American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Meta-Analysis of C-Reactive Protein in Patients With Alzheimers Disease
Inflammation may be associated with Alzheimer’s disease (AD). This meta-analysis aimed to compare the level of C-reactive protein (CRP) in patients having AD to healthy controls. A total of 10 cross-sectional studies (n = 2093) were identified from PubMed and EMBASE after systematic searching and evaluation. The combined standardized mean difference (SMD) of CRP level between the disease and control group was analyzed. In the meta-analysis, there was no significant difference in serum between the CRP level of patients with AD and that of healthy controls (SMD: –0.400, 95% confidence interval [CI]: –0.827 ...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 19, 2016 Category: Geriatrics Authors: Gong, C., Wei, D., Wang, Y., Ma, J., Yuan, C., Zhang, W., Yu, G., Zhao, Y. Tags: Reviews Source Type: research

Editorial
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - April 19, 2016 Category: Geriatrics Authors: Chang, R. C.-C. Tags: Editorial Source Type: research

Promote the Health of Dementia Caregivers
Caregivers of people with Alzheimer’s dementia (AD) will become increasingly important as governments across the world cut health care funding. The vast majority of the care for people with AD is and will be carried out by informal caregivers, in other words, their spouses, children, and friends, people who typically have no training in this task and, certainly in the early days after diagnosis, little knowledge of what the person with AD is going through or what the future holds. The fact that people with AD face progressive cognitive and functional decline and that widespread individual differences are the norm rat...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Mark, R. E. Tags: Thoughts, Opinions and Controversies Source Type: research

Not Calm and Aminoff Suffering Syndrome in Advanced Alzheimers Disease
We studied 183 patients with advanced dementia who had been admitted to the Geriatric-Internal Medicine Department of a general hospital, with a 1 year follow-up evaluated by Mini-Suffering State Examination (MSSE) scores on first days after admission. The not calm compared to calm patients with advanced dementia had a high suffering level (6.12 ± 2.16 versus 3.21 ± 1.71) with a statistically significant difference (P = 0.001). The not calm patients were sicker, a higher percentage had fever (P = 0.005), elevated levels of white blood cells WBC (P = 0.003) and C-reactive protein (CRP) (P = 0.020). The Kaplan&...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Aminoff, B. Z. Tags: Current Topics in Research Source Type: research

Identification of Biomarkers Associated With Alzheimers Disease by Bioinformatics Analysis
Conclusion: The target genes SEC22B, RAB10, and FLT1 may be potential biomarkers of AD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Zhao, Y., Tan, W., Sheng, W., Li, X. Tags: Current Topics in Research Source Type: research

Quality Improvement in Skilled Nursing Facilities for Residents With Alzheimers Disease
Conclusion: The SNFs had >95% baseline performance in both the frequency of cognitive assessments and documented medication reviews. The percentage of residents who received a quality-of-life assessment and those who had a mental health care plan in place represent areas for improvement. As part of this activity, a toolkit was developed to help guide facilities and clinicians in instituting care improvements for residents with AD/dementia. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Farlow, M. R., Borson, S., Connor, S. R., Grossberg, G. T., Mittelman, M. S. Tags: Current Topics in Care Source Type: research

Effects of a Psychoeducational Intervention for Direct Care Workers Caring for People With Dementia: Results From a 6-Month Follow-Up Study
This study aimed to assess the effects of a psychoeducational intervention, designed to improve direct care workers’ stress, burnout and job satisfaction, and person-centered communicative behavior in people with dementia. A pretest–posttest control group design was conducted in 4 aged-care facilities. Two experimental facilities received a psychoeducational intervention, and 2 control facilities received an education only. Data were gathered from 53 care workers at baseline, immediately, and 6 months after the intervention, through self-administrated instruments and video-recorded morning care sessions. The ex...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Barbosa, A., Nolan, M., Sousa, L., Marques, A., Figueiredo, D. Tags: Current Topics in Care Source Type: research

Assessing Fluctuating Cognition in Dementia Diagnosis: Interrater Reliability of the Clinician Assessment of Fluctuation
This study assessed the reliability and validity of the Clinician Assessment of Fluctuation (CAF), which assesses FC in patients with dementia. Interrater agreement of CAF outcomes (FC present and FC severe) was evaluated between physicians and nonphysicians in 141 patients with Alzheimer’s disease (AD) or DLB. Frequency of CAF outcomes by clinical and neuropathological diagnosis was examined. We found that interrater reliability was fair on FC present and almost perfect on FC severe, and both outcomes were higher in patients with clinical DLB than with clinical AD and were qualitatively more often endorsed in cases ...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Van Dyk, K., Towns, S., Tatarina, O., Yeung, P., Dorrejo, J., Zahodne, L. B., Stern, Y. Tags: Current Topics in Care Source Type: research

