A distinct immunophenotype identifies a subset of NPM1 ‐mutated AML with TET2 or IDH1/2 mutations and improved outcome
American Journal of Hematology,Volume 93, Issue 4, Page 504-510, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

JAK2 exon 12 mutated polycythemia vera: Mayo ‐Careggi MPN Alliance study of 33 consecutive cases and comparison with JAK2V617F mutated disease
American Journal of Hematology,Volume 93, Issue 4, Page E93-E96, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

Developmental differences between neonatal and adult human erythropoiesis
American Journal of Hematology,Volume 93, Issue 4, Page 494-503, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

A single center experience with romiplostim for the management of chemotherapy ‐induced thrombocytopenia
American Journal of Hematology,Volume 93, Issue 4, Page E86-E88, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

Prognostic impact of bone marrow fibrosis and dyserythropoiesis in autoimmune hemolytic anemia
American Journal of Hematology,Volume 93, Issue 4, Page E88-E91, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E91-E93, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 504-510, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E93-E96, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 494-503, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E86-E88, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E88-E91, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Source Type: research

Developmental Differences Between Neonatal and Adult Human Erythropoiesis
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: Hongxia Yan, John Hale, Julie Jaffray, Jie Li, Yaomei Wang, Yumin Huang, Xiuli An, Christopher Hillyer, Nan Wang, Sandrina Kinet, Naomi Taylor, Narla Mohandas, Anupama Narla, Lionel Blanc Tags: Research Article Source Type: research

Sarcoid ‐like granulomatosis in a patient receiving anti‐TNFα for psoriasis
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: Vasiliki Leventaki, Jamie Flerlage Tags: Images in Hematology Source Type: research

A Single Center Experience with Romiplostim for the Management of Chemotherapy ‐Induced Thrombocytopenia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: Jennifer Miao, Houry Leblebjian, Bridget Scullion, Aric Parnes Tags: Correspondence Source Type: research

Prognostic impact of bone marrow fibrosis and dyserythropoiesis in autoimmune hemolytic anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: B Fattizzo, A Zaninoni, U Gianelli, A Zanella, A Cortelezzi, AG Kulasekararaj, W Barcellini Tags: Correspondence Source Type: research

Intestinal microbiome analysis revealed dysbiosis in sickle cell disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: Seah H Lim, Alison Morris, Kelvin Li, Adam C Fitch, Loren Fast, Laura Goldberg, Matthew Quesenberry, Philippa Sprinz, Barbara Meth é Tags: Correspondence Source Type: research

A Distinct Immunophenotype Identifies a Subset of NPM1 ‐mutated AML With TET2 or IDH1/2 Mutations and Improved Outcome
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 23, 2017 Category: Hematology Authors: Emily F. Mason, Frank C. Kuo, Robert P. Hasserjian, Adam C. Seegmiller, Olga Pozdnyakova Tags: Research Article Source Type: research

Clinical and biological characterization of MPN patients harboring two driver mutations, a French Intergroup of Myeloproliferative neoplasms (FIM) study
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 21, 2017 Category: Hematology Authors: Olivier Mansier, Damien Luque Paz, Jean ‐Christophe Ianotto, Yannick Le Bris, Aurélie Chauveau, Françoise Boyer, Carole Conejero, Olivier Fitoussi, Jérémie Riou, Didier Adiko, Mohamed Touati, Jasmine Chauzeix, Jean‐François Viallard, Marie C Bén Tags: Correspondence Source Type: research

Clinical and biological characterization of MPN patients harboring two driver mutations, a French intergroup of myeloproliferative neoplasms (FIM) study
American Journal of Hematology,Volume 93, Issue 4, Page E84-E86, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 21, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page E84-E86, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 21, 2017 Category: Hematology Source Type: research

