Severe Thrombocytopenia in a Patient Following Liver Transplantation Caused by HPA ‐1a Antibodies Produced by the Liver Donor
(Source: American Journal of Hematology)
Source: American Journal of Hematology - October 1, 2017 Category: Hematology Authors: Paul F. Lindholm, Hau C. Kwaan, Glenn Ramsey, Brian R. Curtis, Jonathan Fryer Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Prognostic significance of additional chromosomal abnormalities at the time of diagnosis in patients with chronic myeloid leukemia treated with frontline tyrosine kinase inhibitors
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - October 1, 2017 Category: Hematology Authors: Ahmad Alhuraiji, Hagop Kantarjian, Prajwal Boddu, Farhad Ravandi, Gautam Borthakur, Courtney DiNardo, Naval Daver, Tapan Kadia, Naveen Pemmaraju, Sherry Pierce, Guillermo Garcia ‐Manero, William Wierda, Srdan Verstovsek, Elias Jabbour, Jorge Cortes Tags: Research Article Source Type: research

Program Expansion of a Day Hospital Dedicated to Manage Sickle Cell Pain
(Source: American Journal of Hematology)
Source: American Journal of Hematology - October 1, 2017 Category: Hematology Authors: Jin Han, Santosh L. Saraf, Laura Kavoliunaite, Shivi Jain, Johara Hassan, Lewis L Hsu, Robert E. Molokie, Victor R. Gordeuk, Michel Gowhari Tags: Correspondence Source Type: research

Impact of screening and exclusion of high anti ‐A titer donors on the risk of hemolytic anemia with intravenous immunoglobulin treatment – a hospital‐based cohort study in the US
(Source: American Journal of Hematology)
Source: American Journal of Hematology - October 1, 2017 Category: Hematology Authors: Carlos Martinez, Douglas J Watson, Amgad Shebl, Christopher Wallenhorst, Alphonse Hubsch, Toby L Simon Tags: Correspondence Source Type: research

Revised Prevalence Estimate of Possible Hereditary Xerocytosis as Derived from a Large U.S. Laboratory Database
(Source: American Journal of Hematology)
Source: American Journal of Hematology - October 1, 2017 Category: Hematology Authors: Harvey W. Kaufman, Justin K. Niles, Denis R. Gallagher, Alicia Rivera, Seth L. Alper, Carlo Brugnara, L. Michael Snyder Tags: Correspondence Source Type: research

Late infections and secondary malignancies after bendamustine/rituximab or RCHOP/RCVP chemotherapy for B ‐cell lymphomas
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 30, 2017 Category: Hematology Authors: Adam J Olszewski, John L Reagan, Jorge J Castillo Tags: Correspondence Source Type: research

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 29, 2017 Category: Hematology Authors: Lukas Gaksch, Karl Kashofer, Ellen Heitzer, Franz Quehenberger, Shruti Daga, Sybille Hofer, Iris Halbwedl, Ricarda Graf, Nina Krisper, Gerald Hoefler, Armin Zebisch, Heinz Sill, Albert W ölfler Tags: Research Article Source Type: research

Urological complications associated with adult allogeneic stem cell transplantation
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 29, 2017 Category: Hematology Authors: Laila Schneidewind, Thomas Neumann, Kathrin Zimmermann, Christian Andreas Schmidt, William Kr üger Tags: Correspondence Source Type: research

Timing and deepness of response to tyrosine kinase inhibitors as a measure of potential treatment discontinuation in chronic myeloid leukemia patients managed in the real ‐life
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 28, 2017 Category: Hematology Authors: Massimo Breccia, Gioia Colafigli, Matteo Molica, Emilia Scalzulli, Daniela Diverio, Roberto Latagliata, Anna Guarini, Robin Fo à Tags: Correspondence Source Type: research

Utility and limitations of exome sequencing in the molecular diagnosis of pediatric inherited platelet disorders
In conclusion, ES has the potential to molecularly diagnose causes of IPD, and to identify candidate genes for functional evaluation. Robust exome sequencing also requires that coverage of genes known to be associated with clinical findings of interest need to be carefully examined and supplemented if necessary. Clinicians who undertake ES should understand the limitations of the test and the full significance of results that may be returned. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 27, 2017 Category: Hematology Authors: Edward J. Romasko, Batsal Devkota, Sawona Biswas, Vijayakumar Jayaraman, Ramakrishnan Rajagopalan, Matthew C. Dulik, Christopher S. Thom, Jiwon Choi, Sowmya Jairam, Maria I. Scarano, Ian D. Krantz, Nancy B. Spinner, Laura K. Conlin, Michele P. Lambert Tags: Research Article Source Type: research

