American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vascular Function in Alzheimers Disease and Vascular Dementia
We investigated vascular functioning in patients with a clinical and radiological diagnosis of either Alzheimer’s disease (AD) or vascular dementia (VaD) and examined a possible relationship between vascular function and cognitive status. Twenty-seven patients with AD, 23 patients with VaD, and 26 healthy control patients underwent measurements of flow-mediated dilation (FMD), ankle–brachial index (ABI), cardioankle vascular index (CAVI), and intima–media thickness (IMT). The FMD was significantly lower in patients with AD or VaD compared to controls. There were no significant differences in ABI, CAVI, or...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Tachibana, H., Washida, K., Kowa, H., Kanda, F., Toda, T. Tags: Current Topics in Research Source Type: research

Retinal Nerve Fiber Layer Thinning in Alzheimers Disease: A Case-Control Study in Comparison to Normal Aging, Parkinsons Disease, and Non-Alzheimers Dementia
Retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and macular volume (MV) utilizing spectral domain optical coherence tomography (SD-OCT) were compared among patients with Alzheimer’s disease (AD) dementia, non-Alzheimer’s disease (non-AD) dementia, amnestic mild cognitive impairment (aMCI), Parkinson’s disease (PD), and age- and sex-matched controls in a cross-sectional cohort study. A total of 116 participants were diagnosed and evaluated (21 AD, 20 aMCI, 20 non-AD, 20 PD, and 34 controls) after comprehensive neurological, neuropsychology, and magnetic resonance imaging (M...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Pillai, J. A., Bermel, R., Bonner-Jackson, A., Rae-Grant, A., Fernandez, H., Bena, J., Jones, S. E., Ehlers, J. P., Leverenz, J. B. Tags: Current Topics in Research Source Type: research

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia
To investigate the value of hydrogen proton magnet resonance spectroscopy (1H-MRS) in the differential diagnosis of multiple-domain amnestic mild cognitive impairment (M-aMCI) and vascular cognitive impairment with no dementia (VCIND); 1H-MRS was performed in patients with M-aMCI and VCIND. The level was determined for N-acetylaspartate (NAA), glutamate (Glu), inositol (mI), choline (Cho), and creatine (Cr). Compared with the normal control group, the NAA–Cr ratio in all regions studied was significantly lower in the M-aMCI and VCIND groups. The Glu–Cr ratio in the posterior cingulate gyrus of the M-aMCI group ...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Chen, S.-Q., Cai, Q., Shen, Y.-Y., Xu, C.-X., Zhou, H., Zhao, Z. Tags: Current Topics in Research Source Type: research

Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimers Disease
Conclusion: These data suggest that TLJN might have protective effects and could potentially act to attenuate inflammatory stress in the pathogenesis of AD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Gao, A.-S., Du, H., Gao, Q., Wang, Y.-J., Wang, X.-Y., Liu, J.-W., Lu, B. Tags: Current Topics in Research Source Type: research

Toxicological Differences Between NMDA Receptor Antagonists and Cholinesterase Inhibitors
Cholinesterase inhibitors (ChEIs), represented by donepezil, rivastigmine, and galantamine, used to be the only approved class of drugs for the treatment of Alzheimer’s disease. After the approval of memantine by the Food and Drug Administration (FDA), N-methyl-d-aspartic acid (NMDA) receptor antagonists have been recognized by authorities and broadly used in the treatment of Alzheimer’s disease. Along with complementary mechanisms of action, NMDA antagonists and ChEIs differ not only in therapeutic effects but also in adverse reactions, which is an important consideration in clinical drug use. And the number o...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Shi, X., Lin, X., Hu, R., Sun, N., Hao, J., Gao, C. Tags: Current Topics in Research Source Type: research

Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure
Conclusion: This study found no difference in risk of dementia among the current and former users of ACEI/ARB as compared with the nonusers in an already at-risk HF population. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Chitnis, A. S., Aparasu, R. R., Chen, H., Kunik, M. E., Schulz, P. E., Johnson, M. L. Tags: Current Topics in Research Source Type: research

Association of Dementia and Peptic Ulcer Disease: A Nationwide Population-Based Study
Conclusion: Dementia might increase the risk of developing PUD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: Hsu, C.-C., Hsu, Y.-C., Chang, K.-H., Lee, C.-Y., Chong, L.-W., Lin, C.-L., Kao, C.-H. Tags: Current Topics in Research Source Type: research

A Systematic Review of Metacognitive Differences Between Alzheimers Disease and Frontotemporal Dementia
Clinicians often have difficulty distinguishing between various forms of dementia to achieve a correct diagnosis. Little research has been done to examine whether awareness of one’s cognitive deficits, or metacognitive monitoring, might differ between dementia diagnoses, thereby providing an additional means of differentiating between dementia subtypes. We review articles examining metacognitive comparisons between two of the most common dementia subtypes: Alzheimer’s disease and frontotemporal dementia. Greater monitoring deficits were apparent in frontotemporal dementia than in Alzheimer’s disease, and ...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 11, 2016 Category: Geriatrics Authors: DeLozier, S. J., Davalos, D. Tags: Review Source Type: research

