Multidimensional assessment of patient condition and mutational analysis in peripheral blood, as tools to improve outcome prediction in myelodysplastic syndromes: A prospective study of the Spanish MDS Group
This study aimed to evaluate the relative contribution of patient condition and mutational status in peripheral blood when added to the IPSS‐R, for estimating overall survival and the risk of leukemic transformation in patients with MDS. A prospective cohort (2006‐2015) of 200 consecutive patients with MDS were included in the study series and categorized according to the IPSS‐R. Patients were further stratified according to patient condition (assessed using the multidimensional Lee index for older adults) and genetic mutations (peripheral blood samples screened using next‐generation sequencing). The change in like...
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Fernando Ramos, Cristina Robledo, Arturo Pereira, Carmen Pedro, Roc ío Benito, Raquel de Paz, Mónica del Rey, Andrés Insunza, Mar Tormo, María Díez‐Campelo, Blanca Xicoy, Eduardo Salido, Javier Sánchez‐del‐Real, Leonor Arenillas, Lourdes Flore Tags: Research Article Source Type: research

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis and management
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Maria Domenica Cappellini, Josep Comin ‐Colet, Angel de Francisco, Axel Dignass, Wolfram Doehner, Carolyn SP Lam, Iain C Macdougall, Gerhard Rogler, Clara Camaschella, Rezan Kadir, Nicholas J Kassebaum, Donat R Spahn, Ali T Taher, Khaled M Musallam, Tags: Critical Review Source Type: research

Juvenile myelomonocytic leukemia in an infant with congenital HIV and CMV infection
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Jessica Bazin, Leena Karnik, Gareth Tudor ‐Williams, Anne M. Kelly, Barbara J. Bain Tags: Morphology Update Source Type: research

Genetic Determinants of HbF in Saudi Arabian and African Benin Haplotype Sickle Cell Anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Elmutaz M. Shaikho, John J. Farrell, Abdulrahman Alsultan, Paola Sebastiani, Martin H. Steinberg Tags: Correspondence Source Type: research

Impact of Comorbidities on Outcomes of Elderly Patients with Diffuse Large B ‐cell Lymphoma
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Caner Saygin, Xuefei Jia, Brian Hill, Robert Dean, Brad Pohlman, Mitchell R. Smith, Deepa Jagadeesh Tags: Research Article Source Type: research

Day 14 bone marrow examination in the management of acute myeloid leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Authors: Christopher M Terry, Rory M Shallis, Elihu Estey, Seah H Lim Tags: Critical Review Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 13, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low ‐resource setting
Abstract Sickle cell disease (SCD) is associated with adverse pregnancy outcome. In women with SCD living in low‐resource settings, pregnancy is associated with significantly increased maternal and perinatal mortality rates. We tested the hypothesis that implementing a multidisciplinary obstetric and hematology care team in a low‐resource setting would significantly reduce maternal and perinatal mortality rates. We conducted a before‐and‐after study, at the Korle‐Bu Teaching Hospital in Accra, Ghana, to evaluate the effect of a multidisciplinary obstetric‐hematology care team for women with SCD in a combined SC...
Source: American Journal of Hematology - June 9, 2017 Category: Hematology Authors: Eugenia Vicky Asare, Edeghonghon Olayemi, Theodore Boafor, Yvonne Dei ‐Adomakoh, Enoch Mensah, Harriet Ghansah, Yvonne Osei‐Bonsu, Selina Crabbe, Latif Musah, Charles Hayfron‐Benjamin, Brittany Covert, Adetola A. Kassim, Andra James, Mark Rodeghier, Tags: RESEARCH ARTICLE Source Type: research

Clinical impact of pretransplant use of multiple tyrosine kinase inhibitors on the outcome of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia
Abstract Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with chronic myelogenous leukemia in the chronic phase (CML‐CP), and outcomes of TKI treatment for patients with CML‐CP have been excellent. Since multiple TKIs are currently available, second‐line or third‐line TKI therapy is considered for patients who are intolerant of or resistant to the previous TKI treatment. Therefore, allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is considered only for patients with disease progression or for patients after treatment failure with multiple TKIs. To reflect the current clinical sit...
Source: American Journal of Hematology - June 9, 2017 Category: Hematology Authors: Takeshi Kondo, Tokiko Nagamura ‐Inoue, Arinobu Tojo, Fumitaka Nagamura, Naoyuki Uchida, Hirohisa Nakamae, Takahiro Fukuda, Takehiko Mori, Shingo Yano, Mineo Kurokawa, Hironori Ueno, Heiwa Kanamori, Hisako Hashimoto, Makoto Onizuka, Minoko Takanashi, Tat Tags: RESEARCH ARTICLE Source Type: research