Non ‐invasive monitoring of liver fibrosis in Sickle Cell Disease: Longitudinal observation of a cohort of adult patients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 27, 2017 Category: Hematology Authors: Valeria Pinto, Barbara Gianesin, Manuela Balocco, Lorenzo Bacigalupo, Gian Luca Forni Tags: Correspondence Source Type: research

Impact of involved free light chain (FLC) levels in patients achieving normal FLC ratio after initial therapy in light chain amyloidosis (AL)
We examined if elevated involved free light chain (hiFLC) impacts outcomes in patients achieving normal FLCr. We retrospectively analyzed 345 AL patients who were diagnosed within a 10‐year period (2006‐2015) and had 2 consecutive normal FLCr values after 1st line treatment. Among these, patients with hiFLC at 1st reading of normal FLCr (hiFLC1; n=166; 48.1%) were compared to those who did not (n=179; 51.9%). Patients with AL who have hiFLC1 after initial therapy had higher rates of multi‐organ involvement (63.3 vs 46.4%; p=0.002) and patients in advanced Mayo stage (42.9 vs 32.2%; p=0.04) at diagnosis. The median pr...
Source: American Journal of Hematology - September 27, 2017 Category: Hematology Authors: Nidhi Tandon, Surbhi Sidana, Angela Dispenzieri, Morie A. Gertz, Martha Q. Lacy, David Dingli, Francis K. Buadi, Amie L. Fonder, Suzanne R. Hayman, Yi Lisa Hwa, Miriam A. Hobbs, Prashant Kapoor, Wilson I. Gonsalves, Nelson Leung, Ronald S. Go, John A. Lus Tags: Research Article Source Type: research

Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
Abstract Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess. The bone morphogenetic protein (BMP)‐SMAD signaling pathway, through the ligand BMP6 and the co‐receptor hemojuvelin, is a central regulator of hepcidin transcription in the liver in response to iron. Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6‐/‐ mice, effects that are blocked by a neutralizing...
Source: American Journal of Hematology - September 25, 2017 Category: Hematology Authors: Susanna Canali, Chia ‐Yu Wang, Kimberly B. Zumbrennen‐Bullough, Abraham Bayer, Jodie L. Babitt Tags: RESEARCH ARTICLE Source Type: research

Clinical outcomes in adult patients with aplastic anemia: A single institution experience
Abstract Newer treatment modalities are being investigated to improve upon historical outcomes with standard immunosuppressive therapy (IST) in aplastic anemia (AA). We analyzed outcomes of adult patients with AA treated with various combinatorial anti‐thymoglobulin‐based IST regimens in frontline and relapsed/refractory (R/R) settings. Pretreatment and on‐treatment clinical characteristics were analyzed for relationships to response and outcome. Among 126 patients reviewed, 95 were treatment‐naïve (TN) and 63, R/R (including 32 from the TN cohort); median ages were 49 and 50 years, respectively. Overall survi...
Source: American Journal of Hematology - September 25, 2017 Category: Hematology Authors: Prajwal Boddu, Guillermo Garcia ‐Manero, Farhad Ravandi, Gautam Borthakur, Elias Jabbour, Courtney DiNardo, Nitin Jain, Naval Daver, Naveen Pemmaraju, Paolo Anderlini, Simrit Parmar, Devendra KC, Mary Akosile, Sherry A. Pierce, Richard Champlin, Jorge C Tags: RESEARCH ARTICLE Source Type: research

Diagnostic value of targeted next ‐generation sequencing (NGS) in suspected hemochromatosis patients with a single copy of the HFE p.Cys282Tyr causative allele
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Kevin Uguen, Virginie Scotet, Chandran Ka, Isabelle Gourlaouen, Carine L'Hostis, Marie ‐Christine Merour, Tania Cuppens, Claude Ferec, Gerald Le Gac Tags: Correspondence Source Type: research

