert, William Harwin, David Waterhouse, Steven Papish, Jeffrey A Jones, John Hainsworth, John C. Byrd Tags: Research Article Source Type: research

Dense red blood cell and oxygen desaturation in sickle ‐cell disease
Abstract Production of abnormal hemoglobin (HbS) in sickle‐cell disease (SCD) results in its polymerization in deoxygenated conditions and in sickled‐RBC formation. Dense RBCs (DRBCs), defined as density>1.11 and characterized by increased rigidity are absent in normal AA subjects, but present at percentages that vary of a patient to another remaining stable throughout adulthood for each patient. Polymerized HbS has reduced affinity for oxygen, demonstrated by the rightward shift of the oxygen‐dissociation curve, leading to disturbances in oxygen transport. Ninety‐two SCD patients' total RBCs were separated into...
Source: American Journal of Hematology - July 5, 2016 Category: Hematology Authors: Gaetana Di Liberto, Laurent Kiger, Michael C. Marden, Laurent Boyer, Florence Canoui Poitrine, Marc Conti, Marie Georgine Rakotoson, Anoosha Habibi, Sanam Khorgami, Benoit Vingert, Bernard Maitre, Fr édéric Galactéros, France Pirenne, Pablo Bartolucci Tags: Research Article Source Type: research

Dense red blood cell and oxygen desaturation in sickle‐cell disease
Abstract Production of abnormal hemoglobin (HbS) in sickle‐cell disease (SCD) results in its polymerization in deoxygenated conditions and in sickled‐RBC formation. Dense RBCs (DRBCs), defined as density>1.11 and characterized by increased rigidity are absent in normal AA subjects, but present at percentages that vary of a patient to another remaining stable throughout adulthood for each patient. Polymerized HbS has reduced affinity for oxygen, demonstrated by the rightward shift of the oxygen‐dissociation curve, leading to disturbances in oxygen transport. Ninety‐two SCD patients' total RBCs were separated into...
Source: American Journal of Hematology - July 5, 2016 Category: Hematology Authors: Gaetana Di Liberto, Laurent Kiger, Michael C. Marden, Laurent Boyer, Florence Canoui Poitrine, Marc Conti, Marie Georgine Rakotoson, Anoosha Habibi, Sanam Khorgami, Benoit Vingert, Bernard Maitre, Frédéric Galactéros, France Noizat‐Pirenne, Pablo Bar Tags: Research Article Source Type: research

The scientific legacy of Ronald L. Nagel (1936 –2016), a true renaissance man
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Eric E. Bouhassira, Henny H. Billett, Mary E. Fabry, Rhoda E. Hirsch, Rajagopal Krishnamoorthy Tags: Commentary Source Type: research

Monocyte aggregates: A clue to an unsuspected monoclonal B ‐cell lymphoproliferative disorder
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Lynh Nguyen, Ronald Cleveland, Lawrence Kass Tags: Correspondence Source Type: research

A giant adrenal myelolipoma in a beta ‐thalassemia major patient: Does ineffective erythropoiesis play a role?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Irene Motta, Leonardo Boiocchi, Paola Delbini, Margherita Migone De Amicis, Elena Cassinerio, Daniele Dondossola, Giorgio Rossi, Maria Domenica Cappellini Tags: Images in Hematology Source Type: research

Successful management of mixed chimerism after bone marrow transplant in beta ‐thalassemia major
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Gabriele Kropshofer, Sieghart Sopper, Michael Steurer, Wolfgang Schwinger, Roman Crazzolara Tags: Correspondence Source Type: research

The scientific legacy of Ronald L. Nagel (1936–2016), a true renaissance man
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Eric E. Bouhassira, Henny H. Billett, Mary E. Fabry, Rhoda E. Hirsch, Rajagopal Krishnamoorthy Tags: Commentary Source Type: research

Erythroblast morphology in refractory anemia with ring sideroblasts and thrombocytosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: Giovanni Caocci, Giorgio La Nasa, Barbara J. Bain Tags: Morphology Update Source Type: research

Epigenetically centered evolution in an example of myeloid malignancy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - July 3, 2016 Category: Hematology Authors: josé adélaide, nathalie cervera, nadine carbuccia, séverine garnier, arnaud guille, marie‐joelle mozziconnaci, raynier devillier, max chaffanet, norbert vey, daniel birnbaum, véronique gelsi‐boyer Tags: Correspondence Source Type: research