Validation of Neuropsychological Tests to Screen for Dementia in Chinese Patients With Parkinsons Disease
To compare the accuracy of different neuropsychological tests and their combinations for deriving reliable cognitive indices for dementia diagnosis in Parkinson’s disease (PD). One hundred forty consecutive patients with PD were recruited and administrated an extensive battery of neuropsychological tests. Discriminant analysis and receiver–operator characteristic curve were used to evaluate their correct classifications and validity. Patients with PD having dementia (PDD; 23.5%) performed significantly worse in all tests than patients without dementia. Age of onset, disease duration, Hoehn-Yahr grade, Unified P...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Qiao, J., Wang, X., Lu, W., Cao, H., Qin, X. Tags: Current Topics in Research Source Type: research

Knowledge and Attitudes in Alzheimers Disease in a Cohort of Older African Americans and Caucasians
African American participation in Alzheimer’s disease (AD) research studies has been historically low. To determine whether older African Americans and Caucasians had different knowledge or attitudes related to AD, we administered the Alzheimer’s Disease Knowledge Scale (ADKS) to 67 older African Americans and 140 older caucasians in the greater Atlanta area as well as questions targeting locus of control over general health and AD risks. Older African Americans scored slightly lower on ADKS than older caucasians, with race only accounting for 1.57 (95% confidence interval [CI] 0.57-2.61, P < .001) points of...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Howell, J. C., Soyinka, O., Parker, M., Jarrett, T. L., Roberts, D. L., Dorbin, C. D., Hu, W. T. Tags: Current Topics in Research Source Type: research

Deficits in Attention and Visual Processing but not Global Cognition Predict Simulated Driving Errors in Drivers Diagnosed With Mild Alzheimers Disease
This study sought to predict driving performance of drivers with Alzheimer’s disease (AD) using measures of attention, visual processing, and global cognition. Simulated driving performance of individuals with mild AD (n = 20) was contrasted with performance of a group of healthy controls (n = 21). Performance on measures of global cognitive function and specific tests of attention and visual processing were examined in relation to simulated driving performance. Strong associations were observed between measures of attention, notably the Test of Everyday Attention (sustained attention; r = –.651, P = .002) and ...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Yamin, S., Stinchcombe, A., Gagnon, S. Tags: Current Topics in Research Source Type: research

Multisensory Stimulation as an Intervention Strategy for Elderly Patients With Severe Dementia: A Pilot Randomized Controlled Trial
The objective of this study was to compare the effect of multisensory stimulation environment (MSSE) and one-to-one activity sessions in the symptomatology of elderly individuals with severe dementia. Thirty-two participants were randomly assigned to the following 3 groups: MSSE, activity, and control group. The MSSE and activity groups participated in two 30-minute weekly sessions over 16 weeks. Pre-, mid-, and posttrial; 8-week follow-up behavior; mood; cognitive status; and dementia severity were registered. Patients in the MSSE group demonstrated a significant improvement in the Neuropsychiatric Inventory and Bedford A...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Sanchez, A., Marante-Moar, M. P., Sarabia, C., de Labra, C., Lorenzo, T., Maseda, A., Millan-Calenti, J. C. Tags: Current Topics in Research Source Type: research

Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimers Disease: An 18F-FDG-PET Study
Conclusion: Our data indicate that the changed glucose metabolism in cerebral regions in 18F-FDG-PET imaging could be an important predictor for early AD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Lu, Y., Ren, J., Cui, S., Chen, J., Huang, Y., Tang, C., Shan, B., Nie, B., Xinsheng, L. Tags: Current Topics in Research Source Type: research

Neuropsychological and Neuroanatomical Correlates of the Social Norms Questionnaire in Frontotemporal Dementia Versus Alzheimers Disease
Traditional neuropsychological batteries may not distinguish early behavioral variant frontotemporal dementia (bvFTD) from Alzheimer’s disease (AD) without the inclusion of a social behavioral measure. We compared 33 participants, 15 bvFTD, and 18 matched patients with early-onset AD (eAD), on the Social Norms Questionnaire (SNQ), neuropsychological tests and 3-dimensional T1-weighted magnetic resonance imaging (MRI). The analyses included correlations of SNQ results (total score, overendorsement or "overadhere" errors, and violations or "break" errors) with neuropsychological results and tensor-based morphometry reg...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Panchal, H., Paholpak, P., Lee, G., Carr, A., Barsuglia, J. P., Mather, M., Jimenez, E., Mendez, M. F. Tags: Current Topics in Research Source Type: research

Rapidly Versus Slowly Progressing Patients With Alzheimers Disease: Differences in Baseline Cognition
Rate of progression of cognitive deficits is variable among patients with Alzheimer’s disease (AD). The purpose of the current study was to compare demographic characteristics and performance on neuropsychological measures at baseline evaluation between rapidly and slowly progressing patients. Participants were divided into 2 groups based on change in Alzheimer’s Disease Assessment Scale-Cognitive subscale score from baseline to 2-year follow-up, and baseline performance was compared between the groups. Participants were 55 rapidly progressing and 55 slowly progressing patients with probable AD who had a follow...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2016 Category: Geriatrics Authors: Seidl, J. N. T., Massman, P. J. Tags: Current Topics in Research Source Type: research