IGHV Mutational Status Testing in Chronic Lymphocytic Leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 7, 2017 Category: Hematology Authors: Jennifer Crombie, Matthew S. Davids Tags: Test of the Month Source Type: research

Safety and Efficacy of Recombinant Activated Coagulation Factor VII in Congenital Hemophilia with Inhibitors in the Home Treatment Setting: A Review of Clinical Studies and Registries
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 7, 2017 Category: Hematology Authors: Guy Young, Miguel A. Escobar, Steven W. Pipe, David L. Cooper Tags: Critical Review Source Type: research

Losartan for the Nephropathy of Sickle Cell Anemia: A Phase ‐2, Multi‐Center Trial
This study forms the basis for a phase‐3, randomized, placebo‐controlled trial of losartan for the nephropathy of SCA. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 7, 2017 Category: Hematology Authors: Charles T. Quinn, Santosh L. Saraf, Victor R. Gordeuk, Courtney D. Fitzhugh, Susan E. Creary, Prasad Bodas, Alex George, Ashok B. Raj, Alecia C. Nero, Catherine E. Terrell, Lisa McCord, Adam Lane, Hans C. Ackerman, Yu Yang, Omar Niss, Michael D. Taylor, P Tags: Research Article Source Type: research

A hit to current “hit” wisdom: A century later, it's time for a change
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 5, 2017 Category: Hematology Authors: Francesco Rodeghiero Tags: COMMENTARY Source Type: research

Cross ‐altitude analysis suggests a turning point at the elevation of 4,500m for polycythemia prevalence in Tibetans
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 1, 2017 Category: Hematology Authors: Hui Zhang, Yaoxi He, Chaoying Cui, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Yongyue Pan, Qula, Kangmin, Cirenyangji, Baimayangji, Caijuan Bai, Wei Guo, Yangla, Yi Peng, Xiaoming Zhang, Kun Xiang, Zhaohui Yang, Shiming Liu, Tags: Correspondence Source Type: research

A somatic mosaicism in the G6PD gene inducing a late onset chronic non ‐spherocytic hemolytic anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - June 1, 2017 Category: Hematology Authors: Lucile Couronn é, Gérard Tertian, Audrey Boutron, Véronique Picard, Hakim Ouled‐Haddou, Patricia Hughes, Olivier Hermine, Claude Préhu, Gil Tchernia, Loïc Garçon Tags: CORRESPONDENCE Source Type: research

Developmentally ‐Faithful and Effective Human Erythropoiesis in Immunodeficient and Kit Mutant Mice
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - June 1, 2017 Category: Hematology Authors: Claudia Fiorini, Nour J. Abdulhay, Sean K. McFarland, Mathias Munschauer, Jacob C. Ulirsch, Roberto Chiarle, Vijay G. Sankaran Tags: Research Article Source Type: research

Cardiac Tamponade in Myelofibrosis: A Mayo Clinic Series of 9 Consecutive Cases
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Sravanthi Lavu, Ayalew Tefferi Tags: Correspondence Source Type: research

A follow ‐up on Desiderosmia (olfactory craving), a novel symptom associated with iron deficiency anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Bryar R. Hansen, Wayne A. Bottner, Aishwarya Ravindran, Ramona DeJesus, Ronald S. Go Tags: Correspondence Source Type: research

Autoimmune neutropenia of childhood secondary to other autoimmune disorders: data from the Italian Neutropenia Registry
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Piero Farruggia, Giuseppe Puccio, Francesca Fioredda, Tiziana Lanza, Laura Porretti, Ugo Ramenghi, Angelica Barone, Sonia Bonanomi, Andrea Finocchi, Roberta Ghilardi, Saverio Ladogana, Nicoletta Marra, Baldassare Martire, Lucia Dora Notarangelo, Daniela O Tags: Correspondence Source Type: research