Adolescent Fatigue: Is Intravenous Iron a Better Solution?
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 30, 2016 Category: Hematology Authors: Richard Derman, Michael Auerbach Tags: Commentary Source Type: research

Improving prognostic tools in systemic mastocytosis: Insights from mutations
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 30, 2016 Category: Hematology Authors: Lisa Pieri, Alessandro M. Vannucchi Tags: Commentary Source Type: research

Intense focal pituitary FDG uptake due to Intravascular Large B‐Cell Lymphoma in Pyrexia of Unknown Origin
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 30, 2016 Category: Hematology Authors: David A. Pattison, Michael S. Hofman, Ali Bazargan, Peter Colman, Rodney J. Hicks Tags: Diagnostic Imaging in Hematology Source Type: research

Development and validation of multivariable predictive model for thromboembolic events in lymphoma patients
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 30, 2016 Category: Hematology Authors: Darko Antic, Natasa Milic, Srdjan Nikolovski, Milena Todorovic, Jelena Bila, Predrag Djurdjevic, Bosko Andjelic, Vladislava Djurasinovic, Aleksandra Sretenovic, Vojin Vukovic, Jelena Jelicic, Suzanne Hayman, Biljana Mihaljevic Tags: Research Article Source Type: research

Impact of sarcopenia on treatment tolerance in United States veterans with diffuse large B‐cell lymphoma treated with CHOP‐based chemotherapy
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 30, 2016 Category: Hematology Authors: Daphne Y. Xiao, Suhong Luo, Katiuscia O'Brian, Arun Ganti, Peter Riedell, Kristen M. Sanfilippo, Ryan C. Lynch, Weijian Liu, Kenneth R. Carson Tags: Research Article Source Type: research

Final results of a single institution experience with a pediatric ‐based regimen, the augmented Berlin–Frankfurt–Münster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper‐CVAD regimen
Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric‐based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin–Frankfurt–Münster (ABFM) regimen, and its comparison with hyper‐fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone (hyper‐CVAD) in AYA patients. One hundred and six AYA patients (median age 22 years) with Philadelphia chromosome‐ (Ph) negative ALL received ABFM from October 2006 through March 2014. Their outcome was compared to 102 AYA pati...
Source: American Journal of Hematology - June 29, 2016 Category: Hematology Authors: Michael E. Rytting, Elias J. Jabbour, Jeffrey L. Jorgensen, Farhad Ravandi, Anna R. Franklin, Tapan M. Kadia, Naveen Pemmaraju, Naval G. Daver, Alessandra Ferrajoli, Guillermo Garcia ‐Manero, Marina Y. Konopleva, Gautam Borthakur, Rebecca Garris, Sa Wan Tags: Original Article Source Type: research

Impact of sarcopenia on treatment tolerance in United States veterans with diffuse large B ‐cell lymphoma treated with CHOP‐based chemotherapy
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 29, 2016 Category: Hematology Authors: Daphne Y. Xiao, Suhong Luo, Katiuscia O'Brian, Arun Ganti, Peter Riedell, Kristen M. Sanfilippo, Ryan C. Lynch, Weijian Liu, Kenneth R. Carson Tags: Research Article Source Type: research

Validation of new renal staging system in AL amyloidosis treated with high dose melphalan and stem cell transplantation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 29, 2016 Category: Hematology Authors: Andrea Havasi, Lauren Stern, Stephen Lo, Fangui Sun, Vaishali Sanchorawala Tags: Correspondence Source Type: research

Intravenous Iron Therapy in Non‐Anemic Iron‐Deficient Menstruating Adolescent Females with Fatigue
Abstract Menstruating women, with or without underlying bleeding disorders, are at increased risk for developing iron deficiency‐related fatigue, even in the absence of anemia. Oral iron therapy has limitations which include poor absorption and non‐adherence due to gastrointestinal side effects. We performed a prospective clinical trial of post‐menarchal adolescent females with iron‐deficiency with or without mild anemia and fatigue who received a standardized regimen of intravenous iron sucrose. The baseline mean (SD) hemoglobin was 11.96 g/dl (1.05) in 20 girls (ages 14‐21 years); with a range of 10.3‐14.1 g/...
Source: American Journal of Hematology - June 29, 2016 Category: Hematology Authors: Ruchika Sharma, Joseph R. Stanek, Terah L. Koch, Linda Grooms, Sarah H. O'Brien Tags: Research Article Source Type: research