Sleep disordered breathing does not predict acute severe pain episodes in children with sickle cell anemia
Abstract Conflicting evidence has suggested that low mean nocturnal hemoglobin oxygen saturation (SpO2) predicts future hospital days for acute severe pain in children with sickle cell anemia (SCA). In an unselected multi‐center prospective cohort study, we tested the hypothesis that either low mean nocturnal SpO2 or high obstructive apnea‐hypopnea index (OAHI; the number of obstructive apneas and hypopneas with ≥ 3% desaturation or arousal per hour of sleep) or high oxygen desaturation index (ODI; number of ≥ 3% desaturation from baseline saturation per hour of sleep) is associated wi...
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Authors: Shaina M. Willen, Mark Rodeghier, Carol L. Rosen, Michael R. DeBaun Tags: Research Article Source Type: research

Sleep disordered breathing does not predict acute severe pain episodes in children with sickle cell anemia
American Journal of Hematology,Volume 93, Issue 4, Page 478-485, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Source Type: research

A phase I/II trial of vorinostat (SAHA) in combination with rituximab ‐CHOP in patients with newly diagnosed advanced stage diffuse large B‐cell lymphoma (DLBCL): SWOG S0806
American Journal of Hematology,Volume 93, Issue 4, Page 486-493, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 478-485, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 486-493, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Source Type: research

A Phase I/II Trial of Vorinostat (SAHA) in Combination with Rituximab ‐CHOP in Patients with Newly Diagnosed Advanced Stage Diffuse Large B‐Cell Lymphoma (DLBCL): SWOG S0806
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 20, 2017 Category: Hematology Authors: Daniel O. Persky, Hongli Li, Lisa M. Rimsza, Paul M. Barr, Leslie L. Popplewell, Charles L. Bane, Ann Von Gehr, Michael LeBlanc, Richard I. Fisher, Sonali M. Smith, Jonathan W. Friedberg Tags: Research Article Source Type: research

Lack of correlation between heart, liver and pancreas MRI ‐R2*: Results from long term follow‐up in a cohort of adult β‐thalassemia major patients
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 19, 2017 Category: Hematology Authors: Valeria Maria Pinto, Lorenzo Bacigalupo, Barbara Gianesin, Manuela Balocco, Lucia De Franceschi, Roberto Malag ò, John Wood, Gian Luca Forni Tags: Correspondence Source Type: research

Efficacy and safety of rituximab for systemic lupus erythematosus ‐associated immune cytopenias. A multicenter retrospective cohort study of 71 adults
In conclusion, RTX seems effective and relatively safe for treating SLE‐associated immune cytopenias. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 17, 2017 Category: Hematology Authors: Alexandra Serris, Zahir Amoura, Florence Canou ï‐Poitrine, Benjamin Terrier, Eric Hachulla, Nathalie Costedoat‐Chalumeau, Thomas Papo, Olivier Lambotte, David Saadoun, Miguel Hié, Philippe Blanche, Bertrand Lioger, Jacques‐Eric Gottenberg, Bertran Tags: Research Article Source Type: research

The Role of Extracellular Matrix Stiffness in Megakaryocyte Development and Function
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 16, 2017 Category: Hematology Authors: Orly Leiva, Catherine Leon, Seng Kah Ng, Pierre Mangin, Christian Gachet, Katya Ravid Tags: Critical Review Source Type: research

Intravenous Immunoglobulin as Salvage Therapy for Refractory Thrombotic Thrombocytopenic Purpura
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 16, 2017 Category: Hematology Authors: Jennifer Ding, Maria R. Baer, John R. Hess, Ann B. Zimrin Tags: Correspondence Source Type: research

Design and Implementation of a Novel Advanced Training Curriculum in Hemoglobinopathies
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 11, 2017 Category: Hematology Authors: Richard Ward Tags: Correspondence Source Type: research

No Major Differences in Outcomes Between the Initial and Relapse Episodes in Patients with Thrombotic Thrombocytopenic Purpura: The Experience from the Ohio State University Registry
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 11, 2017 Category: Hematology Authors: Camila Masias, Haiwa Wu, Michael McGookey, Lauren Jay, Spero Cataland, Shangbin Yang Tags: Correspondence Source Type: research

Age is the only predictor of small decrease in lung function in children with sickle cell anemia
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 11, 2017 Category: Hematology Authors: Shaina M. Willen, Robyn Cohen, Mark Rodeghier, Fenella Kirkham, Susan S. Redline, Carol Rosen, Jane Kirkby, Michael R. DeBaun Tags: Research Article Source Type: research