The Prognostic Significance of Polyclonal Bone Marrow Plasma Cells in Patients with Relapsing Multiple Myeloma
Abstract Prior studies have revealed that the presence of increasing number of polyclonal plasma cells (pPCs) in the bone marrow (BM) are associated with better outcomes in newly diagnosed multiple myeloma (MM) patients. This effect has not been studied in patients with MM at the time of disease relapse. We determined the prognostic value of depletion of pPCs in the BM by 7‐color multiparameter flow cytometry in a series of 174 relapsing MM patients. The time to next therapy (TTNT) in those with
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Toshi Ghosh, Wilson I. Gonsalves, Dragan Jevremovic, Angela Dispenzieri, David Dingli, Michael M. Timm, William G. Morice, Prashant Kapoor, Taxiarchis V. Kourelis, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Nelson Leung, Ronald S. Go, Yi Lin, St Tags: Research Article Source Type: research

Transformation in Pre ‐treatment Manifestations of Gaucher Disease Type 1 during Two Decades of Alglucerase/Imiglucerase Enzyme Replacement Therapy in the International Collaborative Gaucher Group (ICGG) Registry
This study tests the hypothesis that the prevalence of severe clinical manifestations in Gaucher disease type 1 (GD1) patients at the time of treatment initiation has changed since alglucerase/imiglucerase enzyme replacement therapy (ERT) was approved in the United States (US) in 1991. US alglucerase/imiglucerase‐treated GD1 patients from the International Collaborative Gaucher Group Gaucher Registry were stratified by age at ERT initiation (
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Pramod K. Mistry, Julie L. Batista, Hans C. Andersson, Manisha Balwani, Thomas Andrew Burrow, Joel Charrow, Paige Kaplan, Aneal Khan, Priya S. Kishnani, Edwin H. Kolodny, Barry Rosenbloom, C. Ronald Scott, Neal Weinreb Tags: Research Article Source Type: research

Allogeneic hematopoietic cell transplantation in morphologic leukemia ‐free aplastic state
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 31, 2017 Category: Hematology Authors: Armin Rashidi, Alaa M. Ali, Kiran R. Vij, Ryan Shanley, Rizwan Romee, Sarah A Cooley, Peter Westervelt, John F. DiPersio, Jeffrey S. Miller, Daniel J. Weisdorf, Celalettin Ustun Tags: Correspondence Source Type: research

Factors associated with risk of central nervous system relapse in patients with non ‐core binding factor acute myeloid leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 27, 2017 Category: Hematology Authors: Elias Jabbour, Naval Guastad Daver, Nicholas James Short, Xuelin Huang, Hsiang ‐Chun Chen, Abhishek Maiti, Farhad Ravandi, Jorge Cortes, Simon Abi Aad, Guillermo Garcia‐Manero, Zeev Estrov, Tapan Kadia, Susan O'Brien, Bouthaina Dabaja, Carlos Bueso‐ Tags: Research Article Source Type: research

A multicenter prospective study on efficacy and safety of imatinib generics: A report from Polish Adult Leukemia Group imatinib generics registry
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 26, 2017 Category: Hematology Authors: Tomasz Sacha, Joanna G óra‐Tybor, Monika Szarejko, Grażyna Bober, Olga Grzybowska‐Izydorczyk, Joanna Niesiobędzka‐Krężel, Marek Dudziński, Ewa Wasilewska, Krzysztof Myśliwiec, Justyna Gil, Michał Gniot, Iwona Pietkun, Ewa Mędraś, Jadwiga H Tags: CORRESPONDENCE Source Type: research

Chronic lymphocytic leukemia and prognostic models: A bridge between clinical and biological markers
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 26, 2017 Category: Hematology Authors: Gianluigi Reda, Ramona Cassin, Bruno Fattizzo, Diana Giannarelli, Veronica Mattiello, Wilma Barcellini, Agostino Cortelezzi Tags: CORRESPONDENCE Source Type: research

Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre ‐diagnostic period
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 26, 2017 Category: Hematology Authors: Jakob Werner Hansen, H åkon Sandholdt, Volkert Siersma, Andreas Due Ørskov, Staffan Holmberg, Ole Weis Bjerrum, Hans Carl Hasselbalch, Niels de Fine Olivarius, Kirsten Grønbæk, Christen Lykkegaard Andersen Tags: CORRESPONDENCE Source Type: research