Transplant‐associated thrombotic microangiopathy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 28, 2016 Category: Hematology Authors: Edward Renaudon‐Smith, Josu De La Fuente, Barbara J. Bain Tags: Morphology Update Source Type: research

Health‐Related Quality of Life and Burden of Fatigue in Patients with Primary Immune Thrombocytopenia by Phase of Disease
Abstract The main objective of this study was to compare health‐related quality of life (HRQOL) of primary immune thrombocytopenia (pITP) patients with that of general population, overall, and by patient group (i.e., newly diagnosed, persistent, and chronic patients). Fatigue was also investigated as a secondary objective. Overall, 424 adult patients were enrolled in a multicenter observational study and the control group consisted of a representative sample from the general population. Propensity score matching plus further multivariate linear regression adjustment was used to compare HRQOL outcomes between pITP patient...
Source: American Journal of Hematology - June 27, 2016 Category: Hematology Authors: Fabio Efficace, Franco Mandelli, Paola Fazi, Cristina Santoro, Gianluca Gaidano, Francesco Cottone, Alessandra Borchiellini, Monica Carpenedo, Maria Pina Simula, Valeria Di Giacomo, Micaela Bergamaschi, Iolanda Donatella Vincelli, Francesco Rodeghiero, Ma Tags: Research Article Source Type: research

Delayed hemolytic transfusion reaction in adult sickle‐cell disease: Presentations, outcomes and treatments of 99 referral center episodes
In conclusion, clinicians and patients must recognize early DHTR signs to avoid additional transfusions. For patients with a history of RBC immunization or DHTR, transfusion indications should be restricted. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 26, 2016 Category: Hematology Authors: Anoosha Habibi, Armand Mekontso‐Dessap, Constance Guillaud, Marc Michel, Keyvan Razazi, Mehdi Khellaf, Btissam Chami, Dora Bachir, Claire Rieux, Giovanna Melica, Bertrand Godeau, Frédéric Galacteros, Pablo Bartolucci, France Pirenne Tags: Research Article Source Type: research

Deferasirox in thalassemia patients with end‐stage renal disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 25, 2016 Category: Hematology Authors: Hassan G. Beydoun, Antoine N. Saliba, Ali T. Taher Tags: Correspondence Source Type: research

Phase I study of evofosfamide, an investigational hypoxia ‐activated prodrug, in patients with advanced leukemia
Tumor hypoxia causes resistance to radiation and chemotherapy. Evofosfamide (TH‐302) has exhibited specific hypoxia‐dependent cytotoxicity against primary acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) samples in vitro. Based on these findings, a Phase I study of evofosfamide was designed for patients with relapsed/refractory leukemia (NCT01149915). In this open‐label study, patients were treated with evofosfamide as a 30–60 min/day infusion on Days 1–5 of a 21–day cycle (Arm A, n = 38) or as a continuous infusion over 120 hr over Days 1–5 of a 21‐day cycle...
Source: American Journal of Hematology - June 24, 2016 Category: Hematology Authors: Talha Badar, Damian R. Handisides, Juliana M. Benito, Mary Ann Richie, Gautam Borthakur, Elias Jabbour, Karine Harutyunyan, Sergej Konoplev, Stefan Faderl, Stew Kroll, Michael Andreeff, Tillman Pearce, Hagop M. Kantarjian, Jorge E. Cortes, Deborah A. Thom Tags: Original Article Source Type: research

Are we missing the mark? Fever, respiratory symptoms, chest radiographs, and acute chest syndrome in sickle cell disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 24, 2016 Category: Hematology Authors: Sarah G. Lazarus, Michael Kelleman, Olufolake Adisa, April R. Zmitrovich, Robert Hagbom, Stephanie Cohen, Courtney E. McCracken, Claudia R. Morris Tags: Correspondence Source Type: research

