The National Institute on Aging and Alzheimer's Association research framework: A commentary from the Cochrane Dementia and Cognitive Improvement Group
Publication date: January 2019Source: Alzheimer's & Dementia, Volume 15, Issue 1Author(s): Jenny McCleery, Leon Flicker, Edo Richard, Terence J. Quinn (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 12, 2019 Category: Geriatrics Source Type: research

“Alzheimer's disease” is neither “Alzheimer's clinical syndrome” nor “dementia”
Publication date: January 2019Source: Alzheimer's & Dementia, Volume 15, Issue 1Author(s): William Jagust, Clifford R. Jack, David A. Bennett, Kaj Blennow, Samantha Budd Haeberlein, David M. Holtzman, Frank Jessen, Jason Karlawish, Enchi Liu, Jose Luis Molinuevo, Thomas Montine, Creighton Phelps, Katherine P. Rankin, Christopher C. Rowe, Philip Scheltens, Eric Siemers, Reisa Sperling (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 12, 2019 Category: Geriatrics Source Type: research

Vascular dysfunction—The disregarded partner of Alzheimer's disease
Publication date: January 2019Source: Alzheimer's & Dementia, Volume 15, Issue 1Author(s): Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Daniel A. Nation, Lon S. Schneider, Helena C. Chui, Michael G. Harrington, Judy Pa, Meng Law, Danny J.J. Wang, Russell E. Jacobs, Fergus N. Doubal, Joel Ramirez, Sandra E. Black, Maiken Nedergaard, Helene Benveniste, Martin Dichgans, Costantino Iadecola, Seth Love, Philip M. BathAbstractIncreasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently u...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 12, 2019 Category: Geriatrics Source Type: research

Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer's Disease Neuroimaging Initiative
We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative (ADNI).MethodsCN and MCI participants were identified as remaining stable, progressing, or reverting at 1-year of follow-up (Year 1). Application of ADNI's MCI criteria at Year 1 in addition to Alzheimer's disease biomarkers by group were examined.ResultsThe MCI-to-CN reversion rate was 3.0%. When specific components were examined, 22.5% of stable MCI participants had normal memory performance at Year 1 and their Alzheimer's disease biomarkers were consistent with the sta...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 12, 2019 Category: Geriatrics Source Type: research

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease
DiscussionOur study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case-control study. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 4, 2019 Category: Geriatrics Source Type: research

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease
DiscussionOur results provide new insight into AP composition. We demonstrate unexpected differences between AD, non-AD, and APP/PS1 mouse APs, which may relate to different pathological processes. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - January 3, 2019 Category: Geriatrics Source Type: research

Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016
Publication date: Available online 21 December 2018Source: Alzheimer's & DementiaAuthor(s): Andrew Sommerlad, Gayan Perera, Archana Singh-Manoux, Glyn Lewis, Robert Stewart, Gill Livingston (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 22, 2018 Category: Geriatrics Source Type: research

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need
Publication date: Available online 13 December 2018Source: Alzheimer's & DementiaAuthor(s): Ganesh M. Babulal, Yakeel T. Quiroz, Benedict C. Albensi, Eider Arenaza-Urquijo, Arlene J. Astell, Claudio Babiloni, Alex Bahar-Fuchs, Joanne Bell, Gene L. Bowman, Adam M. Brickman, Gaël Chételat, Carrie Ciro, Ann D. Cohen, Peggye Dilworth-Anderson, Hiroko H. Dodge, Simone Dreux, Steven Edland, Anna Esbensen, Lisbeth Evered, Michael EwersAbstractAlzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatical...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 14, 2018 Category: Geriatrics Source Type: research

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
DiscussionSCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 14, 2018 Category: Geriatrics Source Type: research

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease
DiscussionOur observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 12, 2018 Category: Geriatrics Source Type: research

Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
DiscussionDietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 4, 2018 Category: Geriatrics Source Type: research

Contents
Publication date: December 2018Source: Alzheimer's & Dementia, Volume 14, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 3, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2018Source: Alzheimer's & Dementia, Volume 14, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 3, 2018 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: December 2018Source: Alzheimer's & Dementia, Volume 14, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 3, 2018 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: December 2018Source: Alzheimer's & Dementia, Volume 14, Issue 12Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - December 3, 2018 Category: Geriatrics Source Type: research