Pure erythroid leukemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 11, 2017 Category: Hematology Authors: Barbara J. Bain Tags: Correspondence Source Type: research

Similar outcome of allogeneic stem cell transplantation after myeloablative and sequential conditioning regimen in patients with refractory or relapsed acute myeloid leukemia: A study from the Soci été Francophone de Greffe de Moelle et de Thérapie Cellulaire
Abstract Patients with acute myeloid leukemia (AML) in relapse or refractory to induction therapy have a dismal prognosis. Allogeneic hematopoietic stem cell transplantation is the only curative option. In these patients, we aimed to compare the results of a myeloablative transplant versus a sequential approach consisting in a cytoreductive chemotherapy followed by a reduced intensity conditioning regimen and prophylactic donor lymphocytes infusions. We retrospectively analyzed 99 patients aged 18‐50 years, transplanted for a refractory (52%) or a relapsed AML not in remission (48%). Fifty‐eight patients received a seq...
Source: American Journal of Hematology - December 11, 2017 Category: Hematology Authors: Justine Decroocq, Rapha ël Itzykson, Stéphane Vigouroux, Mauricette Michallet, Ibrahim Yakoub‐Agha, Anne Huynh, Florence Beckerich, Felipe Suarez, Patrice Chevallier, Stéphanie Nguyen‐Quoc, Marie‐Pierre Ledoux, Laurence Clement, Yosr Hicheri, Ga Tags: Research Article Source Type: research

Comparing Apples to Oranges: A commentary on the Mayo study of MYD88 significance in Waldenstrom's Macroglobulinemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 8, 2017 Category: Hematology Authors: Jorge J. Castillo, Joshua N. Gustine, Kirsten Meid, Lian Xu, Zachary R. Hunter, Steven P. Treon Tags: Correspondence Source Type: research

Successful liver transplantation for homozygous protein C deficiency with a Type II mutation using a heterozygous living related donor
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 8, 2017 Category: Hematology Authors: Alexander A. Boucher, Lori Luchtman ‐Jones, Jaimie D. Nathan, Joseph S. Palumbo Tags: Solving Clinical Problems in Blood Diseases Source Type: research

Clinical Experience with the BCL2 ‐inhibitor Venetoclax in Combination Therapy for Relapsed and Refractory Acute Myeloid Leukemia and Related Myeloid Malignancies
Conclusion: Low‐intensity chemotherapy, i.e. HMAs or LDAC, in combination with VEN is a viable salvage option, even in multiply relapsed/refractory patients with AML, MDS, and BPDCN. Notable responses were identified in patients with diploid/intermediate cytogenetics, RUNX1 and/or IDH1/2 mutations. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 8, 2017 Category: Hematology Authors: Courtney D DiNardo, Caitlin R Rausch, Christopher Benton, Tapan Kadia, Nitin Jain, Naveen Pemmaraju, Naval Daver, Wendy Covert, Kayleigh R Marx, Morgan Mace, Elias Jabbour, Jorge Cortes, Guillermo Garcia ‐Manero, Farhad Ravandi, Kapil N Bhalla, Hagop Ka Tags: Research Article Source Type: research

Myelodysplastic syndromes: 2018 update on diagnosis, risk ‐stratification and management
Abstract Disease overviewThe myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy. DiagnosisDiagnosis of MDS is based on morphological evidence of dysplasia upon visual examination of a bone marrow aspirate and biopsy. Information obtained from additional studies such as karyotype, flow cytometry or molecular genetics is usually complementary and may help refine diagnosis. Ri...
Source: American Journal of Hematology - December 7, 2017 Category: Hematology Authors: Guillermo Montalban ‐Bravo, Guillermo Garcia‐Manero Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Source Type: research

Issue information – table of contents
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 7, 2017 Category: Hematology Tags: ISSUE INFORMATION – TABLE OF CONTENTS Source Type: research