Phase I study of evofosfamide, an investigational hypoxia‐activated prodrug, in patients with advanced leukemia
Tumor hypoxia causes resistance to radiation and chemotherapy. Evofosfamide (TH‐302) has exhibited specific hypoxia‐dependent cytotoxicity against primary acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) samples in vitro. Based on these findings, a Phase I study of evofosfamide was designed for patients with relapsed/refractory leukemia (NCT01149915). In this open‐label study, patients were treated with evofosfamide as a 30–60 min/day infusion on Days 1–5 of a 21–day cycle (Arm A, n = 38) or as a continuous infusion over 120 hr over Days 1–5 of a 21‐day cycle...
Source: American Journal of Hematology - June 24, 2016 Category: Hematology Authors: Talha Badar, Damian R. Handisides, Juliana M. Benito, Mary Ann Richie, Gautam Borthakur, Elias Jabbour, Karine Harutyunyan, Sergej Konoplev, Stefan Faderl, Stew Kroll, Michael Andreeff, Tillman Pearce, Hagop M. Kantarjian, Jorge E. Cortes, Deborah A. Thom Tags: Research Article Source Type: research

Usual risk factors do not predict venous thromboembolism in newly diagnosed myeloma treated with immunomodulatory drugs
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 24, 2016 Category: Hematology Authors: Emilie Chalayer, Céline Chapelle, Xavier Leleu, Ismail Elalamy, Silvy Laporte, Bernard Tardy Tags: Correspondence Source Type: research

The Prognostic Impact of Bone Marrow Fibrosis in Primary Myelofibrosis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 23, 2016 Category: Hematology Authors: Michelle A Elliott, Ayalew Tefferi Tags: Correspondence Source Type: research

FISHing in the dark: How the combination of FISH and conventional karyotyping improves the diagnostic yield in CpG‐stimulated Chronic Lymphocytic Leukemia (CLL)
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 23, 2016 Category: Hematology Authors: Adrian M. Dubuc, Matthew S. Davids, Mirela Pulluqi, Olja Pulluqi, Kevin Hoang, Jesus M Hernandez‐Sánchez, Cathy Schlich, Jesus M Hernández‐Rivas, Jennifer R Brown, Paola Dal Cin Tags: Research Article Source Type: research

Mixed angioinvasive Exserohilum and Scedosporium infection in a patient with AML
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 23, 2016 Category: Hematology Authors: Preetesh Jain, Priyadharsini Nagarajan, Parikshit Prayag, Christopher B. Benton, Tapan Kadia, Roman Groisberg, Dimitrios P. Kontoyiannis, Victor E. Mulanovich, Naveen Pemmaraju Tags: Images in Hematology Source Type: research

Induction Therapy Pre‐Autologous Stem Cell Transplantation in Immunoglobulin Light Chain Amyloidosis: A Retrospective Evaluation
This study investigated the relationships between baseline bone marrow plasmacytosis (BMPC), cardiac staging, and pre‐transplant induction in AL patients. All patients who received ASCT for AL within 12 months of diagnosis were included. Patient characteristics and outcomes were abstracted. Univariate and multivariate modeling was performed. Among 415 AL patients, 35% had induction prior to ASCT. Post‐ASCT hematologic CR plus VGPR rates were significantly higher in those with baseline BMPC ≤ 10% compared to BMPC>10% (58% versus 40%, p=0.0013). Significant risk factors for lack of attainment of CR in...
Source: American Journal of Hematology - June 23, 2016 Category: Hematology Authors: Yi L Hwa, Shaji K Kumar, Morie A Gertz, Martha Q Lacy, Francis K Buadi, Taxiarchis V Kourelis, Wilson I Gonsalves, S. Vincent Rajkumar, Ronald S Go, Nelson Leung, Prashant Kapoor, David Dingli, Robert A Kyle, Stephen Russell, John A lust, Suzanne R Hayman Tags: Research Article Source Type: research

CA‐125 secreting IgG kappa Multiple Myeloma (MM)
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 23, 2016 Category: Hematology Authors: Mariam Boota, Carolina Schinke, Shawn Ledoux, Daisy Alapat, Rashid Khan, Bart Barlogie Tags: Correspondence Source Type: research

Dasatinib in imatinib ‐resistant or ‐intolerant chronic‐phase, chronic myeloid leukemia patients: 7‐year follow‐up of study CA180‐034
Dasatinib was approved at 100 mg once daily for imatinib‐resistant or ‐intolerant patients with chronic myeloid leukemia (CML) in chronic phase, based on results of the phase 3 CA180‐034 (NCT00123474) study. Here we present the final 7‐year analysis of this pivotal study, the longest follow‐up to date of any second‐generation BCR–ABL1 tyrosine kinase inhibitor (TKI). Patients (n = 670) with imatinib‐resistant or ‐intolerant CML in chronic phase received dasatinib. Nineteen percent of patients continued on study treatment, with a greater proportion in the 100 mg once daily arm remai...
Source: American Journal of Hematology - June 19, 2016 Category: Hematology Authors: Neil P. Shah, Philippe Rousselot, Charles Schiffer, Delphine Rea, Jorge E. Cortes, Jorge Milone, Hesham Mohamed, Diane Healey, Hagop Kantarjian, Andreas Hochhaus, Giuseppe Saglio Tags: Research Article Source Type: research