Adherence to Medication Regimens is an Effective Indicator of Cognitive Dysfunction in Elderly Individuals
Conclusion: Declining IADL scores in the shopping and responsibility for own medications categories may be effective indices for predicting early-stage cognitive dysfunction in elderly individuals. Cognitive dysfunction screening at pharmacy counters may be useful. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Mizokami, F., Mase, H., Kinoshita, T., Kumagai, T., Furuta, K., Ito, K. Tags: Current Topics in Care Source Type: research

Caring for a Person With Amnestic Mild Cognitive Impairment
While much of the literature on caregiver burden has focused on caregiving for people living with Alzheimer's disease (AD) there is little information on the experience of caring for a loved one living with amnestic Mild Cognitive Impairment (aMCI), the group most likely to convert to AD. A hermeneutic phenomenological approach was used to understand the organizing principles that give experiences of being form and meaning in the lifeworld. Study findings highlight the precarious nature of caregiver role acquisition and the heterogeneity that is present among informal care providers. Specifically, the findings suggest that...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Woolmore-Goodwin, S., Kloseck, M., Zecevic, A., Fogarty, J., Gutmanis, I. Tags: Current Topics in Care Source Type: research

Perspectives of People with Dementia About Meaningful Activities: A Synthesis
Qualitative studies were synthesized to describe perspectives of people with dementia regarding meaningful activities. Themes of connectedness were identified using a meta-ethnography approach. The theme of being connected with self encompasses engagement for continuity, health promotion, and personal time. The theme of being connected with others includes being with others not to feel alone, doing an activity with others, and meaningful relationships. The theme of being connected with the environment encompasses being connected to one’s familiar environment, community, and nature. This synthesis suggests that connec...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Han, A., Radel, J., McDowd, J. M., Sabata, D. Tags: Reviews Source Type: research

From Subjective Cognitive Complaints to Dementia: Who Is at Risk?: A Systematic Review
Subjective cognitive complaints (SCCs) are frequent in the elderly population. The majority of individuals with subjective complaints never progress to significant cognitive decline, but some of them have a higher risk of progression to objective cognitive impairment than persons with no cognitive concerns. We performed a systematic review of community-based studies that focused on the progression risk associated with SCC and on the complainers’ characteristics associated with progression. Seventeen studies were included. As a group, SCCs are associated with a significantly higher risk of progression to dementia. Wor...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 16, 2016 Category: Geriatrics Authors: Mendonca, M. D., Alves, L., Bugalho, P. Tags: Reviews Source Type: research

Blood Pressure and the Risk of Alzheimers Disease: Is There a Link?
The objective of this study was to validate whether or not blood pressure is indeed associated with AD. We compared different prospective studies and ultimately found that it is also a controversial issue. Large prospective double-blinded and placebo-controlled studies conducted with the use of standardized outcome measures in different levels are necessary to assess the association of blood pressure and Alzheimer disease. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - January 13, 2016 Category: Geriatrics Authors: Yuan, M., Chen, S.-j., Li, X.-l., Xu, L.-j. Tags: Thoughts, Opinions and Controversies Source Type: research

Severe Impairment Rating Scale: A Useful and Brief Cognitive Assessment Tool for Advanced Dementia for Nursing Home Residents
To investigate the utility of the Severe Impairment Rating Scale (SIRS) as a cognitive assessment tool among nursing home residents with advanced dementia, we conducted a cross-sectional study of 96 residents in 3 nursing homes with Functional Assessment Staging Test (FAST) stage 6a and above. We compared the discriminatory ability of SIRS with the Chinese version of Mini-Mental State Examination, Abbreviated Mental Test, and Clock Drawing Test. Among the cognitive tests, SIRS showed the least "floor" effect and had the best capacity to distinguish very severe (FAST stages 7d-f) dementia (area under the curve 0.80 vs 0.46-...
Source: American Journal of Alzheimer's Disease and Other Dementias - January 13, 2016 Category: Geriatrics Authors: Yeo, C., Lim, W. S., Chan, M., Ho, X. Q., Anthony, P. V., Han, H. C., Chong, M. S. Tags: Current Topics in Research Source Type: research

Glucose Dysregulation Interacts With APOE-isin4 to Potentiate Temporoparietal Cortical Thinning
This study supports aggressive management of cerebrovascular factors and earlier preclinical detection of AD among individuals presenting with genetic and metabolic risks. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - January 13, 2016 Category: Geriatrics Authors: Foley, J. M., Salat, D. H., Stricker, N. H., McGlinchey, R. E., Milberg, W. P., Grande, L. J., Leritz, E. C. Tags: Current Topics in Research Source Type: research