Laboratory tests for identification or exclusion of heparin induced thrombocytopenia: HIT or miss?
Abstract Heparin induced thrombocytopenia (HIT) is a potentially fatal condition that arises subsequent to formation of antibodies against complexes containing heparin, usually platelet‐factor 4‐heparin (“anti‐PF4‐heparin”). Assessment for HIT involves both clinical evaluation and, if indicated, laboratory testing for confirmation or exclusion, typically using an initial immunological assay (“screening”), and only if positive, a secondary functional assay for confirmation. Many different immunological and functional assays have been developed. The most common contemporary immunological assay...
Source: American Journal of Hematology - December 6, 2017 Category: Hematology Authors: Emmanuel J. Favaloro Tags: TEST OF THE MONTH Source Type: research

Macrophage activation syndrome and post ‐transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia
American Journal of Hematology,Volume 93, Issue 4, Page 588-589, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 2, 2017 Category: Hematology Source Type: research

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American Journal of Hematology,Volume 93, Issue 4, Page 588-589, April 2018. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 2, 2017 Category: Hematology Source Type: research

Hereditary xerocytosis: Diagnostic considerations
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Mary Risinger, Edyta Glogowska, Satheesh Chonat, Kejian Zhang, Neha Dagaonkar, Clinton H. Joiner, Charles T. Quinn, Theodosia A. Kalfa, Patrick G. Gallagher Tags: Correspondence Source Type: research

Comprehensive Management Reduces Incidence and Mortality of Acute Chest Syndrome in Patients with Sickle Cell Disease
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Givi Basishvili, Joseph Gotesman, Kathy Vandervoort, Charleen Jacobs, Leena Vattappally, Caterina P. Minniti Tags: Correspondence Source Type: research

Macrophage activation syndrome and post ‐transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: James O. J. Davies, Alice C. Hart, Josu De La Fuente, Barbara J. Bain Tags: Morphology Update Source Type: research

“Double‐hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Elise Chapiro, Claude Lesty, Cl émentine Gabillaud, Eric Durot, Simon Bouzy, Marine Armand, Magali Le Garff‐Tavernier, Nadia Bougacha, Stéphanie Struski, Audrey Bidet, Elodie Laharanne, Carole Barin, Lauren Veronese, Nolwen Prié, Virginie Eclache, Ba Tags: Research Article Source Type: research

The role of tmprss6 and hfe variants in iron deficiency anemia in celiac disease
Abstract We investigated the role of HFE C282Y, H63D and TMPRSS6 A736V variants in the pathogenesis of iron deficiency anemia (IDA) in celiac disease (CD) patients, at diagnosis and after 1‐year of gluten free diet (GFD). Demographic and clinical features were prospectively recorded for all CD patients between 2013 and 2017. C282Y, H63D and A736V variants were evaluated for CD patients and controls. Finally, 505 consecutive CD patients and 539 age‐matched control subjects were enrolled. At diagnosis, 229 CD subjects had IDA (45.3%), with a subgroup of anemic patients (45.4%) presented persistent IDA at follow‐up. C28...
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Luigia De Falco, Raffaella Tortora, Nicola Imperatore, Mariasole Bruno, Mario Capasso, Domenico Girelli, Annalisa Castagna, Nicola Caporaso, Achille Iolascon, Antonio Rispo Tags: Research Article Source Type: research

Survival Following Salvage Therapy for Primary Refractory Peripheral T ‐Cell Lymphomas (PTCL)
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Janie Y. Zhang, Robert Briski, Sumana Devata, Mark S. Kaminski, Tycel J. Phillips, Tera L. Mayer, Nathanael G. Bailey, Ryan A. Wilcox Tags: Research Article Source Type: research

Splanchnic vein thrombosis in patients with myeloproliferative neoplasms: The Mayo Clinic experience with 84 consecutive cases
(Source: American Journal of Hematology)
Source: American Journal of Hematology - December 1, 2017 Category: Hematology Authors: Sravanthi Lavu, Natasha Szuber, Mythri Mudireddy, Meera Yogarajah, Naseema Gangat, Animesh Pardanani, Curtis A. Hanson, Rhett P. Ketterling, Aneel A. Ashrani, Patrick S. Kamath, Ayalew Tefferi Tags: Correspondence Source Type: research