Next ‐generation sequencing in systemic mastocytosis: Derivation of a mutation‐augmented clinical prognostic model for survival
In routine practice, the World Health Organization classification of systemic mastocytosis (SM) is also the de facto prognostic system; a core value is distinguishing indolent (ISM) from advanced SM (includes aggressive SM [ASM], SM with associated hematological neoplasm [SM‐AHN] and mast cell leukemia [MCL]). We sequenced 27 genes in 150 SM patients to identify mutations that could be integrated into a clinical‐molecular prognostic model for survival. Forty four patients (29%) had ISM, 25 (17%) ASM, 80 (53%) SM‐AHN and 1 (0.7%) MCL; overall KITD816V prevalence was 75%. In 87 patients, 148 non‐KIT mutations were de...
Source: American Journal of Hematology - June 19, 2016 Category: Hematology Authors: Animesh Pardanani, Terra Lasho, Yoseph Elala, Emnet Wassie, Christy Finke, Kaaren K. Reichard, Dong Chen, Curtis A. Hanson, Rhett P. Ketterling, Ayalew Tefferi Tags: Research Article Source Type: research

Gender and duration of disease differentiate responses to rituximab –dexamethasone therapy in adults with immune thrombocytopenia
Adults often develop chronic immune thrombocytopenia (ITP) for which treatment order is uncertain. Rituximab and three cycles of dexamethasone (4R + 3Dex) improve treatment responses and short‐term disease control but long‐term outcome is not known. In adults with ITP treated with 4R + 3D, we sought long‐term outcome and associated prognostic variables. Forty‐nine adults treated at Weill‐Cornell received 4R + 3Dex. Their clinical characteristics were reviewed. Duration was median time to treatment failure; Kaplan‐Meier estimates were developed. Vbeta Tcell receptor (VBT...
Source: American Journal of Hematology - June 19, 2016 Category: Hematology Authors: John Chapin, Christina S. Lee, Haiyu Zhang, James L. Zehnder, James B. Bussel Tags: Research Article Source Type: research

Long ‐term therapy‐free remission in a patient with platelet‐derived growth factor receptor beta‐rearranged myeloproliferative neoplasm
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 19, 2016 Category: Hematology Authors: marco cerrano, elena cris à, enrico gottardi, chiara aguzzi, mario boccadoro, dario ferrero Tags: Correspondence Source Type: research

Gender and duration of disease differentiate responses to rituximab–dexamethasone therapy in adults with immune thrombocytopenia
Adults often develop chronic immune thrombocytopenia (ITP) for which treatment order is uncertain. Rituximab and three cycles of dexamethasone (4R + 3Dex) improve treatment responses and short‐term disease control but long‐term outcome is not known. In adults with ITP treated with 4R + 3D, we sought long‐term outcome and associated prognostic variables. Forty‐nine adults treated at Weill‐Cornell received 4R + 3Dex. Their clinical characteristics were reviewed. Duration was median time to treatment failure; Kaplan‐Meier estimates were developed. Vbeta Tcell receptor (VBT...
Source: American Journal of Hematology - June 19, 2016 Category: Hematology Authors: John Chapin, Christina S. Lee, Haiyu Zhang, James L. Zehnder, James B. Bussel Tags: Research Article Source Type: research

Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B‐cell lymphoma
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 17, 2016 Category: Hematology Authors: Fabrice Jardin, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, Brigitte Sola, Marlène Ochmann, François Lemonnier, Pierre‐Julien Viailly, Philippe Bertrand, Catherine Maingonnat, Alexandra Traverse‐Gle Tags: Research Article Source Type: research

Epigenetically‐centered evolution in an example of myeloid malignancy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 15, 2016 Category: Hematology Authors: José Adélaide, Nathalie Cervera, Nadine Carbuccia, Séverine Garnier, Arnaud Guille, Marie‐Joelle Mozziconnaci, Raynier Devillier, Max Chaffanet, Norbert Vey, Daniel Birnbaum, Véronique Gelsi‐Boyer Tags: Correspondence Source Type: research