Alzheimer's Association Update
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: October 2019Source: Alzheimer's & Dementia, Volume 15, Issue 10Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Longitudinal study of self-reported hearing loss and subjective cognitive function decline in women
DiscussionSelf-reported hearing loss was associated with higher risk of incident subjective cognitive function decline in women. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people
This study offers robust evidence that brief cognitive testing could be a valuable addition to dementia prediction models. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2019 Category: Geriatrics Source Type: research

Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors
DiscussionAβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 12, 2019 Category: Geriatrics Source Type: research

Sex/gender differences in cognitive trajectories vary as a function of race/ethnicity
This study takes an important first step in understanding interactions between race/ethnicity and sex/gender on cognitive trajectories by demonstrating variability in sex/gender differences across race/ethnicity. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 10, 2019 Category: Geriatrics Source Type: research

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics
DiscussionThese results suggest that additional genetic variation in the APOE region influences AD risk beyond APOE E2/E3/E4. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 10, 2019 Category: Geriatrics Source Type: research

Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos
ConclusionLong sleep duration predicted seven-year cognitive decline. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 10, 2019 Category: Geriatrics Source Type: research

Association between enrollment factors and incident cognitive impairment in Blacks and Whites: Data from the Alzheimer's Disease Center
We examined the influence of enrollment factors demonstrated to differ by race on incident mild cognitive impairment and dementia using Alzheimer's Disease Center data.MethodsDifferences in rates of incident impairment between non-Latino Whites and Blacks (n = 12,242) were examined with age-at-progression survival models. Models included race, sex, education, source of recruitment, health factors, and family history of dementia.ResultsNo significant race differences in progression were observed in cognitively unimpaired participants. In those with mild cognitive impairment at baseline, Whites evidenced greater risk for p...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 8, 2019 Category: Geriatrics Source Type: research

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project
The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort.MethodsWe calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in post–positron emission tomography diagnosis and management change between “AUC-consistent” and “AUC-inconsistent” patients.ResultsAlmost half (250/507) of patients were AUC-consistent. In both AUC-consistent and AUC-inconsistent patients,...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 6, 2019 Category: Geriatrics Source Type: research

Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults
DiscussionLTPA both throughout life and later in life are associated with lower risk of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 4, 2019 Category: Geriatrics Source Type: research

Declining incidence of dementia: A national registry-based study over 20 years
DiscussionThis is the first study to report continuous time trends of incidence and prevalence in an entire national population. The incidence rate has declined steadily since 2003, while the total prevalence is still increasing. Future health care planning on prevention and treatment of dementia should take these findings into account. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 4, 2019 Category: Geriatrics Source Type: research