Recognition of early mortality in multiple myeloma by a prediction matrix
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 24, 2017 Category: Hematology Authors: Howard Terebelo, Shankar Srinivasan, Mohit Narang, Rafat Abonour, Cristina Gasparetto, Kathleen Toomey, James W. Hardin, Gail Larkins, Amani Kitali, Robert M. Rifkin, Jatin J. Shah Tags: Research Article Source Type: research

Ibrutinib Therapy for Lymphoplasmacytic Lymphoma
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 24, 2017 Category: Hematology Authors: Margaret J. Helber, Jeremiah E. Moore, AnnaLynn M. Williams, Philip J. Meacham, Paul G. Rothberg, Clive S. Zent Tags: Correspondence Source Type: research

Multicenter analysis of the use of transjugular intrahepatic portosystemic shunt (TIPS) for management of MPN ‐associated portal hypertension
In conclusion, TIPS can be an effective intervention for MPN‐associated pHTN regardless of etiology. However, TIPS thrombosis is a frequent complication in the MPN population and indefinite anticoagulation post‐TIPS should be considered. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 24, 2017 Category: Hematology Authors: Christopher R. Reilly, Daria V. Babushok, Karlyn Martin, Jerry L. Spivak, Michael Streiff, Ranjeeta Bahirwani, Jeffrey Mondschein, Brady Stein, Alison Moliterno, Elizabeth O. Hexner Tags: Research Article Source Type: research

Clinical impact of pre ‐transplant use of multiple tyrosine kinase inhibitors on the outcome of allo‐HSCT for CML
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 20, 2017 Category: Hematology Authors: Takeshi Kondo, Tokiko Nagamura ‐Inoue, Arinobu Tojo, Fumitaka Nagamura, Naoyuki Uchida, Hirohisa Nakamae, Takahiro Fukuda, Takehiko Mori, Shingo Yano, Mineo Kurokawa, Hironori Ueno, Heiwa Kanamori, Hisako Hashimoto, Makoto Onizuka, Minoko Takanashi, Tat Tags: Research Article Source Type: research

Pre ‐fibrotic/early primary myelofibrosis vs. WHO‐defined essential thrombocythemia: The impact of minor clinical diagnostic criteria on the outcome of the disease
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 20, 2017 Category: Hematology Authors: Georg Jeryczynski, Juergen Thiele, Bettina Gisslinger, Albert W ölfler, Martin Schalling, Andreas Gleiß, Sonja Burgstaller, Veronika Buxhofer‐Ausch, Thamer Sliwa, Ernst Schlögl, Klaus Geissler, Maria‐Theresa Krauth, Alexander Nader, Michael Vesely, Tags: Research Article Source Type: research

Chimeric Antigen Receptor Modified T cells That Target Chemokine Receptor CCR4 as a Therapeutic Modality for T ‐cell Malignancies
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 20, 2017 Category: Hematology Authors: Liyanage P. Perera, Meili Zhang, Masao Nakagawa, Michael N. Petrus, Michiyuki Maeda, Marshall E. Kadin, Thomas A. Waldmann, Pin ‐Yu Perera Tags: Research Article Source Type: research

The aggressive peripheral T ‐cell lymphomas: 2017
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 18, 2017 Category: Hematology Authors: James O. Armitage Tags: Annual Clinical Updates in Hematological Malignancies: A Continuing Medical Education Series Source Type: research

Outcomes of patients with relapsed/refractory Hodgkin lymphoma progressing after autologous stem cell transplant in the current era of novel therapeutics: A retrospective analysis
Abstract Patients with relapsed/refractory Hodgkin lymphoma (RR‐HL) who progress or relapse following autologous stem cell transplantation (ASCT) have historically had a poor prognosis. Several novel agents, particularly brentuximab vedotin, have shown efficacy in this setting. However, there remains a paucity of data characterizing outcomes outside of clinical trials and how these novel agents impacted prognosis in general population of patients with RR‐HL. Here, we conducted a retrospective analysis to evaluate outcomes in 87 patients with RR‐HL with relapse post‐ASCT. Treatment with novel agents (including brent...
Source: American Journal of Hematology - May 17, 2017 Category: Hematology Authors: SM Bair, L Strelec, SJ Nagle, SD Nasta, DJ Landsburg, AR Mato, AW Loren, SJ Schuster, EA Stadtmauer, J Svoboda Tags: Research Article Source Type: research