The eutos long ‐term survival score (elts) accurately predicts the risk of death in chronic myeloid leukaemia patients treated outside of clinical trials
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Matteo Molica, Martina Canichella, Danilo Alunni Fegatelli, Gioia Colafigli, Fulvio Massaro, Roberto Latagliata, Robin Fo à, Massimo Breccia Tags: Correspondence Source Type: research

Safety and Pharmacokinetics of the Oral Iron Chelator SP ‐420 in β‐thalassemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Ali T Taher, Antoine N Saliba, Kevin H Kuo, Patricia J Giardina, Alan R Cohen, Ellis J Neufeld, Yesim Aydinok, Janet L Kwiatkowski, Brenda I Jeglinski, Keith Pietropaolo, Gregory Berk, Vip Viprakasit Tags: Research Article Source Type: research

Liver Dysfunction in Chronic Lymphocytic Leukemia: Prevalence, Outcomes, and Pathological Findings
Abstract The prevalence of liver dysfunction and its association with outcomes in patients with previously untreated chronic lymphocytic leukemia (CLL) is unknown. Newly diagnosed (
Source: American Journal of Hematology - September 22, 2017 Category: Hematology Authors: Paul J. Hampel, Kari G. Chaffee, Rebecca L. King, Douglas Simonetto, Melissa C. Larson, Sara Achenbach, Timothy G. Call, Wei Ding, Saad S. Kenderian, Jose F. Leis, Asher A. Chanan ‐Khan, Deborah A. Bowen, Michael J. Conte, Susan M. Schwager, Curtis A. H Tags: Research Article Source Type: research

Effects of Pre ‐ and Post‐transplantation Minimal Residual Disease on Outcomes in Pediatric Patients with Acute Myeloid Leukemia Receiving Human Leukocyte Antigen‐matched or Mismatched Related Donor Allografts
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 20, 2017 Category: Hematology Authors: Ying ‐Jun Chang, Xiao‐Su Zhao, Yu Wang, Yan‐Rong Liu, Lan‐Ping Xu, Xiao‐Hui Zhang, Huan Chen, Yu‐Hong Chen, Wei‐ Han, Yu‐Qian Sun, Chen‐Hua Yan, Xiao‐Dong Mo, Kai‐Yan Liu, Xiao‐Jun Huang Tags: Correspondence Source Type: research

Treatment of hepatitis C virus infection with direct ‐acting antiviral drugs is safe and effective in patients with hemoglobinopathies
In conclusion, the use of DAAs appears to be safe and effective in patients with hemoglobinopathies and advanced liver disease due to HCV. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 20, 2017 Category: Hematology Authors: Raffaella Origa, Maria Laura Ponti, Aldo Filosa, Alfonso Galeota Lanza, Antonio Piga, Giorgio Maria Saracco, Valeria Pinto, Antonino Picciotto, Paolo Rigano, Salvatore Madonia, Rosamaria Rosso, Domenico D'Ascola, Maria Domenica Cappellini, Roberta D'Ambro Tags: Research Article Source Type: research

Bone marrow xanthomas associated with hypertriglyceridemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 19, 2017 Category: Hematology Authors: Nelson CN Chan, Chak ‐Chung Chan, Natalie PH Chan Tags: Diagnostic Imaging in Hematology Source Type: research

Incidence and predictive score for delayed hemolytic transfusion reaction in adult patients with sickle cell disease
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 19, 2017 Category: Hematology Authors: David Narbey, Anoosha Habibi, Philippe Chadebech, Armand Mekontso ‐Dessap, Mehdi Khellaf, Jean‐Daniel Lelièvre, Bertrand Godeau, Marc Michel, Frédéric Galactéros, Rachid Djoudi, Pablo Bartolucci, France Pirenne Tags: Research Article Source Type: research

A Clinically Meaningful Fetal Hemoglobin Threshold for Children with Sickle Cell Anemia During Hydroxyurea Therapy
Abstract Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be dose‐dependent. However, it is unknown whether maximizing HbF% improves clinical outcomes. HUSTLE (NCT00305175) is a prospective observational study with a primary goal of describing the long‐term clinical effects of hydroxyurea escalated to maximal tolerated dose (MTD) in children with SCA. In 230 children, providing 610 patient‐years of follow up, the mean...
Source: American Journal of Hematology - September 15, 2017 Category: Hematology Authors: Jeremie H. Estepp, Matthew P. Smeltzer, Guolian Kang, Chen Li, Winfred C. Wang, Christina Abrams, Banu Aygun, Russell E. Ware, Kerri Nottage, Jane S. Hankins Tags: Research Article Source Type: research

