Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies–like model
DiscussionSpecific active immunotherapy targeting Aβ and/or α-syn may be of potential interest for the treatment of dementia with Lewy bodies. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2019 Category: Geriatrics Source Type: research

Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease
DiscussionOur results demonstrate that vascular risk factors may enhance neurodegeneration but not amyloid accumulation in preclinical AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2019 Category: Geriatrics Source Type: research

Persistent impact of housing loss on cognitive decline after the 2011 Great East Japan earthquake and tsunami: Evidence from a 6-year longitudinal study
DiscussionExperiences of housing loss continued to be significantly associated with cognitive disability even six years after the disaster. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality
DiscussionEducation did not convey differential survival advantages to individuals with higher genetic risk of AD, but may reduce hospitalization risk associated with AD genetic risk. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Preventing dementia by preventing stroke: The Berlin Manifesto
This article summarizes the evidence for translation into action. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Strategic goals and roadmap for dementia prevention by stroke prevention
Publication date: July 2019Source: Alzheimer's & Dementia, Volume 15, Issue 7Author(s): Zaven S. Khachaturian, Lewis H. Kuller, Ara S. Khachaturian (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging
DiscussionIn a large cohort of Italian older individuals without cognitive impairment at baseline, a BF model was a short- and long-term predictor of overall dementia, particularly VaD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 3, 2019 Category: Geriatrics Source Type: research

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration
DiscussionIndividualized quantification of baseline brain atrophy is a promising predictor of progression in asymptomatic familial frontotemporal lobar degeneration mutation carriers. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 2, 2019 Category: Geriatrics Source Type: research

Bioinformatics strategy to advance the interpretation of Alzheimer's disease GWAS discoveries: The roads from association to causation
DiscussionInterpretation of LOAD-GWAS discoveries requires the integration of brain-specific functional genomic data sets and information related to regulatory activity. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 29, 2019 Category: Geriatrics Source Type: research

Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis
We examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age>75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment.ResultsIncreased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairment participants.DiscussionThere was an inverse association b...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 28, 2019 Category: Geriatrics Source Type: research