Implementation of Multi ‐Disciplinary Care Reduces Maternal Mortality in Women with Sickle Cell Disease Living in Low‐resource Setting
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 16, 2017 Category: Hematology Authors: Eugenia Vicky Asare, Edeghonghon Olayemi, Theodore Boafor, Yvonne Dei ‐Adomakoh, Enoch Mensah, Harriet Ghansah, Yvonne Osei‐Bonsu, Selina Crabbe, Latif Musah, Charles Hayfron‐Benjamin, Brittany Covert, Adetola A. Kassim, Andra James, Mark Rodeghier, Tags: Research Article Source Type: research

A hit to current ‘HIT' wisdom: A century later, it's time for a change
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 16, 2017 Category: Hematology Authors: Francesco Rodeghiero Tags: Commentary Source Type: research

Look Into My Eyes: An Unusual First Presentation of Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 12, 2017 Category: Hematology Authors: Rupali Sood, Kim Jiramongkolchai, Michael Streiff, Christopher Gonzalez, Satish Shanbhag, Sophie Lanzkron, J. Fernando Arevalo, Rakhi Naik Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Correlates of resistance and relapse during blinatumomab therapy for relapsed/refractory acute lymphoblastic leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 11, 2017 Category: Hematology Authors: Ibrahim Aldoss, Joo Song, Tracey Stiller, Tina Nguyen, Joycelynne Palmer, Margaret O'Donnell, Anthony S Stein, Guido Marcucci, Stephen Forman, Vinod Pullarkat Tags: Research Article Source Type: research

Estimates of total body iron indicate 19 mg and 38 mg oral iron are equivalent for the mitigation of iron deficiency in individuals experiencing repeated phlebotomy
Abstract Iron deficiency anemia is a common clinical condition often treated with tablets containing 65 mg of elemental iron. Such doses can elicit gastrointestinal side effects lowering patient compliance. Oral iron supplements also increase hepcidin production causing decreased fractional absorption of subsequent doses. Frequent blood donors often become iron deficient. Therefore, they were enrolled in a two‐year study involving continued blood donations and randomization to receive no pill, placebo, 19, or 38 mg ferrous gluconate for 60 days. Total body iron (TBI) did not change for the subset of donors in the no pill...
Source: American Journal of Hematology - May 11, 2017 Category: Hematology Authors: Walter Bialkowski, Joseph E. Kiss, David J. Wright, Ritchard Cable, Rebecca Birch, Pam D'Andrea, Barbara J. Bryant, Bryan R. Spencer, Alan E. Mast Tags: Research Article Source Type: research

Minimal Residual Disease Eradication with Epigenetic Therapy in Core Binding Factor Acute Myeloid Leukemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 11, 2017 Category: Hematology Authors: Brittany Knick Ragon, Naval Daver, Guillermo Garcia ‐Manero, Farhad Ravandi, Jorge Cortes, Tapan Kadia, Betul Oran, Maro Ohanian, Alessandra Ferrajoli, Naveen Pemmaraju, Hagop M Kantarjian, Gautam Borthakur Tags: Research Article Source Type: research

Characterization of TP53 mutations in clonal cytopenia of undetermined significance
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 11, 2017 Category: Hematology Authors: Wei Wang, Mark J. Routbort, Chi Young OK, Keyur P. Patel, Yi Sun, Rashmi Kanagal ‐Shamanna, L. Jeffrey Medeiros, Sa A. Wang Tags: Correspondence Source Type: research

Urinary Prednisolone Excretion is a Determinant of Serum Hepcidin Levels in Renal Transplant Recipients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 11, 2017 Category: Hematology Authors: Michele F. Eisenga, Robin P. F. Dullaart, Stefan P. Berger, Daan J. Touw, Stephan J.L. Bakker, Carlo A.J.M. Gaillard Tags: Correspondence Source Type: research

Issue Information – Table of Contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 8, 2017 Category: Hematology Tags: Issue Information – Table of Contents Source Type: research

A novel in vivo model for studying conditional dual loss of BLIMP ‐1 and p53 in B‐cells, leading to tumor transformation
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 5, 2017 Category: Hematology Authors: Antonio Sacco, Yawara Kawano, Michele Moschetta, Oksana Zavidij, Daisy Huynh, Michaela Reagan, Yuji Mishima, Salomon Manier, Jihye Park, Elizabeth Morgan, Satoshi Takagi, Kwok K Wong, Ruben Carrasco, Irene M. Ghobrial, Aldo M. Roccaro Tags: Research Article Source Type: research