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study)
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Takashi Kobayashi, Yasuhito Nannya, Motoshi Ichikawa, Kenji Oritani, Yuzuru Kanakura, Akihiro Tomita, Hitoshi Kiyoi, Masayoshi Kobune, Junji Kato, Hiroshi Kawabata, Motohiro Shindo, Yoshihiro Torimoto, Yuji Yonemura, Nobuyoshi Hanaoka, Hideki Nakakuma, Da Tags: Research Article Source Type: research

Clinical management of peripherally ‐inserted central catheters (PICCs) compared to conventional central venous catheters (cCVCs) in patients with hematological malignancies: a large multicenter study of the REL GROUP (Rete Ematologica Lombarda ‐ Lombardy Hematologic Network, Italy)
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Nicola Stefano Fracchiolla, Elisabetta Todisco, Andrea Bilancia, Sara Gandolfi, Nicola Orofino, Francesca Guidotti, Valentina Mancini, Laura Marbello, Andrea Assanelli, Massimo Bernardi, Armando Santoro, Roberto Cairoli, Dario Consonni, Agostino Cortelezz Tags: Correspondence Source Type: research

Unrelated matched versus autologous transplantation in adult patients with good and intermediate risk acute myelogenous leukemia in first molecular remission
Abstract Patients with Acute Myelogenous Leukemia have a better outcome if reaching molecular remission. We compared the outcome of 373 patients autografted and 335 patients allografted with a 10/10 compatible unrelated donor in first molecular remission. Patients were stratified using the ELN European Leukemia Net classification. ELN favorable group: (234 auto and 70 unrelated transplants). By univariate analysis, in the auto group, the Non Relapse Mortality (NRM) was lower (3.7% versus 19%; p
Source: American Journal of Hematology - September 11, 2017 Category: Hematology Authors: Norbert ‐Claude Gorin, Myriam Labopin, Thomas Pabst, Peter Remenyi, Depei Wu, Anne Huynh, Liisa Volin, Jean Yves Cahn, Ibrahim Yakoub‐Agha, Melanie Mercier, Mohamed Houhou, Mohamad Mohty, Arnon Nagler, Tags: Research Article Source Type: research

Identification of novel mutations in the HbF repressor gene BCL11A in patients with autism and intelligence disabilities
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 10, 2017 Category: Hematology Authors: Tao Cai, Xiang Chen, Jinchen Li, Bingwu Xiang, Liu Yang, Yidian Liu, Qiuli Chen, Zhouwen He, Kevin Sun, P. Paul Liu Tags: Correspondence Source Type: research

Diagnosis of thrombotic thrombocytopenic purpura among patients with ADAMTS13 Activity 10% ‐20%
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 8, 2017 Category: Hematology Authors: Adanma Ayanambakkam, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George Tags: CORRESPONDENCE Source Type: research

Targeted next ‐generation sequencing in myelodysplastic syndromes and prognostic interaction between mutations and IPSS‐R
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 6, 2017 Category: Hematology Authors: Ayalew Tefferi, Terra L Lasho, Mrinal M Patnaik, Lyla Saeed, Mythri Mudireddy, Dame Idossa, Christy Finke, Rhett P Ketterling, Animesh Pardanani, Naseema Gangat Tags: Research Article Source Type: research

Cutaneous T ‐cell lymphoma: 2017 update on diagnosis, risk‐stratification, and management
Abstract Disease overviewCutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DiagnosisThe diagnosis of MF or SS requires the integration of clinical and histopathologic data. Risk‐adapted therapyTNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multi‐disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or ...
Source: American Journal of Hematology - September 5, 2017 Category: Hematology Authors: Ryan A. Wilcox Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - September 5, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

Causes of Hospital Admission in β‐Thalassemia (CHAT) in Lebanon from 1995 to 2015: A pilot retrospective study from a tertiary care center
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 31, 2017 Category: Hematology Authors: Antoine N. Saliba, Hassan M. Moukhadder, Afif Harb, Hassan Beydoun, Rayan Bou ‐Fakhredin, Ali T. Taher Tags: Correspondence Source Type: research

Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 31, 2017 Category: Hematology Authors: Betty S. Pace, Levi H. Makala, Rita Sarkar, Li Liu, Mayuko Takezaki, Narla Mohandas, Glorias Dixon, Ellen M. Werner, Donna B. Jeffe, Treva K. Rice, Nita J. Maihle, Juan Gonz ález Tags: Commentary Source Type: research

Long ‐term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment
In conclusion, the 30‐year survival rate of ex‐thalassemia patients after HSCT was similar to that expected in CT thalassemia patients, with the vast majority of HSCT survivors cured from thalassemia. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 29, 2017 Category: Hematology Authors: Giovanni Caocci, Maria Grazia Orofino, Adriana Vacca, Antonio Piroddi, Eugenia Piras, Maria Carmen Addari, Rossella Caria, Maria Paola Pilia, Raffaella Origa, Paolo Moi, Giorgio La Nasa Tags: Research Article Source Type: research

Clinical Outcomes in Adult Patients with Aplastic Anemia ‐ a single institution experience
Abstract Newer treatment modalities are being investigated to improve upon historical outcomes with standard immunosuppressive therapy (IST) in aplastic anemia (AA). We analyzed outcomes of adult patients with AA sequentially treated with various combinatorial anti‐thymoglobulin‐based IST regimens in frontline and relapsed/refractory (R/R) settings. Pretreatment and on‐treatment clinical characteristics were analyzed for relationships to response and outcome. Among 126 patients reviewed, 95 were treatment‐naïve (TN) and 63, R/R (including 32 from the TN cohort); median ages were 49 and 50 years, respectively. ...
Source: American Journal of Hematology - August 29, 2017 Category: Hematology Authors: Prajwal Boddu, Guillermo Garcia ‐Manero, Farhad Ravandi, Gautam Borthakur, Elias Jabbour, Courtney DiNardo, Nitin Jain, Naval Daver, Naveen Pemmaraju, Paolo Anderlini, Simrit Parmar, Devendra KC, Mary Akosile, Sherry A. Pierce, Richard Champlin, Jorge C Tags: Research Article Source Type: research

Changes in intestinal microbiota and their effects on allogeneic stem cell transplantation
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 26, 2017 Category: Hematology Authors: Rory M Shallis, Christopher M Terry, Seah H Lim Tags: Critical Review Source Type: research

A Single Center Phase II Study of Ixazomib in Patients with Relapsed or Refractory Cutaneous or Peripheral T ‐cell Lymphomas
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 26, 2017 Category: Hematology Authors: Philip S. Boonstra, Avery Polk, Noah Brown, Alexandra C. Hristov, Nathanael G. Bailey, Mark S. Kaminski, Tycel Phillips, Sumana Devata, Tera Mayer, Ryan A. Wilcox Tags: Research Article Source Type: research

Imatinib ‐induced psoriasiform eruption in a patient with chronic myeloid leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: Connie R. Shi, Vinod E. Nambudiri Tags: Images in Hematology Source Type: research

Limitations of poor bone marrow aspirations (for an accurate diagnosis) despite the multimodal analytical era: A longitudinal retrospective study
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: John M. Astle, Mina L. Xu, Tamir Friedman, Elliott Brown Tags: CORRESPONDENCE Source Type: research

Risk factors and a prognostic model for postsplenectomy survival in myelofibrosis
Abstract Palliative treatment in myelofibrosis (MF) includes transfusion support, JAK2 inhibitors, involved field radiotherapy and splenectomy. To assist in selecting patients who are likely to benefit from splenectomy, we looked into risk factors for postsplenectomy survival, in 120 consecutive cases (median age 66 years); at the time of splenectomy, 61% displayed red cell transfusion need, 49% platelet count 25 × 10(9)/L, 60% constitutional symptoms and 13% circulating blasts ≥5%; dynamic international prognostic scoring system risk categories were 21% high, 55% intermediate‐2, 21% intermediate‐1 and 3% low....
Source: American Journal of Hematology - August 24, 2017 Category: Hematology Authors: Ayalew Tefferi, Mythri Mudireddy, Naseema Gangat, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, David M. Nagorney Tags: RESEARCH ARTICLE Source Type: research

Considerations on POEMS associated optic neuropathy
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 23, 2017 Category: Hematology Authors: Julio Gonz ález Martín‐Moro, Inés Contreras Martín, María Castro‐Rebollo, Belén Pilo de la Fuente Tags: Correspondence Source Type: research