Daratumumab Monotherapy Compared With Historical Control Data in Heavily Pretreated and Highly Refractory Patients With Multiple Myeloma: An Adjusted Treatment Comparison
This study compared the efficacy of daratumumab monotherapy versus historical controls through adjusted treatment comparison. Patient‐level data were pooled from 2 daratumumab monotherapy studies (16 mg/kg; GEN501 and SIRIUS) and 2 independent US databases (IMS LifeLink and OPTUM), which reflect treatments used in real‐world patients with MM who received ≥3 prior LOTs or were double refractory to a PI and an IMiD. Using a multivariate proportional hazards regression model, the relative treatment effect of daratumumab versus historical controls was estimated, adjusting for imbalances in characteristics between cohort...
Source: American Journal of Hematology - May 5, 2017 Category: Hematology Authors: Saad Z Usmani, Joris Diels, Tetsuro Ito, Maneesha Mehra, Imran Khan, Annette Lam Tags: Research Article Source Type: research

Chronic lymphocytic leukemia in Brazil: A retrospective analysis of 1903 cases
(Source: American Journal of Hematology)
Source: American Journal of Hematology - May 5, 2017 Category: Hematology Authors: Matheus Vescovi Gon çalves, Celso Arrais Rodrigues, Irene Gyongyver Heidemarie Lorand Metze, Marcelo Pitombeira Lacerda, Alita Azevedo, Cintia Machado, Carlos Sérgio Chiattone, Sérgio Fortier, Leila Perobelli, Maura Rosane Valerio Ikoma, Nelma Clementi Tags: Correspondence Source Type: research

Outcome of Elderly Patients after Failure to Hypomethylating Agents Given as Frontline Therapy for Acute Myeloid Leukemia (AML): Single Institution Experience
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 1, 2017 Category: Hematology Authors: Rama Nanah, Kristen McCullough, William Hogan, Kebede Begna, Mrinal Patnaik, Michelle Elliott, Mark Litzow, Aref Al ‐Kali Tags: Research Article Source Type: research

Acquired hemophilia A: Updated review of evidence and treatment guidance
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - May 1, 2017 Category: Hematology Authors: Rebecca Kruse ‐Jarres, Christine L. Kempton, Francesco Baudo, Peter W. Collins, Paul Knoebl, Cindy A. Leissinger, Andreas Tiede, Craig M. Kessler Tags: Critical Review Source Type: research

The BCR ‐ABL1 transcript type influences response and outcome in Philadelphia chromosome‐positive chronic myeloid leukemia patients treated frontline with imatinib
ABSTRACT The most frequent BCR‐ABL1 fusion transcripts in chronic myeloid leukemia (CML) are the e13a2 (b2a2) and the e14a2 (b3a2) ones. In the imatinib era few studies addressing the prognostic significance of the BCR‐ABL1 transcript type in early chronic phase CML have been published. Overall, these studies suggest that in e14a2 patients the response to imatinib is faster and deeper. To evaluate if the BCR‐ABL1 transcript type (e13a2 compared to e14a2) affect the response to imatinib and the clinical outcome in newly diagnosed adult CML patients, 559 patients enrolled in 3 prospective studies (NCT00514488, NCT00510...
Source: American Journal of Hematology - May 1, 2017 Category: Hematology Authors: Fausto Castagnetti, Gabriele Gugliotta, Massimo Breccia, Alessandra Iurlo, Luciano Levato, Francesco Albano, Paolo Vigneri, Elisabetta Abruzzese, Giuseppe Rossi, Serena Rupoli, Francesco Cavazzini, Bruno Martino, Ester Orlandi, Patrizia Pregno, Mario Annu Tags: Research Article Source Type: research

Validation of the 2016 Revisions to the WHO Classification in Lower ‐Risk Myelodysplastic Syndrome
(Source: American Journal of Hematology)
Source: American Journal of Hematology - April 29, 2017 Category: Hematology Authors: Rashmi Kanagal ‐Shamanna, Juliana E. Hidalgo Lopez, Denái R. Milton, Hye Ryoun Kim, Chong Zhao, Zhuang Zuo, Michelle Janania Martinez, Francesco Stingo, John Lee, Rajyalakshmi Luthra, Elias J. Jabbour, Guillermo Garcia‐Manero, L. Jeffrey Medeiros, Ca Tags: Correspondence Source Type: research