Comprehensive Evaluation of the Revised International Staging System in Multiple Myeloma Patients Treated with Novel Agents as a Primary Therapy
Abstract The revised International Staging System (R‐ISS) has recently been developed to improve the risk stratification of multiple myeloma (MM) patients over the ISS. We assessed the R‐ISS in MM patients who were treated with novel agents as a primary therapy and evaluated its discriminative power and ability to reclassify patients from the ISS. A total of 514 newly diagnosed MM patients treated with novel agents including thalidomide, bortezomib, and lenalidomide as a primary therapy were included in this retrospective analysis. With a median follow‐up duration of 42.3 months (range, 40.5–44.1), the median o...
Source: American Journal of Hematology - August 22, 2017 Category: Hematology Authors: Hyungwoo Cho, Dok Hyun Yoon, Jung Bok Lee, Sung ‐Yong Kim, Joon Ho Moon, Young Rok Do, Jae Hoon Lee, Yong Park, Ho Sup Lee, Hyeon Seok Eom, Ho‐Jin Shin, Chang‐Ki Min, Jin Seok Kim, Jae‐Cheol Jo, Hye Jin Kang, Yeung‐Chul Mun, Won Sik Lee, Je‐Ju Tags: Research Article Source Type: research

Clinical and Laboratory Findings Associated with Sleep Disordered Breathing in Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 22, 2017 Category: Hematology Authors: Christopher M. Worsham, Stephon T. Martin, Mehdi Nouraie, Robyn T. Cohen, Elizabeth S. Klings Tags: Correspondence Source Type: research

First ‐line treatment selection and early monitoring patterns in chronic phase‐chronic myeloid leukemia in routine clinical practice: SIMPLICITY
Abstract Achieving successful outcomes in chronic phase‐chronic myeloid leukemia (CP‐CML) requires careful monitoring of cytogenetic/molecular responses (CyR/MR). SIMPLICITY (NCT01244750) is an observational study exploring tyrosine kinase inhibitor use and management patterns in patients with CP‐CML receiving first‐line imatinib (n=416), dasatinib (n=418) or nilotinib (n=408) in the US and 6 European countries in routine clinical practice. Twelve‐month follow‐up data of 1,242 prospective patients (enrolled October 01 2010–September 02 2015) are reported. 81% of patients had baseline comorbidities. Treatm...
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Stuart L. Goldberg, Jorge Cortes, Carlo Gambacorti ‐Passerini, Rüdiger Hehlmann, H. Jean Khoury, Mauricette Michallet, Ron Paquette, Bengt Simonsson, Teresa Zyczynski, Aimee Foreman, Elisabetta Abruzzese, David Andorsky, Aart Beeker, Pascale Cony‐Mak Tags: Research Article Source Type: research

A distinctive histidine residue is essential for in vivo glycation ‐inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Rupam Sahoo, Pamela Ghosh, Michael Chorev, Jose A Halperin Tags: Research Article Source Type: research

Diagnosis of thrombotic thrombocytopenic purpura among patients with adamts13 activity 10 ‐20%
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Adanma Ayanambakkam, Johanna A. Kremer Hovinga, Sara K. Vesely, James N. George Tags: Correspondence Source Type: research

Ibrutinib ‐associated Pneumocystis jirovecii pneumonia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Regina Lee, Afrouz Nayernama, S. Christopher Jones, Tanya Wroblewski, Peter E. Waldron Tags: Correspondence Source Type: research

Bmp2 controls iron homeostasis in mice independent of Bmp6
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Susanna Canali, Chia ‐Yu Wang, Kimberly B. Zumbrennen‐Bullough, Abraham Bayer, Jodie L. Babitt Tags: Research Article Source Type: research

Treatment of Individuals Who Cannot Receive Blood Products for Religious or Other Reasons
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2017 Category: Hematology Authors: Carlton D. Scharman, Joseph J. Shatzel, Edward Kim, Thomas G. DeLoughery Tags: Critical Review Source Type: research

Rare complication of treated immune thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - August 12, 2017 Category: Hematology Authors: Radhika Gangaraju, Anton Rets, Kristi J Smock, Nahla M Heikal Tags: Solving Clinical Problems in Blood Diseases Source Type: research